Journal
MOLECULAR CELL
Volume 64, Issue 1, Pages 25-36Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2016.08.015
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Funding
- Spanish Ministry of Economy and Competitiveness [BFU2015-64437-P, FEDER, BFU2014-52125-REDT, BFU2014-51672-REDC, BFU2014-52333-P, SAF2015-70553, BIO2014-57518-R]
- Asociacion Espanola Contra el Cancer
- Catalan Government [2014SGR599]
- Fundacion Botin
- Banco Santander through its Santander Universities Global Division
- Institucio Catalana de Recerca i Estudis Avancats (ICREA) Academia award (Generalitat de Catalunya)
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Control of the G1/S phase transition by the Retinoblastoma (RB) tumor suppressor is critical for the proliferation of normal cells in tissues, and its inactivation is one of the most fundamental events leading to cancer. Cyclin-dependent kinase (CDK) phosphorylation inactivates RB to promote cell cycle-regulated gene expression. Here we show that, upon stress, the p38 stress-activated protein kinase (SAPK) maximizes cell survival by downregulating E2F gene expression through the targeting of RB. RB undergoes selective phosphorylation by p38 in its N terminus; these phosphorylations render RB insensitive to the inactivation by CDKs. p38 phosphorylation of RB increases its affinity toward the E2F transcription factor, represses gene expression, and delays cell-cycle progression. Remarkably, introduction of a RB phosphomimetic mutant in cancer cells reduces colony formation and decreases their proliferative and tumorigenic potential in mice.
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