☆ 4.7 Review

The potential role of reprogrammed glucose metabolism: an emerging actionable codependent target in thyroid cancer

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Article Radiology, Nuclear Medicine & Medical Imaging

[18F]FAPI-42 PET/CT in differentiated thyroid cancer: diagnostic performance, uptake values, and comparison with 2-[18F]FDG PET/CT

Xingyu Mu et al.

Summary: This study compared the diagnostic performance of two PET/CT techniques in patients with differentiated thyroid cancer. The results showed that [F-18]FAPI-42 PET/CT is comparable to 2-[F-18]FDG PET/CT in detecting lesions and reflecting FAP expression.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2023)

Add to Collection

Review Medicine, Research & Experimental

Endoplasmic reticulum stress mediates the myeloid-derived immune suppression associated with cancer and infectious disease

Xiaoli Lou et al.

Summary: Myeloid-derived suppressor cells (MDSCs) are described as potent immune regulators in human and murine cancer models. MDSCs induce immune suppression by inactivating NK cells, CD4+, and CD8+ T cells through various mechanisms, promoting the formation of a tumor immunosuppressive microenvironment. ER stress plays a crucial role in the survival of MDSCs and exacerbates tumor immunosuppression. Additionally, ferroptosis can reverse the immunosuppressive microenvironment and promote an anti-tumor immune response. This review highlights the immune suppression by MDSCs, with a focus on the role of ER stress-mediated immune suppression in cancer and infectious diseases such as leprosy and tuberculosis.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

Add to Collection

Article Endocrinology & Metabolism

Differentiated thyroid carcinoma: An update

Pepijn van Houten et al.

Summary: Differentiated thyroid carcinoma (DTC) is the most common endocrine cancer, and the incidence of small clinically indolent tumors has been increasing. However, DTC-related mortality has remained unchanged. The management of DTC recently underwent a critical appraisal, focusing on reducing unnecessary burden for low-risk patients and identifying those who require more intensive treatment and follow-up. This review discusses recent developments in diagnosis, staging, and management of DTC, emphasizing an individualized risk assessment-based approach.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

Add to Collection

Article Oncology

Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics?

Mamta Singh et al.

Summary: Due to metabolic reprogramming, cancer cells exhibit high levels of glycolysis, resulting in excessive lactate production and increased extracellular acidity. Proton-linked monocarboxylate transporters (MCTs) play a crucial role in maintaining this metabolic phenotype by facilitating the transport of lactate across cell membranes and regulating cancer cell pH. MCT1 and MCT4 isoforms, encoded by the SLC16 gene family, are extensively studied in various cancers and are found to be overexpressed. These isoforms mediate lactate shuttling between cancer cells and also between cancer and stromal cells in the tumor microenvironment, contributing to cancer aggressiveness and therapy resistance. Understanding the functions and regulation of MCTs offers potential for the development of novel inhibitors for clinical application.

SEMINARS IN CANCER BIOLOGY (2023)

Add to Collection

Review Endocrinology & Metabolism

Clinical use of Molecular Data in Thyroid Nodules and Cancer

Ali S. Alzahrani

Summary: Advancements in molecular genetics have led to diagnostic tests, prognostic markers, and therapeutic agents for thyroid cancer. Genetic alterations in MAPK and PI3K/Akt pathways play a key role in differentiated thyroid cancer. Molecular tests like ThyroSeq v.3, Afirma Gene Sequencing Classifier, and ThyGeNEXT/ThyraMIR have been developed for diagnosing indeterminate thyroid nodules. They have high sensitivities and negative predictive values, reducing unnecessary surgeries. Molecular testing is also important for targeted therapy options and managing advanced disease.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

Add to Collection

Correction Cell Biology

Regulators of glucose uptake in thyroid cancer cell lines (vol 18, 83, 2020)

Shabnam Heydarzadeh et al.

CELL COMMUNICATION AND SIGNALING (2022)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Potential and Most Relevant Applications of Total Body PET/CT Imaging

Abass Alavi et al.

Summary: The introduction of total body PET/CT instruments has brought about a new era in medical imaging. These instruments with higher sensitivity allow for whole-body imaging, accurate assessment of disease extent, improved detection of cancer and chemotherapy complications, and evaluation of systemic diseases and musculoskeletal disorders.

CLINICAL NUCLEAR MEDICINE (2022)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Quantitative classification and radiomics of [18F]FDG-PET/CT in indeterminate thyroid nodules

Elizabeth J. de Koster et al.

Summary: The study aimed to evaluate whether quantitative [F-18]FDG-PET/CT assessment and radiomic analysis of [F-18]FDG-positive thyroid nodules could improve the preoperative differentiation of indeterminate thyroid nodules. The results showed that applying distinct SUV cut-offs for non-Hurthle cell and Hurthle cell nodules can optimize the ability to rule out malignancy, while radiomic analysis did not provide additional differentiation for [F-18]FDG-positive nodules.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

Add to Collection

Article Oncology

Molecular targets of tyrosine kinase inhibitors in thyroid cancer

Poupak Fallahi et al.

Summary: Thyroid cancer is a common cancer with a rising incidence worldwide. Surgery is the primary treatment strategy, but some patients experience recurrence during follow-up. Resistance to radioactive iodine is a poor prognostic factor. Significant advances have been made in understanding the molecular pathways of thyroid cancer, leading to the development of tyrosine kinase inhibitors as new treatment options. However, further research is needed.

SEMINARS IN CANCER BIOLOGY (2022)

Add to Collection

Article Oncology

Fasting- Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri et al.

Summary: Cyclic fasting or fasting-mimicking diets (FMD) enhance antineoplastic treatments by modulating systemic metabolism and boosting antitumor immunity. In a clinical trial, the five-day FMD was found to be safe and resulted in consistent decrease of blood glucose and growth factor concentration, recapitulating metabolic changes observed in preclinical experiments. The FMD also reshapes anticancer immunity and improves clinical outcomes in patients with cancer.

