4.5 Review

ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe

Related references

Note: Only part of the references are listed.
Review Cell Biology

Interplays of AMPK and TOR in Autophagy Regulation in Yeast

John-Patrick Alao et al.

Summary: Cells regulate their metabolism and ensure survival and growth under stress conditions by balancing growth and anabolism with stress programs and catabolism. Autophagy, an essential quality control mechanism, plays a pivotal role in cell survival and lifespan by clearing damaged macromolecules and organelles in response to nutrient levels and cellular damage.

CELLS (2023)

Article Cell Biology

The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast

Hokuto Ohtsuka et al.

Summary: In Schizosaccharomyces pombe, the ecl family genes are induced by various signals including nutrient starvation and environmental stress. The induction of these genes is important for cell viability and sexual differentiation. This study identifies phosphate starvation as a specific condition that induces the ecl3+ gene, providing insights into the regulation of these genes and their contribution to cellular responses and starvation adaptations.

JOURNAL OF CELL SCIENCE (2023)

Article Cell Biology

TOR and MAP kinase pathways synergistically regulate autophagy in response to nutrient depletion in fission yeast

Cristina Corral-Ramos et al.

Summary: General autophagy is a conserved process in eukaryotes, with its molecular basis widely described in Saccharomyces cerevisiae. Studies in different yeast species have shown both evolutionary similarity and diversity of autophagy components. Little is known about signals, pathways, and roles of autophagy in distant yeast, highlighting the need for further investigation in this area.

AUTOPHAGY (2022)

Review Cell Biology

Fission Yeast Autophagy Machinery

Dan-Dan Xu et al.

Summary: Autophagy is a process that transports cellular components to the vacuole/lysosome, playing important roles in maintaining cellular homeostasis and stress resistance. In the fission yeast, autophagy is crucial for cell survival during nutrient depletion and ER stress. Research on fission yeast autophagy machinery has revealed similarities and differences with other eukaryotic models, such as budding yeast Saccharomyces cerevisiae. Recent discoveries of selective autophagy pathways in fission yeast provide new insights into cargo selectivity in autophagy.

CELLS (2022)

Article Genetics & Heredity

Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations

Alia Ebrahim et al.

Summary: This study used bioinformatics analysis to investigate the role of three genes, spGrx4, spFep1, and spPhp4, in maintaining iron homeostasis in the fission yeast Schizosaccharomyces pombe. Multiple sequence alignment and protein-protein interaction analysis provided insights into their similarities with sequence homologs in other species and their cooperative roles in iron homeostasis.

FRONTIERS IN GENETICS (2022)

Article Biochemistry & Molecular Biology

A multiplexed, three-dimensional pooling and next-generation sequencing strategy for creating barcoded mutant arrays: construction of a Schizosaccharomyces pombe transposon insertion library

Yanhui Li et al.

Summary: In this study, we developed an efficient method to construct a library of barcoded insertion mutants with a wider range of phenotypes. By leveraging sequence information, we were able to identify the barcode sequences and DNA insertion sites of 4391 Schizosaccharomyces pombe insertion mutations with only 40 sequencing preparations.

NUCLEIC ACIDS RESEARCH (2022)

Review Microbiology

Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe

Hokuto Ohtsuka et al.

Summary: The fission yeast S. pombe adapts to the environment and survives in nutrient-starved conditions through sexual differentiation and extension of the chronological lifespan. Spore formation in S. pombe is highly resistant to stresses and spores can survive for a long period. This minireview focuses on the molecular mechanisms of spore formation induced by starvation and highlights the presence of an effective survival mechanism.

MICROBIOLOGYOPEN (2022)

Article Biochemistry & Molecular Biology

Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast

Hokuto Ohtsuka et al.

Summary: Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. However, its analog, Mochimganine, exhibits a significantly weaker growth inhibition effect while still being able to extend the lifespan.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2022)

Review Biotechnology & Applied Microbiology

Response to leucine in Schizosaccharomyces pombe (fission yeast)

Hokuto Ohtsuka et al.

Summary: Leucine (Leu) is an essential branched-chain amino acid in animals, including humans. Although Leu auxotrophy is inconvenient for the fission yeast Schizosaccharomyces pombe, it has enhanced its usefulness as a model organism in laboratories. Leu auxotrophy induces intracellular responses and phenotypes different from those of the prototrophic strains, which necessitates caution in the analysis and interpretation of experimental results. Understanding the intracellular responses caused by Leu auxotrophy can contribute to the research using this model organism and to the understanding of intracellular responses in higher organisms. This minireview summarizes the latest research on leucine metabolism mechanism and starvation response in the fission yeast Schizosaccharomyces, along with the identification of the ilv3+ gene involved in leucine synthesis.

