The role of GLUT2 in glucose metabolism in multiple organs and tissues

The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in & beta;-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis.

Automated summary

The glucose transporter family, especially GLUT2, plays a crucial role in the initial stage of glucose metabolism, transporting glucose into multiple organs and maintaining glucose homeostasis. Variations in GLUT2 are associated with endocrine and metabolic disorders. This study examines the role of GLUT2 in glucose metabolism and regulation in various organs and tissues.