4.6 Article

CCL2 Knockdown Attenuates Inflammatory Response After Spinal Cord Injury Through the PI3K/Akt Signaling Pathway: Bioinformatics Analysis and Experimental Validation

Related references

Note: Only part of the references are listed.
Article Neurosciences

Identification of Regeneration and Hub Genes and Pathways at Different Time Points after Spinal Cord Injury

Sheng Fang et al.

Summary: This study aimed to verify differential gene time-course expression in SCI and identified hub genes, signaling pathways, and regeneration genes involved in secondary SCI. These results provide new insights into understanding SCI-related biological processes and developing targeted intervention strategies.

MOLECULAR NEUROBIOLOGY (2021)

Article Immunology

Recruitment of γδ T cells to the lesion via the CCL2/CCR2 signaling after spinal cord injury

Ping Xu et al.

Summary: This study demonstrates that γδ T cells are recruited to the site of spinal cord injury through CCL2/CCR2 signaling, exacerbating inflammatory response and worsening neurological impairment. This mechanism could be a potential therapeutic target for future SCI treatment.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Neurosciences

Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury

Nicolas Pelisch et al.

Summary: This study demonstrated the therapeutic potential of FANA ASO in inhibiting inflammatory responses after spinal cord injury, offering a promising approach to improve functional recovery. The novel strategy of targeting specific inflammatory molecules may have implications for new treatment strategies in SCI and other CNS pathologies.

ENEURO (2021)

Article Oncology

Identification of four genes and biological characteristics associated with acute spinal cord injury in rats integrated bioinformatics analysis

Qiang Li et al.

Summary: SCI is a serious condition that involves physical disability and sensory dysfunction. Cytokines play a crucial role in the acute phase of SCI. This study identified differentially expressed cytokines and indicated that cytokine-related pathways, cell death, and proliferation might be crucial during secondary SCI.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Cell Biology

VX-765 reduces neuroinflammation after spinal cord injury in mice

Jing Chen et al.

Summary: The study found that VX-765 could reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1 beta/interleukin-18. This may be a potential strategy for treating spinal cord injury.

NEURAL REGENERATION RESEARCH (2021)

Article Immunology

CCL3 contributes to secondary damage after spinal cord injury

Nicolas Pelisch et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Review Neurosciences

Macrophage biology in the peripheral nervous system after injury

Richard E. Zigrnond et al.

PROGRESS IN NEUROBIOLOGY (2019)

Article Multidisciplinary Sciences

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

Victor Bellver-Landete et al.

NATURE COMMUNICATIONS (2019)

Editorial Material Clinical Neurology

Global burden of traumatic brain and spinal cord injury

Jetan H. Badhiwala et al.

LANCET NEUROLOGY (2019)

Review Neurosciences

Neuroprotection and secondary damage following spinal cord injury: concepts and methods

Brett J. Hilton et al.

NEUROSCIENCE LETTERS (2017)

Article Clinical Neurology

Traumatic Spinal Cord Injury-Repair and Regeneration

Christopher S. Ahuja et al.

NEUROSURGERY (2017)

Article Neurosciences

Spinal cord injury: overview of experimental approaches used to restore locomotor activity

Marc Fakhoury

REVIEWS IN THE NEUROSCIENCES (2015)

Article Endocrinology & Metabolism

CCL2-CCR2 Signaling in Disease Pathogenesis

Tracy O'Connor et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2015)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Biotechnology & Applied Microbiology

Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model

Mahmood Chamankhah et al.

BMC GENOMICS (2013)

Review Critical Care Medicine

The Therapeutic Role of Interleukin-10 after Spinal Cord Injury

Colton D. Thompson et al.

JOURNAL OF NEUROTRAUMA (2013)

Article Medicine, Research & Experimental

Anti-interleukin-6 receptor antibody reduces neuropathic pain following spinal cord injury in mice

Tomotoshi Murakami et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

Article Biochemistry & Molecular Biology

Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats

Chengwen Chen et al.

NEUROCHEMICAL RESEARCH (2010)

Article Critical Care Medicine

TNF-alpha blockage in a mouse model of SCI: Evidence for improved outcome

Tiziana Genovese et al.

SHOCK (2008)

Article Biochemistry & Molecular Biology

Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2

Graeme O'Boyle et al.

MOLECULAR IMMUNOLOGY (2007)

Article Clinical Neurology

The cellular inflammatory response in human spinal cords after injury

Jennifer C. Fleming et al.

BRAIN (2006)

Article Clinical Neurology

Gene profiling in spinal cord injury shows role of cell cycle neuronal death

S Di Giovanni et al.

ANNALS OF NEUROLOGY (2003)

Article Clinical Neurology

The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation

PG Popovich et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

Article Immunology

Sequential expression of chemokines in experimental autoimmune neuritis

BC Kieseier et al.

JOURNAL OF NEUROIMMUNOLOGY (2000)