Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 67, Issue 21, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.202300185
Keywords
allyl isothiocyanate; anti-malarial activity; N-acetyl-S-(N-allylthiocarbamoyl)-l-cysteine; Plasmodium berghei; Plasmodium falciparum
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The study found that AITC can be metabolized into NAC-AITC, which exhibits anti-malarial activity against malaria parasites. These findings suggest that consuming AITC-containing foods may help prevent malaria.
Scope: Malaria remains one of the most important infectious diseases in the world. Allyl isothiocyanate (AITC) is a main ingredient of traditional spice Wasabia japonica, which is reported to have anti-bacterial and antiparasitic activities. However, there is no information on effects of AITC against malaria. The present study investigates the anti-malarial activity of dietary AITC in vivo and that of AITC metabolites in vitro.Methods and results: The ad libitum administration of 35, 175, or 350 mu M AITC-containing drinking water to ICR mice significantly inhibit the parasitemia induced after infection with Plasmodium berghei. On the other hand, after single oral administration of AITC (20 mg kg(-1) body weight), N-acetyl-S-(N-allylthiocarbamoyl)-l-cysteine (NAC-AITC) as one of the AITC metabolites displays a serum C-max of 11.4 mu M at a T(max )of 0.5 h, but AITC is not detected at any time point. Moreover, NAC-AITC shows anti-malarial activity against Plasmodium falciparum in vitro, and its 50% inhibitory concentration (IC50) against parasitemia is 12.6 mu M.Conclusions: These results indicate that orally administered AITC is metabolized to NAC-AITC and exerts anti-malarial activity against malaria parasites in blood, suggesting that the consumption of AITC-containing food stuffs such as cruciferous plants may prevent malaria.
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