☆ 4.7 Review

Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

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Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis

Alexander M. Markin et al.

Summary: Mitochondrial dysfunction is associated with a wide range of chronic human disorders, leading to functional impairment and energy deficiency in cells. The processes of mitochondrial turnover, involving fission and fusion, are tightly regulated and crucial for cell function. Correction of mitochondrial dynamics may offer new therapeutic approaches for various chronic diseases.

LIFE-BASEL (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor

Rajendiran Keerthiga et al.

Summary: Mitochondria play a crucial role in tumor progression, with dysfunctional mitochondria contributing to proliferation of tumor cells in harsh environments. The activation of the UPRmt pathway through mitochondrial-nucleus retrograde signaling enhances carcinoma progression by reprogramming molecular metabolism.

CELL AND BIOSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase

Marco Fiorillo et al.

Summary: This study identifies high ATP production by the mitochondrial ATP-synthase as a new therapeutic target for anticancer therapy, particularly for inhibiting tumor progression. ATP-high cancer cells exhibit aggressive phenotypes with increased proliferation, stemness, anchorage-independence, cell migration, invasion, and multi-drug resistance, along with high antioxidant capacity. ATP depletion through targeting ATP5F1C may serve as a promising strategy for preventing metastasis and avoiding treatment failure, making ATP5F1C a potential biomarker and molecular target for future drug development to prevent metastatic disease progression.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Physiology

Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR-18a-5p-HIF-1α Axis

Shyam S. Nandi et al.

Summary: The study investigated the molecular mechanisms behind neurogenic hypertension-induced cardiac dysfunction, suggesting that enhanced sympatho-excitation suppresses miR-18a-5p/HIF-1 alpha signaling and leads to mitochondrial abnormalities, cardiac remodeling, and pathological cardiac hypertrophy commonly seen in neurogenic hypertension.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mitophagy in Human Diseases

Laura Doblado et al.

Summary: Mitophagy is a selective autophagic process that plays a crucial role in maintaining cellular homeostasis by eliminating dysfunctional mitochondria. Both defective and excessive mitophagy have been associated with various chronic diseases, suggesting that restoring mitophagy homeostasis could be a potential therapeutic approach.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

Targeting Mitochondrial Protein Expression as a Future Approach for Cancer Therapy

Daniela Criscuolo et al.

Summary: Extensive metabolic remodeling is a key feature of cancer cells, with mitochondria playing central roles in cancer development and progression. Coordinated regulation of mitochondrial and cytosolic mRNA translation is crucial for maintaining the integrity of the mitochondrial proteome and functions in cancer cells.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy

Marco Fiorillo et al.

Summary: The study suggests that high mitochondrial ATP production is a new therapeutic target for cancer treatment, isolating metabolically fit cancer cells with enhanced stem-like properties and invasive abilities. By regulating mitochondrial ATP-synthase, prevention of metastasis in cancer cells is possible.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia

Shilpi Chaudhary et al.

Summary: The study found that increased mtDNA copy number in pediatric AML patients was associated with disease aggressiveness and decreased survival rates, possibly due to the action of PGC1A enhancing mtDNA copy number. At the cellular level, PGC1A inhibition decreased mtDNA copy number, while MYC inhibition had no significant effect.

MITOCHONDRION (2021)

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Review Oncology

Common Pathophysiology in Cancer, Atrial Fibrillation, Atherosclerosis, and Thrombosis JACC: CardioOncology State-of-the-Art Review

Orly Leiva et al.

Summary: Cardiovascular disease and cancer share common mechanisms, including atrial fibrillation and atherosclerosis. Advances in cancer therapies and screening have led to improved survival rates and outcomes for cancer patients.

JACC: CARDIOONCOLOGY (2021)

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Article Multidisciplinary Sciences

Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy

Yung Ting Hsiao et al.

