Investigation on anti-quorum sensing activities of chitosan AgNP's-chitosanase against MDR pathogens

Marine bio-nanotechnology is a new promising field having high perspective in the area of biological research. In 2018 the production of crustacean shells especially from shrimp is about 54,500 tons on South East coast of India. The current study focuses on the use of extracted chitosan (Squilla shells) polymer in silver nanoparticle synthesis along with immobilized chitosanase synergistically improves the antimicrobial and quorum quenching effects against the multi drug resistant (MDR) pathogens. The main objective of the study is to synthesize the chitosan AgNPs and to immobilize the enzyme chitosanase with it and to study the anti quorum sensing (quorum quenching) activity against MDR pathogens. This study will render a new ideology to eliminate biofilm formation and suppress the pathogenicity of planktonic MDR pathogens. Since the combinations of chitosanase, as well as chitosan AgNPs, are very efficient in eliminating them.

Automated summary

Marine bio-nanotechnology is a promising field with high potential in biological research. This study focuses on using extracted chitosan polymer from shrimp shells and immobilized chitosanase for silver nanoparticle synthesis to enhance antimicrobial and quorum quenching effects against multi drug resistant pathogens. The main objective is to synthesize chitosan AgNPs, immobilize chitosanase, and study their anti-quorum sensing activity against MDR pathogens. The study aims to eliminate biofilm formation and suppress pathogenicity of planktonic MDR pathogens.