☆ 4.7 Article

Phloretin as an add-on therapy to losartan attenuates diabetes-induced AKI in rats: A potential therapeutic approach targeting TLR4-induced inflammation

LIFE SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Article Cell Biology

Toll-like receptors 2 and 4 stress signaling and sodium-glucose cotransporter-2 in kidney disease

Vishwadeep Shelke et al.

Summary: Kidney disease is a major global health concern that requires effective therapies, and Toll-like receptors (TLR) 2 and 4 play significant roles in the inflammatory response associated with kidney diseases. TLR2/4 signaling is elevated by SGLT2 and ER stress, leading to inflammation and disease progression. The interactions between TLR2/4, ER stress, and SGLT2 suggest that TLR2/4 may be a potential therapeutic target for kidney disease. Preclinical studies using SGLT2 inhibitors have shown promising results in inhibiting TLR2/4 signaling and reducing inflammation in kidney diseases.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

Add to Collection

Article Cell Biology

Phloretin inhibits glucose transport and reduces inflammation in human retinal pigment epithelial cells

Maria Hytti et al.

Summary: Age-related macular degeneration (AMD) is caused by chronic inflammation, possibly fueled by high glucose levels. Phloretin, found in apples, has anti-inflammatory effects and inhibits glucose uptake. In this study, ARPE-19 cells were exposed to lipopolysaccharide (LPS) and then treated with phloretin. Phloretin reduced the release of pro-inflammatory cytokines and increased intracellular reactive oxygen species levels. The Nrf2 pathway was found to be the main mechanism of phloretin's anti-inflammatory effects.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Evaluating the potential of tauroursodeoxycholic acid as add-on therapy in amelioration of streptozotocin-induced diabetic kidney disease

Himanshu Sankrityayan et al.

Summary: This study evaluated the potential and underlying molecular mechanism of the bile acid tauroursodeoxycholic acid (TUDCA) as a monotherapy and as an add-on therapy to telmisartan for treating diabetic kidney disease (DKD). The results showed that the addition of TUDCA to telmisartan treatment was more effective in restoring renal function and suppressing apoptotic and fibrotic signaling compared to monotherapies. This suggests that TUDCA, traditionally used in Chinese medicine, could be a potential renoprotective compound when used in combination with telmisartan.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2023)

Add to Collection

Review Pharmacology & Pharmacy

Renin-angiotensin-aldosterone pathway modulators in chronic kidney disease: A comparative review

Saeed Alshahrani

Summary: Chronic kidney disease is a complex condition with various underlying causes. Current pharmacotherapeutic treatment options aim to slow disease progression and improve quality of life but cannot achieve complete cure. The first-line treatment for controlling blood pressure in chronic kidney disease is the use of renin-angiotensin-aldosterone system modulators. These modulators, including direct renin inhibitors, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers, have different structures and mechanisms of action, leading to varying treatment outcomes. The choice of modulator depends on patient presentation, comorbidities, treatment availability and affordability, and healthcare provider expertise. Comparative studies between these modulators are currently lacking, which could provide valuable information for healthcare providers and researchers. This review compares the direct renin inhibitor (aliskiren) with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, aiming to identify specific areas of interest for intervention and the best possible treatment option.

FRONTIERS IN PHARMACOLOGY (2023)

Add to Collection

Article Pharmacology & Pharmacy

Tetrahydrocurcumin Add-On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury

Mahyar Khazaeli et al.

Summary: In a rat model of type 2 diabetes mellitus, the effects of tetrahydrocurcumin (THC) were examined on kidney oxidative stress and fibrosis as add-on therapy to losartan. The combination treatment of THC, PPC, and losartan significantly improved antioxidant levels, decreased fibrosis, and lowered blood pressure in diabetic CKD rats.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Transcriptomic evidence of hypothalamus for maternal fructose exposure induced offspring hypertension through AT1R/TLR4 pathway

Qing Guo et al.

Summary: Maternal fructose exposure during pregnancy and lactation can cause hypertension in offspring. The study used various methods to evaluate the effects of maternal fructose exposure on blood pressure levels and the development of the hypothalamus in offspring. The findings suggest that maternal fructose exposure alters the transcriptome of the hypothalamus and activates the AT1R/TLR4 pathway, leading to hypertension.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2023)

Add to Collection

Article Medicine, Research & Experimental

Epigenetic restoration of endogenous Klotho expression alleviates acute kidney injury-diabetes comorbidity

Ajinath Kale et al.

Summary: This study aimed to explore the mechanisms of Klotho regulation in hyperglycemia augmented AKI and evaluate epigenetic ways to restore Klotho expression in AKI-diabetes comorbidity. The findings suggest that hyperglycemia exacerbates AKI, but inhibition of kidney-specific HDACs can protect the kidney by restoring endogenous Klotho loss, preventing inflammation and apoptosis.