Summary: Prognosis of severe heart failure remains poor and urgent new therapies are required. Some heart failure patients, classified as non-responders, show significantly reduced levels of the mitochondrial fusion protein Mfn1. This study reveals that Mfn1 may serve as a biomarker for heart failure in non-responders, with potential therapeutic targeting of mitochondrial dynamics to improve outcomes.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria

Ruben Quintana-Cabrera et al.

Summary: The study shows that the mitochondrial fusion and cristae shape protein Opa1 requires mitochondrial ATP synthase oligomers to reduce ROS accumulation. In some cells fueled with galactose to force ATP production by mitochondria, cristae are enlarged, ATP synthase oligomers destabilized, and ROS accumulate.

REDOX BIOLOGY (2021)

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Article Medicine, General & Internal

Epigenetic Regulation of Mitochondrial Quality Control Genes in Multiple Myeloma: A Sequenom MassARRAY Pilot Investigation on HMCLs

Patrizia D'Aquila et al.

Summary: The dysregulated expression of mitochondrial quality control genes and altered CpG methylation profile in plasma cell dyscrasias suggest potential new myeloma biomarkers that warrant further functional investigation in the future.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Oncology

5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent

Soudeh Ghafouri-Fard et al.

Summary: Non-coding RNAs play a central role in determining the response of patients to 5-FU by modulating cancer-related pathways and cell behavior; Modulating the expression levels of microRNAs or long non-coding RNAs may sensitize tumor cells to 5-FU treatment; There is increasing interest in targeting these transcripts in various cancers treated with 5-FU.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure

Lei Chen et al.

Summary: Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane, playing a crucial role in mitochondrial network regulation and participating in various biological processes. Dysfunction of Mfn2 has been associated with cardiovascular diseases, such as heart failure and dilated cardiomyopathy.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biophysics

Mitophagy mechanisms in neuronal physiology and pathology during ageing

Maria Markaki et al.

Summary: Ageing in diverse species is associated with decreased neuronal function and increased susceptibility to neurodegeneration, partly due to declining mitochondrial integrity and function. The coordination of mitochondrial biogenesis with mitophagy is crucial for maintaining cellular energy homeostasis, contributing to the maintenance of neuronal homeostasis and health. Impaired mitophagy has been implicated in age-related decline of nervous system function and the pathogenesis of neurodegenerative diseases.

BIOPHYSICAL REVIEWS (2021)

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Review Medicine, Research & Experimental

Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

Pushkar Singh Rawat et al.

Summary: Doxorubicin, a commonly used anti-cancer drug, exerts its activity through DNA intercalation and inhibition of topoisomerase II enzyme. However, its use is limited by its dose-dependent cardiotoxicity, which is believed to involve oxidative stress, apoptosis, and various other mechanisms. Pharmacological strategies have been explored to mitigate Doxorubicin-induced cardiotoxicity.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Oncology

Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics

Yanjie Guan et al.

Summary: Mitophagy is a crucial process that clears damaged mitochondria to maintain homeostasis, and is involved in various physiological processes. Research has shown its role in carcinogenesis and drug resistance, offering a new frontier for anticancer therapeutics.

CANCER CELL INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development

Sergi Casellas-Diaz et al.

Summary: Research has shown that Mfn2 stimulation of mitochondrial metabolism requires localization in the endoplasmic reticulum (ER) rather than its fusion function. Interaction between ER-located Mfn2 and mitochondrial Mfn1/2 facilitates Ca2+ transfer from ER to mitochondria to enhance mitochondrial bioenergetics. Increased ER-mitochondria contact during neurite outgrowth is essential for proper neuronal arbor growth, and manipulating these contacts could be a potential treatment for pathologic conditions involving Mfn2.

EMBO REPORTS (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis

Mary Adebayo et al.

Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.

FASEB JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?

Sharon Negri et al.

