☆ 4.7 Article

Anti-inflammation nanomedicine shots through atherosclerotic plaques for targeted treatment and precise diagnosis

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Article Biochemistry & Molecular Biology

CISD1 protects against atherosclerosis by suppressing lipid accumulation and inflammation via mediating Drp1

Jinghai Hua et al.

Summary: The study revealed that CISD1 could improve mitochondrial dysfunction and inflammation in ox-LDL-stimulated macrophages by interacting with Drp1, thereby inhibiting the progression of atherosclerosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Cardiac & Cardiovascular Systems

Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis

Qiao Lei et al.

Summary: The study reveals that impaired chaperone-mediated autophagy (CMA) during atherosclerosis progression increases NLRP3 inflammasome activation and IL-1β secretion, promoting vascular inflammation and atherosclerosis. This suggests a potential therapeutic strategy for atherosclerosis and other NLRP3 inflammasome/IL-1β-driven diseases through pharmacological activation of CMA.

CIRCULATION RESEARCH (2021)

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Article Chemistry, Multidisciplinary

Synthetic high-density lipoproteins delivering liver X receptor agonist prevent atherogenesis by enhancing reverse cholesterol transport

Wenmin Yuan et al.

Summary: LXR agonists have potential anti-atherosclerotic effects by increasing cholesterol efflux, but may cause liver toxicity and hypertriglyceridemia. Encapsulating the LXR agonist in synthetic HDL nanoparticles improves drug efficacy and reduces side effects.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy

Qingle Ma et al.

Summary: Engineering platelet-derived extracellular vesicles (PEVs) to load MCC950, an NLRP3-inflammasome inhibitor, for atherosclerosis-targeted therapy can significantly reduce plaque formation, lower local inflammation, and inhibit proliferation of macrophages and T cells at the plaque site compared with free drug administration. This strategy indicates the promising potential of PEVs for targeted drug delivery in atherosclerosis treatment.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Biotechnology & Applied Microbiology

miRNA-576 Alleviates the Malignant Progression of Atherosclerosis through Downregulating KLF5

Jing Wang et al.

Summary: The study revealed that miRNA-576 alleviates the deterioration of AS by downregulating KLF5, leading to modulation of inflammatory factors and lipid metabolism, influencing the progression of atherosclerosis.

DISEASE MARKERS (2021)

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Article Cardiac & Cardiovascular Systems

Macrophage NFAT c3 prevents foam cell formation and atherosclerosis: evidence and mechanisms

Xiu Liu et al.

Summary: The study showed that macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, indicating a potential therapeutic target against atherosclerosis.

EUROPEAN HEART JOURNAL (2021)

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Article Oncology

MicroRNA-22 inhibition promotes the development of atherosclerosis via targeting interferon regulator factor 5

Zhenhua Wu et al.

Summary: Research demonstrated that miR-22 plays a negative regulatory role in atherosclerosis. Treatment of ApoE(-/-) mice with miR-22 inhibitors showed that miR-22 inhibition significantly promoted the formation of atherosclerotic plaques, attenuated plaque stabilization, and exacerbated inflammation and foam cell formation.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Cytotoxin-associated gene A (CagA) promotes aortic endothelial inflammation and accelerates atherosclerosis through the NLRP3/caspase-1/IL-1β axis

Bo-Wei Li et al.

Summary: This study found that Helicobacter pylori strains expressing CagA were positively correlated with atherosclerosis, promoting plaque growth and inflammation. NLRP3 was identified as a potential therapeutic target for CagA-positive H. pylori infection-related atherosclerosis, highlighting the importance of inflammation in atherosclerosis pathology.

FASEB JOURNAL (2021)

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Article Immunology

SIRT6 inhibits inflammatory response through regulation of NRF2 in vascular endothelial cells

Yanhao He et al.

Summary: SIRT6 protects against vascular inflammation through its deacetylase activity and the NRF2-dependent signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Platelet-Derived PCSK9 Is Associated with LDL Metabolism and Modulates Atherothrombotic Mechanisms in Coronary Artery Disease

Alvaro Petersen-Uribe et al.

Summary: Platelets play a significant role in atherothrombosis, and this study found that they are a major source of PCSK9 in coronary artery disease (CAD). PCSK9 released by platelets contributes to platelet activation and thrombo-inflammation, with inhibition of PCSK9 showing beneficial effects in reducing these processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Trends in Research on Exosomes in Cancer Progression and Anticancer Therapy

Dona Sinha et al.

Summary: Exosomes, as crucial mediators of intercellular communication, play a significant role in cancer progression and possess unique biological properties with potential therapeutic applications.

CANCERS (2021)

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Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2021 Update A Report From the American Heart Association

Salim S. Virani et al.

Summary: The American Heart Association, in partnership with the National Institutes of Health, publishes annual statistics on heart disease, stroke, and cardiovascular risk factors, including the impact of health behaviors and factors on cardiovascular health. The Statistical Update covers a range of clinical heart and circulatory conditions, providing data on quality of care, procedures, and economic costs. It serves as a critical resource for various stakeholders seeking the best available data on these factors and conditions.

CIRCULATION (2021)

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Review Biochemistry & Molecular Biology

Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Eze-timibe and PCSK9 Monoclonal Antibodies

Adel Hajj Ali et al.

Summary: Cardiovascular disease remains the primary cause of global morbidity and mortality, with atherosclerosis playing a key role in its pathogenesis. Along with traditional lipid-lowering therapies, recent molecular and genetic interventions such as PCSK9 monoclonal antibodies are gaining attention in the field of cardiovascular medicine.

CURRENT MEDICINAL CHEMISTRY (2021)

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Article Oncology

MiR-375 silencing attenuates pro-inflammatory macrophage response and foam cell formation by targeting KLF4

Yanyan Qiu et al.

Summary: MiR-375 plays a crucial role in atherosclerosis development by inhibiting foam cell formation, increasing cholesterol efflux gene expression, reducing cholesterol influx gene expression, promoting resolving M2 macrophages, and decreasing proinflammatory M1 macrophage markers expression. These effects are partially mediated through the activation of the KLF4-dependent mechanism in macrophages.

EXPERIMENTAL CELL RESEARCH (2021)

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Review Oncology

Research methods for animal models of atherosclerosis

Yali Zhang et al.

