Sleep-associated insulin resistance promotes neurodegeneration

Lifestyle modification can lead to numerous health issues closely associated with sleep. Sleep deprivation and disturbances significantly affect inflammation, immunity, neurodegeneration, cognitive depletion, memory impairment, neuroplasticity, and insulin resistance. Sleep significantly impacts brain and memory formation, toxin excretion, hormonal function, metabolism, and motor and cognitive functions. Sleep restriction associated with insulin resistance affects these functions by interfering with the insulin signalling pathway, neurotransmission, inflammatory pathways, and plasticity of neurons. So, in this review, We discuss the evidence that suggests that neurodegeneration occurs via sleep and is associated with insulin resistance, along with the insulin signalling pathways involved in neurodegeneration and neuroplasticity, while exploring the role of hormones in these conditions. [Graphics] .

Automated summary

Lifestyle modification can lead to various health issues related to sleep, including inflammation, immunity, neurodegeneration, cognitive decline, memory impairment, neuroplasticity, and insulin resistance. Sleep significantly affects brain and memory formation, toxin excretion, hormonal function, metabolism, and motor and cognitive functions. Sleep restriction associated with insulin resistance interferes with insulin signaling pathway, neurotransmission, inflammatory pathways, and neuronal plasticity. This review discusses the evidence suggesting the relationship between sleep, neurodegeneration, and insulin resistance, and explores the role of hormones in these conditions.