☆ 4.7 Review

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

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Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer's Disease

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DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons

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The association between urinary pentosidine levels and cognition in drug-naive patients with Parkinson's disease

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The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders

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Summary: This review examines the relationship between advanced glycation end products (AGEs) and neurocognitive and mental health disorders. Studies show that elevated circulating AGEs are associated with poorer cognitive function and increased risk of developing dementia, while higher skin AGE accumulation may be associated with mental disorders. The effects of AGEs are mediated by increased oxidative stress and neuroinflammation, and reducing dietary intake of AGEs may improve neurological and mental disorder outcomes.

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Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer's Disease-Related Pathologies in Wild-Type Mice

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Advanced Glycation End Products (AGEs) and Chronic Kidney Disease: Does the Modern Diet AGE the Kidney?

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Summary: Since the 1980s, the incidence of chronic kidney disease (CKD) has increased by almost 25%. This is partly due to changes in lifestyle and the global consumption of a western diet, which is high in energy, low in fruits and vegetables, and rich in animal protein and processed foods. These dietary trends have led to an increase in the consumption of advanced glycation end products (AGEs) and metabolic disorders, obesity, and diabetes, which contribute to the production of endogenous AGEs in the body. Excessive accumulation of AGEs can be pathologic through receptor-mediated and non-receptor-mediated pathways. AGEs are cleared by the kidneys, making them particularly susceptible to AGE-mediated damage, and high levels of circulating AGEs are associated with an increased risk of CKD and all-cause mortality. Individuals with significant loss of renal function have increased AGE burden, particularly in those with uremia, and there is evidence that lowering AGEs through diet or pharmacological inhibition may be beneficial for CKD. This review explores the pathways of AGE formation and regulation in the body, the impact of diet on endogenous AGE production and dietary AGE consumption, the contribution of AGEs to kidney disease, and the potential of AGE-targeted therapies for kidney disease.

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Correlation between Glycation-Related Biomarkers and Quality of Life in the General Japanese Population: The Iwaki Cross-Sectional Research Study

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Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus

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Summary: Diabetes Mellitus is a metabolic disorder that is spreading rapidly worldwide. Quercetin, a flavonoid, has therapeutic potential in the management of Type-2 DM, as it improves pancreatic beta-cell function, inhibits inflammation, and shows antidiabetic effects.

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Advanced glycation end products induce Aβ1-42 deposition and cognitive decline through H19/miR-15b/BACE1 axis in diabetic encephalopathy

Lei Jiang et al.

Summary: In this study, the role of advanced glycation end products (AGEs) in the pathogenesis of diabetic encephalopathy (DE) and its underlying mechanisms were investigated. The study found that AGEs induced A81-42 deposition and cognitive decline through the H19/miR15b/BACE1 axis in DE. MiR-15b was downregulated, while H19 and BACE1 were upregulated in the hippocampus of DE rats and AGEs-treated HT-22 cells. The expression of BACE1 protein was negatively regulated by miR-15b at the post-transcriptional level in HT-22 cells. The administration of miR-15b mimics improved cognitive decline in DE rats. The luciferase activity assay confirmed the binding site of miR15b to both the 3'-untranslated region (3'-UTR) of BACE1 mRNA and H19. In addition, the miR-15b inhibitor reversed H19 knockdown-mediated decrease of A81-42 level in AGEs-treated HT-22 cells.

BRAIN RESEARCH BULLETIN (2022)

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Article Biochemistry & Molecular Biology

Metformin encapsulated gold nanoparticles (MTF-GNPs): A promising antiglycation agent

Fahaad Alenazi et al.

Summary: The combination of metformin and glycation-derived synthesized gold nanoparticles (MTF-GNPs) shows significant antiglycating capacity and may serve as a promising treatment for AGE-related and metabolic disorders.

CELL BIOCHEMISTRY AND FUNCTION (2022)

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Article Biochemistry & Molecular Biology

D-ribose-mediated glycation of fibrinogen: Role in the induction of adaptive immune response

Sultan Alouffi et al.

Summary: The nonenzymatic reaction between reducing sugars and amino groups of proteins leads to the formation of advanced glycation end products, which are associated with chronic progressive diseases. This study found that D-ibose-glycated fibrinogen is more immunogenic than its native form and can induce an immune response. The immune response to Rb-gly-Fb resulted in the deposition of antibodies in the glomerular basement membrane of the kidneys and increased expression of proinflammatory cytokine genes.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Biochemistry & Molecular Biology

Glycation of Immunoglobulin-G from Pentose Sugar: A Cause for Structural Perturbations

Fahaad Alenazi et al.

Summary: This study analyzed the effects of deoxyribose-induced IgG glycation on IgG structure and AGEs formation. The experimental results confirmed the modification in IgG structure and the formation of AGEs, which may contribute to secondary complications of diabetes.

CURRENT PROTEIN & PEPTIDE SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Mineralocorticoid interaction with glycated albumin downregulates NRF-2 signaling pathway in renal cells: Insights into diabetic nephropathy

Deepesh D. Gaikwad et al.

Summary: This study discovers that the interaction between aldosterone and glycated albumin in diabetic nephropathy can cause oxidative stress, reduce levels of antioxidants and glycation detoxifying enzymes, and result in renal cell damage.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Understanding the role of glycation in the pathology of various non-communicable diseases along with novel therapeutic strategies

Nilima S. Bangar et al.

Summary: Glycation refers to the reaction between reducing sugars and free amino groups in proteins, resulting in the formation of various products. Glycation plays a significant role in metabolic diseases, brain disorders, aging, and gut microbiome dysregulation. It affects the development of diseases by altering protein structure and function.

