Journal
MOLECULAR CELL
Volume 62, Issue 5, Pages 777-787Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2016.05.021
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Funding
- NIH [K99 CA184122, R01 CA185660]
- Hecksher Foundation for Children
- MSK Cancer Center Support Grant/Core Grant [NIH P30 CA008748]
- MSK Functional Genomics Initiative - Cycle for Survival
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Genetic abnormalities are present in all tumor types, although the frequency and type can vary. Chromosome abnormalities include highly aberrant structures, particularly chromothriptic chromosomes. The generation of massive sequencing data has illuminated the scope of the mutational burden in cancer genomes, identifying patterns of mutations (mutation signatures), which have the potential to shed light on the relatedness and etiologies of cancers and impact therapy response. Some mutation patterns are clearly attributable to disruptions in pathways that maintain genomic integrity. Here we review recent advances in our understanding of genetic changes occurring in cancers and the roles of genome maintenance pathways.
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