Related references
Note: Only part of the references are listed.Characterizing Experimental Monoclonal Antibody Interactions and Clustering Using a Coarse-Grained Simulation Library and a Viscosity Model
Amjad Chowdhury et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2023)
Predictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks
Jonathan Schmitt et al.
mAbs (2023)
Investigating the Orientation of an Interfacially Adsorbed Monoclonal Antibody and Its Fragments Using Neutron Reflection
Sean Ruane et al.
MOLECULAR PHARMACEUTICS (2023)
Using Cluster Theory to Calculate the Experimental Structure Factors of Antibody Solutions
Nicholas Skar-Gislinge et al.
MOLECULAR PHARMACEUTICS (2023)
Simulation of high-concentration self-interactions for monoclonal antibodies from well-behaved to poorly-behaved systems
James K. K. Forder et al.
AICHE JOURNAL (2023)
Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis
W. Jiskoot et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2022)
Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics
Pin-Kuang Lai et al.
MABS (2022)
Viscosity Reduction and Stability Enhancement of Monoclonal Antibody Formulations Using Derivatives of Amino Acids
Arvind Srivastava et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2022)
Computational models for studying physical instabilities in high concentration biotherapeutic formulations
Marco A. Blanco
MABS (2022)
How neutron scattering techniques benefit investigating structures and dynamics of monoclonal antibody
Tingting Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2022)
Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
Matic Proj et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)
Self-diffusion of nonspherical particles fundamentally conflicts with effective sphere models
Felix Roosen-Runge et al.
JOURNAL OF PHYSICS-CONDENSED MATTER (2021)
Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements
Advait Badkar et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2021)
Molecular Flexibility of Antibodies Preserved Even in the Dense Phase after Macroscopic Phase Separation
Anita Girelli et al.
MOLECULAR PHARMACEUTICS (2021)
Adsorption of non-ionic surfactant and monoclonal antibody on siliconized surface studied by neutron reflectometry
Zhenhuan Zhang et al.
JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)
FDA approves 100th monoclonal antibody product
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2021)
Microscopic Dynamics of Liquid-Liquid Phase Separation and Domain Coarsening in a Protein Solution Revealed by X-Ray Photon Correlation Spectroscopy
Anita Girelli et al.
PHYSICAL REVIEW LETTERS (2021)
Caffeine as a Viscosity Reducer for Highly Concentrated Monoclonal Antibody Solutions
Yuhong Zeng et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2021)
Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters
Pin-Kuang Lai et al.
MABS (2021)
Physicochemical Stability of Monoclonal Antibodies: A Review
Yoann Le Basle et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2020)
Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction
Lorenzo Gentiluomo et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2020)
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
Cholpon Tilegenova et al.
MABS (2020)
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
James R. Apgar et al.
PLOS ONE (2020)
Comparison of Strategies in Development and Manufacturing of Low Viscosity, Ultra-High Concentration Formulation for IgG1 Antibody
Vaibhav Deokar et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2020)
Enhancing Stability and Reducing Viscosity of a Monoclonal Antibody With Cosolutes by Weakening Protein-Protein Interactions
Barton J. Dear et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2019)
Protein Short-Time Diffusion in a Naturally Crowded Environment
Marco Grimaldo et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2019)
Dynamic cluster formation determines viscosity and diffusion in dense protein solutions
Soeron von Buelow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Dynamics of proteins in solution
Marco Grimaldo et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2019)
Monoclonal Antibodies in Multiple Sclerosis: Present and Future
Natalia V. Voge et al.
BIOMEDICINES (2019)
The pharmacology and therapeutic applications of monoclonal antibodies
Maria Sofia Castelli et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2019)
Improvements to the APBS biomolecular solvation software suite
Elizabeth Jurrus et al.
PROTEIN SCIENCE (2018)
Viscosity Control of Protein Solution by Small Solutes: A Review
Taehun Hong et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2018)
Subcutaneous delivery of monoclonal antibodies: How do we get there?
Margarida Viola et al.
JOURNAL OF CONTROLLED RELEASE (2018)
Nanosecond Tracer Diffusion as a Probe of the Solution Structure and Molecular Mobility of Protein Assemblies: The Case of Ovalbumin
Christian Beck et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2018)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
High-concentration protein formulations: How high is high?
Patrick Garidel et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)
Impact of additives on the formation of protein aggregates and viscosity in concentrated protein solutions
Katharina Christin Bauer et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)
Effective Interactions and Colloidal Stability of Bovine γ-Globulin in Solution
Stefano Da Vela et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2017)
In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions
Dheeraj S. Tomar et al.
MABS (2017)
Strategic deployment of CHO expression platforms to deliver Pfizer's Monoclonal Antibody Portfolio
John J. Scarcelli et al.