GLYCOBIOLOGY (2022)

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Article Cell Biology

In vitro differentiation of human pancreatic duct-derived PANC-1 cells into β-cell phenotype using Tinospora cordifolia

Hemangee Damame et al.

Summary: This study evaluated the potential of Tinospora cordifolia extract in inducing differentiation of PANC-1 cells into functional beta cells. The results showed that the extract effectively promoted the formation of beta cells and increased insulin expression and secretion.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2022)

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Article Nutrition & Dietetics

Rapid pretreatment for multi-sample analysis of advanced glycation end products and their role in nephropathy

Sayuri Kato et al.

Summary: This study developed a highly efficient automated analysis system for advanced glycation end products (AGEs) and applied it to evaluate AGEs in nephropathy. The results demonstrate that the system performs well in column operations and pretreatment stability, and can accurately measure the levels of AGEs. Furthermore, the study results indicate that the levels of N-epsilon-(carboxymethyl)lysine (CML) and N-epsilon-(carboxyethyl)lysine (CEL) are associated with declined kidney function and significantly elevated in patients with nephropathy.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2022)

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Article Nutrition & Dietetics

Food-Related Carbonyl Stress in Cardiometabolic and Cancer Risk Linked to Unhealthy Modern Diet

Carla Iacobini et al.

Summary: Carbonyl stress refers to the increase in reactive carbonyl species and the formation of irreversible covalent adducts with biological molecules. It is associated with inflammation and damage, and plays a role in diabetic cardiovascular complications, cancer risk, and the impact of modern diet on cardiometabolic and cancer risk.

NUTRIENTS (2022)

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Article Endocrinology & Metabolism

Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study

M. Piazza et al.

Summary: The study found that irbesartan treatment does not alter plasma levels of dicarbonyls in patients with type 2 diabetes, indicating the need for alternative approaches to reduce systemic dicarbonyls in this population.

DIABETIC MEDICINE (2021)

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Review Medicine, Research & Experimental

Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

Periyanaina Kesika et al.

Summary: Gut microbiota plays a crucial role in the development of Alzheimer's disease (AD) through dysbiosis, leading to inflammatory signaling pathway disturbances that promote neuroinflammation and neuronal death. Understanding the relationship between gut microbiota and CNS can help identify probiotic-based supplementation as a potential therapeutic option for AD.

LIFE SCIENCES (2021)

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Article Neurosciences

Methylglyoxal-Mediated Dopamine Depletion, Working Memory Deficit, and Depression-Like Behavior Are Prevented by a Dopamine/Noradrenaline Reuptake Inhibitor

Gudrian Ricardo Lopes de Almeida et al.

Summary: MGO, an endogenous toxin produced during glycolysis, has been linked to aging, Alzheimer's disease, and inflammation. In vivo administration of MGO affects monoaminergic systems in the cerebral cortex, leading to depression-like behavior and cognitive impairment. Treatment with a dopamine/noradrenaline reuptake inhibitor can reverse these effects.

MOLECULAR NEUROBIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Glyoxal damages human aortic endothelial cells by perturbing the glutathione, mitochondrial membrane potential, and mitogen-activated protein kinase pathways

Ming-Zhang Xie et al.

Summary: Exposure to glyoxal was found to be linked to abnormal glutathione activity, the collapse of mitochondrial membrane potential, and the activation of mitogen-activated protein kinase pathways. However, DNA damage and thioredoxin oxidation were not induced by dialdehydes. These findings provide novel insights into the molecular mechanisms perturbed by glyoxal, and may facilitate the development of new therapeutics and diagnostic markers for cardiovascular diseases.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Biochemistry & Molecular Biology

Age-dependent accumulation of dicarbonyls and advanced glycation endproducts (AGEs) associates with mitochondrial stress

Firoz Akhter et al.

Summary: The accumulation of metabolites associated with aging can lead to oxidative stress and mitochondrial dysfunction in the brain, but scavenging mitochondrial ROS can help reduce AGEs and dicarbonyls accumulation, improving mitochondrial function.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Review Gastroenterology & Hepatology

The Microbiota-Gut-Brain Axis: From Motility to Mood

Kara G. Margolis et al.

Summary: The gut-brain axis is crucial in maintaining homeostasis, with the microbiome playing a significant role in modulating signaling along this axis. This axis impacts disorders like irritable bowel syndrome and mood disorders, with serotonin being a key neurotransmitter involved in these conditions. More research is needed before these findings can be applied for diagnostic and therapeutic purposes in patient populations.

GASTROENTEROLOGY (2021)

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Article Food Science & Technology

Methylglyoxal affects cognitive behaviour and modulates RAGE and Presenilin-1 expression in hippocampus of aged mice

M. Pucci et al.

Summary: The study demonstrated that high MG oral intake directly affects brain health and may establish an environment predisposing to AD-like pathological conditions.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis

Michal Smiga et al.

Summary: The study found that glycation increases the ability of Porphyromonas gingivalis to acquire heme from hemoglobin and promotes bacterial biofilm formation, thus enhancing its pathogenic potential in vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

Jinluan Chen et al.

Summary: The study found that the AGE-RAGE system is associated with cognitive decline and dementia cross-sectionally but not longitudinally. This suggests a short-term association or reverse causality. Further research is needed to confirm cross-sectional associations between higher skin autofluorescence and cognitive function, as well as the association with APOE status.

JAMA NETWORK OPEN (2021)

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Article Immunology

Glycation of gut proteins initiates microbial dysbiosis and can promote establishment of diabetes in experimental animals

Rahul Patil et al.

Summary: The study reveals that high fructose feed can lead to microbial dysbiosis, reducing gut flora and promoting pathogenic succession, thereby exacerbating glycation of gut proteins and triggering an inflammatory response. These changes increase the likelihood of insulin resistance.

