Updates in Cardiorenal Syndrome

The CRS is a term that refers to a collection of disorders involving both the heart and kidneys, encompassing multi-directional pathways between the 2 organs mediated through low arterial perfusion, venous congestion, and neurohormonal activation. There have been a number of trials of pharmacological agents that have demonstrated improved cardiovascular and kidney outcomes, particularly among chronic ambula-tory patients. Management for ADHF remains focused on decongestion and ways to overcome the intense sodium and fluid avidity of the CRS.

Automated summary

The term CRS refers to a range of disorders involving the heart and kidneys, with pathways between the two organs mediated through low arterial perfusion, venous congestion, and neurohormonal activation. Several trials of pharmacological agents have shown improved cardiovascular and kidney outcomes, especially in chronic ambulatory patients. Management for ADHF focuses on decongestion and overcoming the intense sodium and fluid avidity of the CRS.