BIOTECHNOLOGY PROGRESS (2017)
Effect of Hierarchical Cluster Formation on the Viscosity of Concentrated Monoclonal Antibody Formulations Studied by Neutron Scattering
P. Douglas Godfrin et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2016)
Ewald Summation for Molecular Simulations
Brad A. Wells et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Mechanism of Reversible Self-Association of a Monoclonal Antibody: Role of Electrostatic and Hydrophobic Interactions
Reza Esfandiary et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Intermolecular Interactions and the Viscosity of Highly Concentrated Monoclonal Antibody Solutions
Elaheh Binabaji et al.
PHARMACEUTICAL RESEARCH (2015)
The NeXus data format
Mark Koennecke et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2015)
Evaluation of the impact of viscosity, injection volume, and injection flow rate on subcutaneous injection tolerance
Cecile Berteau et al.
MEDICAL DEVICES-EVIDENCE AND RESEARCH (2015)
Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity
Eric J. Yearley et al.
BIOPHYSICAL JOURNAL (2014)
Explaining the Non-Newtonian Character of Aggregating Monoclonal Antibody Solutions Using Small-Angle Neutron Scattering
Maria Monica Castellanos et al.
BIOPHYSICAL JOURNAL (2014)
Validating Solution Ensembles from Molecular Dynamics Simulation by Wide-Angle X-ray Scattering Data
Po-chia Chen et al.
BIOPHYSICAL JOURNAL (2014)
Diffusion and Dynamics of γ-Globulin in Crowded Aqueous Solutions
Marco Grimaldo et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2014)
Mantid-Data analysis and visualization package for neutron scattering and μ SR experiments
O. Arnold et al.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT (2014)
Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties
Li Li et al.
PHARMACEUTICAL RESEARCH (2014)
In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
Vikas K. Sharma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
IgG subclasses and allotypes: from structure to effector functions
Gestur Vidarsson et al.
FRONTIERS IN IMMUNOLOGY (2014)
Small-Angle Neutron Scattering Characterization of Monoclonal Antibody Conformations and Interactions at High Concentrations
Eric J. Yearley et al.
BIOPHYSICAL JOURNAL (2013)
Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases
Michela Flego et al.
BMC MEDICINE (2013)
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
Jing Huang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2013)
Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations
Wayne G. Lilyestrom et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2013)
Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies
Zheng Guo et al.
PHARMACEUTICAL RESEARCH (2012)
Prediction of Hydrodynamic and Other Solution Properties of Rigid Proteins from Atomic- and Residue-Level Models
A. Ortega et al.
BIOPHYSICAL JOURNAL (2011)
PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions
Mats H. M. Olsson et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2011)
Software News and Updates MDAnalysis: A Toolkit for the Analysis of Molecular Dynamics Simulations
Naveen Michaud-Agrawal et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)
The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases
Valeria Bruno et al.
NEUROLOGICAL SCIENCES (2011)
Protein self-diffusion in crowded solutions
Felix Roosen-Runge et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies
Ron J. Keizer et al.
CLINICAL PHARMACOKINETICS (2010)
Specific Interactions in High Concentration Antibody Solutions Resulting in High Viscosity
Sandeep Yadav et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
Recent Backscattering Instrument Developments at the ILL and SNS
Bernhard Frick et al.
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS (2010)
Biopython: freely available Python tools for computational molecular biology and bioinformatics
Peter J. A. Cock et al.
BIOINFORMATICS (2009)
Short-time transport properties in dense suspensions:: From neutral to charge-stabilized colloidal spheres
Adolfo J. Banchio et al.
JOURNAL OF CHEMICAL PHYSICS (2008)
Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy
Alexandra Bonner et al.
JOURNAL OF IMMUNOLOGY (2008)
Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity
Sonoko Kanai et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Multiple Alignment of protein structures and sequences for VMD
J Eargle et al.
BIOINFORMATICS (2006)
Scalable molecular dynamics with NAMD
JC Phillips et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)
Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution
J Liu et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications, and information resources
NS Lipman et al.
ILAR JOURNAL (2005)
Human antibodies from transgenic animals
N Lonberg
NATURE BIOTECHNOLOGY (2005)
Small-angle scattering studies of biological macromolecules in solution
DI Svergun et al.
REPORTS ON PROGRESS IN PHYSICS (2003)
Interest of the normalized second virial coefficient and interaction potentials for crystallizing large macromolecules
F Bonneté et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2002)
Structure and dynamics of the TIP3P, SPC, and SPC/E water models at 298 K
P Mark et al.
JOURNAL OF PHYSICAL CHEMISTRY A (2001)
Crystal structure of a neutralizing human IgG against HIV-1: A template for vaccine design
EO Saphire et al.
SCIENCE (2001)
Extended corresponding-states behavior for particles with variable range attractions
MG Noro et al.
JOURNAL OF CHEMICAL PHYSICS (2000)
Confined molecular motions of globular proteins studied in powder samples and in solution
J Fitter
JOURNAL DE PHYSIQUE IV (2000)