MICROBIAL PATHOGENESIS (2021)

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Article Neurosciences

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease

Velma T. E. Aho et al.

Summary: This study found that intestinal inflammatory responses and reductions in fecal SCFAs occur in Parkinson's disease (PD), are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels.

MOLECULAR NEURODEGENERATION (2021)

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Article Microbiology

Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease

Yan-fang Hou et al.

Summary: The study showed that osteocalcin (OCN) can improve motor deficits and dopaminergic neuronal loss in a Parkinson's disease mouse model. Manipulating the gut microbiome by OCN led to increased propionate levels, which correlated with improvements in motor deficits and dopaminergic neuronal loss in the PD mice. The activation of FFAR3 receptor by propionate in the enteric nervous system might be the main mechanism behind the neuroprotective effects of OCN on Parkinson's disease.

MICROBIOME (2021)

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Article Biochemistry & Molecular Biology

Protein glycation ? biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine

Naila Rabbani et al.

Summary: Protein glycation provides a widely used biomarker, A1C, for diagnosing diabetes and prediabetes as well as monitoring medium-term glycemic control in patients with established diabetes. Glycation biomarkers are influenced by various factors such as heritability, aging, decline in metabolic and vascular health, and are applicable to populations of different ethnicities. They have potential for continued and expanding clinical use, including in the era of developing precision medicine.

REDOX BIOLOGY (2021)

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Article Food Science & Technology

Role of curd and yogurt in establishment and progression of diabetes through protein glycation and induction of inflammation

Rahul Patil et al.

Summary: The study shows that curd and yogurt can lead to protein glycation and inflammation, causing oxidative stress in animals. Regular consumption of curds can exacerbate diabetes due to glycation of proteins, inflammation, and oxidative stress.

FOOD BIOSCIENCE (2021)

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Article Cell Biology

Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

Zongxin Ling et al.

Summary: The study found that gut dysbiosis in Chinese Alzheimer's disease (AD) patients results in a decrease in bacterial diversity, a reduction in butyrate-producing genera positively correlated with cognitive scores, and an increase in lactate-producing genera inversely correlated with these indicators. This shift in gut dysbiosis contributes to immune disturbances in the host, serving as potential non-invasive biomarkers for distinguishing AD patients from controls. Additionally, altered functional modules in the gut microbiota of AD patients may produce immunomodulatory metabolites.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Epigenetics of Alzheimer's Disease

Matea Nikolac Perkovic et al.

Summary: Validated biomarkers for accurately diagnosing Alzheimer's disease (AD) are currently lacking, but epigenetic modifications have been identified as important factors in the pathogenesis of AD. DNA methylation, hydroxymethylation, histone modifications, and non-coding RNA regulation play critical roles in the development of AD, while mitochondrial DNA may serve as a potential biomarker for AD.

BIOMOLECULES (2021)

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Article Neurosciences

Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation

Stefano Romano et al.

Summary: Recent studies have shown significant alterations in the gut microbiome of Parkinson's disease patients compared to healthy individuals, which may result in a pro-inflammatory status and impact the symptoms and pathophysiology of the disease.

NPJ PARKINSONS DISEASE (2021)

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Article Food Science & Technology

Methylglyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells

Hee-Weon Lee et al.

Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Endocrinology & Metabolism

Elevated serum pentosidine is independently associated with the high prevalence of sarcopenia in Chinese middle-aged and elderly men with type 2 diabetes mellitus

Xiaofan Zhang et al.

Summary: This study found a negative correlation between serum pentosidine levels and sarcopenia in middle-aged and elderly men with type 2 diabetes mellitus, suggesting that pentosidine could be used as a screening marker for monitoring sarcopenia in patients with type 2 diabetes mellitus.

JOURNAL OF DIABETES INVESTIGATION (2021)

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Review Food Science & Technology

Dysbiosis-Related Advanced Glycation Endproducts and Trimethylamine N-Oxide in Chronic Kidney Disease

Kensei Taguchi et al.

Summary: Chronic kidney disease affects approximately 10% of the global population and is associated with high frequencies of comorbidities such as heart failure and cardiovascular disease. Gut microbial dysbiosis, an imbalance of the gut microbial community, accelerates CKD progression by producing more uremic toxins in the gastrointestinal tracts. The gut-kidney axis has emerged as a potential therapeutic target for treating CKD.

TOXINS (2021)

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Article Endocrinology & Metabolism

Glycation by glyoxal leads to profound changes in the behavior of dermal fibroblasts

Cecile Guillon et al.

Summary: The study found that glyoxal glycation significantly reduced the proliferation and migration capabilities of fibroblasts, while increasing cellular tensile strength. Glyoxal did not affect the secretion of type I collagen, but disrupted its maturation and prevented deposition in the extracellular matrix, while also promoting the accumulation of lipid droplets.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

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Article Food Science & Technology

Highland Barley and Its By-Products Enriched with Phenolic Compounds for Inhibition of Pyrraline Formation by Scavenging α-Dicarbonyl Compounds

Dianwei Zhang et al.

Summary: Pyrraline, a type of advanced glycation end product, can be inhibited by phenolic compounds extracted from highland barley and vinasse. The antioxidant activity of the extracts and their regulation on pyrraline formation were studied using UPLC-PAD-MS/MS. The results suggest that highland barley and its by-products have the potential to be used as functional foods to regulate pyrraline formation during food processing.

FOODS (2021)

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Article Nutrition & Dietetics

Increased Added Sugar Consumption Is Common in Parkinson's Disease

Natalie C. Palavra et al.