Summary: Atherosclerosis is a chronic inflammatory disease that can lead to vascular stenosis and plaque rupture, posing a threat to human health. Various animal models, with mice and rabbits being the most commonly used ones, have been employed for atherosclerosis research. However, these animal models do not entirely replicate human atherosclerotic lesions in terms of location, composition and structure, emphasizing the importance of selecting an appropriate model for research purposes and including quantitative analysis of lesion size and plaque composition.

MOLECULAR MEDICINE REPORTS (2021)

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Article Chemistry, Multidisciplinary

Poly-β-cyclodextrin Supramolecular Nanoassembly with a pH-Sensitive Switch Removing Lysosomal Cholesterol Crystals for Antiatherosclerosis

Yan Zhang et al.

Summary: The study utilized poly-beta-cyclodextrin and dextran sulfate grafted with benzimidazole to self-assemble into a supramolecular nanoassembly to address cholesterol crystals in lysosomes. The nanoassembly can release cholesterol crystals in lysosomes, promoting cholesterol efflux and aiding in the regression of atherosclerosis.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models

Moumita Rakshit et al.

Summary: Atherosclerosis is a multifactorial disease triggered by risk factors such as high cholesterol, high blood pressure, and unhealthy lifestyle. In this study, a simvastatin-loaded nanoliposomal formulation (LIPOSTAT) was developed to deliver the drug into atherosclerotic plaque, reducing inflammation and promoting cholesterol efflux.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Article Cell Biology

Prosaposin mediates inflammation in atherosclerosis

Mandy M. T. van Leent et al.

Summary: Macrophages play a central role in atherosclerosis pathogenesis, with their inflammatory activity regulated by the mTOR signaling pathway. Targeting mTOR and S6K1 pathways can reduce plaque inflammation, and Psap gene encoding prosaposin is closely related to mTOR signaling pathway, influencing glycolysis and oxidative phosphorylation. Prosaposin may serve as a potential therapeutic target for atherosclerosis.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques

Yi Ma et al.

Summary: Atherosclerotic plaque is the primary cause of cardiovascular disorders, and traditional clinical strategies are often limited. Researchers have designed a biomimic photodynamic therapeutic system that can target foam cells in early atherosclerotic plaques using platelet membrane-coated upconversion nanoparticle cores loaded with photosensitizer, which shows promising results in alleviating plaque progression.

ADVANCED SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

An atherosclerotic plaque-targeted single-chain antibody for MR/NIR-II imaging of atherosclerosis and anti-atherosclerosis therapy

Liwei Zhang et al.

Summary: A novel human single-chain variable fragment antibody specific to OSEs, named ASA6, was successfully developed for imaging and inhibiting atherosclerosis. ASA6 exhibited significant anti-atherosclerosis effects, which were related to the regulation of fatty acid metabolism and inhibition of M1 macrophage polarization. Moreover, ASA6 antibody conjugated to nanoparticles allowed for noninvasive imaging of atherosclerotic plaques.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Targeting Nanostrategies for Imaging of Atherosclerosis

Angela Costagliola di Polidoro et al.

Summary: Despite advancements in cardiovascular research, atherosclerosis remains the leading cause of death globally. Current imaging methods for diagnosing ASCVD lack the ability to accurately identify high-risk plaque rupture. Utilizing hydrogel nanoparticles encapsulating Gd-DTPA with active targeting of plaque macrophages can potentially enable earlier and more accurate diagnosis in the complex environment of human atherosclerotic plaque.

CONTRAST MEDIA & MOLECULAR IMAGING (2021)

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Article Medicine, General & Internal

Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation

Yonghong Luo et al.

Summary: miNano is a potential nanoparticle for treating atherosclerosis by dissolving cholesterol crystals and stabilizing plaques to improve the disease.

EBIOMEDICINE (2021)

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Article Chemistry, Multidisciplinary

Ratiometric Semiconducting Polymer Nanoparticle for Reliable Photoacoustic Imaging of Pneumonia-Induced Vulnerable Atherosclerotic Plaque in Vivo

Yuan Ma et al.

Summary: The developed RSPN nanoparticles in this study can accurately assess the rupture risk of vulnerable plaque caused by acute pneumonia and successfully reflect the oxidative stress level in vulnerable plaque, providing a promising approach to reduce the mortality of atherosclerotic-induced cardiovascular disease.

NANO LETTERS (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Multidisciplinary Sciences

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

Trevor P. Fidler et al.

Summary: Clonal haematopoiesis, particularly driven by JAK2(VF) mutation, increases the risk of cardiovascular diseases independently of traditional risk factors. Targeting interleukin-1 beta or specific inflammasomes may reduce cardiovascular risk associated with clonal haematopoiesis.

NATURE (2021)

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Review Biotechnology & Applied Microbiology

Targeting inflammation in atherosclerosis - from experimental insights to the clinic

Oliver Soehnlein et al.

Summary: Inflammation plays a substantial role in atherosclerosis and targeting inflammatory pathways could provide a promising new avenue to prevent and treat the disease. Clinical studies have shown that modulation of inflammation can help prevent the clinical complications of atherosclerosis. Refining strategies for combatting inflammation in the disease is crucial for further progress in managing atherosclerotic risk.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Biotechnology & Applied Microbiology

Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE-/- mice

Tieying Yin et al.

Summary: The study investigated the effects of PLGA NPs on the development of aortic atherosclerotic plaques in ApoE(-/-) mice, showing that the accumulation of PLGA NPs significantly increased plaque extension, expression of inflammatory factors, and accelerated macrophage conversion to foam cells. These results highlight the importance of understanding the interaction between PLGA NPs and atherosclerotic plaques for future nanomaterial design and use in cardiovascular disease treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Near-Infrared Light-Driven Multifunctional Tubular Micromotors for Treatment of Atherosclerosis

Xiaoyun Li et al.

Summary: This near-infrared light-driven multifunctional micromotor can rapidly target damaged blood vessels and release different drugs, promoting penetration into plaque sites through motion effects and achieving photothermal ablation of inflammatory macrophages through heat effects. In vivo experiments have demonstrated that these micromotors can provide good therapeutic effects for atherosclerosis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Ultrasmall Fe(III)-Tannic Acid Nanoparticles To Prevent Progression of Atherosclerotic Plaques

Dan Mu et al.

