4.5 Article

Role of protein induced by vitamin-K absence-II in transplanted patients with HCC not producing alpha-fetoprotein

Related references

Note: Only part of the references are listed.
Review Gastroenterology & Hepatology

Utility of combining PIVKA-II and AFP in the sur- veillance and monitoring of hepatocellular carci- noma in the Asia-Pacific region

Do Young Kim et al.

Summary: PIVKA-II is valuable for detecting AFP-negative hepatocellular carcinoma (HCC), and could be used in combination with AFP for early HCC detection. It is clinically useful for monitoring HCC treatment, predicting recurrence and microvascular invasion risk, and facilitating patient selection for liver transplant. However, more evidence is needed for its role in surveillance, including small HCC.

CLINICAL AND MOLECULAR HEPATOLOGY (2023)

Review Transplantation

The impact of biological features for a better prediction of posttransplant hepatocellular cancer recurrence

Quirino Lai et al.

Summary: In the past decade, the exploration and validation of biological tumor characteristics have improved the ability to predict patients at high risk for recurrence. The addition of biological aspects to morphological criteria has enhanced the discrimination between high- and low-risk patients.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2022)

Article Gastroenterology & Hepatology

GALAD demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis

Amit G. Singal et al.

Summary: Evaluation of the biomarker GALAD for early detection of HCC in a cohort of patients with cirrhosis demonstrates high sensitivity.

HEPATOLOGY (2022)

Letter Gastroenterology & Hepatology

DCP and AFP-L3 Are Complementary to AFP in Predicting High-Risk Explant Features: Results of a Prospective Study

Prashant Kotwani et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Surgery

Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: A retrospective cohort study

Ming-Da Wang et al.

Summary: This study evaluated and compared the use of AFP and PIVKA-II as biomarkers for detecting and predicting HCC. The results showed that preoperative PIVKA-II positivity was an independent risk factor for early recurrence after HCC resection, while the positivity rate of AFP was lower.

INTERNATIONAL JOURNAL OF SURGERY (2022)

Article Gastroenterology & Hepatology

Quantitative Prognostic Prediction Using ADV Score for Hepatocellular Carcinoma Following Living Donor Liver Transplantation

Shin Hwang et al.

Summary: The study evaluated the prognostic impact of the ADV score for predicting HCC recurrence and patient survival after LDLT in 843 HCC patients. The ADV score showed a significant correlation with TR and OS, providing further prognostic stratification beyond existing criteria. Compared to pre-existing selection criteria, the ADV score with a cutoff of 5log exhibited the highest prognostic contrast for TR and OS, making it a valuable prognostic tool for posttransplant prognosis in HCC patients.

JOURNAL OF GASTROINTESTINAL SURGERY (2021)

Article Surgery

Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma

Karim J. Halazun et al.

Summary: This study validates the importance of AFP-R in selecting patients with HCC for liver transplant, showing its accurate prediction of recurrence and overall survival. AFP-R is a truly objective pre-transplant biological characteristic, and its incorporation into selection criteria allows for safe expansion of existing models and offers transplant opportunities to patients with acceptable tumor characteristics who might otherwise be denied potential cure.

JAMA SURGERY (2021)

Review Surgery

Hepatocellular cancer selection systems and liver transplantation: from the tower of babel to an ideal comprehensive score

Jan Lerut et al.

Summary: A systematic review of literature from 1993-2021 identified 59 different inclusion criteria for HCC patients undergoing liver transplantation, with new selection systems increasing transplantability by 31% without compromising patient outcomes. The development of an accepted comprehensive HCC-LT Score should be a priority to offer more patients a fair chance of justified transplantation. Further research is needed to establish internationally accepted expanded selection criteria for HCC patients seeking liver transplantation.

UPDATES IN SURGERY (2021)

Review Biotechnology & Applied Microbiology

Des-gamma-carboxy prothrombin in hepatocellular cancer patients waiting for liver transplant: a systematic review and meta-analysis

Quirino Lai et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2017)

Article Gastroenterology & Hepatology

Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion

Nicolas Pote et al.

JOURNAL OF HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

Combinations of Biomarkers and Milan Criteria for Predicting Hepatocellular Carcinoma Recurrence After Liver Transplantation

Roongruedee Chaiteerakij et al.

LIVER TRANSPLANTATION (2015)

Article Gastroenterology & Hepatology

Milan Criteria in Liver Transplantation for Hepatocellular Carcinoma: An Evidence-Based Analysis of 15 Years of Experience

Vincenzo Mazzaferro et al.

LIVER TRANSPLANTATION (2011)

Article Gastroenterology & Hepatology

Liver transplantation for hepatocellular carcinoma: the Kyoto experience

Yasutsugu Takada et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2010)

Article Gastroenterology & Hepatology

Extending indication: Role of living donor liver transplantation for hepatocellular carcinoma

Sol Todo et al.

LIVER TRANSPLANTATION (2007)

Review Medicine, General & Internal

Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration

Jan P. Vandenbroucke et al.

PLOS MEDICINE (2007)

Article Mathematical & Computational Biology

Proportional hazards models with frailties and random effects

J O'Quigley et al.

STATISTICS IN MEDICINE (2002)