Summary: The study found that compared to healthy controls, Parkinson's Disease patients consume more total carbohydrates and sugars. PD patients who experience chronic pain, depression, or impulse control disorders consumed more sugars, and increased sugar consumption was associated with worsening non-motor symptoms.

FRONTIERS IN NUTRITION (2021)

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Article Clinical Neurology

Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)

Kumar B. Rajan et al.

Summary: This study estimated the prevalence of clinical Alzheimer's disease in 2020 and projected future increases, finding a more significant growth among Hispanics and Blacks.

ALZHEIMERS & DEMENTIA (2021)

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Article Biochemistry & Molecular Biology

Detecting beta-amyloid glycation by intrinsic fluorescence-Understanding the link between diabetes and Alzheimer's disease

Abeer Alghamdi et al.

Summary: Monitoring the aggregation of Aβ1-40 in the presence of high glucose concentrations reveals the impact of glycation on oligomerization, altering the aggregation pathway and providing insights into the pathophysiology of Alzheimer's disease. The formation of advanced glycation end products plays a significant role in these pathways, highlighting the connection between AGEs, diabetes, and AD progression.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

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Review Medical Laboratory Technology

Carbonyl stress in diabetics with acute coronary syndrome

Sushmita Bora et al.

Summary: The prevalence and incidence of diabetes mellitus (DM) are increasing worldwide, leading to higher rates of complications. Mechanisms such as carbonyl stress are responsible for the pathogenesis of DM and its complications, with potential therapeutic targets aimed at minimizing their harmful effects. Extensive research is needed in developing treatment strategies targeting carbonyl stress in patients with diabetes.

CLINICA CHIMICA ACTA (2021)

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Review Biochemistry & Molecular Biology

Understanding the Role of Protein Glycation in the Amyloid Aggregation Process

Ivana Sirangelo et al.

Summary: The study provides an overview of the molecular effects induced by glycation on the amyloid aggregation process of protein models associated with misfolding diseases. Glycation plays a key role in protein folding, kinetics of amyloid formation, and amyloid cytotoxicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Physical

Exploring the Impact of Glyoxal Glycation on β-Amyloid Peptide (Aβ) Aggregation in Alzheimer's Disease

Kai-Wei Hu et al.

Summary: The study showed that glycation significantly slows down the aggregation process of A beta and induces more cytotoxicity, especially at position 28. The higher toxicity might result from a relatively stable oligomeric form of the peptide, rather than ROS production.

JOURNAL OF PHYSICAL CHEMISTRY B (2021)

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Article Multidisciplinary Sciences

Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration

Chenyin Wang et al.

Summary: This study reveals the critical role of gut microbiota in regulating neurodegenerative diseases, particularly through influencing the formation and aggregation of amyloid fibrils. This provides a new research direction for the treatment of neurodegenerative diseases.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Chemistry, Multidisciplinary

α-Synuclein: An All-Inclusive Trip Around its Structure, Influencing Factors and Applied Techniques

Nicolo Bisi et al.

Summary: Alpha-synuclein is a highly expressed and conserved protein found in neuronal presynaptic terminals, and its misfolding and aggregation are associated with several neurodegenerative diseases. Studies have shown that the structure of alpha-synuclein can be influenced by various factors, including mutations, biological environment, and interactions with exogenous compounds.

FRONTIERS IN CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Role of Epigenetics in Type 2 Diabetes and Obesity

Rosanna Capparelli et al.

Summary: Epigenetic marks the genome through DNA methylation, histone modification, or non-coding RNAs, guiding cells to respond to environmental cues and maintain stable gene expression. Studies have revealed associations between DNA methylation and conditions such as body mass index, obesity, and Type 2 Diabetes, highlighting the potential therapeutic value of epigenetic research.

BIOMEDICINES (2021)

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Article Endocrinology & Metabolism

Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes

Nordin M. J. Hanssen et al.

Summary: The study revealed that plasma MGO levels are associated with adverse outcomes in SLI, showing a strong correlation with mortality and amputation rates in patients.

DIABETES CARE (2021)

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Review Clinical Neurology

Parkinson's disease and the gastrointestinal microbiome

Michal Lubomski et al.

JOURNAL OF NEUROLOGY (2020)

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Article Chemistry, Medicinal

Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Kavya Jash et al.

DRUG DEVELOPMENT RESEARCH (2020)

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Article Gastroenterology & Hepatology

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model

Min-Soo Kim et al.

GUT (2020)

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Review Medical Laboratory Technology

Glycated albumin

Mustapha Zendjabil

CLINICA CHIMICA ACTA (2020)

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Article Endocrinology & Metabolism

Butyrate modulates diabetes-linked gut dysbiosis: epigenetic and mechanistic modifications

Mohamed H. Noureldein et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2020)

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Article Pharmacology & Pharmacy

Inhibition of GLUT2 transporter by geraniol from Cymbopogon martinii: a novel treatment for diabetes mellitus in streptozotocin-induced diabetic rats

Snehalata Prakash Kamble et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Repeated Methylglyoxal Treatment Depletes Dopamine in the Prefrontal Cortex, and Causes Memory Impairment and Depressive-Like Behavior in Mice

Jozimar Carlos Szczepanik et al.

NEUROCHEMICAL RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Effect of Glyoxal Modification on a Critical Arginine Residue (Arg-31α) of Hemoglobin: Physiological Implications of Advanced Glycated End Product an In Vitro Study

Sauradipta Banerjee

PROTEIN AND PEPTIDE LETTERS (2020)

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Article Neurosciences

Bacillus Subtilis Delays Neurodegeneration and Behavioral Impairment in the Alzheimer's Disease Model Caenorhabditis Elegans

Sebastian Cogliati et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Review Biotechnology & Applied Microbiology

Gut, oral and nasal microbiota and Parkinson's disease

Liang Shen

MICROBIAL CELL FACTORIES (2020)

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Article Food Science & Technology

The Effect of Lactobacillus fermentum ME-3 Treatment on Glycation and Diabetes Complications

Axel Guilbaud et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

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Review Medicine, General & Internal

Role of gut microbiota in type 2 diabetes pathophysiology

Manoj Gurung et al.