Summary: The intracellular Ca2+ concentration plays a significant role in endothelial cell functions, and both moderate and excessive amounts of ROS can regulate endothelial functions and lead to disorders.ROS-induced endothelial Ca2+ signals are crucial for vascular functions, but aberrant ROS generation can result in endothelial dysfunction and various diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

A new Mfn-2 related synthetic peptide promotes vascular smooth muscle cell apoptosis via regulating the mitochondrial apoptotic pathway by inhibiting Akt signaling

Xinxin Zhang et al.

Summary: In summary, the study demonstrated that MRSP treatment induces a strong proapoptotic effect by activating the mitochondrial apoptotic cascade through suppression of the PI3K/Akt pathway. This led to significantly increased VSMC apoptosis, inhibition of neointimal hyperplasia and VSMC accumulation.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect

Marisa W. Friederich et al.

Summary: Cardiac dysfunction is a common phenotypic manifestation of primary mitochondrial disease caused by various pathogenic variants, including those affecting mitochondrial translation. Mutations in the MRPL44 gene have been linked to hypertrophic cardiomyopathy in infants and myopathy with neurological symptoms in adolescents. Compound heterozygous variants in MRPL44 were identified through exome sequencing, leading to a deficiency in respiratory chain enzymes affecting heart muscle tissue more than skeletal muscle. The impairment of mitochondrial protein synthesis due to different pathogenic variants correlates with the dysfunction of oxidative phosphorylation, providing insights into the pathogenesis of MRPL44-associated mitochondrial disorder.

MOLECULAR GENETICS AND METABOLISM (2021)

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Article Pathology

Atovaquone at clinically relevant concentration overcomes chemoresistance in ovarian cancer via inhibiting mitochondrial respiration

Yue Guo et al.

Summary: Atovaquone, an antimicrobial drug, has shown potential in inhibiting ovarian cancer cells by disrupting mitochondrial function. It can effectively suppress the growth of ovarian cancer cells and induce apoptosis, while showing minimal effects on normal cells. Studies suggest that Atovaquone could be a promising candidate for the treatment of ovarian cancer, especially in combination with cisplatin.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Review Pharmacology & Pharmacy

Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development

Vincenzo Lionetti et al.

Summary: Research indicates that during the COVID-19 pandemic, HBA dysfunction in critically ill patients plays a crucial role and may exacerbate the development of MODS, potentially affecting the prognosis of COVID-19 patients.

PHARMACOLOGICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

SUMOylation modification-mediated cell death

Zenghua Sheng et al.

Summary: There is a close relationship between SUMOylation modification and cellular death processes, which can regulate cell death patterns according to specific conditions and is of great significance for the development of new disease treatment strategies.

OPEN BIOLOGY (2021)

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Article Biology

Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

Mieradilijiang Abudupataer et al.

Summary: Bicuspid aortic valve (BAV) is a common congenital cardiovascular disease associated with thoracic aortic aneurysm (TAA). Insufficiency of NOTCH1 expression is related to BAV-TAA, with impaired mitochondrial dynamics observed. Knockdown of NOTCH1 in HAoSMCs resulted in reduced contractile phenotype and attenuated mitochondrial fusion, which could be partially rescued by mitochondrial fusion activators or fission inhibitor. This study suggests impaired mitochondrial dynamics as a potential therapeutic target for BAV-TAA.

ELIFE (2021)

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Article Pharmacology & Pharmacy

Cardiovascular Toxicity Induced by Chronic Vincristine Treatment

Esperanza Herradon et al.

Summary: Chronic treatment with vincristine causes alterations in vascular function, including endothelial dysfunction in the aorta and decreased contractile function in mesenteric arteries, but these changes disappear after treatment cessation. Vincristine treatment leads to significant changes in the expression of proteins like eNOS, TNF alpha, and connexin 43 in cardiovascular tissues, indicating direct toxicity during treatment.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury

Yue Wang et al.

Summary: Mitophagy and UPRmt, although slightly activated by myocardial stress, work together to maintain mitochondrial performance and protect against inflammation-related myocardial injury. Mitophagy modulation of UPRmt could be a potential therapeutic strategy for myocardial stress.