CANCER DISCOVERY (2022)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic Performance of Dynamic Contrast-Enhanced MRI and 18F-FDG PET/CT for Evaluation of Soft Tissue Tumors and Correlation with Pathology Parameters

Yu Zhang et al.

Summary: This study assessed the diagnostic performance of DCE-MRI and 18F-FDG PET/CT parameters in evaluating the biological behavior of soft tissue tumors. The results showed that these parameters can effectively differentiate between benign and malignant tumors as well as high and low-proliferation malignant tumors.

ACADEMIC RADIOLOGY (2022)

Add to Collection

Article Plant Sciences

Joint interactions of carbon and nitrogen metabolism dominated by bicarbonate and nitrogen in Orychophragmus violaceus and Brassica napus under simulated karst habitats

Antong Xia et al.

Summary: Karst habitats have negative effects on the growth and biodiversity of plants. This study compared the joint effects of carbon and nitrogen metabolism in karst-adaptable Orychophragmus violaceus and non-karst-adaptable Brassica napus under simulated karst habitats. The results showed that factors such as bicarbonate and nitrate had a significant impact on the carbon and nitrogen metabolism and growth of Orychophragmus violaceus, while their effects on Brassica napus were insignificant. The carbon and nitrogen metabolism in Orychophragmus violaceus played a vital role in its adaptation to karst habitats.

BMC PLANT BIOLOGY (2022)

Add to Collection

Article Endocrinology & Metabolism

Overview of the 2022 WHO Classification of Thyroid Neoplasms

Zubair W. Baloch et al.

Summary: This review summarizes the changes in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors that relate to the thyroid gland. The new classification provides a more detailed understanding of the different types of thyroid tumors based on their cell of origin, pathologic features, molecular profiles, and biological behavior. It also introduces new categories, such as thyroid follicular nodular disease, non-invasive follicular thyroid neoplasm with papillary-like nuclear features, and high-grade differentiated thyroid carcinomas. The classification emphasizes the importance of biomarkers in diagnosis and prognosis.

ENDOCRINE PATHOLOGY (2022)

Add to Collection

Article Surgery

Glycolytic inhibition with 3-bromopyruvate suppresses tumor growth and improves survival in a murine model of anaplastic thyroid cancer

Bixiao Zhao et al.

Summary: Inhibiting glycolysis through targeted inhibition was found to suppress the growth of anaplastic thyroid cancer and improve outcomes when combined with a ketogenic diet. Monotherapy with either a ketogenic diet or 3-bromopyruvate alone did not have the same effect, suggesting that this treatment approach may only be effective in specific contexts.

SURGERY (2022)

Add to Collection

Article Genetics & Heredity

Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial

Solomon A. Sowah et al.

Summary: This study analyzed the changes in gut microbiota in overweight and obese adults under intermittent and continuous calorie restriction diets. The results showed that both diets led to weight loss, but there were no significant differences in gut microbiome composition between the two groups. Overall weight loss was associated with metabolic improvements, but not with changes in the gut microbiome. However, there were significant correlations between gut bacterial families and metabolic biomarkers, anthropometric measures, and dietary composition.

GENOME MEDICINE (2022)

Add to Collection

Article Endocrinology & Metabolism

FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels

Chantal A. Lebbink et al.

Summary: This study demonstrates the potential usefulness of FDG PET/CT in detecting persistent or recurrent DTC in patients with low detectable thyroglobulin levels. However, a negative result on FDG PET/CT does not exclude the possibility of DTC, necessitating further investigations.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2022)

Add to Collection

Review Nutrition & Dietetics

Mediterranean Diet and Thyroid: An Interesting Alliance

Giuseppe Bellastella et al.

Summary: The aim of this review is to examine the correlation between the Mediterranean diet and thyroid function, and to evaluate the pathophysiological connection between selected food intake and thyroid disorders.

NUTRIENTS (2022)

Add to Collection

Article Surgery

Effect of Lactate Export Inhibition on Anaplastic Thyroid Cancer Growth and Metabolism

Bixiao Zhao et al.

Summary: This study found that inhibiting lactate shuttles can significantly reduce the proliferation and glycolytic capacity of anaplastic thyroid cancer cells in a low-glucose environment.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2022)

Add to Collection

Review Neurosciences

Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology

S. J. Kierans et al.

Summary: Under hypoxic conditions, eukaryotic cells can shift metabolism towards glycolysis to maintain ATP levels, a process regulated by HIF-1 alpha. This metabolic switch is crucial for cellular survival during acute hypoxic stress and has implications for cancer cell survival and growth. Understanding the mechanisms central to this reprogramming is important for both physiological and pathophysiological processes.

JOURNAL OF PHYSIOLOGY-LONDON (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Knockdown of circPUM1 impedes cell growth, metastasis and glycolysis of papillary thyroid cancer via enhancing MAPK1 expression by serving as the sponge of miR-21-5p

Yanqi Li et al.

Summary: The study revealed that circPUM1 is upregulated in papillary thyroid cancer and inhibits the expression of MAPK1 by targeting miR-21-5p, thereby impeding the progression of cancer.

GENES & GENOMICS (2021)

Add to Collection

Article Medical Laboratory Technology

Lactic acid in tumor invasion

Dun Niu et al.

Summary: Tumor invasion is a complex process involving cell-matrix interactions, dysregulated metabolism, and the role of lactic acid. Lactic acid plays a significant role in tumor invasion by impacting extracellular matrix remodeling and epithelial-mesenchymal transition through various pathways.