EBIOMEDICINE (2020)

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Article Cell Biology

Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans

Maria Eugenia Goya et al.

CELL REPORTS (2020)

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Review Geriatrics & Gerontology

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease

Gurjit Kaur Bhatti et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Biochemistry & Molecular Biology

Hsp27 reduces glycation-induced toxicity and aggregation of alpha-synuclein

Hugo Vicente Miranda et al.

FASEB JOURNAL (2020)

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Article Endocrinology & Metabolism

The Association between HbA1c Levels, Olfactory Memory and Cognition in Normal, Pre-Diabetic and Diabetic Persons

Burak Yulug et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

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Article Multidisciplinary Sciences

Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study

Kristine B. Holte et al.

PLOS ONE (2020)

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Article Multidisciplinary Sciences

Bifidobacteria shape host neural circuits during postnatal development by promoting synapse formation and microglial function

Berkley Luck et al.

SCIENTIFIC REPORTS (2020)

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Article Clinical Neurology

Microbiota Composition and Metabolism Are Associated With Gut Function in Parkinson's Disease

Mihai S. Cirstea et al.

MOVEMENT DISORDERS (2020)

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Review Neurosciences

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

Larissa-Nele Schaffert et al.

BRAIN SCIENCES (2020)

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Article Clinical Neurology

Refined carbohydrate-rich diet is associated with long-term risk of dementia and Alzheimer's disease in apolipoprotein E ε4 allele carriers

Melissa Gentreau et al.

ALZHEIMERS & DEMENTIA (2020)

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Article Biology

Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions

Federico Baldini et al.

BMC BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease

Amit Sharma et al.

REDOX BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

The Role of Glycation on the Aggregation Properties of IAPP

Giulia Milordini et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Biochemistry & Molecular Biology

Generation and Characterization of Anti-Glucosepane Antibodies Enabling Direct Detection of Glucosepane in Retinal Tissue

Matthew D. Streeter et al.

ACS CHEMICAL BIOLOGY (2020)

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Article Clinical Neurology

Meta-Analysisof Gut Dysbiosis in Parkinson's Disease

Hiroshi Nishiwaki et al.

MOVEMENT DISORDERS (2020)

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Article Geriatrics & Gerontology

Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer’s disease

Harpreet Kaur et al.

NEUROBIOLOGY OF AGING (2020)

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Review Biochemistry & Molecular Biology

RAGE and its ligands: from pathogenesis to therapeutics

Nitish Jangde et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2020)

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Article Multidisciplinary Sciences

High fractional excretion of glycation adducts is associated with subsequent early decline in renal function in type 1 diabetes

Bruce A. Perkins et al.

SCIENTIFIC REPORTS (2020)

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Article Geriatrics & Gerontology

Pathological Mechanisms Linking Diabetes Mellitus and Alzheimer's Disease: the Receptor for Advanced Glycation End Products (RAGE)

Yanyan Kong et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Neurosciences

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer's Disease

Moira Marizzoni et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

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Article Endocrinology & Metabolism

Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study

Sebastian Brings et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2020)

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Article Clinical Neurology

Helicobacter pyloriEradication in Parkinson's Disease: A Randomized Placebo-Controlled Trial

Ai Huey Tan et al.

MOVEMENT DISORDERS (2020)

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Article Genetics & Heredity

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease

Raffaella Nativio et al.

NATURE GENETICS (2020)

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Article Neurosciences

Epigenomic analysis of Parkinson's disease neurons identifies Tet2 loss as neuroprotective

Lee L. Marshall et al.

NATURE NEUROSCIENCE (2020)

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Article Gastroenterology & Hepatology

Characterization of the intestinal microbiota duringCitrobacter rodentiuminfection in a mouse model of infection-triggered Parkinson's disease

Tyler Cannon et al.

GUT MICROBES (2020)

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Article Pharmacology & Pharmacy

Synergy Effects of Metformin and Berberine on Glyoxal-induced Carbonyl Stress in Isolated Rat Liver Mitochondria

Mohsen Rezaei et al.

CURRENT DRUG THERAPY (2020)

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Article Pharmacology & Pharmacy

In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells

Hemangee H. Damame et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2020)

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Article Chemistry, Multidisciplinary

Unravelling the effect of N(ε)-(carboxyethyl)lysine on the conformation, dynamics and aggregation propensity of α-synuclein

Laura Marino et al.

CHEMICAL SCIENCE (2020)

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Article Neurosciences

Sex specific cognitive differences in Parkinson disease

Tyler Harrison Reekes et al.

NPJ PARKINSONS DISEASE (2020)

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Article Endocrinology & Metabolism

Action of metformin therapy against advanced glycation, oxidative stress and inflammation in type 2 diabetes patients: 3 months follow-up study

Krishna A. Adeshara et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide

Yunxiang Sun et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Article Medicine, Research & Experimental

Early metabolic changes in the gut leads to higher expression of intestinal alpha glucosidase and thereby causes enhanced postprandial spikes

Megha L. Nalawade et al.