LIFE SCIENCES (2022)

Add to Collection

Article Pharmacology & Pharmacy

Toll-like receptor 4 mutation protects the kidney from Ang-II-induced hypertensive injury

Suravi Majumder et al.

Summary: TLR4 mutation may alleviate hypertension-induced renal injury by activating autophagy and suppressing apoptosis.

PHARMACOLOGICAL RESEARCH (2022)

Add to Collection

Article Plant Sciences

Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras/MAPKs/PPAR-γ signaling pathway

Beibei Zhang et al.

Summary: OA effectively ameliorated renal function, alleviated inflammatory response and oxidative stress, transformed apoptotic, MAPK and PPAR-gamma signaling pathways in AKI mice, regulated metabolisms of phenylalanine, purine, sphingolipid, taurine, and hypotaurine. Moreover, the role of OA in NRK-52e injury was blocked by FTS.

PHYTOMEDICINE (2022)

Add to Collection

Review Genetics & Heredity

Epigenetic regulation of Toll-like receptors 2 and 4 in kidney disease

Vishwadeep Shelke et al.

Summary: Kidney disease affects a significant portion of the global population, and epigenetic mechanisms play a crucial role in its progression. Toll-like receptor 2 and Toll-like receptor 4 (TLR2 and TLR4) are expressed by various kidney cells and are involved in promoting inflammation. This review discusses the intricate relationship between epigenetic mechanisms and TLR2 and TLR4 in different forms of kidney diseases.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Metformin Is Associated with the Inhibition of Renal Artery AT1R/ET-1/iNOS Axis in a Rat Model of Diabetic Nephropathy with Suppression of Inflammation and Oxidative Stress and Kidney Injury

Amal F. Dawood et al.

Summary: This study reveals the association between diabetes and the renal artery receptor AT1R/ET-1/iNOS axis, as well as the protective effect of metformin in diabetic nephropathy. Metformin was found to reduce inflammation, oxidative stress, hypertension, ketonuria, mesangial matrix expansion, and kidney collagen in diabetes-induced rats.

BIOMEDICINES (2022)

Add to Collection

Article Pharmacology & Pharmacy

Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling

Xin-Sen Chen et al.

Summary: This study investigated the association between the Ang II/AT1R axis and sepsis-induced cardiomyopathy (SIC) and found that the AT1R blocker losartan can reduce myocardial injury in SIC.

PHARMACOLOGICAL RESEARCH (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives

Daniela Maria Tanase et al.

Summary: Diabetes mellitus is a debilitating chronic disease with increasing prevalence worldwide. Diabetic Kidney Disease is a major complication of diabetes, caused by mechanisms such as hyperglycemia, inflammation, and oxidative stress. NRF2-inducing strategies show potential in the treatment of Diabetic Kidney Disease, but limitations such as lack of large-scale clinical trials hinder their clinical use.

BIOMOLECULES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Klotho restoration via ACE2 activation: A potential therapeutic strategy against acute kidney injury-diabetes comorbidity

Ajinath Kale et al.

Summary: Hyperglycemia exacerbates AKI induced by renal ischemia-reperfusion injury, with Klotho deficiency being a novel hallmark of AKI. ACE2, as a protective component of RAS, plays an important role in the development of AKI. Activation of ACE2 can ameliorate AKI and may act as an intermediate for reno-protection.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

Add to Collection

Review Chemistry, Medicinal

Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus

Jana Blahova et al.

Summary: Type 2 diabetes mellitus is a common chronic disease that can be treated with pharmaceutical drugs, but long-term use may have harmful side effects. Therefore, natural therapeutic products, recommended as food supplements, could be a safer alternative to prevent and ameliorate T2DM-related complications. Combination therapy with synthetic agents and natural compounds may lead to more efficient treatment outcomes.

PHARMACEUTICALS (2021)

Add to Collection

Review Peripheral Vascular Disease

Renin-angiotensin system blockade in patients with chronic kidney disease: benefits, problems in everyday clinical use, and open questions for advanced renal dysfunction

Charalampos Loutradis et al.

Summary: Studies have shown significant renoprotective effects of renin-angiotensin system (RAS) blockers in chronic kidney disease (CKD) patients with high levels of albuminuria, particularly in those with more severe conditions. However, randomized trials on the initiation or maintenance of RAS blockers in patients with advanced CKD are scarce, leading to uncertainty among clinicians. Fear of hyperkalemia or acute renal decline also contributes to underprescription of RAS blockers in Stage 4 and 5 CKD patients.

JOURNAL OF HUMAN HYPERTENSION (2021)

Add to Collection

Article Pharmacology & Pharmacy

TLR4 and AT1R mediate blood-brain barrier disruption, neuroinflammation, and autonomic dysfunction in spontaneously hypertensive rats

Francesca E. Mowry et al.