CLINICA CHIMICA ACTA (2021)

Add to Collection

Review Oncology

Critical role of mTOR in regulating aerobic glycolysis in carcinogenesis (Review)

Hui Fan et al.

Summary: mTOR plays a crucial role in regulating various biological processes, especially energy metabolism, and could be a potential target for cancer therapy. Understanding the complex mechanisms by which mTOR regulates glycolysis is essential for developing drugs targeting molecules associated with mTOR and glycolysis to provide strategies for clinical cancer treatment.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

Add to Collection

Article Oncology

PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells

Federica Liotti et al.

Summary: In thyroid cancer, PD-1 expression in epithelial cells is associated with tumor stage and lymph-node metastasis. Overexpressing/stimulating PD-1 promotes TC cell proliferation and migration, while inhibiting PD-1 has the opposite effect. PD-1 blockade not only restores anti-cancer immunity but also directly impairs TC cell growth by inhibiting the SHP2/Ras/MAPK signaling pathway.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Article Medicine, Research & Experimental

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Gladys Ferrere et al.

Summary: Limited experimental evidence suggests a link between nutrition and cancer immunosurveillance. This study demonstrates that ketogenic diet induces an anti-tumor effect through 3HB-mediated T cell-mediated cancer immunosurveillance. 3HB prevents immune checkpoint inhibition and promotes the expansion of specific T cells, while KD also leads to compositional changes in gut microbiota.

JCI INSIGHT (2021)

Add to Collection

Review Oncology

Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment

Varun Sasidharan Nair et al.

Summary: Metabolic dysregulation in the hypoxic tumor microenvironment plays a crucial role in the development of solid tumors, particularly in the metabolic reprogramming of Tregs. This reprogramming can affect the biological properties of Tregs, increasing their presence and proliferation within the TME. Understanding and regulating the metabolism of Tregs may have important implications for the treatment of tumors.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Thyroid Carcinoma: Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy

Jinwei Hu et al.

Summary: Thyroid carcinoma is a group of phenotypically heterogeneous cancers, and recent advances in biological technologies have helped delineate the genetic, epigenetic, and non-genetic factors contributing to their heterogeneities. Understanding the mechanisms of intratumor heterogeneity and therapeutic resistance can facilitate the development of novel targeting therapies for thyroid cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Endocrinology & Metabolism

Multikinase inhibitors in thyroid cancer: timing of targeted therapy

Matti L. Gild et al.

Summary: This review summarizes the evidence from clinical trials on the efficacy of tyrosine kinase inhibitors in treating thyroid cancer. It also discusses the experience with these drugs in clinical practice and factors that can help clinicians decide when to start or continue tyrosine kinase inhibitor therapy.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Add to Collection

Review Immunology

Metabolic regulation of the cancer-immunity cycle

Luis F. Somarribas Patterson et al.

Summary: Metabolic reprogramming of tumor and immune cells within the tumor microenvironment is a key factor in immune evasion. Targeting the metabolism of the tumor microenvironment may help improve tumor responsiveness to CAR-T cells or immune checkpoint blockade therapies.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Article Endocrinology & Metabolism

Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer

Eun Jeong Ban et al.

Summary: The study found that LDHA is aberrantly overexpressed in papillary thyroid cancer (PTC) and is associated with the BRAF(V600E) mutation and aggressive behavior in PTC, suggesting its potential as a prognostic marker and therapeutic target in PTC.

ENDOCRINOLOGY AND METABOLISM (2021)

Add to Collection

Article Oncology

Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics

Susi Zhu et al.

Summary: PKM2 plays a crucial role in tumor metabolism and its dysregulation is associated with cancer development and progression. Researchers are investigating the function and therapeutic potential of PKM2 in cancer, particularly its interactions with lncRNAs. The role of PKM2 in the tumor microenvironment (TME) is also being studied for its implications in cancer therapy.

CANCER LETTERS (2021)

Add to Collection

Article Endocrinology & Metabolism

Continued Discontinuation of TKI Treatment in Medullary Thyroid Carcinoma - Lessons From Individual Cases With Long-Term Follow-Up

Tim Brandenburg et al.

Summary: This study retrospectively analyzed MTC patients with continued discontinuation of vandetanib treatment in a tertiary referral endocrine tumor center. The results suggest that discontinuation of long-term vandetanib treatment with documented stable disease does not automatically result in rapid disease progression but may be followed by prolonged TKI-free stable disease in individual patients. Analysis of calcitonin and CDT during discontinuation is indicated as it will unmask tumor progression earlier than imaging. Restart with the same TKI is possible in case of progression.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Review Oncology

Management of VEGFR-Targeted TKI for Thyroid Cancer

Tomohiro Enokida et al.

Summary: Anti-VEGFR therapy is crucial in treating thyroid cancer but can lead to dangerous adverse reactions. To minimize risks, physicians need to understand the characteristics of these reactions and take appropriate measures. The development of multitarget tyrosine kinase inhibitors has improved prognosis, but effective management of related adverse events is essential.

CANCERS (2021)

Add to Collection

Article Cell Biology

HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA

Jia-Mei Wang et al.

Summary: The study revealed that HYOU1 is highly expressed in papillary thyroid cancer (PTC) and is associated with poor prognosis. Silencing HYOU1 suppressed proliferation, migration, and invasion in PTC cells, promoting oxidative phosphorylation and inhibiting aerobic glycolysis. Mechanistically, HYOU1 silencing indirectly targeted LDHB mRNA and increased miR-375-3p levels, leading to a complex regulatory network in PTC cells.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

PET/CT Variants and Pitfalls in Head and Neck Cancers Including Thyroid Cancer

Jasna Mihailovic et al.

