A novel approach to diagnosing crystal-storing histiocytosis: utility of scanning electron microscopy for formalin-fixed paraffin-embedded tissue specimens

Article Gastroenterology & Hepatology

Generalized crystal-storing histiocytosis with noncirrhotic portal hypertension: an autopsy case report

Yasunao Numata et al.

Summary: Crystal-storing histiocytosis (CSH) is a rare disease characterized by histiocytes containing crystals. The case report describes a female patient who developed portal hypertension due to CSH, leading to her death from an acute subdural hematoma. Autopsy revealed retroperitoneal fibrosis and nodular regenerative hyperplasia in the liver parenchyma.

CLINICAL JOURNAL OF GASTROENTEROLOGY (2023)

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Article

Localized ocular crystal-storing histiocytosis and associated lymphoma - Report of two cases and review of literature

Maryam Eslami et al.

American Journal of Ophthalmology Case Reports (2022)

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Review Medicine, General & Internal

Immunoglobulin-Storing Histiocytosis: A Case Based Systemic Review

Hanne Wiese-Hansen et al.

Summary: Crystal-storing histiocytosis is a rare event associated with monoclonal gammopathy, primarily characterized by the accumulation of immunoglobulins in the cytoplasm of histiocytes. Most patients have an underlying neoplastic B-cell disorder, with bone being the most commonly affected organ system. The disease is typically linked to IgG and kappa light chain expression, and should be considered with unusual findings in various organ systems associated with monoclonal gammopathy.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Pathology