LIFE SCIENCES (2019)

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Review Neurosciences

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

D. Allan Butterfield et al.

NATURE REVIEWS NEUROSCIENCE (2019)

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Review Neurosciences

Entanglement of Genetics and Epigenetics in Parkinson's Disease

H. J. van Heesbeen et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Biochemistry & Molecular Biology

Nitration and Glycation Diminish the α-Synuclein Role in the Formation and Scavenging of Cu2+-Catalyzed Reactive Oxygen Species

Humberto Martinez-Orozco et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Methylglyoxal - An emerging biomarker for diabetes mellitus diagnosis and its detection methods

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Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase

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Site-specific glycation of A1-42 affects fibril formation and is neurotoxic

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Acceleration of protein glycation by oxidative stress and comparative role of antioxidant and protein glycation inhibitor

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The role of short-chain fatty acids in microbiota-gut-brain communication

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Do your gut microbes affect your brain dopamine?

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More Research Is Needed on Lifestyle Behaviors That Influence Progression of Parkinson's Disease

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Methylglyoxal induces glycation and oxidative stress in Saccharomyces cerevisiae

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Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer's Disease

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Fecal microbiota transplantation to treat Parkinson's disease with constipation A case report

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Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice

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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

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A Narrative Review of Lifestyle Factors Associated with Parkinson's Disease Risk and Progression

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The gut microbiota: A novel therapeutic target in Parkinson's disease?

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Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice

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Fecal Calprotectin as a Marker of the Gut Immune System Activation Is Elevated in Parkinson's Disease

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Methylglyoxal and Glyoxal as Potential Peripheral Markers for MCI Diagnosis and Their Effects on the Expression of Neurotrophic, Inflammatory and Neurodegenerative Factors in Neurons and in Neuronal Derived-Extracellular Vesicles

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Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats

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TET2 Regulates the Neuroinflammatory Response in Microglia

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Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

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Diet in Parkinson's Disease: Critical Role for the Microbiome

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Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer's Disease

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Aberrant intestinal microbiota in individuals with prediabetes

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Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson's Disease by Inhibiting the TLR/NF-kappa B Pathway

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Small intestinal bacterial overgrowth in Parkinson's disease: Tribulations of a trial

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Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease

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Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

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Gene Therapy for Parkinson's Disease, An Update

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Effects of Oligosaccharides From Morinda officinalis on Gut Microbiota and Metabolome of APP/PS1 Transgenic Mice

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Pioglitazone inhibits advanced glycation induced protein modifications and down-regulates expression of RAGE and NF-κB in renal cells

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Parkinson's disease and bacteriophages as its overlooked contributors

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Effects of Transcranial Direct Current Stimulation (tDCS) Over the Frontal Polar Area on Motor and Executive Functions in Parkinson's Disease; A Pilot Study

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The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

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Levodopa-induced dyskinesia in Parkinson disease A population-based cohort study

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Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus

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Effect of intensive lifestyle modification & metformin on cardiovascular risk in prediabetes: A pilot randomized control trial

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Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

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Human gut microbiota: the links with dementia development

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Effective inhibition of protein glycation by combinatorial usage of limonene and aminoguanidine through differential and synergistic mechanisms

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Alzheimer's Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome State

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Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model

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Relationship between plasma glycation with membrane modification, oxidative stress and expression of glucose trasporter-1 in type 2 diabetes patients with vascular complications

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Long-term administration of advanced glycation end-product stimulates the activation of NLRP3 inflammasome and sparking the development of renal injury

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Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis

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Past, Present, and Future of Parkinson's Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy

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Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

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Can transcranial direct current stimulation on the dorsolateral prefrontal cortex improves balance and functional mobility in Parkinson's disease?

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Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy

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Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in Drosophila

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Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA-induced dopaminergic denervation

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16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer's Post-Mortem Brain

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Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

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Gut Microbiota Dysbiosis Drives and Implies Novel Therapeutic Strategies for Diabetes Mellitus and Related Metabolic Diseases

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Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer's Disease Brain

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Host-Microbiota Mutualism in Metabolic Diseases

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Alzheimer's Disease and the Amyloid-β Peptide

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Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

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Microbiota modulation counteracts Alzheimer's disease progression influencing neuronal proteolysis and gut hormones plasma levels

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Unveiling the gut microbiota composition and functionality associated with constipation through metagenomic analyses

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Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease

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Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease

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Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

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Cell Therapy for Parkinson's Disease

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Dietary habits and neurological features of Parkinson's disease patients: Implications for practice

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Metformin Use in Prediabetes Among US Adults, 2005-2012

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Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction

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Dynamics of diabetes and obesity: Epidemiological perspective

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Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

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Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

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Analysis of Gut Microbiota in Patients with Parkinson's Disease

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Inflammaging decreases adaptive and innate immune responses in mice and humans

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Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes

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The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease

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Antiglycation and cell protective actions of metformin and glipizide in erythrocytes and monocytes

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Glycation in Parkinson's Disease and Alzheimer's Disease

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Human gut microbes impact host serum metabolome and insulin sensitivity

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Diet-microbiota interactions as moderators of human metabolism

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Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice

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Gram-negative bacterial molecules associate with Alzheimer disease pathology

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Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

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Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

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Glycation induces conformational changes in the amyloid-β peptide and enhances its aggregation propensity: molecular insights

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Exposing the exposures responsible for type 2 diabetes and obesity

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Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

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Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis

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Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis

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Human Intestinal Barrier Function in Health and Disease

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Gut microbiota and immune crosstalk in metabolic disease

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Altered Fecal Microbiota Correlates with Liver Biochemistry in Nonobese Patients with Non-alcoholic Fatty Liver Disease

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Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

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Potential role of antimicrobial peptides in the early onset of Alzheimer's disease

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Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012 A Retrospective Cohort Study

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Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

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Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

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Zinc inhibits glycation induced structural, functional modifications in albumin and protects erythrocytes from glycated albumin toxicity

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Elevated fecal calprotectin in patients with Alzheimer's dementia indicates leaky gut

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Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2 antioxidant signaling pathways

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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

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Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

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A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans

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Dietary Factors in the Etiology of Parkinson's Disease

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Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study

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The composition of the gut microbiota shapes the colon mucus barrier

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Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease

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Prediabetes diagnosis and treatment: A review

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Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus

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Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

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The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade

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Dicarbonyl proteome and genome damage in metabolic and vascular disease

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Intestinal permeability - a new target for disease prevention and therapy

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Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

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Myricitrin Alleviates Methylglyoxal-Induced Mitochondrial Dysfunction and AGEs/RAGE/NF-κB Pathway Activation in SH-SY5Y Cells

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Diet rapidly and reproducibly alters the human gut microbiome

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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Katie Lunnon et al.