Summary: The HFTNPs nanoparticles manufactured in this study can specifically accumulate in inflammatory macrophages in atherosclerotic plaques, provide brighter magnetic resonance images, promote reactive oxygen species generation, induce the death of inflammatory macrophages, without damaging normal cells and tissues.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Plug and Play Functionalized Erythrocyte Nanoplatform for Target Atherosclerosis Management

Yuan Zhong et al.

Summary: A nanoplatform based on red blood cells was developed for targeted drug delivery and controlled release for atherosclerosis treatment, addressing challenges such as low location specificity and side effects.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

SR-A-Targeted Nanoplatform for Sequential Photothermal/Photodynamic Ablation of Activated Macrophages to Alleviate Atherosclerosis

Jingjing Liu et al.

Summary: The study utilized a multifunctional therapeutic nanoplatform, CS-CNCs@Ce6/DS, for selective targeting of activated macrophages in arterial plaques. The photothermal conversion capability of CS-CNCs facilitated efficient therapeutic delivery during photothermal therapy, while near-infrared-accelerated drug release enhanced the concentration of Ce6 in atherosclerotic plaque areas and the efficiency of photodynamic therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Biomimetic-Coated Nanoplatform with Lipid-Specific Imaging and ROS Responsiveness for Atherosclerosis-Targeted Theranostics

Boxuan Ma et al.

Summary: Atherosclerosis, a major cause of cardiovascular diseases, can be targeted and treated with newly designed nanosized drug carriers that have ROS-responsive properties, showing potential for precise theranostics in atherosclerotic lesions.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biochemistry & Molecular Biology

miR-100-5p in human umbilical cord mesenchymal stem cell-derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway

Heng Gao et al.

Summary: The study demonstrates that hUCMSC-Ex-miR-100-5p inhibits cell progression and inflammatory response in eosinophils via the FZD5/Wnt/beta-catenin pathway, thereby alleviating atherosclerosis progression.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Article Chemistry, Multidisciplinary

Ultraselective Carbon Nanotubes for Photoacoustic Imaging of Inflamed Atherosclerotic Plaques

Mahsa Gifani et al.

Summary: Targeting inflammatory immune cells in atherosclerotic plaques may provide clinically relevant diagnostic information about cardiovascular disease, and a new method combining ultraselective nanoparticle targeting and clinically-viable photoacoustic imaging has shown promise in accurately identifying and diagnosing inflamed plaques.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Cell Biology

Pim-2 kinase inhibits inflammation by suppressing the mTORC1 pathway in atherosclerosis

Minqi Liao et al.

Aging-US (2021)

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Article Chemistry, Analytical

Two-Photon, Ratiometric, Quantitative Fluorescent Probe Reveals Fluctuation of Peroxynitrite Regulated by Arginase 1

Shiyu Chen et al.

Summary: A fluorescent probe that selectively reacts with peroxynitrite, yielding over 200-fold change, effectively visualized fluctuations in peroxynitrite generation by arginase 1 in vivo and in vitro. This provides evidence that arginase 1 is a critical regulator of peroxynitrite.

ANALYTICAL CHEMISTRY (2021)

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Article Peripheral Vascular Disease

Delivery of micrornas by reconstituted HDL enhances cholesterol efflux from foam cells in a triple-cell two-dimensional atheroma plaque model

S. Jebari-Benslaiman et al.

ATHEROSCLEROSIS (2021)

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Article Medicine, Research & Experimental

High-density lipoprotein remodeling by phospholipid nanoparticles improves cholesterol efflux capacity and protects from atherosclerosis

Vasily A. Kudinov et al.

Summary: The study demonstrates that lipidating HDL with phospholipid nanoparticles can improve HDL functionality, enhance cholesterol efflux capacity, and provide protection against atherosclerosis progression.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Recapitulating the Complex Pathology of Atherosclerosis

Francesca Bartoli-Leonard et al.

CIRCULATION RESEARCH (2021)

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Review Medicine, Research & Experimental

Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis

Valter Lubrano et al.

Summary: Atherosclerosis is a systemic inflammation that leads to the formation of arterial plaques. The differences between stable and vulnerable plaques may predispose them to rupture and thrombosis. Various circulating biomarkers related to inflammation, ECM, lipid infiltration, angiogenesis, metalloproteinases, and microRNA have been considered as potential diagnostic and prognostic indicators of plaque vulnerability.

CLINICAL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

CITED2 inhibits STAT1-IRF1 signaling and atherogenesis

Atif Zafar et al.

Summary: The transcriptionally dynamic macrophages play key roles in the development of inflammatory vascular diseases. In this study, the CITED2 was identified as a cell-intrinsic negative regulator of inflammation in macrophages. The deficiency of CITED2 elevates pro-inflammatory gene expression and contributes to the development of atherosclerotic plaques.

FASEB JOURNAL (2021)

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Article Medicine, Research & Experimental

KLF5/LINC00346/miR-148a-3p axis regulates inflammation and endothelial cell injury in atherosclerosis

Fangfang Wang et al.

Summary: The study found that KLF5 expression was increased in AS patients and OX-LDL-stimulated HUVECs. The transcription factor KLF5 promoted the transcription of LINC00346. KLF5 interference or LINC00346 interference inhibited the expression of inflammatory factors and functional injury in OX-LDL-stimulated HUVECs.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Effect of Very High Dose Local Vessel Wall Statin Administration: Poly(L,L-Lactide) Biodegradable Microspheres with Simvastatin for Drug Delivery System (DDS)

Piotr Wacinski et al.

Summary: This study aimed to test a vessel wall local drug delivery system using PLA microstructures loaded with simvastatin. The results showed that SVPLA microspheres limited the inflammatory reaction of the endothelium and vessel wall, had no influence on microcirculation, and exhibited potent anti-inflammatory effects of simvastatin after local administration.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nanoscience & Nanotechnology

Effective Oxidation-Responsive Polyester Nanocarriers for Anti-Inflammatory Drug Delivery

Pan He et al.

Summary: This study demonstrates the feasibility of a novel oxidation-sensitive nanocarrier for curcumin in anti-inflammatory therapy, with significant potential shown in both in vitro and in vivo anti-inflammatory effects.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

miR-141-5p suppresses vascular smooth muscle cell inflammation, proliferation, and migration via inhibiting the HMGB1/NF-κB pathway

Yadong Li et al.