FEMS YEAST RESEARCH (2022)

Article Cell Biology

Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast

Catalina A. Romila et al.

Summary: Ageing-related processes are largely conserved, with yeast cells providing an effective model system for studying cellular ageing. By decoding barcodes and using barcode sequencing methods, many new ageing-associated genes were successfully identified.

MICROBIAL CELL (2021)

Article Biochemistry & Molecular Biology

Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast)

Hokuto Ohtsuka et al.

Summary: This mini-review summarizes over 70 genes involved in the chronological lifespan of Schizosaccharomyces pombe and describes the signal transduction pathways affecting lifespan extension. These pathways and genes play important roles in regulating the chronological lifespan extension in S. pombe.

MOLECULAR MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast

Angela Rubio et al.

Summary: Translational control is crucial in response to stress, with different stresses inducing common and specific translational responses in cells. The transcription factor Fil1 plays a key role in the cellular response to most stresses, while many mRNAs encoding proteins for ribosome biogenesis are translationally downregulated. Additionally, tryptophan codon stalling upon oxidative stress affects translation elongation and contributes to the ISR-mediated inhibition of initiation.

NUCLEIC ACIDS RESEARCH (2021)

Article Cell Biology

Analysis of the TORC1 interactome reveals a spatially distinct function of TORC1 in mRNP complexes

Yeonji Chang et al.

Summary: Research has shown that TORC1 has functional relationships with mRNA, interacts with mRNP complexes, and inhibits the activity of translational repressor protein Scd6 through phosphorylation.

JOURNAL OF CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

3,3'-Diindolylmethane induces apoptosis and autophagy in fission yeast

Parvaneh Emami et al.

Summary: Research shows that DIM induces apoptosis and autophagy in fission yeast, which are crucial for cell survival.

PLOS ONE (2021)

Article Biology

Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase

Tomoyuki Fukuda et al.

Summary: The GATOR2 subunit Sea3 unexpectedly attenuates TORC1 activity by being physically and functionally proximal to GATOR1 in fission yeast. The GATOR complex in fission yeast is dispensable for TORC1 regulation in response to amino acid starvation, as cells instead activate the Gcn2 pathway to inhibit TORC1 and induce autophagy.

ELIFE (2021)

Review Cell Biology

Extension of chronological lifespan in Schizosaccharomyces pombe

Hokuto Ohtsuka et al.

Summary: The mechanism of longevity control in unicellular organisms shows evolutionary conservation with higher multicellular organisms. Research on chronological lifespan of fission yeast Schizosaccharomyces pombe has identified multiple compounds, nutrient restrictions, and genes that extend lifespan. These mechanisms involve nutritional response, stress responses, autophagy, and other pathways, suggesting a link between lifespan control and resource management in unicellular organisms.

GENES TO CELLS (2021)

Article Microbiology

Magnesium depletion extends fission yeast lifespan via general amino acid control activation

Hokuto Ohtsuka et al.

Summary: This study demonstrates that magnesium depletion extends the lifespan of yeast through the Ecl1 gene family and the general amino acid control pathway. The Ecl1 family genes regulate ribosome amount and contribute to longevity by activating the evolutionarily conserved GAAC pathway.

MICROBIOLOGYOPEN (2021)

Article Cell Biology

Increased fidelity of protein synthesis extends lifespan

Victoria Eugenia Martinez-Miguel et al.

Summary: The loss of proteostasis is a fundamental process driving aging, and the accuracy of translation significantly affects proteostasis. A rare amino acid substitution found in certain hyperthermophilic archaea, when introduced into other organisms, improves translation accuracy, heat shock resistance, and longevity. Anti-aging drugs such as rapamycin, Torin1, and trametinib reduce translation errors and extend organismal longevity, particularly in mutants with high translation accuracy due to this unique substitution in the RPS23 protein.

CELL METABOLISM (2021)

Article Cell Biology

Identification of ksg1 mutation showing long-lived phenotype in fission yeast

Kotaro Matsui et al.

Summary: The nonsense mutation in the ksg1(+) gene of fission yeast was found to reduce the amount and activity of the Ksg1 protein, resulting in increased lifespan. However, the specific substrate responsible for the long-lived phenotype of the ksg1 mutation has not been identified yet. Additionally, genetic analysis suggested that Pck2 may be involved in the lifespan extension caused by ksg1 mutation.

GENES TO CELLS (2021)

Article Biochemistry & Molecular Biology

Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast

Naoya Sawada et al.

Summary: The SPX-RING-type ubiquitin ligase Pqr1 is crucial for maintaining quiescence in Schizosaccharomyces pombe by regulating proper levels of phosphate and its polymer polyphosphate, which in turn affect vacuolar proteolysis and autophagy. Deletion of Pqr1 leads to excessive accumulation of intracellular phosphate and polyphosphate, disrupting autophagy-dependent proteolysis under nitrogen starvation. These findings highlight the importance of polyphosphate metabolism and vacuolar function in maintaining cellular viability during quiescence.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Microbiology

Identification of sur2 mutation affecting the lifespan of fission yeast

Tatsuhiro Kurauchi et al.

