4.7 Article

Improvement of the Effectiveness of HER2+Cancer Therapy by Use of Doxorubicin and Trastuzumab Modified Radioactive Gold Nanoparticles

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer

Rajesh Pradhan et al.

Summary: Triple-negative breast cancer (TNBC) is a deadly form of breast cancer, accounting for 15% of all breast cancer subtypes. Current treatments are not as effective in managing TNBC due to various factors such as poor bioavailability, low specificity, resistance to multiple drugs, limited cellular uptake, and undesirable side effects. Nano-therapeutics, a rapidly advancing field, offers promising alternatives for TNBC treatment by overcoming biological barriers, improving drug circulation, enhancing target-specific drug delivery, and increasing drug accumulation in tumor cells. This review article provides insights into the molecular mechanisms of TNBC, conventional therapies, and recent advancements in nano-carriers for TNBC management.

PHARMACEUTICS (2023)

Article Biochemistry & Molecular Biology

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+Cancers

Kinga Zelechowska-Matysiak et al.

Summary: In this study, a novel bioconjugate (DOX-AuNPs-Tmab) consisting of gold nanoparticles (AuNPs) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), was synthesized. The bioconjugate exhibited specific binding to HER2 receptors and demonstrated high specificity of binding and internalization capabilities to HER2-positive cancer cells. Cytotoxicity experiments showed that DOX-AuNPs-Tmab significantly reduced cancer cell metabolic activity and surface area of spheroids, inducing cell cycle arrest and late apoptosis. These findings suggest that DOX-AuNPs-Tmab has great potential for targeted therapy of HER2-positive tumors.

MOLECULES (2023)

Article Immunology

Near-infrared upconversion multimodal nanoparticles for targeted radionuclide therapy of breast cancer lymphatic metastases

Chuan Zhang et al.

Summary: This study presents a designed nanoprobe and nanonuclear drug for targeted therapy and prediction of lymph node metastasis in breast cancer. The nanoprobe effectively targets and accumulates in lymphatic metastasis, while the nanonuclear drug reduces the incidence and volume of lymph node metastasis. The nanoprobe and nanonuclear drug exhibit excellent stability and minimal toxicity. These findings provide potential alternatives for the diagnosis and treatment of lymph node metastasis.

FRONTIERS IN IMMUNOLOGY (2022)

Article Pharmacology & Pharmacy

Multifunctional Nanoparticles Based on Iron Oxide and Gold-198 Designed for Magnetic Hyperthermia and Radionuclide Therapy as a Potential Tool for Combined HER2-Positive Cancer Treatment

Michal Zuk et al.

Summary: This study synthesized nanoparticles for multimodal HER2-positive cancer treatment by coating a magnetic core with gold-198 and further modification, achieving targeted therapy effectively. The nanoparticles exhibited good heat mediator properties, specific binding and internalization capabilities towards HER2-positive cancer cells, and degradation ability on tumor spheroids.

PHARMACEUTICS (2022)

Article Biochemistry & Molecular Biology

Au@Pt Core-Shell Nanoparticle Bioconjugates for the Therapy of HER2+Breast Cancer and Hepatocellular Carcinoma. Model Studies on the Applicability of 193mPt and 195mPt Radionuclides in Auger Electron Therapy

Kamil Wawrowicz et al.

Summary: The study utilized core-shell nanoparticles for electron Auger therapy of breast cancer and hepatocellular carcinoma, demonstrating the cytotoxicity of platinum may be associated with the generation of reactive oxygen and reactive nitrogen species.

MOLECULES (2021)

Article Pharmacology & Pharmacy

Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

Dorota Nieciecka et al.

Summary: In this study, superparamagnetic iron oxide nanoparticles loaded with anticancer drugs were synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. The hybrid system showed promising properties in terms of size, morphology, magnetic properties, interactions with biological membranes, and cytotoxicity. The results obtained from magnetic hyperthermia and biological studies confirmed the effectiveness of the hybrid for future cancer cell treatment.

PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Encapsulation for Cancer Therapy

Xavier Montane et al.

MOLECULES (2020)

Letter Radiology, Nuclear Medicine & Medical Imaging

The case for combined chemotherapy-peptide receptor radionuclide therapy (chemo-PRRT) strategy in metastatic neuroendocrine tumor: predicting and looking at the possible case scenarios

Sandip Basu et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2016)

Article Nanoscience & Nanotechnology

Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies

Jolanda Spadavecchia et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Article Biotechnology & Applied Microbiology

Monitoring the effects of doxorubicin on 3D-spheroid tumor cells in real-time

NamHuk Baek et al.

ONCOTARGETS AND THERAPY (2016)

Article Chemistry, Multidisciplinary

CA4-loaded doxorubicin prodrug coating Fe3O4 nanoparticles for tumor combination therapy

Hongmei Liu et al.

RSC ADVANCES (2016)

Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

Article Medicine, Research & Experimental

Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer

Bin Chen et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

Article Cell & Tissue Engineering

Optimization of Aqueous Biphasic Tumor Spheroid Microtechnology for Anti-cancer Drug Testing in 3D Culture

Stephanie Lemmo et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody

Marek Pruszynski et al.

NUCLEAR MEDICINE AND BIOLOGY (2013)

Article Medicine, Research & Experimental

Role of Antibody-Mediated Tumor Targeting and Route of Administration in Nanoparticle Tumor Accumulation in Vivo

Niladri Chattopadhyay et al.

MOLECULAR PHARMACEUTICS (2012)

Article Multidisciplinary Sciences

Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer

Ravi Shukla et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Pharmacology & Pharmacy

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Stephanie Hirn et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

Review Biotechnology & Applied Microbiology

In vivo biodistribution of nanoparticles

Joao Paulo Mattos Almeida et al.

NANOMEDICINE (2011)

Article Engineering, Chemical

Folate-Receptor-Targeted Delivery of Doxorubicin Using Polyethylene Glycol-Functionalized Gold Nanoparticles

Bahareh Asadishad et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2010)

Article Nanoscience & Nanotechnology

Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor-bearing mice

Nripen Chanda et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2010)

Article Radiology, Nuclear Medicine & Medical Imaging

Current experience with mIBG therapy in combination with chemotherapy and radiosensitizers

Mark N. Gaze et al.

NUCLEAR MEDICINE AND BIOLOGY (2008)

Review Public, Environmental & Occupational Health

Nanomedicines and nanotoxicology: some physiological principles

M. C. Garnett et al.

OCCUPATIONAL MEDICINE-OXFORD (2006)

Review Oncology

Role of cell cycle in mediating sensitivity to radiotherapy

TM Pawlik et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

Article Oncology

DNA strand breaks and cell cycle perturbation in Herceptin treated breast cancer cell lines

S Mayfield et al.

BREAST CANCER RESEARCH AND TREATMENT (2001)