Journal
MOLECULAR MEDICINE REPORTS
Volume 14, Issue 1, Pages 623-629Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2016.5335
Keywords
osteogenic differentiation; microRNAs; mesenchymal stem cells; signaling
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Funding
- Natural Science Foundation of China [81572577, 81428018]
- Program for New Century Excellent Talents in University [NCET-12-0544]
- Open-End Fund for the Valuable and Precision Instruments of Central South University, Hunan Provincial Natural Science Foundation of China [14JJ1006]
- Project of Innovation-driven Plan of Central South University [2016CX023]
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Osteogenesis is a complex multi-step process involving the differentiation of mesenchymal stem cells ( MSCs) into osteoblast progenitor cells, preosteoblasts, osteoblasts and osteocytes, and the crosstalk between multiple cell types for the formation and remodeling of bone. The signaling regulatory networks during osteogenesis include various components, including growth factors, transcription factors, micro ( mi)RNAs and effectors, a number of which form feedback loops controlling the balance of osteogenic differentiation by positive or negative regulation. miRNAs have been found to be important regulators of osteogenic signaling pathways in multiple aspects and multiple signaling pathways. The present review focusses on the progress in elucidating the role of miRNA in the osteogenesis signaling networks of MSCs as a substitute for bone implantation the the field of bone tissue engineering. In particular, the review classifies which miRNAs promote or suppress the osteogenic process, and summarizes which signaling pathway these miRNAs are involved in. Improvements in knowledge of the characteristics of miRNAs in osteogenesis provide an important step for their application in translational investigations of bone tissue engineering and bone disease.
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