Development and evaluation of a standard for absorbed dose to water from alpha-particle-emitting radionuclides

Targeted radionuclide therapy and brachytherapy with alpha particles has gained significant clinical relevance recently. Absorbed dose traceability to a standard is currently lacking in the dosimetry chain. The short range of alpha particles in water of <100 mu m complicates the absorbed dose measurements in the form of significant attenuation and perturbation effects. The aim of this work was to develop and validate a standard for absorbed dose to water from alpha-particle-emitting radionuclides. A dosimetric formalism to realize surface absorbed dose to water per unit activity using a windowless cylindrical parallel-plate ion chamber (IC) was introduced. IC-based and Monte Carlo (MC)-based correction factors were calculated for a planar circular Po-210 alpha-particle emitter. The measured absorbed dose to air was compared to the MC-calculated absorbed dose. A parallel-plate IC with a nominal 4 mm collector diameter composed of polystyrene-equivalent material was utilized as a standard. MC simulations were performed using the TOPAS MC code and finite source size, backscatter, and emission angle divergence correction factors were calculated by modeling the IC and the source. Multiple measurement trials were performed to measure ionization current at air gaps in the 0.3 mm to 0.525 mm range. The proposed dosimetric formalism was employed to calculate the surface absorbed dose to water from a point-like Po-210 source. The recombination and polarity correction factors were measured to be <0.50% when a 150 V mm(-1) electric field strength was applied. The MC-calculated and measured absorbed dose to air agreed within 2.05%. The finite source size and backscatter corrections were <10% with the emission angle divergence correction being in the 93%-239% range. The surface absorbed dose to water was measured to be 2.8913 x 10(-6) Gy s(-1) Bq(-1) with a combined uncertainty of 4.23% at k = 1. This work demonstrated the ability of a windowless parallel-plate IC as a standard for absorbed dose from alpha-particle-emitting radionuclides.

Automated summary

This study developed and validated a standard for measuring absorbed dose to water from alpha-particle-emitting radionuclides. A dosimetric formalism using a windowless cylindrical parallel-plate ion chamber (IC) was introduced, and correction factors were calculated using Monte Carlo simulations. The results demonstrated the capability of the IC as a reliable standard for measuring absorbed dose from alpha particles.