REDOX BIOLOGY (2021)

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Review Oncology

Defueling the cancer: ATP synthase as an emerging target in cancer therapy

Ting Wang et al.

Summary: Reprogramming of cellular metabolism is a hallmark of cancer, with high expression of ATP synthase playing a role. ATP synthase is involved in angiogenesis, tumorigenesis, and metastasis of cancer.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Review Cell Biology

Mitochondrial Ca2+ Signaling in Health, Disease and Therapy

Lorenzo Modesti et al.

Summary: This study summarizes the dual role of intracellular calcium ions at the mitochondrial level and the impact of mCa(2+) signaling dysregulation on pathological conditions such as cancer, neurological defects, and cardiovascular diseases.

CELLS (2021)

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Article Chemistry, Medicinal

Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis

Nehal Gupta et al.

Summary: Atovaquone shows anti-metastatic effects on triple-negative breast cancer by inducing apoptosis and reducing the expression of genes related to metastatic potential. In vivo experiments demonstrate that atovaquone significantly suppresses the growth of metastatic tumors in the lungs, liver, and brain, suggesting its potential as a treatment for breast cancer metastasis.

PHARMACEUTICALS (2021)

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Review Oncology

Roles of mitochondria in the hallmarks of metastasis

Adam D. Scheid et al.

Summary: Mitochondria play crucial roles in cancer and metastasis, particularly in aspects such as motility, invasion, microenvironment modulation, plasticity, and colonisation. While nuclear genetics has traditionally been the focus in cancer biology, the importance of mitochondria and mtDNA is gaining recognition. The complex dynamics of mitochondrial contributions to cancer can either promote or prevent metastasis, depending on the context.

BRITISH JOURNAL OF CANCER (2021)

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Review Biochemistry & Molecular Biology

The Mitochondrion as an Emerging Therapeutic Target in Cancer

Katherine G. Roth et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Review Toxicology

A review on the cardioprotective mechanisms of metformin against doxorubicin

A. H. Ajzashokouhi et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2020)

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Review Biochemistry & Molecular Biology

Ubiquitin and Receptor-Dependent Mitophagy Pathways and Their Implication in Neurodegeneration

Lauren E. Fritsch et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

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Review Cell Biology

Metformin: current clinical applications in nondiabetic patients with cancer

Kailin Chen et al.

AGING-US (2020)

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Article Biochemistry & Molecular Biology

Cardiac Damage in Anthracyclines Therapy: Focus on Oxidative Stress and Inflammation

Carmine Rocca et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Cardiac & Cardiovascular Systems

Early morphological changes in cardiac mitochondria after subcutaneous administration of trastuzumab in rabbits: possible prevention with oral selenium supplementation

Heather S. Laird-Fick et al.

CARDIOVASCULAR PATHOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction

Hu Qingxun et al.

CIRCULATION RESEARCH (2020)

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Article Cell Biology

Notch1 protects against myocardial ischaemia-reperfusion injury via regulating mitochondrial fusion and function

Shao-hua Dai et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Yasmine J. Liu et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

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Article Cell Biology

OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling

Sehwan Jang et al.

MITOCHONDRION (2020)

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Article Multidisciplinary Sciences

Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

Xiaoyan Guo et al.

NATURE (2020)

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Review Biochemistry & Molecular Biology

The Mitochondrial Lon Protease: Novel Functions off the Beaten Track?

Wolfgang Voos et al.

BIOMOLECULES (2020)

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Article Genetics & Heredity

Associations of mitochondrial DNA 3777-4679 region mutations with maternally inherited essential hypertensive subjects in China

Ye Zhu et al.

BMC MEDICAL GENETICS (2020)

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Review Oncology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sue Han et al.

BRITISH JOURNAL OF CANCER (2020)

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Review Cardiac & Cardiovascular Systems

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy

Kendall B. Wallace et al.

