Assessing Active Bowel Inflammation in Crohn's Disease Using Intestinal Ultrasound

Article Gastroenterology & Hepatology

Bowel ultrasound score is accurate in assessing response to therapy in patients with Crohn's disease

Mariangela Allocca et al.

Summary: The study showed that BUSS is sensitive to changes in CD, accurately detecting changes in lesion severity, but did not significantly change in patients who did not achieve endoscopic remission.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2022)

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Article Gastroenterology & Hepatology

Disease Monitoring in Inflammatory Bowel Disease: Evolving Principles and Possibilities

Nikolas Plevris et al.

Summary: Inflammatory bowel disease is a progressive and debilitating condition, emphasizing the importance of early and effective treatment for improving patient outcomes. Proactive monitoring is crucial to ensuring treatment strategies are working, highlighting the need for an optimal treat-to-target monitoring strategy during key phases of the disease. The advent of new technology may enhance monitoring capabilities and shape future monitoring strategies for inflammatory bowel diseases.

GASTROENTEROLOGY (2022)

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Article Gastroenterology & Hepatology

Point-of-care Intestinal Ultrasound in IBD Patients: Disease Management and Diagnostic Yield in a Real-world Cohort and Proposal of a Point-of-care Algorithm

S. Bots et al.

Summary: Intestinal ultrasound (IUS) plays a vital role in assessing and monitoring inflammatory bowel disease (IBD) patients, with point-of-care (POC) IUS significantly impacting disease management and treatment monitoring, reducing the need for unnecessary procedures.

JOURNAL OF CROHNS & COLITIS (2022)

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Article Gastroenterology & Hepatology

Predictive Value of Bowel Ultrasound in Crohn's Disease: A 12-Month Prospective Study

Mariangela Allocca et al.

Summary: This study evaluated the predictive role of baseline bowel ultrasound findings on the disease course of Crohn's disease (CD) patients for 12 months. The results showed that bowel ultrasound score, presence of disease complications, baseline fecal calprotectin value, and male sex were independent predictors of a worse outcome in CD patients.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Intestinal Ultrasound to Evaluate Treatment Response During Pregnancy in Patients With Inflammatory Bowel Disease

Floris De Voogd et al.

Summary: Assessing disease activity in inflammatory bowel disease patients during pregnancy is crucial for maternal and fetal outcomes. This study evaluated the feasibility and accuracy of intestinal ultrasound in objectively assessing disease activity during pregnancy, showing correlation with clinical activity and FCP results, and providing a noninvasive strategy for monitoring patients during pregnancy.

INFLAMMATORY BOWEL DISEASES (2022)

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Article Gastroenterology & Hepatology

Intestinal ultrasonography and fecal calprotectin for monitoring inflammation of ileal Crohn's disease: two complementary tests

Jose Maria Paredes et al.

Summary: Fecal calprotectin (FC) has a weak but significant correlation with intestinal ultrasonography (IUS) in monitoring activity of ileal Crohn's disease (CD), but it cannot assess the presence of CD complications. Therefore, both tests should be used together for tight control of ileal CD.

INTESTINAL RESEARCH (2022)

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Review Medicine, General & Internal

Comparison of Diagnostic Performance of Ultrasonography and Magnetic Resonance Enterography in the Assessment of Active Bowel Lesions in Patients with Crohn's Disease: A Systematic Review and Meta-Analysis

Da In Lee et al.

Summary: The study compared the diagnostic performances of ultrasonography (US) and magnetic resonance enterography (MRE) in assessing active bowel lesions in patients with Crohn's disease (CD). The results showed that both US and MRE have comparable diagnostic accuracy in diagnosing active bowel lesions in CD patients. The study region, type of US probe, lesion location, study population, and reference standards were identified as potential sources of heterogeneity.

DIAGNOSTICS (2022)

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Article Gastroenterology & Hepatology

Evaluation of Crohn's Disease Activity: Development of an Ultrasound Score in a Multicenter Study

Tomas Ripolles et al.

Summary: In this study, the diagnostic accuracy of ultrasound techniques in identifying disease activity in Crohn's disease patients was tested and a sonographic score was developed for detecting disease activity. The predictive ultrasound score based on wall thickness, color Doppler grade, and contrast parameters showed high accuracy in predicting active disease, with a simpler index without contrast parameters also being effective.

INFLAMMATORY BOWEL DISEASES (2021)

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Review Gastroenterology & Hepatology

Point-of-Care Ultrasound in Inflammatory Bowel Disease

Mariangela Allocca et al.

Summary: Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Bowel ultrasound is a non-invasive, well-tolerated, and cost-effective modality for managing IBD patients.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Gastroenterology & Hepatology

Development and Validation of a Simple Ultrasound Activity Score for Crohn's Disease

Fredrik Saevik et al.

Summary: A simple ultrasound activity index for Crohn's disease was constructed and validated, consisting of bowel wall thickness and colour Doppler, which correlated well with endoscopic disease activity. The index showed good reproducibility and had a strong correlation with endoscopic findings in both patient cohorts.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Gastroenterology & Hepatology

Expert Consensus on Optimal Acquisition and Development of the International Bowel Ultrasound Segmental Activity Score [IBUS-SAS]: A Reliability and Inter-rater Variability Study on Intestinal Ultrasonography in Crohn's Disease

Kerri L. Novak et al.

Summary: This study successfully identified key parameters of Crohn's disease inflammation on intestinal ultrasound, developed a segmental activity score, and demonstrated excellent reliability through expert consensus and standardized approaches.

JOURNAL OF CROHNS & COLITIS (2021)

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Review Gastroenterology & Hepatology

Diagnostic Accuracy of Fecal Calprotectin for the Detection of Small Bowel Crohn's Disease through Capsule Endoscopy: An Updated Meta-Analysis and Systematic Review

Eun Suk Jung et al.

Summary: The study evaluated the diagnostic accuracy of fecal calprotectin (FC) in detecting active small bowel inflammation, showing significant diagnostic accuracy with an FC cutoff of 100 μg/g as a screening tool for small bowel Crohn's disease.

GUT AND LIVER (2021)

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Article Gastroenterology & Hepatology

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

Dan Turner et al.

Summary: STRIDE-II presents treatment targets for both adult and pediatric IBD, including long-term and short-term goals. These targets cover aspects such as clinical response, endoscopic healing, quality of life, and growth, providing guidance for improving patient outcomes.

GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Transmural healing as a therapeutic goal in Crohn's disease: a systematic review

Sophie Geyl et al.

Summary: Transmural healing is a key factor in improving disease-related outcomes for patients with Crohn's disease, often evaluated through bowel wall thickness. Multiple studies have shown a significant association between transmural healing and improvements in disease-related outcomes, as well as a correlation with mucosal healing and selected biomarkers.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Evaluation of Crohn's Disease Activity: Development of an Ultrasound Score in a Multicenter Study

Tomas Ripolles et al.

Summary: The study aimed to assess the disease activity in patients with Crohn's disease using ultrasound, color Doppler imaging, and contrast-enhanced ultrasound. A predictive ultrasound score based on wall thickness, color Doppler grade, and contrast parameters showed high accuracy in predicting active disease. Another simpler index without contrast parameters also demonstrated high accuracy in detecting disease activity.

INFLAMMATORY BOWEL DISEASES (2021)

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Review Gastroenterology & Hepatology