☆ 4.6 Review

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease

MOLECULAR NEURODEGENERATION (2023)

Related references

Note: Only part of the references are listed.
Review Neurosciences

Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation

Sophie I. Hamstra et al.

Summary: Lithium is well-known for its mood-stabilizing effects in bipolar disorder treatment. Studies suggest that low doses of lithium may have beneficial effects on cardiovascular, musculoskeletal, metabolic, and cognitive function, as well as inflammatory and antioxidant processes. This review focuses on the potential benefits of low-dose lithium on the aging process and age-related diseases. Furthermore, it aims to provide mechanistic insights for future research in this field.

CURRENT NEUROPHARMACOLOGY (2023)

Add to Collection
Review Neurosciences

Memantine as a neuroprotective agent in ischemic stroke: Preclinical and clinical analysis

Diego Pichardo-Rojas et al.

Summary: The primary mechanism for neuron death after an ischemic stroke is excessive depolarization leading to NMDA-mediated calcium entry and subsequent cellular death. Memantine, a non-competitive NMDA receptor antagonist, has shown promising preclinical and clinical evidence as a neuroprotective drug for ischemic stroke. Clinical trials have found that high-dose memantine can improve neurological function and aphasia in poststroke patients, but limitations such as small sample sizes limit the impact of these findings. Further research is needed to conclusively determine if memantine improves outcomes in patients post-ischemic stroke.

FRONTIERS IN NEUROSCIENCE (2023)

Add to Collection
Article Neurosciences

NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine

Kenan Yildizhan et al.

Summary: TRPM2 channel is activated by excessive generation of mitochondrial and cytosolic ROS and influx of intracellular free Ca2+. The inhibitions of NMDA receptor and TRPM2 channel decrease ROS and apoptosis in neurons. The modulator role of memantine and NMDA via modulation of TRPM2 on oxidative neurodegeneration and apoptosis in SH-SY5Y cells was investigated. Inhibition of NMDA receptor via memantine treatment modulated HYP-mediated ROS, apoptosis, and TRPM2-induced excessive Ca2+ and may provide a strategy for protecting HYP-mediated neurodegenerative diseases.

BRAIN RESEARCH (2023)

Add to Collection
Letter Clinical Neurology

A new definition of brain reserve

Vladimir Hachinski et al.

Summary: Definitions of brain reserve are a subject of debate, but there is a need for a simplified and overarching definition that captures the concept of adapting to life hardships and preventing age-related neurological degeneration. Brain reserve is the lifelong, dynamic, and accumulating capacity to resist physical, emotional, and/or social harms, emphasizing the continuous development and exercise of the brain.

ALZHEIMERS & DEMENTIA (2022)

Add to Collection
Article Neurosciences

Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons

Lulu Yao et al.

Summary: NMDA subtype glutamate receptors play bidirectional roles in modulating the intrinsic excitability of inhibitory GABAergic neurons, depending on the subunit composition of NMDARs. These findings highlight the importance of NMDARs in inhibitory neurons and contribute to a better understanding of brain diseases.

JOURNAL OF NEUROSCIENCE (2022)

Add to Collection
Review Neurosciences

Role of Calcium Homeostasis in Ischemic Stroke: A Review

Abhilash Ludhiadch et al.

Summary: Stroke is the second leading cause of death worldwide, mainly due to insufficient oxygen supply to the brain. Calcium ions play a crucial role in cell death pathways, and disruption in calcium homeostasis can lead to ischemic cell death. Mitochondrial dysfunction is also associated with delayed neuronal death, triggered by calcium accumulation.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2022)

Add to Collection
Review Clinical Neurology

Genomics and Functional Genomics of Alzheimer's Disease

M. Ilyas Kamboh

Summary: Alzheimer's disease is a complex neurodegenerative disease with a lack of effective treatment, posing a major public health problem globally. Early-onset and late-onset AD exhibit different genetic characteristics, with late-onset showing high genetic heterogeneity. The discovery of APOE as a significant risk factor in 1993 paved the way for identifying 95 additional risk loci from 2009 to early 2022 through large genome-wide association studies.

NEUROTHERAPEUTICS (2022)

Add to Collection
Review Neurosciences

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration

Manish Verma et al.

Summary: Glutamate is a commonly used neurotransmitter in the central nervous system of mammals, but excessive levels can lead to excitotoxicity and neuronal cell death. Excitatory synaptic dysregulation also contributes to neurodegeneration. Optimizing mitochondrial calcium flux can prevent excitatory mitochondrial toxicity and provide neuroprotection in various diseases.

TRANSLATIONAL NEURODEGENERATION (2022)

Add to Collection
Article Clinical Neurology

Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A

Weiwei Zhong et al.

Summary: The study suggests that GluN3A deficiency may lead to Alzheimer's disease by causing neuronal hyperactivity, elevated intracellular Ca2+ levels, neuroinflammation, impaired synaptic integrity/plasticity, and neuronal loss. It also proposes GluN3A as an early biomarker and a therapeutic target independent of amyloid-beta/tau pathology in AD.

ALZHEIMERS & DEMENTIA (2022)

Add to Collection
Review Pharmacology & Pharmacy

Amyloid-beta Targeted Therapeutic Approaches for Alzheimer's Disease: Long Road Ahead

Yuxuan Dai et al.

Summary: Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline. Despite the challenges in developing disease-modifying treatments targeting amyloid plaques, recent studies have shown that active immunotherapy against amyloid-beta may have positive effects.

CURRENT DRUG TARGETS (2022)

Add to Collection
Review Neurosciences

Alzheimer's Disease: Key Insights from Two Decades of Clinical Trial Failures

C. Kwon Kim et al.

Summary: This review examines the failures in Alzheimer's disease drug development over the past two decades and derives key insights for future drug development. The success rate of AD drugs has been only 2.0% since 2003, with reasons for clinical trial failures including lack of evidence to initiate pivotal trials and design shortcomings. It is recommended that future AD therapeutic development should adhere to rational drug development principles.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Add to Collection
Review Neurosciences

Alzheimer's disease - the journey of a healthy brain into organ failure

Todd E. Golde

Summary: As the most common form of dementia, Alzheimer's disease (AD) has a significant impact on individuals, society, and the economy. While we have made progress in understanding the mechanisms underlying AD pathogenesis and diagnosing the disease, there are still many gaps in our knowledge. AD is not solely a disease of aging, as both heritable and non-heritable factors can influence the risk of developing the disease. In order to change how AD is perceived and managed, we need to address these knowledge gaps, develop more effective therapies, and intervene at the appropriate stage of the disease.

MOLECULAR NEURODEGENERATION (2022)

Add to Collection
Article Neurosciences

Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury

Pengyu Zong et al.

Summary: Enhanced excitotoxicity mediated by TRPM2-NMDAR coupling is identified as a novel mechanism underlying neuronal death in ischemic stroke, providing a potential therapeutic target.

NEURON (2022)

Add to Collection
Article Neurosciences

Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer's disease

Kaori Taniguchi et al.

Summary: Recent evidence suggests that soluble amyloid-beta oligomers (AβOs) play a key role in the development of Alzheimer's disease (AD). AβOs induce neurotoxic and synaptotoxic effects by binding to certain receptors, specifically the GluN2B subunits of NMDA receptors and mGluR1. This study highlights the significance of these receptors in synaptic pathology in AD.

NEUROSCIENCE RESEARCH (2022)

Add to Collection
Article

Aducanumab for Alzheimer's Disease: Summarized Data From EMERGE, ENGAGE, and PRIME Studies

Jaylan M. Yuksel et al.

Senior Care Pharmacist (2022)

Add to Collection
Review Cell Biology

Effectiveness of treatments for people living with severe dementia: A systematic review and meta-analysis of randomised controlled clinical trials

Elena Profyri et al.

