Potential implications of protein kinase Ca in pathophysiological conditions and therapeutic interventions

PKCa is a molecule with many functions that play an important role in cell survival and death to maintain cellular homeostasis. Alteration in the normal functioning of PKCa is responsible for the complicated etiology of many pathologies, including cancer, cardiovascular diseases, kidney complications, neurodegenerative diseases, diabetics, and many others. Several studies have been carried out over the years on this kinase's function, and regulation in normal physiology and pathological conditions. A lot of data with antithetical results have therefore accumulated over time to create a complex framework of physiological implications connected to the PKCa function that needs comprehensive elucidation. In light of this information, we critically analyze the multiple roles played by PKCa in basic cellular processes and their molecular mechanism during various pathological conditions. This review further discusses the current approaches to manipulating PKCa signaling amplitude in the patient's favour and proposed PKCa as a therapeutic target to reverse pathological states.

Automated summary

PKCa is a multitasking molecule that is crucial for cell survival and maintaining cellular homeostasis. Alterations in its normal functioning contribute to the development of various diseases such as cancer, cardiovascular diseases, kidney complications, neurodegenerative diseases, and diabetes. Numerous studies have been conducted to understand the roles and regulation of PKCa in physiological and pathological conditions, leading to a complex framework of its implications that require further investigation. This review critically examines the diverse functions and molecular mechanisms of PKCa in basic cellular processes during pathological conditions, and proposes PKCa as a potential therapeutic target for reversing pathological states.