Summary: The study identified that miR-141-5p is downregulated in the plasma and VSMCs of AS patients and animal models. It functions as a protective factor during the development of AS by targeting the HMGB1/NF-kappa B pathway to inhibit VSMCs dysfunction.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Review Chemistry, Multidisciplinary

Inflammatory microenvironment-targeted nanotherapies

Guangshuai Zhang et al.

Summary: Inflammatory microenvironments (IMEs) are common pathological characteristics in chronic diseases and targeted nanotherapies show potential for treating inflammatory conditions. Nanoplatforms play a significant role in improving anti-inflammatory treatments, with enhanced therapeutic effects and reduced side effects drawing interest from research community in IME-targeted therapies. Developing rational targeting strategies for IMEs in damaged tissues can help advance therapies for chronic diseases.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Medicine, Research & Experimental

被撤回的出版物: Mouse bone marrow derived mesenchymal stem cells-secreted exosomal microRNA-125b-5p suppresses atherosclerotic plaque formation via inhibiting Map4k4 (Retracted article. See vol. 319, 2023)

Feng Lin et al.

Summary: Exosomal miR-125b-5p from BMSCs inhibits atherosclerotic plaque formation by targeting Map4k4 expression, leading to reduced inflammation, decreased blood lipid levels, smaller plaque areas, increased expression of smooth muscle cell marker α-SMA, as well as inhibition of apoptosis in AS mice.

LIFE SCIENCES (2021)

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Article Materials Science, Biomaterials

Shear stress and ROS-responsive biomimetic micelles for atherosclerosis via ROS consumption

Meili Shen et al.

Summary: An intelligent response system was developed for the treatment of atherosclerosis by combining red blood cells and simvastatin-loaded micelles, achieving synergistic treatment with drugs and materials, while evading immune system elimination and significantly reducing ROS levels.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Multidisciplinary Sciences

APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans

Dimitrios Tsiantoulas et al.

Summary: This study reveals that genetic ablation or antibody-mediated depletion of APRIL exacerbates atherosclerosis in mice. Mechanistically, APRIL confers atheroprotection by binding to heparan sulfate chains of HSPG2, limiting the retention of low-density lipoproteins. Treatment with a specific anti-APRIL antibody reduces experimental atherosclerosis, indicating the physiological significance of APRIL in vascular homeostasis.

NATURE (2021)

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Article Pharmacology & Pharmacy

The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease

Lee Ohayon et al.

Summary: Extracellular vesicles, including exosomes and micro-vesicles, play a significant role in cardiovascular diseases by transporting bioactive molecules and impacting target cells and tissues through autocrine and paracrine signaling. They can have both beneficial and detrimental effects on inflammation processes in cardiovascular diseases.

PHARMACOLOGICAL RESEARCH (2021)

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Article Multidisciplinary Sciences

ICAM-1-carrying targeted nano contrast agent for evaluating inflammatory injury in rabbits with atherosclerosis

Ping Li et al.

Summary: The study demonstrated that ICAM-1-targeted nano ultrasonic contrast could be used to assess the degree of inflammatory injury at different stages of the abdominal aorta in rabbits with atherosclerosis. This novel imaging method shows potential for clinical applications.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE(-/-) mice

Qi Wang et al.

Summary: The study presented the development of composite mesoporous silica nanoparticle-based nanomedicines for accurate diagnosis and treatment of atherosclerosis. The designed CMSN@SRT@Anti showed excellent biocompatibility, high-performance, and superior atherosclerosis-targeting ability. Animal experimental results demonstrated significant improvements in aortic plaque status and area after treatment with CMSN@SRT@Anti.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis

Yan Zhang et al.

Summary: Atherosclerosis, a typical cardiovascular disease, is closely related to oxidative stress and inflammation. A theranostic agent based on PMPB loaded with Sim was found to effectively regulate the process of atherosclerosis and exhibit high biocompatibility.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

Pyroptosis in the Initiation and Progression of Atherosclerosis

Zhengtao Qian et al.

Summary: Pyroptosis, a newly discovered form of programmed cell death, was initially found to facilitate host defense against pathogenic microorganisms, but later studies revealed its important role in inflammatory immune diseases and tumor resistance. Recent research has linked pyroptosis to the initiation, progression, and complications of atherosclerosis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Low-Intensity Focused Ultrasound-Responsive Ferrite-Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics

Jianting Yao et al.

Summary: Pathological angiogenesis is a crucial factor in atherosclerotic plaque rupture, and a new nanoplatform called PHPMR NPs has been developed for multimodality imaging-guided therapy targeting plaque neovascularization, showing promising results in stabilizing plaques and reducing neovessel density.

ADVANCED SCIENCE (2021)

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Article Cell Biology

Platelet Bone Morphogenetic Protein-4 Mediates Vascular Inflammation and Neointima Formation after Arterial Injury

Marietta Jank et al.

Summary: The study found that platelet BMP-4 plays a crucial role in vascular inflammation and remodeling by inhibiting platelet activation, reducing the expression of adhesion molecules, and mitigating inflammatory responses. Platelet BMP-4 acts as a pro-inflammatory mediator in early atherosclerosis and restenosis.

CELLS (2021)

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Article Materials Science, Biomaterials

ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis

Dan Tang et al.

Summary: The development of nanomedicines provides new opportunities for the treatment of atherosclerosis, but still facing challenges such as short circulation life, lack of specific targeting, and poor drug release controllability. Combining biomimetic strategy with smart nanoagents may be a promising solution.

REGENERATIVE BIOMATERIALS (2021)

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Article Medicine, Research & Experimental

Exosome-mediated delivery of inflammation-responsive Il-10 mRNA for controlled atherosclerosis treatment

Te Bu et al.

Summary: A nano-system has been developed to deliver inflammation-responsive Il-10 mRNA preferentially into macrophages for tailored inflammation control, showing promising potential for treating inflammatory diseases like atherosclerosis.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

Joon Woo Song et al.

Summary: A theranostic nanodrug targeting macrophage mannose receptor was developed to deliver specific medication to high-risk plaques with high inflammatory activity, rapidly stabilizing inflamed plaques in coronary arteries, providing a promising therapeutic strategy for high-risk coronary plaques.

THERANOSTICS (2021)

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Article Biochemistry & Molecular Biology

Mesenchymal stem cell-derived exosomal miR-21a-5p promotes M2 macrophage polarization and reduces macrophage infiltration to attenuate atherosclerosis

Jian Ma et al.