NATURE NEUROSCIENCE (2014)

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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Philip L. De Jager et al.

NATURE NEUROSCIENCE (2014)

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Dietary and lifestyle guidelines for the prevention of Alzheimer's disease

Neal D. Barnard et al.

NEUROBIOLOGY OF AGING (2014)

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Small intestinal bacterial overgrowth in Parkinson's disease

Ai Huey Tan et al.

PARKINSONISM & RELATED DISORDERS (2014)

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Helicobacter pylori Induced Gastric Immunopathology Is Associated with Distinct Microbiota Changes in the Large Intestines of Long-Term Infected Mongolian Gerbils

Markus M. Heimesaat et al.

PLOS ONE (2014)

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Advanced glycation end products, dementia, and diabetes

Simon Lovestone et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Biotechnology & Applied Microbiology

Role of Methylglyoxal in Alzheimer's Disease

Cristina Angeloni et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Type 2 Diabetes as a Risk Factor for Alzheimer's Disease: The Confounders, Interactions, and Neuropathology Associated With This Relationship

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EPIDEMIOLOGIC REVIEWS (2013)

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alpha-Synuclein in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment

Ane Korff et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

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A novel mechanism for antiglycative action of limonene through stabilization of protein conformation

Madhav M. Joglekar et al.

MOLECULAR BIOSYSTEMS (2013)

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Recent Advances in α-Synuclein Functions, Advanced Glycation, and Toxicity: Implications for Parkinson's Disease

Erika Guerrero et al.

MOLECULAR NEUROBIOLOGY (2013)

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Article Clinical Neurology

The role of small intestinal bacterial overgrowth in Parkinson's disease

Alfonso Fasano et al.

MOVEMENT DISORDERS (2013)

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Richness of human gut microbiome correlates with metabolic markers

Emmanuelle Le Chatelier et al.

NATURE (2013)

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Gut metagenome in European women with normal, impaired and diabetic glucose control

Fredrik H. Karlsson et al.

NATURE (2013)

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Article Multidisciplinary Sciences

Altered Serum IgG Levels to α-Synuclein in Dementia with Lewy Bodies and Alzheimer's Disease

Niklas K. U. Koehler et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Effects of Baseline CSF α-Synuclein on Regional Brain Atrophy Rates in Healthy Elders, Mild Cognitive Impairment and Alzheimer's Disease

Niklas Mattsson et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Amandine Everard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura et al.

SCIENCE (2013)

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Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

V. Hugh Perry et al.

SEMINARS IN IMMUNOPATHOLOGY (2013)

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The Role of Oxidative Stress in Parkinson's Disease

Vera Dias et al.

JOURNAL OF PARKINSONS DISEASE (2013)

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Article Cell Biology

Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)

Tomoaki Uchiki et al.

AGING CELL (2012)

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Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse

Marielle S. Kahn et al.

BEHAVIOURAL BRAIN RESEARCH (2012)

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A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

Rashid Deane et al.

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Article Clinical Neurology

Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains

Yulin Deng et al.

JOURNAL OF NEURAL TRANSMISSION (2012)

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Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

Ursula Puentener et al.

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A metagenome-wide association study of gut microbiota in type 2 diabetes

Junjie Qin et al.

NATURE (2012)

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Impact of chronic Helicobacter pylori infection on Alzheimer's disease: preliminary results

Claire Roubaud-Baudron et al.

NEUROBIOLOGY OF AGING (2012)

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Genetics and Epigenetics of Parkinson's Disease

Fabio Coppede

SCIENTIFIC WORLD JOURNAL (2012)

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Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

William M. Johnson et al.

NUTRIENTS (2012)

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Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

Alexander Kurz et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

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Advanced Glycation End Products Are Direct Modulators of β-Cell Function

Melinda T. Coughlan et al.

DIABETES (2011)

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Peripheral Vascular Disease and Peripheral Neuropathy in Individuals With Cardiometabolic Clustering and Obesity National Health and Nutrition Examination Survey 2001-2004

Kelly R. Ylitalo et al.

DIABETES CARE (2011)

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Role of Chronic and Acute Hyperglycemia in the Development of Diabetes Complications

M. Loredana Marcovecchio et al.

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Gastric and Duodenum Microflora Analysis After Long-Term Helicobacter pylori Infection in Mongolian Gerbils

Ya-Ni Yin et al.

HELICOBACTER (2011)

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Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

Maurizio Gabrielli et al.

MOVEMENT DISORDERS (2011)

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Enterotypes of the human gut microbiome

Manimozhiyan Arumugam et al.

NATURE (2011)

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Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

Velandai Srikanth et al.

NEUROBIOLOGY OF AGING (2011)

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Dietary intake and olfactory function in patients with newly diagnosed Parkinson's disease: a case-control study

Emma Aden et al.

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High fat diet induced diabetic cardiomyopathy

Ellen Dirkx et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2011)

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Neuropathological Alterations in Alzheimer Disease

Alberto Serrano-Pozo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

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Nε-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model

Yeong-Gon Choi et al.

