Journal
MOLECULAR CELL
Volume 62, Issue 5, Pages 745-755Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2016.05.003
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Funding
- Cancerfonden
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
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The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.
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