Magnetically recyclable Cu-BTC@Fe3O4-catalyzed synthesis of cyano functionalized chroman-4-ones

An intramolecular radical cascade acyl-cyanation of o-(allyloxy)benzaldehydes with Me3SiCN using magnetically recyclable Cu-BTC@Fe3O4 catalyst (BTC = 1,3,5-benzenetricarboxylate) and peroxides as the stoichiometric oxidants affords 3-cyanomethyl-functionalized chroman-4-ones in moderate to good yields. The catalyst can be readily recovered with an external permanent magnet, with slight decrease in its activity after successive five runs.

Automated summary

Intramolecular radical cascade acyl-cyanation of o-(allyloxy)benzaldehydes with Me3SiCN using magnetically recyclable Cu-BTC@Fe3O4 catalyst and peroxides as the stoichiometric oxidants provides moderate to good yields of 3-cyanomethyl-functionalized chroman-4-ones. The catalyst can be easily recovered with an external permanent magnet, showing slight decrease in activity after five successive runs.