BIOCHIMIE (2010)

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Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

Gavin I. Welsh et al.

CELL METABOLISM (2010)

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Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

Hillary A. Keenan et al.

DIABETES (2010)

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Are Certain Lifestyle Habits Associated with Lower Alzheimer's Disease Risk?

Lana Arab et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Aileen M. Moloney et al.

NEUROBIOLOGY OF AGING (2010)

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Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

Tony Valente et al.

NEUROBIOLOGY OF DISEASE (2010)

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Fermented milk of Lactobacillus helveticus IDCC3801 reduces beta-amyloid and attenuates memory deficit

Seung-Woo Yeon et al.

JOURNAL OF FUNCTIONAL FOODS (2010)

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Article Biochemistry & Molecular Biology

The modification of α-synuclein by dicarbonyl compounds inhibits its fibril-forming process

Daekyun Lee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)

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Adults with type 1 diabetes eat a high-fat atherogenic diet that is associated with coronary artery calcium

J. K. Snell-Bergeon et al.

DIABETOLOGIA (2009)

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Increased Cerebrospinal Fluid Helicobacter Pylori Antibody in Alzheimer's Disease

Jannis Kountouras et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2009)

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RAGE and Alzheimer's Disease: A Progression Factor for Amyloid-beta-Induced Cellular Perturbation?

Shi Du Yan et al.

JOURNAL OF ALZHEIMERS DISEASE (2009)

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Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

Rongzhen Zhang et al.

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Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

Arne Astrup et al.

LANCET (2009)

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Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats

Peter Boor et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2009)

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The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

Peter J. Turnbaugh et al.

SCIENCE TRANSLATIONAL MEDICINE (2009)

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In Skeletal Muscle Advanced Glycation End Products (AGEs) Inhibit Insulin Action and Induce the Formation of Multimolecular Complexes Including the Receptor for AGEs

Angela Cassese et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Advanced glycation end products induce in vitro cross-linking of α-synuclein and accelerate the process of intracellular inclusion body formation

Shamim Shaikh et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2008)

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Prospective study of dietary pattern and risk of Parkinson disease

Xiang Gao et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2007)

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Reduced expression of insulin receptors in the kidneys of insulin-resistant rats

Swasti Tiwari et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

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High-fat diet-induced neuropathy of pre-diabetes and obesity - Effects of healthy diet and aldose reductase inhibition

Irina G. Obrosova et al.

DIABETES (2007)

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Microbial ecology - Human gut microbes associated with obesity

Ruth E. Ley et al.

NATURE (2006)

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Protein intake in parkinsonian patients using the EPIC food frequency questionnaire

Agnieszka Marczewska et al.

MOVEMENT DISORDERS (2006)

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The gut flora as a forgotten organ

Ann M. O'Hara et al.

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Metagenomic analysis of the human distal gut microbiome

Steven R. Gill et al.

SCIENCE (2006)

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Relationship between Helicobacter pylori infection and Alzheimer disease

J Kountouras et al.

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Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus

GJ Biessels et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2006)

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Non-motor symptoms of Parkinson's disease: diagnosis and management

KR Chaudhuri et al.

LANCET NEUROLOGY (2006)

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Ecological and evolutionary forces shaping microbial diversity in the human intestine

RE Ley et al.

CELL (2006)

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Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis

G Dahlquist

DIABETOLOGIA (2006)

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Risk of dementia in diabetes mellitus: a systematic review

GJ Biessels et al.

LANCET NEUROLOGY (2006)

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The formation of Escherichia coli curli amyloid fibrils is mediated by prion-like peptide repeats

I Cherny et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

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Compromised arterial function in human type 2 diabetic patients

EB Okon et al.

DIABETES (2005)

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Albumin antioxidant capacity is modified by methylglyoxal

P Faure et al.

DIABETES & METABOLISM (2005)

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Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains

HJ Lüth et al.

CEREBRAL CORTEX (2005)

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Oxidative stress in childhood - in health and disease states

E Granot et al.

CLINICAL NUTRITION (2004)

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Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats

XX Wang et al.

KIDNEY INTERNATIONAL (2004)

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High carbohydrate diets and Alzheimer's disease

ST Henderson

MEDICAL HYPOTHESES (2004)

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Article Biochemistry & Molecular Biology

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

R Deane et al.

NATURE MEDICINE (2003)

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Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)

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Dietary fats and the risk of incident Alzheimer disease

MC Morris et al.

ARCHIVES OF NEUROLOGY (2003)

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Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal

RH Nagaraj et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)

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Article Neurosciences

Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: Identification of a cellular activation mechanism

LF Lue et al.

EXPERIMENTAL NEUROLOGY (2001)

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Review Endocrinology & Metabolism

Advanced glycation end-products: a review

R Singh et al.

DIABETOLOGIA (2001)

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Crosslinking of α-synuclein by advanced glycation endproducts -: an early pathophysiological step in Lewy body formation?

G Münch et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2000)

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Amyloid in human islets of langerhans: Immunologic evidence that islet amyloid polypeptide is modified in amyloidogenesis

Z Ma et al.

PANCREAS (2000)

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LPS-induced neuroinflammatory effects do not recover with time

B Hauss-Wegrzyniak et al.

NEUROREPORT (2000)

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Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

FS Yang et al.

BRAIN RESEARCH (2000)

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Detection of an Amadori product, 1-hexitol-lysine, in the anterior horn of the amyotrophic lateral sclerosis and spinobulbar muscular atrophy spinal cord: evidence for early involvement of glycation in motoneuron diseases

S Kikuchi et al.

ACTA NEUROPATHOLOGICA (2000)

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