Summary: This systematic review assessed the effectiveness of pharmacological and non-pharmacological treatments for severe dementia. The results indicate that pharmacological treatments may decrease disease severity and improve function, while non-pharmacological treatments may reduce neuropsychiatric symptoms. However, the quality of evidence is limited, highlighting the need for high-quality evidence and user-informed interventions for this underserved group.

AGEING RESEARCH REVIEWS (2022)

Add to Collection
Review Clinical Neurology

Mini review: Prospective therapeutic targets of Alzheimer's disease

Ruchi Mangal et al.

Summary: Alzheimer's disease is a common neurological condition that affects the elderly. There is currently no cure, but promising therapeutic targets have been identified in recent research.

BRAIN CIRCULATION (2022)

Add to Collection
Article Biochemistry & Molecular Biology

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Swagata Ghatak et al.

Summary: Early stages of human Alzheimer's disease (AD) show hyperexcitability in the brain, leading to extensive synapse loss and cognitive dysfunction, with no current disease-modifying therapy available. Utilizing human iPSC models may be a valuable tool for screening drugs to treat hyperexcitability and synaptic damage in AD, potentially increasing the chances of success in treatment.

MOLECULAR PSYCHIATRY (2021)

Add to Collection
Review Cell Biology

Building a Bridge Between NMDAR-Mediated Excitotoxicity and Mitochondrial Dysfunction in Chronic and Acute Diseases

Rodrigo G. Mira et al.

Summary: Glutamate, as a major excitatory neurotransmitter in the brain, is involved in synaptic plasticity and excitotoxicity through NMDAR receptors. Mitochondria also play a crucial role in calcium homeostasis, and disruption of this homeostasis can lead to neuronal death.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

Add to Collection
Review Pharmacology & Pharmacy

Novel Therapeutic Approach for Excitatory/Inhibitory Imbalance in Neurodevelopmental and Neurodegenerative Diseases

Swagata Ghatak et al.

Summary: The balance between excitation and inhibition in a neuronal network, known as excitatory/inhibitory (E/I) balance, is crucial for normal brain function. In pathological conditions, this balance can be disrupted, leading to E/I imbalance and network dysfunction. Developing therapies to rebalance neural networks is important for improving neurological function in diseases associated with E/I imbalance.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

Add to Collection
Article Neurosciences

Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer's Disease

Martina Stazi et al.

Summary: The study demonstrates that chronic treatment with memantine has positive effects on an Alzheimer's disease mouse model, such as reducing neuron loss and improving cognitive function.

MOLECULAR NEUROBIOLOGY (2021)

Add to Collection
Article Neurosciences

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Dorit Trudler et al.

Summary: In Parkinson's disease, synaptic and neuronal loss are prominent features. The study reveals that alpha Syn oligomers induce excessive glutamate release from astrocytes, activating NMDARs on neurons and leading to synaptic damage. However, the drug NitroSynapsin shows promise in protecting synapses from alpha Syn-induced damage.

JOURNAL OF NEUROSCIENCE (2021)

Add to Collection
Review Neurosciences

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease

Audrey Hector et al.

Summary: Recent studies suggest that memory decline in early stages of Alzheimer's disease may be related to neuronal hyperactivity induced by soluble amyloid-beta oligomers, rather than hypoactivity as traditionally believed. Evidence shows that A beta o may induce neuronal hyperactivity in AD animal models, in vitro, and in humans. Cellular and molecular mechanisms are emerging to explain how A beta o induces neuronal hyperactivity, with implications for developing disease-modifying interventions at the onset of AD.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Add to Collection
Article Materials Science, Biomaterials

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease

Juan Yin et al.

Summary: The study successfully generated Alzheimer's disease (AD) models in a human genetic context using self-organizing 3D brain organoids, characterizing them through morphology analysis, neuronal activity, drug sensitivity, and neural apoptosis to find that the AD organoids recapitulated AD-like pathology effectively.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

Add to Collection
Editorial Material Clinical Neurology

ENGAGE and EMERGE: Truth and consequences?

Lewis H. Kuller et al.

Summary: The potential benefit of the anti-amyloid drug aducanumab has sparked controversy based on recent clinical trial results, with conflicting opinions within the FDA and debate on whether it should be approved. The implications for treating MCI and Alzheimer's disease patients with anti-amyloid drugs are significant, as well as the brain amyloid-AD-dementia hypothesis.

ALZHEIMERS & DEMENTIA (2021)

Add to Collection
Article Clinical Neurology

Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits

Briana K. Chen et al.

Summary: The study showed that compared to memantine, fluoroethylnormemtantine (FENM) did not produce nonspecific side effects in animal experiments, reduced immobility in the forced swim test, and significantly facilitated fear extinction learning.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Hippocampal hyperactivity in a rat model of Alzheimer's disease

Liudmila Sosulina et al.

Summary: The study found that increased intrinsic excitability of CA1 neurons in early stages of Alzheimer's disease may precede inhibitory dysfunction in disease progression.

JOURNAL OF NEUROCHEMISTRY (2021)

Add to Collection
Review Neurosciences

Entering a new era of quantifying glutamate clearance in health and disease

Kyle J. Brymer et al.

Summary: Glutamate transporter proteins play a crucial role in regulating neuronal activity, with dysfunction implicated in various CNS diseases. Rapid glutamate uptake is essential for preventing toxic accumulation and ensuring efficient excitatory network activity.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Add to Collection
Article Cell Biology

Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer's disease

Liangmiao Wu et al.

Summary: The novel compound MN-08 was found to inhibit Aβ accumulation, prevent neuronal and dendritic spine loss, and improve cognitive deficits in mouse models of AD. MN-08 also demonstrated the ability to antagonize NMDA receptors and prevent neuronal loss in vitro. These findings suggest that MN-08 could be a promising therapeutic agent for AD.

AGING CELL (2021)

Add to Collection
Article Neurosciences

Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior

Briana K. Chen et al.

Summary: The novel NMDA receptor antagonist FENM was characterized, showing efficacy when administered at various time points before or after stress. It reduced behavioral despair, facilitated extinction learning, and attenuated learned fear, demonstrating potential as a prophylactic and/or antidepressant.

BIOLOGICAL PSYCHIATRY (2021)

Add to Collection
Review Neurosciences

Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer's Disease

Luisa Mueller et al.

Summary: Transgenic mouse models provide valuable insights into the pathogenesis of Alzheimer's disease and its impact on neuronal function, with implications for potential therapeutic interventions and the monitoring of amyloid-related neuronal dysfunction.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Add to Collection
Article Neurosciences

Mortality After Ischemic Stroke in Patients with Alzheimer's Disease Dementia and Other Dementia Disorders

Eva Zupanic et al.

Summary: This study analyzed predictors of death after stroke in patients with dementia and found that dementia was an independent predictor of death compared with non-dementia patients. Differences in receiving intravenous thrombolysis between patients with and without dementia disappeared after 2015.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Add to Collection
Review Neurosciences

Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression

Katarzyna M. Grochowska et al.

Summary: Pyramidal neurons have complex dendritic trees decorated by numerous spine synapses receiving excitatory input. Synaptic signals not only act locally but are also transmitted to the nucleus of the postsynaptic neuron to regulate gene expression. Protein transport from synapse to nucleus has been shown to encode and decode synaptic signals, with a focus on the synapto-nuclear messenger protein Jacob and its potential role in hippocampal neuronal plasticity.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2021)

Add to Collection
Article Ethics

Alzheimer's and Aducanumab: Unjust Profits and False Hopes

Leonard M. Fleck

Summary: The accelerated approval of aducanumab by the U.S. Food and Drug Administration for mild Alzheimer's on June 7, 2021, has sparked significant medical, scientific, and ethical controversy. Despite reducing beta-amyloid, the approval goes against the nearly unanimous judgment of the FDA's Advisory Committee due to limited reliable evidence of significant benefit. The approval has raised three major ethical concerns: unjust utilization of Medicare resources, ethical pressure on physicians to provide the drug to patients, and the generation of false hopes among patients.