Summary: The study demonstrated that MSC-derived exosomes promote M2 polarization of macrophages, reduce plaque area, and decrease macrophage infiltration, thereby attenuating the development of atherosclerosis (AS). This effect is achieved by targeting KLF6 and ERK1/2 signaling pathways, offering a promising treatment option for AS.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2021)

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Review Medicine, General & Internal

Role and implications of the CXCL12/CXCR4/CXCR7 axis in atherosclerosis: still a debate

Hussam A. S. Murad et al.

Summary: Atherosclerosis, a leading cause of mortality and morbidity globally, involves the complex interplay of chemokines and their receptors, particularly CXCL12 and its receptors CXCR4 and ACKR3. The CXCL12/CXCR4/ACKR3 axis in atherosclerosis has a dual role in promoting and protecting against atherosclerosis in various cell types. Due to the functional heterogeneity and cross talk of CXCR4 and ACKR3 at receptor level and downstream pathways, targeted modulation of CXCL12, CXCR4, and ACKR3 with specific spatial and temporal factors is a potential area for further exploration in atherosclerosis research.

ANNALS OF MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke

Chao Li et al.

Summary: This biomimetic nanomedicine utilizes macrophage-disguised manganese dioxide nanospheres loaded with fingolimod to target the damaged brain in ischemic stroke, reducing oxidative stress, promoting microglial transition, and ultimately enhancing neuronal survival. This new strategy offers a multitargeted combined treatment approach for ischemic stroke.

ADVANCED SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Inflammasomes as therapeutic targets in human diseases

Yangxin Li et al.

Summary: Inflammasomes, as protein complexes in the innate immune system, play a dual role in diseases, with outcomes that can be either beneficial or detrimental depending on the disease and genetic background. The concept of inflammasome memory and the two-shot activation process are highlighted, along with the proposed M- and N-type inflammation models for targeting the inflammasome pathway in novel therapy development.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Chemistry, Analytical

A nano-detection system based on a chemical probe for early diagnosis of atherosclerosis in situ

Qiaolei Wang et al.

Summary: This study utilized a fluorescent probe to detect cellular reactive oxygen species and prepared a nano-detection system for early detection of AS. Experimental results showed effective targeting in early AS rats and no acute biological toxicity, indicating promising application potential for early AS detection.

ANALYST (2021)

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Article Medicine, Research & Experimental

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model

Zhelong Li et al.

Summary: The study demonstrated that exosome-mediated delivery of Ldlr mRNA effectively restored receptor expression in Ldlr(-/-) mice, treating the disorders and reducing atherosclerotic plaque formation. Exo(Ldlr) treatment significantly decreased lipid deposition in the liver and lowered LDL-cholesterol levels in the treated mice, providing a new therapeutic approach for FH patients and managing atherosclerosis.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles

Wei Tong et al.

Summary: The novel multimodal imaging platform targeting active myeloperoxidase showed promising results in sensitively differentiating and accurately localizing vulnerable atherosclerotic plaques in vivo. This approach may serve as a method for detecting vulnerable plaques and monitoring inflammation activity related to atherosclerosis.

THERANOSTICS (2021)

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Article Pharmacology & Pharmacy

Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles

Aixue Li et al.

Summary: Nanotechnology provides synthetic carriers for cancer drug delivery, while cell-derived biomimetic vehicles based on the concept of 'mimicking nature' offer low immunogenicity, long circulation time, and targeting ability. Cell membrane-coated carriers and extracellular vesicles are two widely used cell-based biomimetic materials in targeted cancer therapy, but they also face future challenges and development prospects.

DRUG DELIVERY (2021)

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Article Medicine, Research & Experimental

Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications

Yi Wang et al.

Summary: This study aimed to develop an ideal biomimetic nanoparticle for targeted atherosclerosis (AS) therapy. The results showed that the advanced MM/RAPNPs demonstrated good biocompatibility, effectively inhibited the progression of AS, and displayed favorable safety performance in AS mouse models. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications.

THERANOSTICS (2021)

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Article Cardiac & Cardiovascular Systems

Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms

Xiu Liu et al.

Summary: Macrophage NFATc3 up-regulates miR-204 to reduce SR-A and CD36 levels, thereby preventing foam cell formation and atherosclerosis, suggesting that the NFATc3/miR-204 axis may be a potential therapeutic target against atherosclerosis.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Rapamycin-Loaded Biomimetic Nanoparticles Reverse Vascular Inflammation

Christian Boada et al.

CIRCULATION RESEARCH (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Pro-inflammatory atherogenic role of platelets

Gregory B. Lim

NATURE REVIEWS CARDIOLOGY (2020)

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Article Cell Biology

Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis

Xiaohui Xing et al.

AGING-US (2020)

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Article Chemistry, Multidisciplinary

Molecularly Engineered Macrophage-Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

Guanghao Wu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E-/- mice

Manse Kim et al.

BIOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4

Wenyan Li et al.

BIOSCIENCE REPORTS (2020)

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Article Biophysics

Application of a mechanically responsive, inflammatory macrophage-targeted dual-sensitive hydrogel drug carrier for atherosclerosis

Shun Yu Yao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Chemistry, Multidisciplinary

Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity

Heegon Kim et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Physical

Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes

Zhide Guo et al.

NANO RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Affinity-Driven Design of Cargo-Switching Nanoparticles to Leverage a Cholesterol-Rich Microenvironment for Atherosclerosis Therapy

Heegon Kim et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation

Boxuan Ma et al.

ACS NANO (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach

Hilary E. Barrett et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

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Review Biochemistry & Molecular Biology

Current Advances in the Diagnostic Imaging of Atherosclerosis: Insights into the Pathophysiology of Vulnerable Plaque

Nataliya V. Mushenkova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites

Jeong-Kee Yoon et al.

SMALL (2020)

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Article Multidisciplinary Sciences

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

Cheng Gao et al.

NATURE COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

Near-infrared fluorescence imaging in immunotherapy

Yuanyuan Ji et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Pathology

Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques

Yujiro Asada et al.

PATHOLOGY INTERNATIONAL (2020)

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Article Engineering, Biomedical

A self-driven bioinspired nanovehicle by leukocyte membrane-hitchhiking for early detection and treatment of atherosclerosis

Guanghao Wu et al.

BIOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

ORIGINAL RESEARCH Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe

Mona Ahmed et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

Site-Specific MicroRNA-33 Antagonism by pH-Responsive Nanotherapies for Treatment of Atherosclerosis via Regulating Cholesterol Efflux and Adaptive Immunity

Chenwen Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Non-Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque

Xiaoxiao Ge et al.

ADVANCED MATERIALS (2020)

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Article Medicine, Research & Experimental

Hv1 proton channel possibly promotes atherosclerosis by regulating reactive oxygen species production

Zijie Zheng et al.

MEDICAL HYPOTHESES (2020)

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Article Cell Biology

MicroRNA-761 modulates foam cell formation and inflammation through autophagy in the progression of atherosclerosis

Chao Wang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)

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Article Cell Biology

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo

Laura Bouchareychas et al.

CELL REPORTS (2020)

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Article Medicine, General & Internal

Colchicine in Patients with Chronic Coronary Disease

Stefan M. Nidorf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Chemistry, Multidisciplinary

ROS Responsive Nanoplatform with Two-Photon AIE Imaging for Atherosclerosis Diagnosis and Two-Pronged Therapy

Boxuan Ma et al.

SMALL (2020)

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Article Medicine, General & Internal

Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

Nathalie Niyonzima et al.

EBIOMEDICINE (2020)

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Article Chemistry, Multidisciplinary

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Yin Dou et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Engineering, Biomedical

Nanoparticle-based Two-pronged approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux

Hongliang He et al.

BIOMATERIALS (2020)

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Article Medicine, Research & Experimental

Bifunctional supramolecular nanofiber inhibits atherosclerosis by enhancing plaque stability and anti-inflammation in apoE(-/-) mice

Yuna Shang et al.

THERANOSTICS (2020)

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Article Medicine, Research & Experimental

Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine

Tianlei Sun et al.

THERANOSTICS (2020)

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Article Cardiac & Cardiovascular Systems

Imaging of atherosclerosis, targeting LFA-1 on inflammatory cells with 111In-DANBIRT

E. J. Meester et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2019)

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Article Nanoscience & Nanotechnology

Platelet membrane-coated nanoparticle-mediated targeting delivery of Rapamycin blocks atherosclerotic plaque development and stabilizes plaque in apolipoprotein E-deficient (ApoE(-/-)) mice

Yanan Song et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE-/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

Jiangbing Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Delivery of MicroRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux in Vitro and in Vivo

My-Anh Nguyen et al.

ACS NANO (2019)

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Article Hematology

Nanoparticle Therapy for Vascular Diseases

Alyssa M. Flores et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Article Multidisciplinary Sciences

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

Linzhang Huang et al.

NATURE (2019)

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Article Chemistry, Multidisciplinary

Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management

Yi Wang et al.

ADVANCED SCIENCE (2019)

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Article Cardiac & Cardiovascular Systems

18F-FDG PET/MR-imaging in a Gottingen Minipig model of atherosclerosis: Correlations with histology and quantitative gene expression

Trine P. Ludvigsen et al.

ATHEROSCLEROSIS (2019)

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Article Cardiac & Cardiovascular Systems

In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis

William S. Jenkins et al.

HEART (2019)

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Article Chemistry, Multidisciplinary

Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression

Cuiping Jiang et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Biochemistry & Molecular Biology

Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model

Laurent Devel et al.

MOLECULES (2019)

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Article Medicine, General & Internal

Atherosclerosis

Peter Libby et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Article Engineering, Biomedical

Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe

Yabin Wang et al.

BIOMATERIALS (2019)

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Article Medicine, Research & Experimental

The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques

Hanning Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Cell Biology

Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis

Tessa J. Barrett et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Multidisciplinary Sciences

Dual-probe molecular MRI for the in vivo characterization of atherosclerosis in a mouse model: Simultaneous assessment of plaque inflammation and extracellular-matrix remodeling

Carolin Reimann et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, General & Internal

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

JoAnn E. Manson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Engineering, Biomedical

Atheroma Niche-Responsive Nanocarriers for Immunotherapeutic Delivery

Erica B. Peters et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Nanoparticle Imaging of Vascular Inflammation and Remodeling in Atherosclerotic Disease

Darren G. Woodside

CURRENT CARDIOVASCULAR IMAGING REPORTS (2019)

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Review Chemistry, Multidisciplinary

Recent Advances in Managing Atherosclerosis via Nanomedicine

Cecilia Ka Wing Chan et al.

SMALL (2018)

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Article Hematology

CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients

Andreas Gille et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

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Review Pharmacology & Pharmacy

Novel drug discovery strategies for atherosclerosis that target necrosis and necroptosis

Isabelle Coornaert et al.

EXPERT OPINION ON DRUG DISCOVERY (2018)

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Article Biochemistry & Molecular Biology

Long circulating PEGylated-chitosan nanoparticles of rosuvastatin calcium: Development and in vitro and in vivo evaluations

Mukundkumar Rameshbhai Hirpara et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Peripheral Vascular Disease

Thrombus Formation and Propagation in the Onset of Cardiovascular Events

Yujiro Asada et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2018)

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Article Surgery

Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging

Joyce M. S. Chan et al.

JOURNAL OF VASCULAR SURGERY (2018)

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Article Nanoscience & Nanotechnology

Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation

Teng Wu et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Computed Tomography Enterography

Shannon P. Sheedy et al.

RADIOLOGIC CLINICS OF NORTH AMERICA (2018)

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Article Acoustics

ULTRASOUND MOLECULAR IMAGING OF ATHEROSCLEROSIS USING SMALL-PEPTIDE TARGETING LIGANDS AGAINST ENDOTHELIAL MARKERS OF INFLAMMATION AND OXIDATIVE STRESS

Federico Moccetti et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2018)

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Article Chemistry, Multidisciplinary

H2O2-responsive and plaque-penetrating nanoplatform for mTOR gene silencing with robust anti-atherosclerosis efficacy

Wen Gao et al.

CHEMICAL SCIENCE (2018)

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Article Multidisciplinary Sciences

Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis

Wen Gao et al.

NATURE COMMUNICATIONS (2018)

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Review Medicine, Research & Experimental

Exosome Theranostics: Biology and Translational Medicine

Chuanjiang He et al.