Summary: Yeast is a suitable model system for analyzing lifespan mechanisms. In this study, a mutant with an extended chronological lifespan was isolated, and a missense mutation in the sur2(+) gene was identified as being responsible. Loss of sur2 function was found to result in an extended chronological lifespan, and the effect of caloric restriction, a well-known lifespan-extending signal, was suggested to be dependent on the sur2(+) gene.

FEMS MICROBIOLOGY LETTERS (2021)

Review Biotechnology & Applied Microbiology

Response to sulfur in Schizosaccharomyces pombe

Hokuto Ohtsuka et al.

Summary: Studies have shown that sulfur plays essential roles in biological molecules and different yeast models exhibit varying sulfur metabolism pathways. Sulfur starvation induces various cellular responses in fission yeast, contributing to a better understanding of stress and lifespan regulation caused by sulfur depletion.

FEMS YEAST RESEARCH (2021)

Article Biochemistry & Molecular Biology

gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe

Yuki Imai et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Protein Phosphatases in G1 Regulation

Ruth Martin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Aminoacyl-tRNA synthetases

Miguel Angel Rubio Gomez et al.

Review Genetics & Heredity

CDK Regulation of Meiosis: Lessons fromS. cerevisiaeandS. pombe

Anne M. MacKenzie et al.

GENES (2020)

Review Cell Biology

Branched chain amino acids, aging and age-related health

David G. Le Couteur et al.

AGEING RESEARCH REVIEWS (2020)

Article Cell Biology

Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast

Takafumi Shimasaki et al.

GENES TO CELLS (2020)

Review Genetics & Heredity

Novel Links between TORC1 and Traditional Non-Coding RNA, tRNA

Yoko Otsubo et al.

GENES (2020)

Review Oncology

Some like it translated: small ORFs in the 5′UTR

Peter F. Renz et al.

EXPERIMENTAL CELL RESEARCH (2020)

Article Biochemistry & Molecular Biology

SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae

Koji Masumura et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

meiRNA, A Polyvalent Player in Fission Yeast Meiosis

Akira Yamashita

NON-CODING RNA (2019)

Article Multidisciplinary Sciences

General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4

Caia D. S. Duncan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Neurosciences

Experimental Models for Aging and their Potential for Novel Drug Discovery

Jaume Folch et al.

CURRENT NEUROPHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Crystal structure of eIF2B and insights into eIF2-eIF2B interactions

Kazuhiro Kashiwagi et al.

FEBS JOURNAL (2017)

Article Cell Biology

Novel tRNA function in amino acid sensing of yeast Tor complex1

Yoshiaki Kamada

GENES TO CELLS (2017)

Article Biochemistry & Molecular Biology

Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome

Hokuto Ohtsuka et al.

MOLECULAR MICROBIOLOGY (2017)

Article Multidisciplinary Sciences

Activation of Gcn2 in response to different stresses

Silje Anda et al.

PLOS ONE (2017)

Review Biotechnology & Applied Microbiology

Hydrogen sulfide and its roles in Saccharomyces cerevisiae in a winemaking context

Chien-Wei Huang et al.

FEMS YEAST RESEARCH (2017)

Review Biotechnology & Applied Microbiology

Factors extending the chronological lifespan of yeast: Ecl1 family genes

Hokuto Ohtsuka et al.

FEMS YEAST RESEARCH (2017)

Review Cell Biology

Dietary restriction and lifespan: Lessons from invertebrate models

Pankaj Kapahi et al.

AGEING RESEARCH REVIEWS (2017)

Review Biochemistry & Molecular Biology

TORC1-Dependent Phosphorylation Targets in Fission Yeast

Yoko Otsubo et al.

BIOMOLECULES (2017)

Article Microbiology

Identification of a novel protein kinase that affects the chronological lifespan in fission yeast

Tatsuhiro Kurauchi et al.

FEMS MICROBIOLOGY LETTERS (2017)

Article Biochemistry & Molecular Biology

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis

Shigehiro A. Kawashima et al.

Article Biochemistry & Molecular Biology

Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway

Delyan R. Mutavchiev et al.

CURRENT BIOLOGY (2016)

Article Multidisciplinary Sciences

Crystal structure of eukaryotic translation initiation factor 2B

Kazuhiro Kashiwagi et al.

NATURE (2016)

Review Cell Biology

Dietary Restriction and Nutrient Balance in Aging

Julia Santos et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Genetics & Heredity

Php4 Is a Key Player for Iron Economy in Meiotic and Sporulating Cells

Ariane Brault et al.