CIRCULATION RESEARCH (2020)

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Review Pharmacology & Pharmacy

Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury

Jin Wang et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Review Medicine, General & Internal

Mitophagy in Cardiovascular Diseases

Giampaolo Morciano et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia

Joerg Herrmann

NATURE REVIEWS CARDIOLOGY (2020)

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Review Oncology

Oxidative Stress in Cancer

John D. Hayes et al.

CANCER CELL (2020)

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Review Biochemistry & Molecular Biology

SUMOylation-Mediated Response to Mitochondrial Stress

Jianli He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Cell Biology

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

Kaili Ma et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Adiponectin agonist ADP355 ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and oxidative stress

Dan Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Oncology

Modern Radiotherapy and Risk of Cardiotoxicity

Efstratios Koutroumpakis et al.

CHEMOTHERAPY (2020)

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Article Cardiac & Cardiovascular Systems

Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue

Yanming Li et al.

CIRCULATION (2020)

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Article Medicine, Research & Experimental

SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation

Yu Xiang et al.

LIFE SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications

Qinyao Wei et al.

ONCOGENE (2020)

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Article Toxicology

Trastuzumab-induced cardiotoxicity and role of mitochondrial connexin43 in the adaptive response

Michela Pecoraro et al.

TOXICOLOGY IN VITRO (2020)

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Review Geriatrics & Gerontology

The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging

Francisco Munoz-Carvajal et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Biology

Bedaquiline inhibits the yeast and human mitochondrial ATP synthases

Min Luo et al.

COMMUNICATIONS BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Ubiquitination of Intramitochondrial Proteins: Implications for Metabolic Adaptability

Prasad Sulkshane et al.

BIOMOLECULES (2020)

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Article Cell Biology

The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

James T. T. Coates et al.

CELL DEATH DISCOVERY (2020)

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Article Endocrinology & Metabolism

KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth

Susanna Raho et al.

NATURE METABOLISM (2020)

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Review Medicine, General & Internal

Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart

Tomo Svagusa et al.

CROATIAN MEDICAL JOURNAL (2020)

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Review Geriatrics & Gerontology

Role of Mitophagy in Cardiovascular Disease

Yibo Yang et al.

AGING AND DISEASE (2020)

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Article Cardiac & Cardiovascular Systems

Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction

Rachel A. Schlaak et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

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Review Endocrinology & Metabolism

Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Johannes Gollmer et al.

DIABETES & METABOLISM JOURNAL (2020)

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Review Cell Biology

Gene therapy for the mitochondrial genome: Purging mutations, pacifying ailments

M. Aravintha Siva et al.

MITOCHONDRION (2019)

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Article Cardiac & Cardiovascular Systems

Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway

Man Xu et al.

CARDIOVASCULAR RESEARCH (2019)

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Review Cardiac & Cardiovascular Systems

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

Massimo Bonora et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Review Cardiac & Cardiovascular Systems

T cell checkpoint regulators in the heart

Nir Grabie et al.

CARDIOVASCULAR RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

Francesca Nazio et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Cardiac & Cardiovascular Systems

Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction

Anupam A. Kumar et al.

CIRCULATION (2019)

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Article Medicine, Research & Experimental

Balancing mitochondrial dynamics via increasing mitochondrial fusion attenuates infarct size and left ventricular dysfunction in rats with cardiac ischemia/reperfusion injury

Chayodom Maneechote et al.

CLINICAL SCIENCE (2019)

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Review Medicine, Research & Experimental

Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision

Ashif Iqubal et al.

LIFE SCIENCES (2019)

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Review Pharmacology & Pharmacy

GRKs and β-Arrestins: Gatekeepers of Mitochondrial Function in the Failing Heart

Daniela Sorriento et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Oncology

Energetic Cancer Stem Cells (e-CSCs): A New Hyper-Metabolic and Proliferative Tumor Cell Phenotype, Driven by Mitochondrial Energy

Marco Fiorillo et al.