THERANOSTICS (2018)

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Article Medicine, Research & Experimental

Ultrasound Molecular Imaging of Atherosclerosis for Early Diagnosis and Therapeutic Evaluation through Leucocyte-like Multiple Targeted Microbubbles

Fei Yan et al.

THERANOSTICS (2018)

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Article Medicine, Research & Experimental

Precise theranostic nanomedicines for inhibiting vulnerable atherosclerotic plaque progression through regulation of vascular smooth muscle cell phenotype switching

Sai Ma et al.

THERANOSTICS (2018)

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Article Immunology

Cholesterol Crystal-Mediated Inflammation Is Driven by Plasma Membrane Destabilization

Fei Shu et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis

Minmin Liang et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Targeted Therapy of Atherosclerosis by a Broad-Spectrum Reactive Oxygen Species Scavenging Nanoparticle with Intrinsic Anti-inflammatory Activity

Yuquan Wang et al.

ACS NANO (2018)

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Article Biochemistry & Molecular Biology

iRhom2 promotes atherosclerosis through macrophage inflammation and induction of oxidative stress

Cheng Chaohui et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Pretreated Macrophage-Membrane-Coated Gold Nanocages for Precise Drug Delivery for Treatment of Bacterial Infections

Can Wang et al.

ADVANCED MATERIALS (2018)

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Review Cardiac & Cardiovascular Systems

Safety and efficacy of statin therapy

Bhavin B. Adhyaru et al.

NATURE REVIEWS CARDIOLOGY (2018)

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Article Medicine, Research & Experimental

Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPARγ-LXRα-ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque

Huan Wang et al.

THERANOSTICS (2018)

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Article Chemistry, Multidisciplinary

Nanoparticle Functionalization with Platelet Membrane Enables Multifactored Biological Targeting and Detection of Atherosclerosis

Xiaoli Wei et al.

ACS NANO (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68Ga-Pentixafor for PET

Fabien Hyafil et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

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Article Cardiac & Cardiovascular Systems

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

Brian A. Ference et al.

EUROPEAN HEART JOURNAL (2017)

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Article Nanoscience & Nanotechnology

Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy

Mengyuan Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Cardiac & Cardiovascular Systems

Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F] FDG PET Imaging

Jason M. Tarkin et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Review Oncology

Beyond the margins: real-time detection of cancer using targeted fluorophores

Ray R. Zhang et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Cell Biology

Upconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation

Xiaobo B. Han et al.

CELL DEATH & DISEASE (2017)

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Article Cell Biology

Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage

Jiayuan Y. Kou et al.

CELL DEATH & DISEASE (2017)

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Article Multidisciplinary Sciences

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation

Keith A. Bailey et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Monitoring inflammation injuries in the progression of atherosclerosis with contrast enhanced ultrasound molecular imaging

Ruiying Sun et al.

PLOS ONE (2017)

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Article Cardiac & Cardiovascular Systems

Plasmonic photothermal therapy of atherosclerosis with nanoparticles: long-term outcomes and safety in NANOM-FIM trial

Alexander N. Kharlamov et al.

FUTURE CARDIOLOGY (2017)

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Review Peripheral Vascular Disease

Oxidative Stress in Atherosclerosis

Ajoe John Kattoor et al.

CURRENT ATHEROSCLEROSIS REPORTS (2017)

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Article Engineering, Biomedical

Non-proinflammatory and responsive nanoplatforms for targeted treatment of atherosclerosis

Yin Dou et al.

BIOMATERIALS (2017)

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Article Cardiac & Cardiovascular Systems

P2X7 Deficiency Blocks Lesional Inflammasome Activity and Ameliorates Atherosclerosis in Mice

Peter Stachon et al.

CIRCULATION (2017)

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Review Cardiac & Cardiovascular Systems

Macrophage Apoptosis and Necrotic Core Development in Atherosclerosis: A Rapidly Advancing Field with Clinical Relevance to Imaging and Therapy

Leticia Gonzalez et al.

CANADIAN JOURNAL OF CARDIOLOGY (2017)

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Review Cardiac & Cardiovascular Systems

Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis

Ulrich Foerstermann et al.

CIRCULATION RESEARCH (2017)

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Review Cardiac & Cardiovascular Systems

Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque

Abed Janoudi et al.

EUROPEAN HEART JOURNAL (2016)

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Article Chemistry, Multidisciplinary

Targeted Interleukin-10 Nanotherapeutics Developed with.a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis

Nazila Kamaly et al.

ACS NANO (2016)

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Review Biochemistry & Molecular Biology

The arterial microenvironment: the where and why of atherosclerosis

Arif Yurdagul et al.

BIOCHEMICAL JOURNAL (2016)

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Article Cardiac & Cardiovascular Systems

Imaging Atherosclerosis

Jason M. Tarkin et al.

CIRCULATION RESEARCH (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles

Hannah P. Luehmann et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

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Article Multidisciplinary Sciences

Immune cell screening of a nanoparticle library improves atherosclerosis therapy

Jun Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell Biology

Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB

Xuesong Li et al.

CELL DEATH & DISEASE (2016)

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Article Cardiac & Cardiovascular Systems

Transcriptional Profiling of Foam Cells Reveals Induction of Guanylate-Binding Proteins Following Western Diet Acceleration of Atherosclerosis in the Absence of Global Changes in Inflammation

Young-Hwa Goo et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice

David Vancraeynest et al.

EJNMMI RESEARCH (2016)

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Article Oncology

Treating cancer with sonodynamic therapy: A review

David Costley et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2015)

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Article Nanoscience & Nanotechnology

Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

Fleur M. van der Valk et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Article Chemistry, Multidisciplinary

Silica-gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial

Alexander N. Kharlamov et al.

NANOSCALE (2015)

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Article Multidisciplinary Sciences

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

Annika Warnatsch et al.

SCIENCE (2015)

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Review Immunology

Cholesterol, inflammation and innate immunity

Alan R. Tall et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Biochemistry & Molecular Biology

Mechanisms and Functions of Inflammasomes

Mohamed Lamkanfi et al.

CELL (2014)

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Review Biochemistry & Molecular Biology

Shear Stress and Atherosclerosis

Kyung-Sun Heo et al.

MOLECULES AND CELLS (2014)

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Article Cardiac & Cardiovascular Systems

Targeted anti-inflammatory systemic therapy for restenosis: The Biorest Liposomal Alendronate with Stenting sTudy (BLAST)-a double blind, randomized clinical trial

Shmuel Banai et al.

