New perspectives on frailty in light of the Global Leadership Initiative on Malnutrition, the Global Leadership Initiative on Sarcopenia, and the WHO's concept of intrinsic capacity: A narrative review

This review gathered the evidence on the epidemiology of frailty, as well as on screening and diagnostic tools, and new perspectives, in light of the latest global frameworks in malnutrition, sarcopenia, and the World Health Organization's concept of intrinsic capacity. Frailty is a worldwide health challenge and highly prevalent in older adults and the population with chronic diseases independent of age. Regardless of the particular concept of frailty, many screening and diagnostic tools are able to identify frailty in older people, but none of them has shown superiority in every population and healthcare setting. Physical, cognitive, and social components are part of the larger context of frailty. The latest evidence-based initiatives on frailty recommend the use of validated tools to identify frailty's different components, tailored to the needs of specific populations and healthcare systems. Unintentional weight loss is a shared criterion between physical frailty and malnutrition according to the Global Leadership Initiative on Malnutrition criteria. A new definition of sarcopenia by the Global Leadership Initiative on Sarcopenia is awaited, but at present physical frailty shares with sarcopenia the criteria of low muscle function and physical performance (severity grading) according to the revised consensus of the European Working Group on Sarcopenia in Older People (EWGSOP2). The EWGSOP2 includes both muscle mass and function, with most scientific groups agreeing that function is a key hallmark of sarcopenia. The concept of intrinsic capacity features the reserves and positive aspects of aging, and responds to ageism by addressing the deficit model approach. Intrinsic capacity is an emerging, person-centered and public health indicator, aimed at preserving health at mid-life and beyond, to move towards a better aging process in the Decade of Healthy Aging 2020-2030.

Automated summary

This review provides an overview of frailty, including its epidemiology, screening and diagnostic tools, and new perspectives based on global frameworks. Frailty is a significant health challenge worldwide, affecting older adults and those with chronic diseases regardless of age. Although various screening and diagnostic tools exist, none have proven superior in all populations and healthcare settings. Frailty encompasses physical, cognitive, and social components, and the use of validated tools tailored to specific populations and healthcare systems is recommended. Unintentional weight loss is a common criterion for both physical frailty and malnutrition, while sarcopenia shares criteria of low muscle function and physical performance. Intrinsic capacity, a person-centered and public health indicator, focuses on the positive aspects of aging and aims to promote healthier aging in the Decade of Healthy Aging 2020-2030.