HASTINGS CENTER REPORT (2021)

Add to Collection
Article Clinical Neurology

The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke

Nahid Beladi Moghadam et al.

Summary: The study demonstrated that memantine has a significant impact on neurologic function and serum MMP concentrations in patients with ischemic stroke, suggesting its potential as a neuroprotective agent.

JOURNAL OF CLINICAL NEUROSCIENCE (2021)

Add to Collection
Article Geriatrics & Gerontology

Amyloid-β(1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex

Olayemi Joseph Olajide et al.

Summary: The study found that Aβ(1-42) can rapidly disrupt glutamatergic transmission in the entorhinal cortex, primarily by affecting molecular levels presynaptically and postsynaptically, and involving concurrent activation of GluN2A- and GluN2B-containing NMDA receptors.

NEUROBIOLOGY OF AGING (2021)

Add to Collection
Article Neurosciences

Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance

Giovanna Crivellaro et al.

Summary: Migraine is a common but poorly understood sensory circuit disorder. Mouse models of familial hemiplegic migraine show increased susceptibility to cortical spreading depression, which is mainly caused by reduced expression of astrocytic Na+, K+-ATPases. The enhanced NMDAR activation in FHM2 mice is activity-dependent and can be rescued by inhibition of GluN1-N2B NMDARs.

NEUROBIOLOGY OF DISEASE (2021)

Add to Collection
Article Neurosciences

Lithium: A therapeutic option in Alzheimer's disease and its prodromal stages?

Robert Haussmann et al.

Summary: Studies suggest that lithium may help alleviate Alzheimer's disease pathology and promote adult hippocampal neurogenesis, leading to procognitive effects in patients. However, further evaluation is needed to determine the therapeutic efficacy of lithium in Alzheimer's disease and its prodromal stages.

NEUROSCIENCE LETTERS (2021)

Add to Collection
Review Neurosciences

Delta- and beta-secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease

Yiyuan Xia et al.

Summary: The newly identified delta-secretase, AEP, cleaves both APP and Tau, promoting Alzheimer's disease. It also cleaves BACE1, enhancing its enzymatic activity and contributing to senile plaque deposition in AD. The interaction between delta-secretase and BACE1 worsens AD pathogenesis.

PROGRESS IN NEUROBIOLOGY (2021)

Add to Collection
Article Medicine, Research & Experimental

An Investigation of Levetiracetam in Alzheimer's Disease (ILiAD): a double-blind, placebo-controlled, randomised crossover proof of concept study

Arjune Sen et al.

Summary: This study investigates whether the anti-seizure medication levetiracetam can help cognitive function in patients with dementia, showing potential therapeutic benefits.

TRIALS (2021)

Add to Collection
Article Psychiatry

Neurocognitive Effects of Ketamine and Esketamine for Treatment-Resistant Major Depressive Disorder: A Systematic Review

Breno Souza-Marques et al.

Summary: This study systematically reviewed the neurocognitive effects of ketamine and esketamine in patients with treatment-resistant major depressive disorder, finding that these drugs do not seem to have significant deleterious effects on cognitive function and certain brain areas, and may even be beneficial for patients.

HARVARD REVIEW OF PSYCHIATRY (2021)

Add to Collection
Review Neurosciences

Ketamine: Neuroprotective or Neurotoxic?

Divya Choudhury et al.

Summary: Ketamine, a non-competitive NMDAR antagonist, has been used as an intravenous anesthetic since the 1970s and is now being explored for its rapid antidepressant effects in treating various neuropsychiatric syndromes. Studies have shown that ketamine exhibits both neurotoxic and neuroprotective properties depending on the context, affecting intracellular signaling pathways in complex ways. It acts as a powerful activator of neurotrophic signaling cascades at subanesthetic doses, showcasing contrasting neuroprotective and neurotoxic characteristics.

FRONTIERS IN NEUROSCIENCE (2021)

Add to Collection
Article Neurosciences

NMDAR-dependent somatic potentiation of synaptic inputs is correlated with β amyloid-mediated neuronal hyperactivity

Yifei Bao et al.

Summary: The chronic suppression of glutamate reuptake leads to accumulation of ambient glutamate, which can diffuse to the soma and elevate cell excitability. Somatic potentiation of synaptic inputs may represent a novel amplification mechanism that contributes to neuronal hyperactivity in Alzheimer's disease initiated by impaired glutamate reuptake.

TRANSLATIONAL NEURODEGENERATION (2021)

Add to Collection
Article Clinical Neurology

Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019

David S. Knopman et al.

Summary: Aducanumab recently underwent two large phase III clinical trials that were stopped prematurely by the sponsor due to divergent outcomes. One trial showed potential benefits from high doses of Aducanumab, while the other did not show any benefits. Further analysis is needed to determine the true efficacy as a treatment for Alzheimer's disease.

ALZHEIMERS & DEMENTIA (2021)

Add to Collection
Article Clinical Neurology

Amyloid pathology-produced unexpectedmodifications of calcium homeostasis in hippocampal subicular dendrites

Sergio L. Angulo et al.

ALZHEIMERS & DEMENTIA (2020)

Add to Collection
Review Pharmacology & Pharmacy

Excitotoxicity as a Target Against Neurodegenerative Processes

Octavio Binvignat et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Add to Collection
Article Neurosciences

A novel method using ambient glutamate for the electrophysiological quantification of extrasynaptic NMDA receptor function in acute brain slices

Alexander Moldavski et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease

Yingyue Zhou et al.

NATURE MEDICINE (2020)

Add to Collection
Review Clinical Neurology

Risk of hemorrhagic and ischemic stroke in patients with Alzheimer disease: A synthesis of the literature

Reem Waziry et al.

NEUROLOGY (2020)

Add to Collection
Review Pharmacology & Pharmacy

Psychological Stress-Induced Immune Response and Risk of Alzheimer's Disease in Veterans from Operation Enduring Freedom and Operation Iraqi Freedom

Duraisamy Kempuraj et al.

CLINICAL THERAPEUTICS (2020)

Add to Collection
Article Cell Biology

CaMKII/calpain interaction mediates ischemia/reperfusion injury in isolated rat hearts

Hong-Ting Lu et al.

CELL DEATH & DISEASE (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Erik C. B. Johnson et al.

NATURE MEDICINE (2020)

Add to Collection
Review Pharmacology & Pharmacy

Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

Kevin Mullane et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Add to Collection
Article Multidisciplinary Sciences

GluN2D-mediated excitatory drive onto medial prefrontal cortical PV plus fast-spiking inhibitory interneurons

Jonathan Garst-Orozco et al.

PLOS ONE (2020)

Add to Collection
Article Cell Biology

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

Sara Fernandez-Garcia et al.

CELL DEATH & DISEASE (2020)

Add to Collection
Article Multidisciplinary Sciences

Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants

Jing Yan et al.

SCIENCE (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus

Gustavo A. Rodriguez et al.

PLOS BIOLOGY (2020)

Add to Collection
Review Neurosciences

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

Dennis W. Choi

FRONTIERS IN NEUROSCIENCE (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer's Disease

Sofia Toniolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection
Article Multidisciplinary Sciences

The role of dissociation in ketamine's antidepressant effects

Elizabeth D. Ballard et al.

