Risk factors of prolonged intensive care unit stay following cardiac surgery for infective endocarditis

Introduction: Prolonged intensive care unit (ICU) stay is common in serious patients undergoing cardiac surgery. Prolonged ICU stay is associated with increased mortality and worse prognosis. This study was conducted to determine the risk factors for prolonged ICU stay after cardiac surgery for infective endocarditis (IE) and we try to decrease the operative risk of mortality and morbidity of cardiac surgery for IE. Methods: The retrospective study of patients with IE undergoing cardiac surgery between January 2006 and November 2022 at our hospital was performed. Results: 896 patients undergoing cardiac surgery were divided into group of ICU stay <= 3d (n=416) and group p of ICU stay>3d (n=480). There were 48 operative deaths (5.4%). Univariable and multivariable analyses showed that factors are associated with prolonged ICU stay following cardiac surgery for IE, including male (P<.001), age (P<.001), weight (P=.009), vegetation length (P<.001), paravalvular leak (P<.001), aortic cross-clamp time (P<.001), cardiopulmonary bypass (CPB) time (P<.001), mechanical ventilation time (P<.001), hospitalized time postoperative (P=.032), creatinine of serum before surgery (P<.001), creatinine of serum 24h after surgery (P=.005), creatinine of serum 48h after surgery (P<.001), fluid balance on operation day (P<.001), postoperative acute kidney injury (P<.001), left ventricular end diastolic dimension (LVEDD) preoperative (P<.001), LVEDD postoperative (P<.001), chest drainage (P=.032), frozen plasma (P=.016), preoperative aortic insufficiency (P<.001), and packed red cells (P<.001). Conclusions: In our study, shortness of ICU stay and optimization of pre-, peri-, and postoperative factors that can shorten ICU stay, therefore, contribute to a better postoperative outcome and leads to lower rates of mortality and morbidity.

Automated summary

This study aimed to identify the risk factors for prolonged intensive care unit (ICU) stay after cardiac surgery for infective endocarditis (IE) and to reduce the operative risk of mortality and morbidity. The results showed that factors such as male gender, age, weight, vegetation length, paravalvular leak, aortic cross-clamp time, cardiopulmonary bypass time, mechanical ventilation time, and other factors were associated with prolonged ICU stay.