Summary: The study demonstrates that inhibiting TLR4 and AT1R in hypertensive rats can restore neuroinflammation, blood-brain barrier disruption, and autonomic dysfunction, suggesting a potential therapeutic approach for hypertension.

PHARMACOLOGICAL RESEARCH (2021)

Add to Collection

Review Multidisciplinary Sciences

Multifaceted roles of Toll-like receptors in acute kidney injury

Rakhshinda Habib

Summary: Toll-like receptors play a crucial role in renal inflammation and regeneration by mediating cytokine production and autophagy mechanism, ultimately affecting the progression of acute kidney injury. Understanding these pathways may lead to potential therapeutic options for kidney diseases.

HELIYON (2021)

Add to Collection

Article Urology & Nephrology

US Trends in Hospitalizations for Dialysis-Requiring Acute Kidney Injury in People With Versus Without Diabetes

Jessica Lee Harding et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2020)

Add to Collection

Review Immunology

The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy

Qi Feng et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

Add to Collection

Article Peripheral Vascular Disease

Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules Novel Roles of Mitochondrial Ang II/AT1a/O2-and Ang II/AT2/NO Signaling

Xiao Chun Li et al.

HYPERTENSION (2020)

Add to Collection

Review Urology & Nephrology

Blood pressure reduction and RAAS inhibition in diabetic kidney disease: therapeutic potentials and limitations

Giovanna Leoncini et al.

JOURNAL OF NEPHROLOGY (2020)

Add to Collection

Article Endocrinology & Metabolism

Acute Kidney Injury: A Bona Fide Complication of Diabetes

Andrew Advani

DIABETES (2020)

Add to Collection

Article Pharmacology & Pharmacy

Effects of renal ischemia injury on brain in diabetic and non-diabetic rats: Role of angiotensin II type 2 receptor and angiotensin-converting enzyme 2

Nisha Sharma et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Add to Collection

Review Medicine, Research & Experimental

Fiend and friend in the renin angiotensin system: An insight on acute kidney injury

Nisha Sharma et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection

Article Cell Biology

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

Ki Wung Chung et al.

CELL METABOLISM (2019)

Add to Collection

Article Medicine, Research & Experimental

Angiotensin 1 receptor antagonist attenuates acute kidney injury-induced cognitive impairment and synaptic plasticity via modulating hippocampal oxidative stress

Fatemeh Sharifi et al.

LIFE SCIENCES (2019)

Add to Collection

Article Medicine, Research & Experimental

Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats

Nisha Sharma et al.

LIFE SCIENCES (2019)

Add to Collection

Article Pharmacology & Pharmacy

Differential Effects of the Mitochondria-Active Tetrapeptide SS-31 (D-Arg-dimethylTyr-Lys-Phe-NH2) and Its Peptidase-Targeted Prodrugs in Experimental Acute Kidney Injury

Jean-Christophe Wyss et al.

FRONTIERS IN PHARMACOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

AT1 and AT2 receptors modulate renal tubular cell necroptosis in angiotensin II-infused renal injury mice

Yongjun Zhu et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Physiology

Diabetes aggravates renal ischemia-reperfusion injury by repressing mitochondrial function and PINK1/Parkin-mediated mitophagy

Yuan-Yuan Yang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats

Mohamed Balaha et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Cell Biology

Angiotensin II enhances the acetylation and release of HMGB1 in RAW264.7 macrophage

Shanshan Zhou et al.

CELL BIOLOGY INTERNATIONAL (2018)

Add to Collection

Article Urology & Nephrology

A randomised controlled trial evaluating renal protective effects of selenium with vitamins A, C, E, verapamil, and losartan against extracorporeal shockwave lithotripsy-induced renal injury

Ahmed R. El-Nahas et al.

BJU INTERNATIONAL (2017)

Add to Collection

Article Pharmacology & Pharmacy

Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study

Cengiz Kocak et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Losartan reduces ensuing chronic kidney disease and mortality after acute kidney injury

Shun-Yang Cheng et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Pharmacology & Pharmacy

Effect of losartan and atenolol on insulin sensitivity in nondiabetic hypertensive patients

Sandesh Madhukar Bharati et al.

JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS (2016)

Add to Collection

Article Oncology

Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells

Anand R. Nair et al.

EXPERIMENTAL CELL RESEARCH (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation

Shasha Yin et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Add to Collection

Article Medicine, General & Internal

Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy

Linda F. Fried et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Add to Collection

Review Cardiac & Cardiovascular Systems

Hyperkalemia Associated with Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers

Marsha A. Raebel

CARDIOVASCULAR THERAPEUTICS (2012)

Add to Collection

© Peeref 2019-2024. All rights reserved.