Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

Review Biochemistry & Molecular Biology

Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets

Long-Xia Li et al.

Summary: Ethanol exposure can promote iron overload in the liver, exacerbating the damage in alcoholic liver disease (ALD).

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Article Multidisciplinary Sciences

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids

Shaojie Cui et al.

Summary: This study reveals that Fas-associated factor 1 (FAF1) interacts directly with free polyunsaturated fatty acids (PUFAs) and this interaction is crucial for protecting cells from ferroptosis. FAF1 assembles a globular structure that sequesters free PUFAs into a hydrophobic core, preventing PUFA peroxidation and ultimately inhibiting ferroptosis initiation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review

Cristian Sandoval et al.

Summary: The present review examined the relationship between vitamin deficiency and chronic liver disease. It was found that alcohol patients have low blood vitamin levels and that antioxidant mechanisms can prevent alcohol-induced liver damage. However, the effectiveness of antioxidants remains uncertain. Deficiencies in nutritional vitamins can rapidly develop during chronic liver disease.

ANTIOXIDANTS (2022)

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Article Biochemistry & Molecular Biology

FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease

Yajing You et al.

Summary: This study reveals the crucial role of FNDC3B in protecting against hepatic steatosis and ferroptosis in response to chronic alcohol consumption. Our findings suggest that FNDC3B could be a potential therapeutic target for ALD.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.

CELL (2022)

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Article Cell Biology

Mitochondrial event as an ultimate step in ferroptosis

Soo-Jin Oh et al.

Summary: This study investigated the role of mitochondria in ferroptosis using mitochondrial DNA-depleted rho(0) cells. The results showed that increased expression of mitochondrial-type GPx4 (mGPx4) in rho(0) cells conferred resistance to ferroptosis induced by erastin but susceptibility to GPx4 inhibition-induced cell death. Furthermore, the study revealed the critical role of mitochondrial ROS and the involvement of VDAC in the mitochondrial steps of ferroptosis induced by erastin or RSL3.

CELL DEATH DISCOVERY (2022)

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Letter Cell Biology

The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

Renhong Yan et al.

CELL RESEARCH (2022)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Medicine, Research & Experimental

Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways

Alexander Zheleznyak et al.

Summary: The study explores a new treatment approach targeting multiple myeloma, effectively inhibiting disease progression by simultaneously acting on cancer cells and bone cells. Experimental results demonstrate that this combination therapy significantly reduces tumor burden and prevents rapid relapse in mouse models.

THERANOSTICS (2021)

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Article Cell Biology