Summary: PET/CT imaging combines metabolic and structural imaging, with commonly used radiotracers including F-18-FDG and Ga-68. DOTA-TOC. Accurate interpretation of PET/CT imaging requires a comprehensive understanding of normal head and neck anatomy and potential imaging pitfalls, while adjunct structural imaging can enhance diagnostic accuracy and patient outcomes.

SEMINARS IN NUCLEAR MEDICINE (2021)

Add to Collection

Article Cell Biology

LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

Xiukun Hou et al.

Summary: High expression levels of LDHA in papillary thyroid carcinoma are associated with aggressive clinicopathological features and poor prognosis. LDHA promotes cancer cell migration, invasion, and proliferation, making it a potential therapeutic target.

CELL DEATH & DISEASE (2021)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

PET/CT in the management of differentiated thyroid cancer

Emilia Zampella et al.

Summary: The standard treatment for differentiated thyroid cancer usually involves surgery and iodine-131 treatment, with follow-up including monitoring of serum thyroglobulin levels, neck ultrasound, and whole-body scans. PET/CT plays a crucial role in evaluating patients, especially high-risk and metastatic cases.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2021)

Add to Collection

Article Oncology

Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis

Chang Liu et al.

Summary: This study demonstrated that PC promotes TC progression and metastasis by increasing fatty acid synthesis, with higher PC expression in PTC specimens from patients with lymph node metastasis. Knockdown of PC reduced lipid levels, cell aggressiveness, and tumor weight, suggesting that PC-mediated lipogenesis activation plays a crucial role in the aggressiveness of TC cells. Additionally, PC was found to activate the AKT/mTOR pathway and upregulate SREBP1c expression, further enhancing FASN-mediated de novo lipogenesis in TC cells.

BMC CANCER (2021)

Add to Collection

Article Cell Biology

STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis

Nan Huo et al.

Summary: A novel lncRNA LINC00671 was found to be negatively correlated with LDHA, downregulating LDHA expression and predicting a good clinical outcome in thyroid cancer. The STAT3/LINC00671/LDHA axis was established as critical in regulating PTC growth and progression, suggesting potential therapeutic strategies in thyroid cancer.

CELL DEATH & DISEASE (2021)

Add to Collection

Review Medicine, Research & Experimental

Molecular mechanisms of radioactive iodine refractoriness in differentiated thyroid cancer: Impaired sodium iodide symporter (NIS) expression owing to altered signaling pathway activity and intracellular localization of NIS

Ji Min Oh et al.

Summary: Advanced, metastatic differentiated thyroid cancers often have a poor prognosis due to decreased NIS expression and RAI refractoriness caused by genetic aberrations such as BRAF, RAS, and RET/PTC rearrangements. These genetic abnormalities activate MAPK and PI3K/AKT signaling pathways leading to dedifferentiation of DTCs. Research in recent years has focused on strategies to restore NIS expression and RAI uptake.

THERANOSTICS (2021)

Add to Collection

Review Immunology

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Michelangelo Certo et al.

Summary: The microenvironments of cancerous tissues and tissues affected by chronic inflammatory diseases exhibit different immune states but similar metabolic states. Understanding the metabolic signature allows for therapeutic intervention to reset metabolite availability and correct dysregulated immune states.

NATURE REVIEWS IMMUNOLOGY (2021)

Add to Collection

Review Oncology

Cancer Plasticity: The Role of mRNA Translation

Laura J. Lee et al.

Summary: Tumor progression is associated with dedifferentiated histopathologies and cancer cell survival within a changing tumor microenvironment. Cellular plasticity enables rapid shifts in cancer cell phenotypes, fueling tumor heterogeneity, metastasis, and drug resistance. Dysregulated protein synthesis in cancer, along with translational reprogramming, epigenetic, and metabolic programs, contribute to the phenotypic plasticity of neoplasia.

TRENDS IN CANCER (2021)

Add to Collection

Review Cell Biology

Autophagy and mitophagy in cancer metabolic remodelling

Fabio Ferro et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The enhancement of glycolysis regulates pancreatic cancer metastasis

Jinshou Yang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Add to Collection

Review Oncology

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

Btissame El Hassouni et al.

SEMINARS IN CANCER BIOLOGY (2020)

Add to Collection

Article Surgery

Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer

Abha Aggarwal et al.

SURGERY (2020)

Add to Collection

Review Genetics & Heredity

Crucial players in glycolysis: Cancer progress

Zaka Abbaszadeh et al.

GENE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

Shamir Cassim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Metabolism of pancreatic cancer: paving the way to better anticancer strategies

Cheng Qin et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Oncology

GLUT1 expression in high-risk prostate cancer: correlation with 18F-FDG-PET/CT and clinical outcome

Salma Meziou et al.

PROSTATE CANCER AND PROSTATIC DISEASES (2020)

Add to Collection

Review Oncology

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

Kulsoom Zahra et al.

FRONTIERS IN ONCOLOGY (2020)

Add to Collection

Review Medicine, General & Internal

Skeletal Muscle Metastasis in Papillary Thyroid Microcarcinoma Evaluated by F18-FDG PET/CT

Liviu Hitu et al.

DIAGNOSTICS (2020)

Add to Collection

Article Cell Biology

Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

Caihong Wang et al.

CELL REPORTS (2020)

Add to Collection

Review Endocrinology & Metabolism

New Therapies for Advanced Thyroid Cancer

Diprajan Laha et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of simultaneous18F-2-[18F] FDG PET/MR and PET/CT in the follow-up of patients with differentiated thyroid cancer

Michele Klain et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

Add to Collection

Review Cell Biology

Regulators of glucose uptake in thyroid cancer cell lines

Shabnam Heydarzadeh et al.

CELL COMMUNICATION AND SIGNALING (2020)

Add to Collection

Review Biochemistry & Molecular Biology

pH gradient reversal fuels cancer progression

Tianyu Zheng et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

Add to Collection

Review Oncology

Molecular Markers Guiding Thyroid Cancer Management

Carolina Nylen et al.