G3-GENES GENOMES GENETICS (2016)

Review Cell Biology

The role of the ribosome in the regulation of longevity and lifespan extension

Alyson W. MacInnes

WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)

Review Biochemistry & Molecular Biology

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Luigi Fontana et al.

Review Microbiology

Oxidative stress response pathways: Fission yeast as archetype

Manos A. Papadakis et al.

CRITICAL REVIEWS IN MICROBIOLOGY (2015)

Article Biochemistry & Molecular Biology

Nitrogen Regulates AMPK to Control TORC1 Signaling

Elizabeth Davie et al.

CURRENT BIOLOGY (2015)

Article Cell Biology

Stress-induced inhibition of translation independently of eIF2α phosphorylation

Jon Halvor Jonsrud Knutsen et al.

JOURNAL OF CELL SCIENCE (2015)

Article Biochemical Research Methods

A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival

Janel R. Beckley et al.

MOLECULAR & CELLULAR PROTEOMICS (2015)

Article Cell Biology

Regulation of wee1+ expression during meiosis in fission yeast

Yuko Murakami-Tonami et al.

CELL CYCLE (2014)

Article Biochemistry & Molecular Biology

A new pma1 mutation identified in a chronologically long-lived fission yeast mutant

Chikako Naito et al.

FEBS OPEN BIO (2014)

Review Biochemistry & Molecular Biology

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

Jordan Gallinetti et al.

BIOCHEMICAL JOURNAL (2013)

Article Biochemistry & Molecular Biology

The Fission Yeast php2 Mutant Displays a Lengthened Chronological Lifespan

Kazuaki Takuma et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2013)

Article Genetics & Heredity

TORC1 Signaling Is Governed by Two Negative Regulators in Fission Yeast

Ning Ma et al.

GENETICS (2013)

Review Cell Biology

Cell cycle control across the eukaryotic kingdom

Hirofumi Harashima et al.

TRENDS IN CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Extension of Chronological Lifespan by ScEcl1 Depends on Mitochondria in Saccharomyces cerevisiae

Kenko Azuma et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2012)

Editorial Material Cell Biology

Signaling pathways for fission yeast sexual differentiation at a glance

Yoko Otsubo et al.

JOURNAL OF CELL SCIENCE (2012)

Article Nutrition & Dietetics

The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells

Michael S. Kilberg et al.

ADVANCES IN NUTRITION (2012)

Article Biochemistry & Molecular Biology

Ecl1, a Regulator of the Chronological Lifespan of Schizosaccharomyces pombe, Is Induced upon Nitrogen Starvation

Yukiko Miwa et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Oxidative stress in yeast

V. I. Lushchak

BIOCHEMISTRY-MOSCOW (2010)

Review Geriatrics & Gerontology

Fission Yeast and Other Yeasts as Emergent Models to Unravel Cellular Aging in Eukaryotes

Antoine E. Roux et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2010)

Review Multidisciplinary Sciences

The selective elimination of messenger RNA underlies the mitosis-meiosis switch in fission yeast

Masayuki Yamamoto

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2010)

Review Multidisciplinary Sciences

Extending Healthy Life Span-From Yeast to Humans

Luigi Fontana et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Identification and Characterization of an Ecl1-Family Gene in Saccharomyces cerevisiae

Kenko Azuma et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Identification of Ecl Family Genes That Extend Chronological Lifespan in Fission Yeast

Hokuto Ohtsuka et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p

John M. Zaborske et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Cell Biology

The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint

Marit Krohn et al.

JOURNAL OF CELL SCIENCE (2008)

Article Toxicology

A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe

Patrick J. Kennedy et al.

TOXICOLOGICAL SCIENCES (2008)

Article Biochemistry & Molecular Biology

Identification of a fatty acyl-CoA synthetase gene, lcf2+, which affects viability after entry into the stationary phase in Schizosaccharomyces pombe

Yasuyuki Fujita et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2007)

Article Cell Biology

A novel checkpoint mechanism regulating the G1/S transition

Tonje Tvegard et al.

GENES & DEVELOPMENT (2007)

Article Cell Biology

Fission yeast Tor2 promotes cell growth and represses cell differentiation

Beatriz Alvarez et al.

JOURNAL OF CELL SCIENCE (2006)

Article Multidisciplinary Sciences

Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast

Juan Mata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

SCFPof1-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast

C Harrison et al.

EMBO JOURNAL (2005)

Review Microbiology

Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants

D Mendoza-Cozatl et al.

FEMS MICROBIOLOGY REVIEWS (2005)

Article Biochemistry & Molecular Biology

The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast

R Ohmiya et al.

MOLECULAR AND GENERAL GENETICS (2000)