NATURE COMMUNICATIONS (2020)

Add to Collection
Article Pharmacology & Pharmacy

Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice

Ya Wang et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection
Review Clinical Neurology

Updates on the association of brain injury and Alzheimer's disease

Kara Klomparens et al.

BRAIN CIRCULATION (2020)

Add to Collection
Review Anesthesiology

A Review of Nonanesthetic Uses of Ketamine

Abby Pribish et al.

ANESTHESIOLOGY RESEARCH AND PRACTICE (2020)

Add to Collection
Review Clinical Neurology

Therapeutic Strategies Targeting Amyloid-β in Alzheimer's Disease

Lidia Pinheiro et al.

CURRENT ALZHEIMER RESEARCH (2019)

Add to Collection
Article Clinical Neurology

Neurocognitive performance and repeated-dose intravenous ketamine in major depressive disorder

Wei Zheng et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

Add to Collection
Article Medicine, General & Internal

The Alzheimer's Disease Clinical Spectrum Diagnosis and Management

Alireza Atri

MEDICAL CLINICS OF NORTH AMERICA (2019)

Add to Collection
Review Neurosciences

The Role of NMDA Receptors in Alzheimer's Disease

Jinping Liu et al.

FRONTIERS IN NEUROSCIENCE (2019)

Add to Collection
Article Biochemical Research Methods

High-speed imaging of glutamate release with genetically encoded sensors

Celine D. Duerst et al.

NATURE PROTOCOLS (2019)

Add to Collection
Article Multidisciplinary Sciences

Tau is required for the function of extrasynaptic NMDA receptors

Noemi Pallas-Bazarra et al.

SCIENTIFIC REPORTS (2019)

Add to Collection
Article Neurosciences

Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

Ashleigh Duthie et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Structural biology of glutamate receptor ion channels: towards an understanding of mechanism

Ingo H. Greger et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)

Add to Collection
Review Clinical Neurology

Hyperbaric oxygen therapy: A new look on treating stroke and traumatic brain injury

Bella Gonzales-Portillo et al.

BRAIN CIRCULATION (2019)

Add to Collection
Review Cell Biology

Comparative efficacy and safety of cognitive enhancers for treating vascular cognitive impairment: systematic review and Bayesian network meta-analysis

Bo-Ru Jin et al.

NEURAL REGENERATION RESEARCH (2019)

Add to Collection
Review Geriatrics & Gerontology

Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer's Disease: Systematic Review and Network Metaanalysis

Andrea C. Tricco et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2018)

Add to Collection
Review Cell Biology

The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia

Lin-Hua Jiang et al.

AGEING RESEARCH REVIEWS (2018)

Add to Collection
Article Behavioral Sciences

Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease

Lauren S. Whyte et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

Add to Collection
Article Neurosciences

The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK

Razieh Mohammad Jafari et al.

BRAIN RESEARCH BULLETIN (2018)

Add to Collection
Review Biochemistry & Molecular Biology

Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

Balazs Pal

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

Add to Collection
Article Neurosciences

Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-D-aspartate receptor GluN3A subunit

Jin Hwan Lee et al.

EXPERIMENTAL NEUROLOGY (2018)

Add to Collection
Review Pharmacology & Pharmacy

Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder

Madia Lozupone et al.

EXPERT OPINION ON PHARMACOTHERAPY (2018)

Add to Collection
Review Neurosciences

Memantine for the Treatment of Dementia: A Review on its Current and Future Applications

Jaume Folch et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Add to Collection
Review Neurosciences

The Amyloid-beta Oligomer Hypothesis: Beginning of the Third Decade

Erika N. Cline et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Add to Collection
Article Genetics & Heredity

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Rainer Malik et al.

NATURE GENETICS (2018)

Add to Collection
Article Medicine, Research & Experimental

Safety and Optimal Neuroprotection of neu2000 in acute Ischemic stroke with reCanalization: study protocol for a randomized, double-blinded, placebo-controlled, phase-II trial

Ji Man Hong et al.

TRIALS (2018)

Add to Collection
Article Neurosciences

Lithium Inhibits GSK3β and Augments GluN2A Receptor Expression in the Prefrontal Cortex

Sarah A. Monaco et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Add to Collection
Review Geriatrics & Gerontology

Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications

Md. Sahab Uddin et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Add to Collection
Review Neurosciences

Targeting NMDA receptors in stroke: new hope in neuroprotection

Qiu Jing Wu et al.

MOLECULAR BRAIN (2018)

Add to Collection
Review Neurosciences

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

Fuyuki Kametani et al.

FRONTIERS IN NEUROSCIENCE (2018)

Add to Collection
Article Psychiatry

Expression of NMDA receptor subunits in human blood lymphocytes: A peripheral biomarker in online computer game addiction

Mitra-Sadat Sadat-Shirazi et al.

JOURNAL OF BEHAVIORAL ADDICTIONS (2018)

Add to Collection
Article Geriatrics & Gerontology

Fibronectin induces the perivascular deposition of cerebrospinal fluid-derived amyloid-β in aging and after stroke

Matthew D. Howe et al.

NEUROBIOLOGY OF AGING (2018)

Add to Collection
Article Neurosciences

Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

Thuy-Vi V. Nguyen et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Add to Collection
Article Multidisciplinary Sciences

Structures and gating mechanism of human TRPM2

Longfei Wang et al.

SCIENCE (2018)

Add to Collection
Article Multidisciplinary Sciences

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Teddy Grand et al.

NATURE COMMUNICATIONS (2018)

Add to Collection
Article Public, Environmental & Occupational Health

A phenotyping algorithm to identify acute ischemic stroke accurately from a national biobank: the Million Veteran Program

Tasnim F. Imran et al.

CLINICAL EPIDEMIOLOGY (2018)

Add to Collection
Review Physiology

Triheteromeric NMDA receptors: from structure to synaptic physiology

David Stroebel et al.

CURRENT OPINION IN PHYSIOLOGY (2018)

Add to Collection
Article Clinical Neurology

Long-term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice

Michael Qize Jiang et al.

BRAIN PATHOLOGY (2017)

Add to Collection
Article Oncology

Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke

Bin Chen et al.

EXPERIMENTAL CELL RESEARCH (2017)

Add to Collection
Review Neurosciences

Role of Glutamate and NMDA Receptors in Alzheimer's Disease

Rui Wang et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Add to Collection
Review Immunology

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

Hilmar Bading

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Add to Collection
Article Medicine, Research & Experimental

Memantine improves semantic memory in patients with amnestic mild cognitive impairment: A single-photon emission computed tomography study

Demet Ilhan Algin et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2017)

Add to Collection
Review Clinical Neurology

Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease

Rebecca P. Haberman et al.

NEUROTHERAPEUTICS (2017)

Add to Collection
Article Neurosciences

Preconditioning in neuroprotection: From hypoxia to ischemia

Sijie Li et al.

PROGRESS IN NEUROBIOLOGY (2017)

Add to Collection
Article Multidisciplinary Sciences

Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

Qian Yang et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Review Clinical Neurology

On the path to 2025: understanding the Alzheimer's disease continuum

Paul S. Aisen et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Add to Collection
Review Neurosciences

The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind

Roberta Ricciarelli et al.

CURRENT NEUROPHARMACOLOGY (2017)

Add to Collection
Review Clinical Neurology

Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis

Ottavio Arancio et al.

ALZHEIMERS & DEMENTIA (2017)

Add to Collection
Review Medicine, General & Internal

Post-stroke dementia - a comprehensive review

Milija D. Mijajlovic et al.

BMC MEDICINE (2017)

Add to Collection
Article Hematology

Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation

Ming-Yi Shen et al.

BLOOD (2016)

Add to Collection
Article Anatomy & Morphology

Expression of the NMDA receptor subunit GluN3A (NR3A) in the olfactory system and its regulatory role on olfaction in the adult mouse

Jin Hwan Lee et al.

