Dissection of action mechanisms of Zuogui Pill in the treatment of liver cancer based on machine learning and network pharmacology: A review

Review Chemistry, Medicinal

An evaluation of the effects and safety of Zuogui pill for treating osteoporosis: Current evidence for an ancient Chinese herbal formula

Jinyu Li et al.

Summary: The study systematically evaluated the effectiveness of Chinese herbal formula Zuogui pill (ZGP) in treating osteoporosis. Results showed that ZGP, in combination with anti-osteoporosis drugs, significantly increased bone mineral density and improved bone metabolism markers. However, further high-quality trials with larger sample sizes are needed to validate these findings.

PHYTOTHERAPY RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hep- atocellular Carcinoma

Arunaksharan Narayanankutty

Summary: Hepatocellular carcinoma is closely related to fatty liver disease and cirrhosis, with chronic inflammation and lipotoxicity driving its progression. The PI3K/Akt signaling pathway plays a key role in the development and progression of HCC, with natural inhibitors showing promise in HCC prevention.

CURRENT MOLECULAR PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma

Eun Jin Sun et al.

Summary: This review article discusses the pivotal role of the PI3K/Akt/mTOR pathway in HCC, focusing on its impact on cellular processes and providing an update on the ongoing clinical development of therapies targeting this pathway for HCC treatments.

BIOMEDICINES (2021)

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Article Biochemistry & Molecular Biology

Local anesthetic bupivacaine inhibits proliferation and metastasis of hepatocellular carcinoma cells via suppressing PI3K/Akt and MAPK signaling

Lei Wang et al.

Summary: Bupivacaine has shown inhibitory effects on proliferation, migration, and invasion of HCC cells, as well as induction of apoptosis. The drug achieves this through suppression of the PI3K/Akt and MAPK signaling pathways.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Article Multidisciplinary Sciences