Porphyromonas gingivalis suppresses oral squamous cell carcinoma progression by inhibiting MUC1 expression and remodeling the tumor microenvironment

Review Cell Biology

The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence

Seyyede Fatemeh Hashemi et al.

Summary: Chemokines, including CXCL-17, play diverse roles in cancer pathogenesis. This review investigates the dual role of CXCL-17 in human malignancies and explores potential treatment options in cancer therapy.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2023)

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Article Engineering, Biomedical

Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy

Yuyue Zhao et al.

Summary: We have developed a nanoplatform capable of improving the immunosuppressive tumor microenvironment (TME) by actively targeting it. By camouflaging the surface of gold nanorods (GNRs) with myeloid-derived suppressor cells (MDSCs) membrane, we have achieved targeted adjustment of the TME. This nanoplatform also enables multimodal cancer imaging and dual immunotherapy.

BIOACTIVE MATERIALS (2023)

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Article Oncology

NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells

Li Guan et al.

Summary: Radiotherapy is a primary treatment for head and neck squamous cell carcinoma (HNSCC), but there is currently no reliable biomarker for predicting radioresistance. This study found that mutations in the NFE2L2 gene are associated with higher rates of locoregional failure in HNSCC patients treated with surgery and (chemo)radiotherapy. NFE2L2 mutations lead to radioresistance through Nrf2 activation, but this can be overcome by the glutaminase inhibitor CB-839.

CANCER RESEARCH (2023)

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Article Chemistry, Multidisciplinary

Intravenous Delivery of Living Listeria monocytogenes Elicits Gasdmermin-Dependent Tumor Pyroptosis and Motivates Anti-Tumor Immune Response

Yao Liu et al.

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ACS NANO (2022)

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Article Multidisciplinary Sciences

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

Tetsuhiro Harimoto et al.

Summary: This study developed a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides to enhance systemic delivery. The system allowed bacteria to temporarily evade immune attack and be effectively cleared in vivo. The results showed that this strategy increased the maximum tolerated dose of bacteria and improved anti-tumor efficacy.

CURRENT SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Microbiota in Tumors: From Understanding to Application

Yifan Xie et al.

Summary: Intratumor microbiota, as a potential component in tumor microenvironments, can affect tumor progression through various mechanisms. Its composition and abundance are highly heterogeneous in different types of tumors. Recent progress in studying intratumor microbiota using omics and immunological methods has provided insights into the development of antitumor treatment strategies.

ADVANCED SCIENCE (2022)

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Article Dentistry, Oral Surgery & Medicine

CD24 blockade promotes anti-tumor immunity in oral squamous cell carcinoma

Ke-Long Zou et al.

Summary: The high expression of CD24 in OSCC is associated with poor prognosis and is significantly correlated with CD68. Inhibiting CD24 can delay tumor growth, reduce TAMs number, increase T cell number, and impair tumor proliferation.

ORAL DISEASES (2022)

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Review Biochemistry & Molecular Biology

Altered glycosylation in cancer: A promising target for biomarkers and therapeutics

Divya Thomas et al.

Summary: Glycosylation is a crucial post-translational modification that plays a significant role in health and diseases. Aberrantly glycosylated proteins have been recognized as modulators of cancer cell phenotype, highlighting the potential of glycans as novel clinical biomarkers. The roles of glycans in tumor progression emphasize their promising target for cancer therapy.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Biochemistry & Molecular Biology

The effects of periodontitis associated microbiota on the development of oral squamous cell carcinoma

Xiaoyu Hu et al.

Summary: The research found that periodontitis positive correlated microbiota promotes the development of oral squamous cell carcinoma, while periodontitis negative correlated microbiota inhibits its development.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Oncology

MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans

Satish Sagar et al.

Summary: The study demonstrates that MUC4 enhances tumorigenesis in PDAC, increasing malignant properties and gemcitabine resistance through altering signaling pathways and expression of nucleoside transporters.

CANCER LETTERS (2021)

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Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope

Xinyu Lou et al.

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NANO-MICRO LETTERS (2021)

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Article Oncology

MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer

Nami Yamashita et al.

Summary: The study demonstrates that MUC1-C is a key regulator of the TNBC transcriptome through activation of the IFN-gamma pathway, leading to immunosuppression and depletion of TILs in the TNBC TIME. MUC1-C may be a potential target for improving TNBC treatment, especially in combination with ICIs, and is already being explored as a target for CAR T cells and ADCs in clinical development.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Multidisciplinary

Wrapping Porphyromonas gingivalis for tumor microenvironment immunomodulation and photothermal immunotherapy

Qi Chen et al.

Summary: The study introduces a new approach using red blood cell membrane-coated Porphyromonas gingivalis bacteria (cmPg) to modulate the ratio of M1 and M2 macrophages in the tumor microenvironment for cancer immunotherapy. The cm coating improves bacteria's size distribution, reduces their uptake by macrophages, and sustains the polarization behavior. Additionally, the melanin in cmPg serves as a photothermal therapy agent, enabling the conversion of light to heat and facilitating photothermal-induced immunogenic cell death of cancer cells.

NANO TODAY (2021)

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Article Microbiology

Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans

Caroline A. Werlang et al.

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NATURE MICROBIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers

Nicolas Jonckheere et al.

Summary: Mucin proteins are potential therapeutic targets in the progression of epithelial cancers, with their expression levels related to patient prognosis and associated with epigenetic regulatory mechanisms. Investigating the relationship between specific mucin-pattern expression and epigenetic regulation can lead to biomarkers with better specificity and sensitivity in various epithelial cancers.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Oncology

MUC1 is an oncoprotein with a significant role in apoptosis (Review)

Katarzyna Supruniuk et al.

Summary: MUC1 is a crucial protein involved in tumor development and resistance to treatment.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Yun-Fan Sun et al.

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Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

Degao Chen et al.

Summary: The article discusses the metabolic regulation between TME and TAMs. Immune molecules from TAMs and TME act as mediators of signal transduction. TAMs are influenced by metabolites produced in the TME.

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Review Dentistry, Oral Surgery & Medicine

Role of Porphyromonas gingivalis in oral squamous cell carcinoma development: A systematic review

Irene Lafuente Ibanez de Mendoza et al.

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Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

Sarah Greene et al.

CLINICAL CANCER RESEARCH (2020)

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Tumor-associated O-glycans of MUC1: Carriers of the glyco-code and targets for cancer vaccine design

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Mucins and the Microbiome

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Blockade of β-Catenin-Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration

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Unraveling mucin domains in cancer and metastasis: when protectors become predators

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Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells

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Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway

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TNFRSF11B activates Wnt/beta-catenin signaling and promotes gastric cancer progression

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Cancer-associated mucins: role in immune modulation and metastasis

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Possible role of Porphyromonas gingivalis in orodigestive cancers

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CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB

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LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway

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MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer

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Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral Epithelial Cells

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Porphyromonas gingivalis suppresses oral squamous cell carcinoma progression by inhibiting MUC1 expression and remodeling the tumor microenvironment

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