FRONTIERS IN ONCOLOGY (2019)

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Review Biochemistry & Molecular Biology

Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury

Mingjie Yang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Article Cardiac & Cardiovascular Systems

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy

Bereketeab Haileselassie et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

Ioannis Smyrnias et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Review Cell Biology

Mitophagy in Cancer: A Tale of Adaptation

Monica Vara-Perez et al.

CELLS (2019)

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Review Biochemistry & Molecular Biology

Progress in the emerging role of selenoproteins in cardiovascular disease: focus on endoplasmic reticulum-resident selenoproteins

Carmine Rocca et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Review Cardiac & Cardiovascular Systems

Cancer and heart disease: associations and relations

Rudolf A. de Boer et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

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Article Biochemistry & Molecular Biology

4′-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming

Jasmine George et al.

MOLECULAR CARCINOGENESIS (2019)

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Article Cardiac & Cardiovascular Systems

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

Yves T. Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

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Article Medicine, General & Internal

Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases

Helen Strongman et al.

LANCET (2019)

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Article Physiology

Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes

Lea K. Seidlmayer et al.

FRONTIERS IN PHYSIOLOGY (2019)

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Article Medicine, General & Internal

Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer

Jae Ho Seo et al.

EBIOMEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

A population-based study of cardiovascular diseasemortality risk in US cancer patients

Kathleen M. Sturgeon et al.

EUROPEAN HEART JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors

Maxim Shevtsov et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Mitochondrial dysfunction and oxidative stress in heart disease

Jessica N. Peoples et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

Sundararajan Venkatesh et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

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Article Oncology

Doxorubicin-induced cardiotoxicity involves IFNγ-mediated metabolic reprogramming in cardiomyocytes

Chen Ni et al.

JOURNAL OF PATHOLOGY (2019)

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Article Oncology

The roles of sirtuins family in cell metabolism during tumor development

Shunqin Zhu et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Article Cell Biology

Signaling and Regulation of the Mitochondrial Unfolded Protein Response

Nandhitha Uma Naresh et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

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Article Oncology

Cancer Therapy-Related Cardiac Dysfunction of Nonanthracycline Chemotherapeutics What Is the Evidence?

Janine A. M. Kamphuis et al.

JACC: CARDIOONCOLOGY (2019)

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Review Oncology

Immune checkpoint inhibitor-related myocarditis

Kazuko Tajiri et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2018)

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Review Biochemistry & Molecular Biology

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

Kumsal Tekirdag et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

Ernestina M. de Francesco et al.

BIOCHEMICAL JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Mitochondrial Cx43, an important component of cardiac preconditioning

Antonio Rodriguez-Sinovas et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)

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Review Biology

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

Shiori Sekine et al.

BMC BIOLOGY (2018)

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Article Oncology

The risk of cardiovascular disease following breast cancer by Framingham risk score

Sofie A. M. Gernaat et al.

BREAST CANCER RESEARCH AND TREATMENT (2018)

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Article Cardiac & Cardiovascular Systems

Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide

Hani N. Sabbah et al.

CARDIOVASCULAR DRUGS AND THERAPY (2018)

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Article Biochemistry & Molecular Biology

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer

Harvey R. Fernandez et al.

CELL DEATH AND DIFFERENTIATION (2018)

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UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

Andrew Melber et al.

CELL RESEARCH (2018)

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Article Cardiac & Cardiovascular Systems

Left Ventricular Mass Change After Anthracycline Chemotherapy

Jennifer H. Jordan et al.

CIRCULATION-HEART FAILURE (2018)

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The unfolded protein response as a target for anticancer therapeutics

Mengxiong Wang et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2018)

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Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Sarah Pickles et al.

CURRENT BIOLOGY (2018)

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The multifaceted contributions of mitochondria to cellular metabolism

Jessica B. Spinelli et al.