AMERICAN HEART JOURNAL (2013)

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Article Cardiac & Cardiovascular Systems

Anti-Atherogenic Effects of Methotrexate Carried by a Lipid Nanoemulsion That Binds to LDL Receptors in Cholesterol-fed Rabbits

Adriana Bulgarelli et al.

CARDIOVASCULAR DRUGS AND THERAPY (2013)

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Editorial Material Medicine, General & Internal

Antioxidant Supplements to Prevent Mortality

Goran Bjelakovic et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2013)

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Article Neurosciences

Sequential Imaging of Asymptomatic Carotid Atheroma Using Ultrasmall Superparamagnetic Iron Oxide-enhanced Magnetic Resonance Imaging: A Feasibility Study

Umar Sadat et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2013)

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Article Medicine, Research & Experimental

Interleukin-10: An Anti-Inflammatory Marker To Target Atherosclerotic Lesions via PEGylated Liposomes

Gunter Almer et al.

MOLECULAR PHARMACEUTICS (2013)

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Article Multidisciplinary Sciences

Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm?

Goran Bjelakovic et al.

PLOS ONE (2013)

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Review Hematology

Animal Models of Atherosclerosis

Godfrey S. Getz et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

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Review Chemistry, Medicinal

Inflammatory Mechanisms in Atherosclerosis: The Impact of Matrix Metalloproteinases

Gerasimos Siasos et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)

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Article Biochemistry & Molecular Biology

Exosomes: Small vesicles participating in intercellular communication

Anna-Kristin Ludwig et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

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Article Cardiac & Cardiovascular Systems

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

Sungwoo Ryoo et al.

ATHEROSCLEROSIS (2011)

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Review Biochemistry & Molecular Biology

Macrophages in the Pathogenesis of Atherosclerosis

Kathryn J. Moore et al.

CELL (2011)

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Article Cardiac & Cardiovascular Systems

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

Fei Fang et al.

CIRCULATION RESEARCH (2011)

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Article Surgery

Toll-like Receptor 4 Mediates Oxidized LDL-Induced Macrophage Differentiation to Foam Cells

Kenneth W. Howell et al.

JOURNAL OF SURGICAL RESEARCH (2011)

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Review Multidisciplinary Sciences

Progress and challenges in translating the biology of atherosclerosis

Peter Libby et al.

NATURE (2011)

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Review Cell Biology

Rolling Cell Adhesion

Rodger P. McEver et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 26 (2010)

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Review Cardiac & Cardiovascular Systems

Inflammation in Atherosclerosis: Transition From Theory to Practice

Peter Libby et al.

CIRCULATION JOURNAL (2010)

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Article Cardiac & Cardiovascular Systems

Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation

Ryan E. Feaver et al.

CIRCULATION RESEARCH (2010)

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Review Cell Biology

The vicious circle between oxidative stress and inflammation in atherosclerosis

Maarten Hulsmans et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)

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Article Multidisciplinary Sciences

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell et al.

NATURE (2010)

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Article Hematology

Macrophage Diversity and Polarization in Atherosclerosis A Question of Balance

Alberto Mantovani et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

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Article Biophysics

Markers of inflammation collocate with increased wall stress in human coronary arterial plaque

Karen Melissa Hallow et al.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2009)

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Review Cardiac & Cardiovascular Systems

Contrast ultrasound molecular imaging of inflammation in cardiovascular disease

Jonathan R. Lindner

CARDIOVASCULAR RESEARCH (2009)

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Review Biochemistry & Molecular Biology

Lipoprotein modification by secretory phospholipase A(2) enzymes contributes to the initiation and progression of atherosclerosis

Katariina Oorni et al.

CURRENT OPINION IN LIPIDOLOGY (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: A comparison of symptomatic and asymptomatic individuals

S. P. S. Howarth et al.

EUROPEAN JOURNAL OF RADIOLOGY (2009)

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Article Hematology

Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells

M. GAWAZ et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)

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Article Cardiac & Cardiovascular Systems

Ultrasound molecular imaging of cardiovascular disease

Flordeliza S. Villanueva et al.

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2008)

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Review Cardiac & Cardiovascular Systems

Subendothelial lipoprotein retention as the initiating process in atherosclerosis -: Update and therapeutic implications

Ira Tabas et al.

CIRCULATION (2007)

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Article Cell Biology

PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties

M. Amine Bouhlel et al.

CELL METABOLISM (2007)

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Article Cardiac & Cardiovascular Systems

Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis

Manu O. Platt et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

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Article Mathematical & Computational Biology

Atherosclerosis Initiation Modeled as an Inflammatory Process

N. El Khatib et al.

MATHEMATICAL MODELLING OF NATURAL PHENOMENA (2007)

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Article Cardiac & Cardiovascular Systems

Inflammation in atherosclerosis - Visualizing matrix metalloproteinase action in macrophages in vivo

Jun-o Deguchi et al.

CIRCULATION (2006)

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Review Medical Laboratory Technology

Initiation and progression of atherosclerosis - enzymatic or oxidative modification of low-density lipoprotein?

Michael Torzewski et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2006)

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Article Multidisciplinary Sciences

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2, macrophages subvert, immunity to (myco)bacteria

FAW Verreck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Review Immunology

The chemokine system in diverse forms of macrophage activation and polarization

A Mantovani et al.

TRENDS IN IMMUNOLOGY (2004)

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Article Hematology

Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis

HS Carlsen et al.

BLOOD (2004)

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Review Cardiac & Cardiovascular Systems

Role of platelets in the development of atherosclerosis

YQ Huo et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2004)

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Review Physiology

Role of oxidative modifications in atherosclerosis

R Stocker et al.

PHYSIOLOGICAL REVIEWS (2004)

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Article Multidisciplinary Sciences

T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions

M Benagiano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Biochemistry & Molecular Biology

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

YQ Huo et al.

NATURE MEDICINE (2003)

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Article Multidisciplinary Sciences

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

K Skålén et al.

NATURE (2002)

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Article Chemistry, Multidisciplinary

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

JD Luo et al.

CHEMICAL COMMUNICATIONS (2001)

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Article Cell Biology

Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis

S Lindemann et al.

JOURNAL OF CELL BIOLOGY (2001)

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Review Multidisciplinary Sciences

Atherosclerosis

AJ Lusis

NATURE (2000)

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