CANCERS (2020)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

Diagnostic role of F-18 FDG PET/CT for preoperative lymph node staging in thyroid cancer patients; A systematic review and metaanalysis

Dae-Hwan Kim et al.

CLINICAL IMAGING (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Phosphoribosyl Pyrophosphate Amidotransferase Promotes the Progression of Thyroid Cancer via Regulating Pyruvate Kinase M2

Bing Liu et al.

ONCOTARGETS AND THERAPY (2020)

Add to Collection

Article Multidisciplinary Sciences

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Chunqing Wang et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Oncology

Kidney Cancer, Version 1.2021 Featured Updates to the NCCN Guidelines

Robert J. Motzer et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Add to Collection

Review Cell Biology

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

Rui Liu et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Review Oncology

The Warburg Effect 97 Years after Its Discovery

Rosa Maria Pascale et al.

CANCERS (2020)

Add to Collection

Review Oncology

Clinical Development of BRAF plus MEK Inhibitor Combinations

Vivek Subbiah et al.

TRENDS IN CANCER (2020)

Add to Collection

Review Oncology

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

Gerta Hoxhaj et al.

NATURE REVIEWS CANCER (2020)

Add to Collection

Review Cell Biology

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Frank Madeo et al.

CELL METABOLISM (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial metabolism is inhibited by the HIF1-MYC-PGC-1 axis in BRAF V600E thyroid cancer

Yanyan Gao et al.

FEBS JOURNAL (2019)

Add to Collection

Review Genetics & Heredity

The clinicopathologic impacts and prognostic significance of GLUT1 expression in patients with lung cancer: A meta-analysis

Bo Zhang et al.

GENE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

S100A4 alters metabolism and promotes invasion of lung cancer cells by up-regulating mitochondrial complex I protein NDUFS2

Lili Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Kirsten L. Bryant et al.

NATURE MEDICINE (2019)

Add to Collection

Review Oncology

Oncometabolites as biomarkers in thyroid cancer: a systematic review

Fatemeh Khatami et al.

CANCER MANAGEMENT AND RESEARCH (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression

Sajid Amin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Sunitinib in the Treatment of Thyroid Cancer

Silvia Martina Ferrari et al.

CURRENT MEDICINAL CHEMISTRY (2019)

Add to Collection

Article Pathology

Proteomic characterization of early lung response to breast cancer metastasis in mice

Anna Kurpinska et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Mast Cells, Angiogenesis and Lymphangiogenesis in Human Gastric Cancer

Giuseppe Sammarco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Endocrinology & Metabolism

Reprogramming of Energy Metabolism: Increased Expression and Roles of Pyruvate Carboxylase in Papillary Thyroid Cancer

Aurelie Strickaert et al.

THYROID (2019)

Add to Collection

Review Oncology

Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment

Deepshikha Mishra et al.

CANCERS (2019)

Add to Collection

Article Oncology

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial

Sarah R. Brown et al.

BMC CANCER (2019)

Add to Collection

Review Oncology

Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer

Miguel A. Zaballos et al.

ENDOCRINE-RELATED CANCER (2019)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

Rosa Angela Cardone et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Chemistry, Medicinal

Warburg effect and its role in tumourigenesis

Maphuti T. Lebelo et al.

ARCHIVES OF PHARMACAL RESEARCH (2019)

Add to Collection

Review Endocrinology & Metabolism

Targeted Therapy for Advanced Thyroid Cancer: Kinase Inhibitors and Beyond

Maria E. Cabanillas et al.

ENDOCRINE REVIEWS (2019)

Add to Collection

Article Oncology

Potentiated anti-tumor effects of BETi by MEKi in anaplastic thyroid cancer

Xuguang Zhu et al.

ENDOCRINE-RELATED CANCER (2019)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

18F-FDG PET/CT in pancreatic adenocarcinoma: A role at initial imaging staging?

M. Wartski et al.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2019)

Add to Collection

Review Oncology

Radioiodine-Refractory Thyroid Cancer: Molecular Basis of Redifferentiation Therapies, Management, and Novel Therapies

Mohamed Aashiq et al.

CANCERS (2019)

Add to Collection

Article Oncology

Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

S. Filetti et al.

ANNALS OF ONCOLOGY (2019)

Add to Collection

Article Physiology

The Acidic Tumor Microenvironment as a Driver of Cancer

Ebbe Boedtkjer et al.

Annual Review of Physiology (2019)

Add to Collection

Article Biochemistry & Molecular Biology

LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma

Xiao-ming Hou et al.

BIOSCIENCE REPORTS (2019)

Add to Collection

Review Oncology

Tumor pH and metastasis: a malignant process beyond hypoxia

Oliver Thews et al.

CANCER AND METASTASIS REVIEWS (2019)

Add to Collection

Article Oncology

Dysregulation of glutaminase and glutamine synthetase in cancer

Jose M. Mates et al.

CANCER LETTERS (2019)

Add to Collection

Review Biochemistry & Molecular Biology

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

Ayako Nagao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Endocrinology & Metabolism

European Perspective on 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: Proceedings of an Interactive International Symposium

Markus Luster et al.

THYROID (2019)

Add to Collection

Article Oncology

LDHA Promotes Oral Squamous Cell Carcinoma Progression Through Facilitating Glycolysis and Epithelial-Mesenchymal Transition

Hongshi Cai et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Novel Peptide Inhibitors for Lactate Dehydrogenase A (LDHA): A Survey to Inhibit LDHA Activity via Disruption of Protein-Protein Interaction

Farzaneh Jafary et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Cell Biology

AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-κB axis

Bin Zheng et al.