NATURE CELL BIOLOGY (2018)

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Article Pharmacology & Pharmacy

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes

Teresa Cunha-Oliveira et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

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Article Toxicology

Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway

Jian Yin et al.

TOXICOLOGY IN VITRO (2018)

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Calcium Dynamics as a Machine for Decoding Signals

Carlotta Giorgi et al.

TRENDS IN CELL BIOLOGY (2018)

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Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

Yi-Tong Lu et al.

CELL DEATH & DISEASE (2018)

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Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

Grace R. Anderson et al.

NATURE COMMUNICATIONS (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Radiotherapy Utilization and Fractionation Patterns During the First Course of Cancer Treatment in the United States From 2004 to 2014

Trevor J. Royce et al.

JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY (2018)

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Review Physiology

Redox Aspects of Chaperones in Cardiac Function

Claudia Penna et al.

FRONTIERS IN PHYSIOLOGY (2018)

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DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways

Qinhua Jin et al.

REDOX BIOLOGY (2018)

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The different axes of the mammalian mitochondrial unfolded protein response

Christian Muench

BMC BIOLOGY (2018)

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A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX

Federica Sotgia et al.

CELL CYCLE (2018)

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Role of NLRP-3 Inflammasome in Hypertension: A Potential Therapeutic Target

Teresa Pasqua et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2018)

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Metformin as an Anticancer Agent

Ales Vancura et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

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Mitochondrial DNA 7908-8816 region mutations in maternally inherited essential hypertensive subjects in China

Ye Zhu et al.

BMC MEDICAL GENOMICS (2018)

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Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

Teresa Arnandis et al.

DEVELOPMENTAL CELL (2018)

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Article Biochemistry & Molecular Biology

Experimental diabetes mellitus exacerbates ischemia/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt/Drp1 interaction

Aibin Tao et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

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Letter Cardiac & Cardiovascular Systems

Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass

Brent A. McLean et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Oncology

Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study

Cristian Scatena et al.

FRONTIERS IN ONCOLOGY (2018)

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Cancer stem cells as key drivers of tumour progression

Ain Zubaidah Ayob et al.

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Mitochondrial metabolism and cancer

Paolo Ettore Porporato et al.

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GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion

Antonietta Franco et al.

CELL DEATH DISCOVERY (2018)

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Cardiotoxicity of Anticancer Therapeutics

Jerry Dong et al.

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Mitochondrial Membrane Dynamics-Functional Positioning of OPA1

Hakjoo Lee et al.

ANTIOXIDANTS (2018)

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The role of mitochondrial dysfunction in cardiovascular disease: a brief review

Dimitry A. Chistiakov et al.

ANNALS OF MEDICINE (2018)

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Trastuzumab cardiotoxicity: from clinical trials to experimental studies

Balazs T. Nemeth et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Cancer metabolism: a therapeutic perspective

Ubaldo E. Martinez-Outschoorn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

Hakjoo Lee et al.

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Cardioprotective Effects of Carvedilol in Inhibiting Doxorubicin-induced Cardiotoxicity

Maryam Nabati et al.

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Protective Role of GPER Agonist G-1 on Cardiotoxicity Induced by Doxorubicin

Ernestina M. De Francesco et al.

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Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101-Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity

Edith Pituskin et al.

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Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells

Hee Kyoung Joo et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2017)

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Cancer stem cells revisited

Eduard Batlle et al.

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Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan

Shigeaki Suzuki et al.

NEUROLOGY (2017)

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Targeting the unfolded protein response in cancer

Rani Ojha et al.

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Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart

Xin Liu et al.

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Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

Lindsay Wilde et al.

SEMINARS IN ONCOLOGY (2017)

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The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy

Yaojie Fu et al.

ONCOTARGET (2017)

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SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

Chun Guo et al.

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Control of mitochondrial biogenesis and function by the ubiquitin - proteasome system

Piotr Bragoszewski et al.

OPEN BIOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening

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Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

Marco Corazzari et al.