BRAIN STRUCTURE & FUNCTION (2016)

Add to Collection
Article Neurosciences

Tonically active NMDA receptors - a signalling mechanism critical for interneuronal excitability in the CA1 stratum radiatum

Ilse Riebe et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons

Karen Siaw-Ling Wee et al.

NEUROCHEMICAL RESEARCH (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Stroke injury, cognitive impairment and vascular dementia

Raj N. Kalaria et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Add to Collection
Review Neurosciences

Stroke, Vascular Dementia, and Alzheimer's Disease: Molecular Links

Murali Vijayan et al.

JOURNAL OF ALZHEIMERS DISEASE (2016)

Add to Collection
Article Neurosciences

Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis

Brooke L. Sinnen et al.

JOURNAL OF NEUROSCIENCE (2016)

Add to Collection
Review Critical Care Medicine

Inhibition of Glycogen Synthase Kinase-3: An Emerging Target in the Treatment of Traumatic Brain Injury

Seong S. Shim et al.

JOURNAL OF NEUROTRAUMA (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Nanostructured Antagonist of Extrasynaptic NMDA Receptors

Alex Saychenko et al.

NANO LETTERS (2016)

Add to Collection
Review Neurosciences

Emerging roles of GluN3-containing NMDA receptors in the CNS

Isabel Perez-Otano et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Add to Collection
Review Clinical Neurology

Dysfunction of NMDA receptors in Alzheimer's disease

Yan Zhang et al.

NEUROLOGICAL SCIENCES (2016)

Add to Collection
Review Pharmacology & Pharmacy

A beacon of hope in stroke therapy Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Ashfaqul Hoque et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Add to Collection
Article Cell Biology

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

Xu-Ying Sun et al.

CELL DEATH & DISEASE (2016)

Add to Collection
Article Multidisciplinary Sciences

Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia

Connie Chung et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
News Item Medicine, General & Internal

Approved drugs are to be studied for use in Alzheimer's disease

Janice Hopkins Tanne

BMJ-BRITISH MEDICAL JOURNAL (2016)

Add to Collection
News Item Medicine, General & Internal

Approved drugs are to be studied for use in Alzheimer's disease

Janice Hopkins Tanne

BMJ-BRITISH MEDICAL JOURNAL (2016)

Add to Collection
Article Cell Biology

A neuroprotective role of the NMDA receptor subunit GluN3A (NR3A) in ischemic stroke of the adult mouse

Jin Hwan Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)

Add to Collection
Article Clinical Neurology

A reduced risk of stroke with lithium exposure in bipolar disorder: a population-based retrospective cohort study

Chen-Chia Lan et al.

BIPOLAR DISORDERS (2015)

Add to Collection
Article Neurosciences

Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons

Yan-Na Wu et al.

BRAIN RESEARCH (2015)

Add to Collection
Review Neurosciences

Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

A. Brassai et al.

BRAIN RESEARCH BULLETIN (2015)

Add to Collection
Article Geriatrics & Gerontology

The Effect of Memantine on Cognitive Function and Behavioral and Psychological Symptoms in Mild-to-Moderate Alzheimer's Disease Patients

Nan Zhang et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2015)

Add to Collection
Article Neurosciences

The case for rejecting the amyloid cascade hypothesis

Karl Herrup

NATURE NEUROSCIENCE (2015)

Add to Collection
Article Geriatrics & Gerontology

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

Ildete Luisa Ferreira et al.

NEUROBIOLOGY OF AGING (2015)

Add to Collection
Article Neurosciences

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Victor S. Van Laar et al.

NEUROBIOLOGY OF DISEASE (2015)

Add to Collection
Article Neurosciences

Extrasynaptic glutamate NMDA receptors: Key players in striatal function

Marianela Garcia-Munoz et al.

NEUROPHARMACOLOGY (2015)

Add to Collection
Article Neurosciences

GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice

Jakob von Engelhardt et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Add to Collection
Review Geriatrics & Gerontology

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer's Disease

Carolyn C. Rudy et al.

AGING AND DISEASE (2015)

Add to Collection
Article Neurosciences

Synergistic Exacerbation of Mitochondrial and Synaptic Dysfunction and Resultant Learning and Memory Deficit in a Mouse Model of Diabetic Alzheimer's Disease

Yongfu Wang et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Add to Collection
Article Endocrinology & Metabolism

The dichotomy of memantine treatment for ischemic stroke: dose-dependent protective and detrimental effects

Melissa Trotman et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Add to Collection
Review Neurosciences

Structure and gating of tetrameric glutamate receptors

Alexander I. Sobolevsky

JOURNAL OF PHYSIOLOGY-LONDON (2015)

Add to Collection
Review Multidisciplinary Sciences

Memantine Monotherapy for Alzheimer's Disease: A Systematic Review and Meta-Analysis

Shinji Matsunaga et al.

PLOS ONE (2015)

Add to Collection
Article Anatomy & Morphology

Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain

Marina Mikhaylova et al.

BRAIN STRUCTURE & FUNCTION (2014)

Add to Collection
Article Neurosciences

Necroptosis: Who Knew There were so Many Interesting Ways to Die?

S. M. Fayaz et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2014)

Add to Collection
Article Pharmacology & Pharmacy

NMDA Neurotransmission Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease

Chieh-Hsin Lin et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Add to Collection
Article Medicine, Research & Experimental

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

Federico N. Soria et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Add to Collection
Article Psychology, Clinical

Long-Term, Low-Dose Lithium Treatment Does Not Impair Renal Function in the Elderly: A 2-Year Randomized, Placebo-Controlled Trial Followed by Single-Blind Extension

Ivan Aprahamian et al.

JOURNAL OF CLINICAL PSYCHIATRY (2014)

Add to Collection
Review Neurosciences

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

Matthew P. Parsons et al.

NEURON (2014)

Add to Collection
Article Neurosciences

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

Kasper B. Hansen et al.

NEURON (2014)

Add to Collection
Review Biology

Organization, control and function of extrasynaptic NMDA receptors

Thomas Papouin et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Add to Collection
Editorial Material Multidisciplinary Sciences

Mitochondria impact brain function and cognition

Martin Picard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection
Article Clinical Neurology

Memantine Enhances Recovery From Stroke

Hector E. Lopez-Valdes et al.

STROKE (2014)

Add to Collection
Review Clinical Neurology

Reprogramming the Response to Stroke by Preconditioning

Susan L. Stevens et al.

STROKE (2014)

Add to Collection
Article Clinical Neurology

Ionic Regulation of Cell Volume Changes and Cell Death after Ischemic Stroke

Mingke Song et al.

TRANSLATIONAL STROKE RESEARCH (2014)

Add to Collection
Review Physiology

Structure, Function, and Pharmacology of NMDA Receptor Channels

V. Vyklicky et al.

PHYSIOLOGICAL RESEARCH (2014)

Add to Collection
Article Biochemistry & Molecular Biology

Lithium prevents early cytosolic calcium increase and secondary injurious calcium overload in glycolytically inhibited endothelial cells

Bert Bosche et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Add to Collection
Review Neurosciences

Activation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons

Dan-dan Liu et al.

BRAIN RESEARCH BULLETIN (2013)

Add to Collection
Review Neurosciences

Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

E. S. Vizi et al.

BRAIN RESEARCH BULLETIN (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus

Anna Karpova et al.

CELL (2013)

Add to Collection
Review Cell Biology

Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans

Felipe Simon et al.