CELLULAR SIGNALLING (2018)

Add to Collection

Article Oncology

Genomic Correlates of Response to Everolimus in Aggressive Radioiodine-refractory Thyroid Cancer: A Phase II Study

Glenn J. Hanna et al.

CLINICAL CANCER RESEARCH (2018)

Add to Collection

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Iodine/FDG Flip-Flop Phenomenon Inside a Large Metastatic Thyroid Cancer Lesion Better Characterized on SPECT/CT and PET/CT Studies

Paulo Schiavom Duarte et al.

CLINICAL NUCLEAR MEDICINE (2018)

Add to Collection

Review Chemistry, Medicinal

Targeting Key Transporters in Tumor Glycolysis as a Novel Anticancer Strategy

Yunli Shi et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)

Add to Collection

Review Pharmacology & Pharmacy

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

Philippe Icard et al.

DRUG RESISTANCE UPDATES (2018)

Add to Collection

Article Clinical Neurology

PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

Binbin Wang et al.

JOURNAL OF HEADACHE AND PAIN (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

Ming-Chuan Hsu et al.

MOLECULAR CANCER (2018)

Add to Collection

Review Oncology

Lenvatinib in the Therapy of Aggressive Thyroid Cancer: State of the Art and New Perspectives with Patents Recently Applied

Silvia M. Ferrari et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress

Pedro Gonzalez-Menendez et al.

REDOX BIOLOGY (2018)

Add to Collection

Review Oncology

Metabolic Reprogramming in Thyroid Carcinoma

Raquel Guimaraes Coelho et al.

FRONTIERS IN ONCOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival

Gaurav Pathria et al.

EMBO JOURNAL (2018)

Add to Collection

Article Biochemistry & Molecular Biology

ASSOCIATION BETWEEN OXIDATIVE STRESS AND MELANOMA PROGRESSION

Jelena Pantic Bisevac et al.

JOURNAL OF MEDICAL BIOCHEMISTRY (2018)

Add to Collection

Review Medicine, General & Internal

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

Alessandro Stecco et al.

DIAGNOSTICS (2018)

Add to Collection

Article Oncology

Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway

Xueyan Zhang et al.

MOLECULAR MEDICINE REPORTS (2017)

Add to Collection

Review Cell Biology

Metabolic Interactions in the Tumor Microenvironment

Costas A. Lyssiotis et al.

TRENDS IN CELL BIOLOGY (2017)

Add to Collection

Article Oncology

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E

Lingxiao Cheng et al.

ONCOTARGET (2017)

Add to Collection

Review Oncology

Glucose transporter GLUT1 expression and clinical outcome in solid tumors: a systematic review and meta-analysis

Ji Wang et al.

ONCOTARGET (2017)

Add to Collection

Article Immunology

Group V Secreted Phosphapase A2 Induces the Release of Proanglogenic and Antianglogenic Factors by Human Neutrophils

Stefania Loffredo et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Article Oncology

Potential role of Metabolic intervention in the Management of Advanced Differentiated thyroid cancer

Sri Harsha Tella et al.

FRONTIERS IN ONCOLOGY (2017)

Add to Collection

Article Endocrinology & Metabolism

LONG-TERM OUTCOMES AND PROGNOSTIC FACTORS IN PATIENTS WITH DIFFERENTIATED THYROID CANCER AND DISTANT METASTASES

Dania Hirsch et al.

ENDOCRINE PRACTICE (2017)

Add to Collection

Article Immunology

Suppression of FIP200 and autophagy by tumor-derived lactate promotes naive T cell apoptosis and affects tumor immunity

Houjun Xia et al.

SCIENCE IMMUNOLOGY (2017)

Add to Collection

Article Oncology

The Glycogen Shunt Maintains Glycolytic Homeostasis and the Warburg Effect in Cancer

Robert G. Shulman et al.

TRENDS IN CANCER (2017)

Add to Collection

Review Cell Biology

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Rigel J. Kishton et al.

CELL METABOLISM (2017)

Add to Collection

Article Oncology

Targeted Therapy in Thyroid Cancer: State of the Art

L. Valerio et al.

CLINICAL ONCOLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Emerging Biological Principles of Metastasis

Arthur W. Lambert et al.

CELL (2017)

Add to Collection

Review Oncology

Regulation of PD-L1: a novel role of pro-survival signalling in cancer

J. Chen et al.

ANNALS OF ONCOLOGY (2016)

Add to Collection

Article Cell Biology

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

Almut Brand et al.

Cell Metabolism (2016)

Add to Collection

Review Biochemistry & Molecular Biology

PKM2, cancer metabolism, and the road ahead

Talya L. Dayton et al.

EMBO REPORTS (2016)

Add to Collection

Article Endocrinology & Metabolism

The role of FDG-PET in localization of recurrent lesions of differentiated thyroid cancer (DTC) in patients with asymptomatic hyperthyroglobulinemia in a real clinical practice

A. Kukulska et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2016)

Add to Collection

Article Oncology

PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma

Melanie Ruf et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Add to Collection

Article Oncology

Growth arrest by activated BRAF and MEK inhibition in human anaplastic thyroid cancer cells

Kento Kurata et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

Add to Collection

Article Medicine, Research & Experimental

Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine

James Nagarajah et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Add to Collection

Review Medicine, General & Internal

Thyroid cancer

Maria E. Cabanillas et al.

LANCET (2016)

Add to Collection

Review Biochemistry & Molecular Biology

The HK2 Dependent Warburg Effect and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

Pawel Lis et al.

MOLECULES (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau et al.

NATURE CHEMICAL BIOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Min Peng et al.

SCIENCE (2016)

Add to Collection

Article Endocrinology & Metabolism

2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer

Bryan R. Haugen et al.

