Preparation and Magnetic Manipulation of Fe3O4/Acrylic Resin Core-Shell Microspheres

Core-shell microspheres refer to duo-layer ormultilayermicrospheres, which are widely used in drug delivery, microreactors,etc. Accurate manipulation of microspheres is a research hot spot,while traditional manipulation methods including ultrasonic manipulationand laser manipulation still face some limitations. In this study,magnetic core-shell microspheres were adopted to realize theaccurate manipulation of microspheres. Combined with microfluidictechnology, polystyrene sulfonic acid (PSSA)/Fe3O4 magnetic fluid was utilized as the core material and photosensitiveacrylic resin became the shell material. After UV curing, a magneticcore-shell microsphere with an average size of 55 & mu;mcould be achieved, and the diameter was uniform and controllable.By adjusting the flow rate of the dispersed phase, the dual-core microsphereswith different core particle sizes that ranged from 9.3 to 28.4 & mu;mcould be prepared. Experimental results showed that the prepared Fe3O4/acrylic resin core-shell microspherescan be used as functionalized microspheres that have good magneticresponse properties and self-assembly ability. In addition, the magneticmanipulation and self-assembly of the prepared core-shell microsphereswere presented with different external magnetic fields. The magneticcore-shell microspheres have shown great potential in the fieldsof biomedical engineering and targeted delivery of drugs.

Automated summary

Core-shell microspheres, composed of magnetic core and photosensitive acrylic resin shell, were successfully synthesized for accurate manipulation. The prepared microspheres exhibited good magnetic response properties and self-assembly ability, showing potential in the field of biomedical engineering and targeted drug delivery.