CELLULAR SIGNALLING (2013)

Add to Collection
Review Neurosciences

Slow Excitotoxicity in Alzheimer's Disease

Wei-Yi Ong et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Function and Neuronal Excitotoxicity

Xianju Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Add to Collection
Article Neurosciences

Regulatory roles of the NMDA receptor GluN3A subunit in locomotion, pain perception and cognitive functions in adult mice

Osama Mohamad et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Add to Collection
Article Clinical Neurology

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Clifford R. Jack et al.

LANCET NEUROLOGY (2013)

Add to Collection
Review Neurosciences

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Pierre Paoletti et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Add to Collection
Review Neurosciences

NMDA receptors in nervous system diseases

Qiang Zhou et al.

NEUROPHARMACOLOGY (2013)

Add to Collection
Review Neurosciences

NMDA receptors and memory encoding

Richard G. M. Morris

NEUROPHARMACOLOGY (2013)

Add to Collection
Article Endocrinology & Metabolism

The preventive effect of NR2B and NR2D-containing NMDAR antagonists on Aβ-induced LTP disruption in the dentate gyrus of rats

Junfang Zhang et al.

METABOLIC BRAIN DISEASE (2013)

Add to Collection
Article Neurosciences

PRE- AND POSTSYNAPTIC LOCALIZATION OF NMDA RECEPTOR SUBUNITS AT HIPPOCAMPAL MOSSY FIBRE SYNAPSES

L. K. Berg et al.

NEUROSCIENCE (2013)

Add to Collection
Article Neurosciences

EFFECTS OF MEMANTINE AND MELATONIN ON SIGNAL TRANSDUCTION PATHWAYS VASCULAR LEAKAGE AND BRAIN INJURY AFTER FOCAL CEREBRAL ISCHEMIA IN MICE

U. Kilic et al.

NEUROSCIENCE (2013)

Add to Collection
Review Clinical Neurology

Diversity in NMDA Receptor Composition: Many Regulators, Many Consequences

Antonio Sanz-Clemente et al.

NEUROSCIENTIST (2013)

Add to Collection
Article Multidisciplinary Sciences

Control of Cleft Glutamate Concentration and Glutamate Spill-Out by Perisynaptic Glia: Uptake and Diffusion Barriers

Jean-Pierre Kessler

PLOS ONE (2013)

Add to Collection
Article Multidisciplinary Sciences

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Maria Talantova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Add to Collection
Article Cell Biology

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

C. Tackenberg et al.

CELL DEATH & DISEASE (2013)

Add to Collection
Article Cell Biology

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

X. Zhou et al.

CELL DEATH & DISEASE (2013)

Add to Collection
Article Neurosciences

NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina

Ning Bai et al.

MOLECULAR BRAIN (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

Thomas Papouin et al.

CELL (2012)

Add to Collection
Article Cell Biology

Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-D-aspartate receptors in cortical cultures

I. L. Ferreira et al.

CELL CALCIUM (2012)

Add to Collection
Review Neurosciences

New developments on the role of NMDA receptors in Alzheimer's disease

Roberto Malinow

CURRENT OPINION IN NEUROBIOLOGY (2012)

Add to Collection
Article Geriatrics & Gerontology

Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD

Rainer Hellweg et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2012)

Add to Collection
Article Biochemistry & Molecular Biology

Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity

Parmvir K. Bahia et al.

JOURNAL OF NEUROCHEMISTRY (2012)

Add to Collection
Article Neurosciences

Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death

Christine M. Wroge et al.

JOURNAL OF NEUROSCIENCE (2012)

Add to Collection
Article Neurosciences

The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activation

Rebeca Martinez-Turrillas et al.

NEUROBIOLOGY OF DISEASE (2012)

Add to Collection
Article Neurosciences

The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

Marc-Andre Martel et al.

NEURON (2012)

Add to Collection
Article Multidisciplinary Sciences

Involvement of Calpain/p35-p25/Cdk5/NMDAR Signaling Pathway in Glutamate-Induced Neurotoxicity in Cultured Rat Retinal Neurons

Yanying Miao et al.

PLOS ONE (2012)

Add to Collection
Article Multidisciplinary Sciences

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

Marc Aurel Busche et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection
Review Multidisciplinary Sciences

Distribution of Extrasynaptic NMDA Receptors on Neurons

Ronald S. Petralia

SCIENTIFIC WORLD JOURNAL (2012)

Add to Collection
Review Neurosciences

GluN3 subunit-containing NMDA receptors: not just one-trick ponies

Svenja Pachernegg et al.

TRENDS IN NEUROSCIENCES (2012)

Add to Collection
Article Clinical Neurology

Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease

Lon S. Schneider et al.

ARCHIVES OF NEUROLOGY (2011)

Add to Collection
Article Pharmacology & Pharmacy

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

Oleg Palygin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Add to Collection
Article Psychiatry

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

Orestes V. Forlenza et al.

BRITISH JOURNAL OF PSYCHIATRY (2011)

Add to Collection
Article Cell Biology

Amyloid β peptide oligomers directly activate NMDA receptors

Laura Texido et al.

CELL CALCIUM (2011)

Add to Collection
Review Neurosciences

Molecular basis of NMDA receptor functional diversity

Pierre Paoletti

EUROPEAN JOURNAL OF NEUROSCIENCE (2011)

Add to Collection
Review Neurosciences

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

Clare M. Gladding et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2011)

Add to Collection
Article Geriatrics & Gerontology

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

Heather A. Scott et al.

NEUROBIOLOGY OF AGING (2011)

Add to Collection
Article Geriatrics & Gerontology

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

Raik Roenicke et al.

NEUROBIOLOGY OF AGING (2011)

Add to Collection
Article Neurosciences

Synapses, NMDA receptor activity and neuronal A beta production in Alzheimer's disease

Karim Bordji et al.

REVIEWS IN THE NEUROSCIENCES (2011)

Add to Collection
Review Biochemistry & Molecular Biology

Stroke intervention pathways: NMDA receptors and beyond

Ted Weita Lai et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Add to Collection
Article Cell Biology

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

D. Nguyen et al.

CELL DEATH & DISEASE (2011)

Add to Collection
Article Otorhinolaryngology

A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus

Markus Suckfuell et al.

BMC EAR NOSE AND THROAT DISORDERS (2011)

Add to Collection
Article Pharmacology & Pharmacy

Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-D-aspartate Receptor Subunit-Selective Modulators

Timothy M. Acker et al.

MOLECULAR PHARMACOLOGY (2011)

Add to Collection
Article Physiology

N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct

Adrian Sproul et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Add to Collection
Article Physiology

Collecting duct expression of N-methyl-D-aspartate receptor subtype NR3a regulates urinary concentrating capacity

Jorgen Frokiaer

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Add to Collection
Article Pathology

Memantine Improves Cognition and Reduces Alzheimer's-Like Neuropathology in Transgenic Mice

Hilda Martinez-Coria et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Add to Collection
Article Biochemistry & Molecular Biology

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

Bashayer Mubarak et al.

Channels (2010)

Add to Collection
Article Biochemistry & Molecular Biology

Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by Extrasynaptic N-Methyl-D-aspartate Receptors

Oliver Dick et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Add to Collection
Article Medicine, Research & Experimental

NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice

Sika Zheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Add to Collection
Article Biochemistry & Molecular Biology

Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex

Erin R. Hascup et al.

JOURNAL OF NEUROCHEMISTRY (2010)

Add to Collection
Article Neurosciences

Amyloid-β Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3β in Primary Cultured Hippocampal Neurons

Helena Decker et al.

JOURNAL OF NEUROSCIENCE (2010)

Add to Collection
Article Neurosciences

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

Frederic Leveille et al.

JOURNAL OF NEUROSCIENCE (2010)

Add to Collection
Article Neurosciences

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production

Karim Bordji et al.

JOURNAL OF NEUROSCIENCE (2010)

Add to Collection
Article Neurosciences

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

Peng Xia et al.