THYROID (2016)

Add to Collection

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Add to Collection

Article Oncology

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

Asaf Spiegel et al.

CANCER DISCOVERY (2016)

Add to Collection

Review Oncology

Serine and one-carbon metabolism in cancer

Ming Yang et al.

NATURE REVIEWS CANCER (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Negative feedback of glycolysis and oxidative phosphorylation: Mechanisms of and reasons for it

S. S. Sokolov et al.

BIOCHEMISTRY-MOSCOW (2015)

Add to Collection

Article Oncology

Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

Paul Kachel et al.

BMC CANCER (2015)

Add to Collection

Article Oncology

Metabolic reprogramming supports the invasive phenotype in malignant melanoma

Ingrid J. Bettum et al.

CANCER LETTERS (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chih-Hao Chang et al.

CELL (2015)

Add to Collection

Article Oncology

FDA Approval Summary: Lenvatinib for Progressive, Radio-iodine-Refractory Differentiated Thyroid Cancer

Abhilasha Nair et al.

CLINICAL CANCER RESEARCH (2015)

Add to Collection

Article Oncology

Safety and tolerability of sorafenib in patients with radioiodine-refractory thyroid cancer

Francis Worden et al.

ENDOCRINE-RELATED CANCER (2015)

Add to Collection

Review Immunology

Metabolic Reprogramming of Immune Cells in Cancer Progression

Subhra K. Biswas

IMMUNITY (2015)

Add to Collection

Article Dermatology

Angiogenesis and lymphangiogenesis in inflammatory skin disorders

Gilda Varricchi et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

Add to Collection

Article Pathology

Lymph node and distant metastases of thyroid gland cancer. Metastases in the thyroid glands

K. W. Schmid

PATHOLOGE (2015)

Add to Collection

Review Oncology

Cabozantinib in Thyroid Cancer

Poupak Fallahi et al.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2015)

Add to Collection

Review Cell Biology

Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression

Xin Ye et al.

TRENDS IN CELL BIOLOGY (2015)

Add to Collection

Article

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

Weibo Luo et al.

Oncotarget (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer

Maya Gulubova et al.

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

Nishant Agrawal et al.

CELL (2014)

Add to Collection

Article Oncology

Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation

Rizwan Haq et al.

CLINICAL CANCER RESEARCH (2014)

Add to Collection

Article Oncology

Pharmacological suppression of the Ras/MAPK pathway in thyroid carcinoma cells can provoke opposite effects on cell migration and proliferation: The appearance of yin-yang effects and the need of combinatorial treatments

Alexander Glassmann et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Add to Collection

Review Medicine, Research & Experimental

Mechanisms of lymphatic metastasis

Sinem Karaman et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Add to Collection

Review Cell Biology

Molecular mechanisms of epithelial-mesenchymal transition

Samy Lamouille et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Add to Collection

Article Medical Laboratory Technology

Targeting RAS-MAPK-ERK and PI3K-AKT-mTOR signal transduction pathways to chemosensitize anaplastic thyroid carcinoma

Zorica Milosevic et al.

TRANSLATIONAL RESEARCH (2014)

Add to Collection

Review Oncology

Sorafenib and Thyroid Cancer

Poupak Fallahi et al.

BIODRUGS (2013)

Add to Collection

Review Oncology

Acidic extracellular microenvironment and cancer

Yasumasa Kato et al.

CANCER CELL INTERNATIONAL (2013)

Add to Collection

Article Oncology

Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer

Hanbyoul Cho et al.

CANCER INVESTIGATION (2013)

Add to Collection

Article Oncology

Effects of limiting energy availability via diet and physical activity on mammalian target of rapamycin-related signaling in rat mammary carcinomas

Weiqin Jiang et al.

CARCINOGENESIS (2013)

Add to Collection

Article Oncology

Vandetanib for the Treatment of Medullary Thyroid Cancer

Nicole G. Chau et al.

CLINICAL CANCER RESEARCH (2013)

Add to Collection

Article Endocrinology & Metabolism

Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer

Chen Feng et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Add to Collection

Article Endocrinology & Metabolism

Clinical Outcomes and Molecular Profile of Differentiated Thyroid Cancers With Radioiodine-Avid Distant Metastases

M. M. Sabra et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Add to Collection

Article Oncology

Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas

Cristina Montero-Conde et al.

CANCER DISCOVERY (2013)

Add to Collection

Article Pharmacology & Pharmacy

cGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from Acute Kidney Injury

Ryan M. Whitaker et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)

Add to Collection

Review Radiology, Nuclear Medicine & Medical Imaging

Cellular and molecular basis for thyroid cancer imaging in nuclear medicine

Massimo Bongiovanni et al.

CLINICAL AND TRANSLATIONAL IMAGING (2013)

Add to Collection

Review Endocrinology & Metabolism

Exercise tames the wild side of the Myc network: a hypothesis

Kishorchandra Gohil et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Glucose Transporter 1 Expression, Tumor Proliferation, and Iodine/Glucose Uptake in Thyroid Cancer With Emphasis on Poorly Differentiated Thyroid Carcinoma

Florian Grabellus et al.

CLINICAL NUCLEAR MEDICINE (2012)

Add to Collection

Review Oncology

Glucose transporters in cancer metabolism

Kehinde Adekola et al.

CURRENT OPINION IN ONCOLOGY (2012)

Add to Collection

Article Oncology

Glycolytic Inhibition Alters Anaplastic Thyroid Carcinoma Tumor Metabolism and Improves Response to Conventional Chemotherapy and Radiation

Vlad C. Sandulache et al.

