4.5 Article

Prognostic significance of MALAT1 in clear cell renal cell carcinoma based on TCGA and GEO

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance

Mokhtar Jawad Al-Imam et al.

Summary: DNA methylation is an important mechanism in cancer development and progression. Aberrant methylation of CpG islands within promoter regions leads to dysregulation of tumor suppressors and oncogenes, resulting in malignant features. Recent studies have highlighted the role of LncRNAs in recruiting enzymes involved in methylation and mediating their functions. This opens up potential therapeutic strategies for targeted cancer therapy.

DNA REPAIR (2023)

Article Oncology

Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness

Yize Li et al.

Summary: By integrating histopathologic, proteogenomic, and metabolomic analyses, this study reveals the inter- and intratumoral heterogeneity of clear cell renal cell carcinomas (ccRCCs). It identifies high-risk disease subsets based on tumor grade, BAP1 mutation, genome instability, hypermethylation, and protein glycosylation signature. RNA sequencing provides insights into gene signatures and potential targeted therapies, while in vitro cell line studies validate the efficacy of inhibiting identified phosphoproteome targets.

CANCER CELL (2023)

Article Genetics & Heredity

Comprehensive Analysis to Identify SPP1 as a Prognostic Biomarker in Cervical Cancer

Kaidi Zhao et al.

Summary: This study reveals that SPP1 is overexpressed in cervical cancer tissues and is associated with prognosis and immune cell infiltration, suggesting its potential as a prognostic biomarker for cervical cancer patients.

FRONTIERS IN GENETICS (2022)

Review Urology & Nephrology

Surgical and focal treatment for metastatic renal cell carcinoma: A literature review

Sei Naito et al.

Summary: The concept of focal treatment for metastatic renal cell carcinoma is changing, with immediate cytoreductive nephrectomy now considered only for a limited number of patients. Deferred cytoreductive nephrectomy and metastasectomy have shown potential efficacy in improving overall survival. Radiotherapies have high local disease control rate but their impact on survival is still uncertain. Further investigations are needed given the limited evidence for surgical and focal treatments in metastatic renal cell carcinoma.

INTERNATIONAL JOURNAL OF UROLOGY (2022)

Article Immunology

Immune-Associated Gene Signatures Serve as a Promising Biomarker of Immunotherapeutic Prognosis for Renal Clear Cell Carcinoma

Qi Wang et al.

Summary: By conducting a comprehensive study on the expression and clinical data of renal clear cell carcinoma (ccRCC), a set of immune-related genes were identified and used to predict patient survival and categorize them into high-risk and low-risk subgroups. These subgroups exhibit distinct genomic, immunological characteristics, and different responses to immune checkpoint inhibitors (ICI) treatment.

FRONTIERS IN IMMUNOLOGY (2022)

Article Immunology

Naples Prognostic Score is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer and Nomogram Predictive Model Established

Shuangqing Chen et al.

Summary: This study revealed that Naples prognostic score (NPS) has an independent prognostic impact in small cell lung cancer (SCLC) patients, and a low NPS may predict longer overall survival (OS). Therefore, NPS plays a vital role in the nomogram predictive model of survival rates in SCLC patients.

JOURNAL OF INFLAMMATION RESEARCH (2022)

Article Medicine, Research & Experimental

Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway

Yijing Zhao et al.

Summary: The study revealed that in hepatoma cells, the lncRNA MALAT1 interacts with various loci on mitochondrial DNA, leading to abnormalities in mitochondrial function and subsequently impacting tumor phenotype and pathways related to cellular mitochondria. The findings suggest a critical role of MALAT1 in regulating mitochondrial metabolism and tumor metabolism reprogramming.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Cell Biology

Identification of a Five Autophagy Subtype-Related Gene Expression Pattern for Improving the Prognosis of Lung Adenocarcinoma

Meng-Yu Zhang et al.

Summary: In this study, the gene expression profiles and clinical information of LUAD patients were analyzed to explore autophagy-related genes and establish a predictive risk model to improve prognosis. Through functional enrichment analysis and clustering, potential biomarkers related to autophagy in LUAD were identified. The results provide insights into LUAD subtypes and offer a basis for personalized treatment strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Effects of Inflammation on the Immune Microenvironment in Gastric Cancer

Weidan Zhao et al.

Summary: By establishing the inflammatory response model score Riskscore, the study revealed the relationship between inflammation-related genes and immune gene expression in the development and progression of gastric cancer. The prognosis significantly differed between high- and low-risk groups, with the high-risk group showing lower survival rates and times. These findings contribute to improving prognosis prediction for gastric cancer and provide new insights for immunotherapy in gastric cancer patients.

FRONTIERS IN ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

TRPV4 is a Prognostic Biomarker that Correlates with the Immunosuppressive Microenvironment and Chemoresistance of Anti-Cancer Drugs

Kai Wang et al.

Summary: TRPV4 is highly expressed in colon adenocarcinoma and ovarian cancer, associated with worse overall survival, disease-specific survival, disease-free interval, and progression-free interval. Its expression is closely related to immune regulation pathways and could contribute to tumor-associated macrophage infiltration. High TRPV4 expression may lead to resistance to Cisplatin and Oxaliplatin treatment.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Biochemistry & Molecular Biology

DNA methylation and gene expression profiles characterize epigenetic regulation of lncRNAs in colon adenocarcinoma

Zhijin Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

Review Urology & Nephrology

Oncometabolites in renal cancer

Cissy Yong et al.

NATURE REVIEWS NEPHROLOGY (2020)

Article Biotechnology & Applied Microbiology

Integrative Analysis of Methylation and Transcriptome Identified Epigenetically Regulated lncRNAs With Prognostic Relevance for Thyroid Cancer

Qiuying Li et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Long Noncoding RNA MALAT1 Promotes the Development of Colon Cancer by Regulating miR-101-3p/STC1 Axis

Chunyan Luan et al.

ONCOTARGETS AND THERAPY (2020)

Article Cell Biology

LncRNA DHRS4-AS1 Inhibits the Stemness of NSCLC Cells by Sponging miR-224-3p and Upregulating TP53 and TET1

Fei Yan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemical Research Methods

The small peptide world in long noncoding RNAs

Seo-Won Choi et al.

BRIEFINGS IN BIOINFORMATICS (2019)

Review Oncology

Tumor Microenvironment Dynamics in Clear-Cell Renal Cell Carcinoma

Lynda Vuong et al.

CANCER DISCOVERY (2019)

Review Genetics & Heredity

The Role of DNA Methylation in Renal Cell Carcinoma

Brittany N. Lasseigne et al.

MOLECULAR DIAGNOSIS & THERAPY (2018)

Article Biochemistry & Molecular Biology

MALAT1-mediated tumorigenesis

Jianghua Liu et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2017)

Article Biochemistry & Molecular Biology

Natural antisense RNA promotes 3' end processing and maturation of MALAT1 lncRNA

Xinying Zong et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Multidisciplinary Sciences

Comprehensivemolecular characterization of clear cell renal cell carcinoma

Chad J. Creighton et al.

NATURE (2013)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)