JOURNAL OF NEUROSCIENCE (2010)

Add to Collection
Review Neurosciences

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Giles E. Hardingham et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Add to Collection
Review Neurosciences

Do astrocytes really exocytose neurotransmitters?

Nicola B. Hamilton et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Add to Collection
Article Biochemistry & Molecular Biology

Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria

Ryo Fukumori et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

Add to Collection
Article Clinical Neurology

Mild cognitive impairment in clinical care A survey of American Academy of Neurology members

J. S. Roberts et al.

NEUROLOGY (2010)

Add to Collection
Article Neurosciences

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Austen J. Milnerwood et al.

NEURON (2010)

Add to Collection
Review Pharmacology & Pharmacy

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

Stephen F. Traynelis et al.

PHARMACOLOGICAL REVIEWS (2010)

Add to Collection
Article Multidisciplinary Sciences

CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

Antonella Caccamo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Add to Collection
Review Neurosciences

Influence of the NR3A subunit on NMDA receptor functions

Maile A. Henson et al.

PROGRESS IN NEUROBIOLOGY (2010)

Add to Collection
Article Clinical Neurology

Memantine and Constraint-Induced Aphasia Therapy in Chronic Poststroke Aphasia

Marcelo L. Berthier et al.

ANNALS OF NEUROLOGY (2009)

Add to Collection
Article Cell Biology

Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/β-Catenin Signaling Pathway

Macarena S. Arrazola et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2009)

Add to Collection
Article Neurosciences

Synaptic Activity-Mediated Suppression of p53 and Induction of Nuclear Calcium-Regulated Neuroprotective Genes Promote Survival through Inhibition of Mitochondrial Permeability Transition

David Lau et al.

JOURNAL OF NEUROSCIENCE (2009)

Add to Collection
Article Neurosciences

Neuroprotection by the NR3A Subunit of the NMDA Receptor

Nobuki Nakanishi et al.

JOURNAL OF NEUROSCIENCE (2009)

Add to Collection
Article Neurosciences

Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

Sarah E. Hoey et al.

JOURNAL OF NEUROSCIENCE (2009)

Add to Collection
Article Neurosciences

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

Jian Xu et al.

JOURNAL OF NEUROSCIENCE (2009)

Add to Collection
Article Neurosciences

Long-Term Homeostasis of Extracellular Glutamate in the Rat Cerebral Cortex across Sleep and Waking States

Michael B. Dash et al.

JOURNAL OF NEUROSCIENCE (2009)

Add to Collection
Article Biochemistry & Molecular Biology

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Shu-ichi Okamoto et al.

NATURE MEDICINE (2009)

Add to Collection
Article Neurosciences

Downregulation of NR3A-Containing NMDARs Is Required for Synapse Maturation and Memory Consolidation

Adam C. Roberts et al.

NEURON (2009)

Add to Collection
Review Neurosciences

PARASYNAPTIC SIGNALLING BY FAST NEUROTRANSMITTERS: THE CEREBELLAR CORTEX

G. Szapiro et al.

NEUROSCIENCE (2009)

Add to Collection
Review Neurosciences

MORPHOLOGICAL EVIDENCE FOR VESICULAR GLUTAMATE RELEASE FROM ASTROCYTES

L. H. Bergersen et al.

NEUROSCIENCE (2009)

Add to Collection
Article Multidisciplinary Sciences

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

Mathew Blurton-Jones et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Add to Collection
Article Multidisciplinary Sciences

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

Ruslan I. Stanika et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Add to Collection
Article Pharmacology & Pharmacy

Neramexane: a moderate-affinity NMDA receptor channel blocker: new prospects and indications

Gerhard Rammes

Expert Review of Clinical Pharmacology (2009)

Add to Collection
Article Biochemistry & Molecular Biology

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

Andrey Y. Abramov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2008)

Add to Collection
Article Public, Environmental & Occupational Health

Memantine for the treatment of Alzheimer's disease

Martin R. Farlow et al.

DRUG SAFETY (2008)

Add to Collection
Review Neurosciences

Amyloid beta peptides and glutamatergic synaptic dysregulation

Kodeeswaran Parameshwaran et al.

EXPERIMENTAL NEUROLOGY (2008)

Add to Collection
Article Clinical Neurology

Vascular risk factors and Alzheimer’s disease

David F Cechetto et al.

Expert Review of Neurotherapeutics (2008)

Add to Collection
Article Biochemistry & Molecular Biology

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors

F. Leveille et al.

FASEB JOURNAL (2008)

Add to Collection
Article Clinical Neurology

Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine

R. Schmidt et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2008)

Add to Collection
Article Neurosciences

Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons

Gary Tong et al.

JOURNAL OF NEUROPHYSIOLOGY (2008)

Add to Collection
Article Neurosciences

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Sofia Papadia et al.

NATURE NEUROSCIENCE (2008)

Add to Collection
Review Neurosciences

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

Koji Yashiro et al.

NEUROPHARMACOLOGY (2008)

Add to Collection
Review Behavioral Sciences

Microdialysis of GABA and glutamate: Analysis, interpretation and comparison with microsensors

Miranda van der Zeyden et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2008)

Add to Collection
Article Biochemistry & Molecular Biology

Caldendrin-Jacob: A protein liaison that couples NMDA receptor signalling to the nucleus

Daniela C. Dieterich et al.

PLOS BIOLOGY (2008)

Add to Collection
Article Pharmacology & Pharmacy

Second-by-second measures of L-glutamate in the prefrontal cortex and striatum of freely moving mice

K. N. Hascup et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Add to Collection
Article Neurosciences

Analysis of NR3A receptor subunits in human native NMDA receptors

Anna Nilsson et al.

BRAIN RESEARCH (2007)

Add to Collection
Review Neurosciences

Memantine:: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutarnatergic system -: too little activation is bad, too much is even worse

Chris G. Parsons et al.

NEUROPHARMACOLOGY (2007)

Add to Collection
Article Neurosciences

β-amyloid modulation of synaptic transmission and plasticity

Deepa V. Venkitaramani et al.

JOURNAL OF NEUROSCIENCE (2007)

Add to Collection
Review Clinical Neurology

The pathogenesis of alzheimers disease - Is it a lifelong Calciumopathy?

Grace E. Stutzmann

NEUROSCIENTIST (2007)

Add to Collection
Review Neurosciences

Opinion - Pathologically activated therapeutics for neuroprotection

Stuart A. Lipton

NATURE REVIEWS NEUROSCIENCE (2007)

Add to Collection
Article Neurosciences

Extracellular glutamate concentration in hippocampal slice

Melissa A. Herman et al.

JOURNAL OF NEUROSCIENCE (2007)

Add to Collection
Article Pharmacology & Pharmacy

Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 Subunits

C. Thetford Smothers et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Add to Collection
Review Cell Biology

Changes in the structural complexity of the aged brain

Dara L. Dickstein et al.

AGING CELL (2007)

Add to Collection
Article Neurosciences

Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus

Karim Le Meur et al.

JOURNAL OF PHYSIOLOGY-LONDON (2007)

Add to Collection
Article Biochemistry & Molecular Biology

Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

Fernanda G. De Felice et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Add to Collection
Article Neurosciences

NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo

Yitao Liu et al.

JOURNAL OF NEUROSCIENCE (2007)

Add to Collection
Article Biochemical Research Methods

Monitoring extracellular glutamate in hippocampal slices with a microsensor

W. H. Oldenziel et al.

JOURNAL OF NEUROSCIENCE METHODS (2007)

Add to Collection
Article Neurosciences

Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease

Pascale N. Lacor et al.

JOURNAL OF NEUROSCIENCE (2007)

Add to Collection
Article Neurosciences

Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression

Wade Morishita et al.