MOLECULAR CANCER THERAPEUTICS (2012)

Add to Collection

Review Cell Biology

A two-way street: reciprocal regulation of metabolism and signalling

Kathryn E. Wellen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Add to Collection

Article Medicine, General & Internal

Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Add to Collection

Article Multidisciplinary Sciences

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

Eric T. Clambey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Article Multidisciplinary Sciences

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

Jiangbin Ye et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Review Cell Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Sophia Y. Lunt et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Add to Collection

Article Biotechnology & Applied Microbiology

Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer

J. Du et al.

CANCER GENE THERAPY (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Tumor Metastasis: Molecular Insights and Evolving Paradigms

Scott Valastyan et al.

CELL (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

Add to Collection

Review Pharmacology & Pharmacy

The mTOR protein as a target in thyroid cancer

Elaine Cristina Lima de Souza et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2011)

Add to Collection

Review Biotechnology & Applied Microbiology

Initial steps of metastasis: Cell invasion and endothelial transmigration

Franziska van Zijl et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2011)

Add to Collection

Review Endocrinology & Metabolism

Thyroid cancer stem cells

Reigh-Yi Lin

NATURE REVIEWS ENDOCRINOLOGY (2011)

Add to Collection

Article Multidisciplinary Sciences

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Qian Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Add to Collection

Article Oncology

Anaplastic Thyroid Carcinoma: Pathogenesis and Emerging Therapies

R. C. Smallridge et al.

CLINICAL ONCOLOGY (2010)

Add to Collection

Article Oncology

BRAF mutation-selective inhibition of thyroid cancer cells by the novel MEK inhibitor RDEA119 and genetic-potentiated synergism with the mTOR inhibitor temsirolimus

Dingxie Liu et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

Add to Collection

Article Oncology

Vandetanib for the Treatment of Patients With Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

Samuel A. Wells et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Add to Collection

Review Cell Biology

The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors

Motoyasu Saji et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2010)

Add to Collection

Article Endocrinology & Metabolism

Increased Expression of Vascular Endothelial Growth Factor and Its Receptors, VEGFR-1 and VEGFR-2, in Medullary Thyroid Carcinoma

Clarissa Capp et al.

THYROID (2010)

Add to Collection

Article Oncology

Genetic Alterations in the Phosphoinositide 3-Kinase/Akt Signaling Pathway Confer Sensitivity of Thyroid Cancer Cells to Therapeutic Targeting of Akt and Mammalian Target of Rapamycin

Dingxie Liu et al.

CANCER RESEARCH (2009)

Add to Collection

Review Biochemistry & Molecular Biology

Control of autophagy by oncogenes and tumor suppressor genes

M. C. Maiuri et al.

CELL DEATH AND DIFFERENTIATION (2009)

Add to Collection

Article Endocrinology & Metabolism

Dual Inhibition of Mitogen-Activated Protein Kinase Kinase and Mammalian Target of Rapamycin in Differentiated and Anaplastic Thyroid Cancer

Ning Jin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Add to Collection

Article Oncology

Phase II Study of Safety and Efficacy of Motesanib in Patients With Progressive or Symptomatic, Advanced or Metastatic Medullary Thyroid Cancer

Martin J. Schlumberger et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Add to Collection

Review Biochemistry & Molecular Biology

Role and regulation of prolyl hydroxylase domain proteins

G-H Fong et al.

CELL DEATH AND DIFFERENTIATION (2008)

Add to Collection

Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

Add to Collection

Article Endocrinology & Metabolism

Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers

Zhi Liu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

Add to Collection

Article Endocrinology & Metabolism

Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its Potentiation by suppression of the PI3K and NF-κB pathways

Dingxie Liu et al.

THYROID (2008)

Add to Collection

Article Oncology

Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer

Fumihiko Furuya et al.

CARCINOGENESIS (2007)

Add to Collection

Article Oncology

Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma

Hwei-Ming Wang et al.

ANNALS OF SURGICAL ONCOLOGY (2007)

Add to Collection

Article Oncology

Mutant V600E BRAF increases hypoxia inducible factor-1α expression in melanoma

Suresh M. Kumar et al.

CANCER RESEARCH (2007)

Add to Collection

Review Biochemistry & Molecular Biology

Energy metabolism in tumor cells

Rafael Moreno-Sanchez et al.

FEBS JOURNAL (2007)

Add to Collection

Article Endocrinology & Metabolism

An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases

Dong Wook Kim et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Add to Collection

Article Cell Biology

Lactate stimulates endothelial cell migration

Stefan Beckert et al.

WOUND REPAIR AND REGENERATION (2006)

Add to Collection

Article Hematology

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression

E Gottfried et al.

BLOOD (2006)

Add to Collection

Review Cell Biology

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer

ML Macheda et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2005)

Add to Collection

Review Oncology

Why do cancers have high aerobic glycolysis?

RA Gatenby et al.

NATURE REVIEWS CANCER (2004)

Add to Collection

Article Cell Biology

Advances in Na+/I- symporter (NIS) research in the thyroid and beyond

O Dohán et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)

Add to Collection

Article Endocrinology & Metabolism

MCT1 and its accessory protein CD147 are differentially regulated by TSH in rat thyroid cells

A Fanelli et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)

Add to Collection

Article Oncology

Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral spuamous cell carcinoma

M Kunkel et al.

CANCER (2003)

Add to Collection

Article Nutrition & Dietetics

Physical activity and cancer prevention: Etiologic evidence and biological mechanisms

CM Friedenreich et al.

JOURNAL OF NUTRITION (2002)

Add to Collection

Review Multidisciplinary Sciences

Stem cells, cancer, and cancer stem cells

T Reya et al.

NATURE (2001)

Add to Collection

Article Multidisciplinary Sciences

Cooperation and competition in the evolution of ATP-producing pathways

T Pfeiffer et al.

SCIENCE (2001)

Add to Collection

Article Biochemistry & Molecular Biology

Accelerated publication -: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

RC Osthus et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.