4.7 Article

The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Interleukin-11 drives human and mouse alcohol-related liver disease

Maria Effenberger et al.

Summary: This study found that IL-11 plays a crucial role in the pathogenesis of alcoholic liver disease and could serve as an independent prognostic factor for transplant-free survival. Blocking IL-11 signaling might be a therapeutic option in alcoholic liver disease, particularly alcoholic hepatitis.
Review Andrology

TUNEL assay-Standardized method for testing sperm DNA fragmentation

Rakesh Sharma et al.

Summary: Sperm DNA integrity is crucial for normal reproductive functions, and sperm DNA fragmentation is common in infertile men. The TUNEL assay, which measures both single- and double-strand breaks in DNA, is becoming popular for assessing sperm DNA fragmentation. Various factors can affect the results, and challenges and clinical implications of TUNEL in male infertility evaluation are briefly discussed.

ANDROLOGIA (2021)

Review Gastroenterology & Hepatology

Liver disease and outcomes among COVID-19 hospitalized patients - A systematic review and meta-analysis

Ashish Sharma et al.

Summary: This meta-analysis focused on the occurrence and association of liver injury, comorbid liver disease, and elevated liver enzymes in COVID-19 confirmed hospitalizations. The findings suggest that acute liver injury and elevated liver enzymes were significantly associated with COVID-19 severity, while comorbid liver disease did not have a significant impact on outcomes.

ANNALS OF HEPATOLOGY (2021)

Review Medicine, Research & Experimental

Liver fibrosis: Pathophysiology and clinical implications

Jennifer Berumen et al.

Summary: Liver fibrosis is a significant finding impacting patient morbidity and mortality, primarily involving hepatic stellate cells. Various liver diseases cause hepatocellular damage leading to fibrosis, with progression to cirrhosis increasing liver-related mortality and hepatocellular carcinoma incidence. Despite treatments for Hepatitis B and C, there are currently no therapies directly targeting liver fibrosis, but research on novel drug targets could potentially improve patient survival.

WIRES MECHANISMS OF DISEASE (2021)

Review Cell Biology

Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

Arshi Khanam et al.

Summary: Hepatic fibrosis is a complex pathophysiological process involving interactions between various cells and molecular mechanisms that result in liver damage and cell transformation. While several therapeutic approaches exist to inhibit fibrosis, few have advanced from preclinical studies to clinical trials.

CELLS (2021)

Review Cell Biology

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

Zui Tan et al.

Summary: Liver fibrosis is a result of abnormal wound repair response caused by chronic liver injuries, potentially leading to severe diseases. The detailed mechanism of reversing liver fibrosis is still unclear, posing a challenge in the development of anti-fibrosis drugs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Medicine, Research & Experimental

Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation

Stuart A. Cook et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

Review Pharmacology & Pharmacy

IL-11 in cardiac and renal fibrosis: Late to the party but a central player

Benjamin Corden et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Review Medicine, General & Internal

Dietary and Pharmacological Treatment of Nonalcoholic Fatty Liver Disease

Anna Jeznach-Steinhagen et al.

MEDICINA-LITHUANIA (2019)

Review Cell Biology

Emerging roles for Interleukin-11 in disease

Paul M. Nguyen et al.

GROWTH FACTORS (2019)

Review Medicine, Research & Experimental

Pharmacological Treatment for Non-alcoholic Fatty Liver Disease

Sven Francque et al.

ADVANCES IN THERAPY (2019)

Review Biochemistry & Molecular Biology

Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis

Guobao Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Medicine, Research & Experimental

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis

Jing Li et al.

CLINICAL SCIENCE (2018)

Review Oncology

The role of IL-11 in immunity and cancer

Dixon H. Xu et al.

CANCER LETTERS (2016)

Review Gastroenterology & Hepatology

Hepatic fibrosis: Concept to treatment

Christian Trautwein et al.

JOURNAL OF HEPATOLOGY (2015)

Review Gastroenterology & Hepatology

Apoptosis as a Mechanism for Liver Disease Progression

Maria Eugenia Guicciardi et al.

SEMINARS IN LIVER DISEASE (2010)

Article Gastroenterology & Hepatology

Hepatic fibrosis

Jingjing Jiao et al.

CURRENT OPINION IN GASTROENTEROLOGY (2009)

Article Gastroenterology & Hepatology

Hepatic stellate cells and the reversal of fibrosis

Tatiana Kisseleva et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2006)