NEUROPHARMACOLOGY (2007)

Add to Collection
Article Clinical Neurology

Memantine treatment of cognitive symptoms in mild to moderate Alzheimer disease: Secondary analyses from a placebo-controlled randomized trial

Nunzio Pomara et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2007)

Add to Collection
Article Neurosciences

NR3A modulates the outer vestibule of the NMDA receptor channel

Akira Wada et al.

JOURNAL OF NEUROSCIENCE (2006)

Add to Collection
Review Cell Biology

NMDA receptor function:: subunit composition versus spatial distribution

Georg Koehr

CELL AND TISSUE RESEARCH (2006)

Add to Collection
Article Behavioral Sciences

Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane

Phillip R. Zoladz et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2006)

Add to Collection
Review Neurosciences

Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats

Mireille Basselin et al.

NEUROPSYCHOPHARMACOLOGY (2006)

Add to Collection
Article Biochemistry & Molecular Biology

Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease

Sara L. Kirvell et al.

JOURNAL OF NEUROCHEMISTRY (2006)

Add to Collection
Article Neurosciences

Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits

Paul A. Lapchak

BRAIN RESEARCH (2006)

Add to Collection
Article Neurosciences

Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1

I Pérez-Otaño et al.

NATURE NEUROSCIENCE (2006)

Add to Collection
Article Neurosciences

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons

Anton Ivanov et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

Add to Collection
Article Pharmacology & Pharmacy

Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats

L Wei et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Add to Collection
Article Multidisciplinary Sciences

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation

G Amadoro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Add to Collection
Review Pharmacology & Pharmacy

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists

KW Muir

CURRENT OPINION IN PHARMACOLOGY (2006)

Add to Collection
Review Biotechnology & Applied Microbiology

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

SA Lipton

NATURE REVIEWS DRUG DISCOVERY (2006)

Add to Collection
Review Clinical Neurology

Poststroke dementia

H. Henon et al.

CEREBROVASCULAR DISEASES (2006)

Add to Collection
Review Chemistry, Medicinal

Survival signaling pathways activated by NMDA receptors

M Hetman et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)

Add to Collection
Review Medicine, Research & Experimental

Role of glutamate transporters in the clearance and release of glutamate during ischemia and its relation to neuronal death

A Camacho et al.

ARCHIVES OF MEDICAL RESEARCH (2006)

Add to Collection
Article Neurosciences

Synaptic activity regulates interstitial fluid amyloid-β levels in vivo

JR Cirrito et al.

NEURON (2005)

Add to Collection
Article Neurosciences

NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII

A Barria et al.

NEURON (2005)

Add to Collection
Article Neurosciences

Regulation of NMDA receptor trafficking by amyloid-β

EM Snyder et al.

NATURE NEUROSCIENCE (2005)

Add to Collection
Article Clinical Neurology

Combination therapy in ischemic stroke: Synergistic neuroprotective effects of memantine and clenbuterol

C Culmsee et al.

STROKE (2004)

Add to Collection
Article Neurosciences

β-Amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes:: modulation of uptake as a survival mechanism

P Fernández-Tomé et al.

NEUROBIOLOGY OF DISEASE (2004)

Add to Collection
Review Medicine, Research & Experimental

The rise and fall of NMDA antagonists for ischemic. stroke

L Hoyte et al.

CURRENT MOLECULAR MEDICINE (2004)

Add to Collection
Article Neurosciences

Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression

PV Massey et al.

JOURNAL OF NEUROSCIENCE (2004)

Add to Collection
Article Neurosciences

Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors

T Fellin et al.

NEURON (2004)

Add to Collection
Article Neurosciences

Glutamate released from glial cells synchronizes neuronal activity in the hippocampus

MC Angulo et al.

JOURNAL OF NEUROSCIENCE (2004)

Add to Collection
Article Neurosciences

Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death

HM Wang et al.

JOURNAL OF NEUROSCIENCE (2004)

Add to Collection
Article Neurosciences

Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate

P Bezzi et al.

NATURE NEUROSCIENCE (2004)

Add to Collection
Article Neurosciences

Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats

L Wei et al.

BRAIN RESEARCH (2004)

Add to Collection
Article Multidisciplinary Sciences

Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity

LD Liu et al.

SCIENCE (2004)

Add to Collection
Article Biochemistry & Molecular Biology

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

RA Screaton et al.

CELL (2004)

Add to Collection
Article Geriatrics & Gerontology

Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer's disease

R Doody et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2004)

Add to Collection
Article Clinical Neurology

Stroke and the risk of Alzheimer disease

LS Honig et al.

ARCHIVES OF NEUROLOGY (2003)

Add to Collection
Review Neurosciences

The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease

MA Rogawski et al.

CNS DRUG REVIEWS (2003)

Add to Collection
Article Multidisciplinary Sciences

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

M Hoshi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Add to Collection
Article Medicine, General & Internal

Memantine in moderate-to-severe Alzheimer's disease

B Reisberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Add to Collection
Review Neurosciences

The yin and yang of NMDA receptor signalling

GE Hardingham et al.

TRENDS IN NEUROSCIENCES (2003)

Add to Collection
Article Psychology, Clinical

Memantine in vascular dementia

HJ Mobius et al.

INTERNATIONAL PSYCHOGERIATRICS (2003)

Add to Collection
Review Clinical Neurology

The glutamatergic system and Alzheimer's disease - Therapeutic implications

DA Butterfield et al.

CNS DRUGS (2003)

Add to Collection
Article Biochemistry & Molecular Biology

Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated

GE Hardingham et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2002)

Add to Collection
Article Pharmacology & Pharmacy

A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500)

G Wilcock et al.

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY (2002)

Add to Collection
Article Clinical Neurology

Efficacy and safety of memantine in patients with mild to moderate vascular dementia -: A randomized, placebo-controlled trial (MMM 300)

JM Orgogozo et al.

STROKE (2002)

Add to Collection
Article Neurosciences

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

GE Hardingham et al.

NATURE NEUROSCIENCE (2002)

Add to Collection
Article Neurosciences

Cloning and expression of the human N-methyl-D-aspartate receptor subunit NR3A

M Eriksson et al.

NEUROSCIENCE LETTERS (2002)

Add to Collection
Review Neurosciences

Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons

AY Xiao et al.

JOURNAL OF NEUROSCIENCE (2002)

Add to Collection
Review Physiology

Mechanisms of spreading depression and hypoxic spreading depression-like depolarization

GG Somjen

PHYSIOLOGICAL REVIEWS (2001)

Add to Collection
Article Neurosciences

A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

GE Hardingham et al.

NATURE NEUROSCIENCE (2001)

Add to Collection
Article Multidisciplinary Sciences

Interference by Huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity

FC Nucifora et al.

SCIENCE (2001)

Add to Collection
Article Neurosciences

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

GE Hardingham et al.

NATURE NEUROSCIENCE (2001)

Add to Collection
Article Multidisciplinary Sciences

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

GY Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Add to Collection
Article Clinical Neurology

Absence of cognitive impairment or decline in preclinical Alzheimer's disease

WP Goldman et al.

NEUROLOGY (2001)

Add to Collection
Article Multidisciplinary Sciences

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

GQ Chen et al.

NATURE (2000)

Add to Collection
Article Neurosciences

Antidepressant effects of ketamine in depressed patients

RM Berman et al.

BIOLOGICAL PSYCHIATRY (2000)

Add to Collection
Article Multidisciplinary Sciences

Glutamate release in severe brain ischaemia is mainly by reversed uptake

DJ Rossi et al.

NATURE (2000)

Add to Collection
Article Neurosciences

Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity

R Sattler et al.

JOURNAL OF NEUROSCIENCE (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.