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Targeting flavin-containing enzymes eliminates cancer stem cells (CSCs), by inhibiting mitochondrial respiration: Vitamin B2 (Riboflavin) in cancer therapy

Bela Ozsvari et al.

AGING-US (2017)

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Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention

Farzad Masoudkabir et al.

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Mitochondrial metabolism and energy sensing in tumor progression

Luisa Iommarini et al.

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Dysregulation of mitophagy in carcinogenesis and tumor progression

Joon Young Chang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2017)

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Autophagy and Mitophagy in Cardiovascular Disease

Jose Manuel Bravo-San Pedro et al.

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Mitochondrial DNA mutations and cardiovascular disease

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CURRENT OPINION IN CARDIOLOGY (2017)

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The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species

Evan A. Bordt et al.

DEVELOPMENTAL CELL (2017)

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Anthracycline Chemotherapy and Cardiotoxicity

John V. McGowan et al.

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Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes

Kah Yong Goh et al.

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Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

Marco Fiorillo et al.

AGING-US (2016)

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IDH mutations in cancer and progress toward development of targeted therapeutics

L. Dang et al.

ANNALS OF ONCOLOGY (2016)

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PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β

Xuefei Zhang et al.

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Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

Ming Chen et al.

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Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

Ruxanda Moschoi et al.

BLOOD (2016)

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Hallmarks of cancer stem cell metabolism

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Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure

Akihiro Shirakabe et al.

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Mitochondrial Function, Biology, and Role in Disease A Scientific Statement From the American Heart Association

Elizabeth Murphy et al.

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The integrated stress response

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Pathophysiology of cardiotoxicity induced by nonanthracycline chemotherapy

Clelia Madeddu et al.

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New protein-protein interactions of mitochondrial connexin 43 in mouse heart

Amanda Denuc et al.

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Mitochondrial dynamics, mitophagy and cardiovascular disease

Cesar Vasquez-Trincado et al.

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The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications

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CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis

Ting Zhang et al.

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Regulated necrosis: disease relevance and therapeutic opportunities

Marcus Conrad et al.

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Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice

Vikrant Vijay et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

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The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

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Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

A. R. Hall et al.

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Repurposing atovaquone: Targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

Marco Fiorillo et al.

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Repurposing metformin for cancer treatment: current clinical studies

Young Kwang Chae et al.

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Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy

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Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model

Sophie Le Page et al.

PLOS ONE (2016)

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Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction

Ke Wang et al.

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Cancer stem cell metabolism

Maria Peiris-Pages et al.

BREAST CANCER RESEARCH (2016)

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Cardiotoxicity associated with targeted cancer therapies (Review)

Zi Chen et al.

MOLECULAR AND CLINICAL ONCOLOGY (2016)

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MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

Patricia Sancho et al.

CELL METABOLISM (2015)

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Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

An S. Tan et al.

CELL METABOLISM (2015)

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Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts

Moshi Song et al.

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The metabolic state of cancer stem cells-a valid target for cancer therapy?

Erina Vlashi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

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Mitochondrial biogenesis and dynamics in the developing and diseased heart

Gerald W. Dorn et al.

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The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications

Thomas M. Durcan et al.

GENES & DEVELOPMENT (2015)

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Mitochondria Retrograde Signaling and the UPRmt: Where Are We in Mammals?

Thierry Arnould et al.

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Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy

Hsiuchen Chen et al.

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SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy

Eun Young Kim et al.

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MicroRNA regulation of unfolded protein response transcription factor XBP1 in the progression of cardiac hypertrophy and heart failure in vivo

Quanlu Duan et al.

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Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis

Aswin Pyakurel et al.

MOLECULAR CELL (2015)

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Targeting mitochondria metabolism for cancer therapy

Samuel E. Weinberg et al.

NATURE CHEMICAL BIOLOGY (2015)

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Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling

Riccardo Filadi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Regulation of of Coronary Blood Flow in Health and Ischemic Heart Disease

Dirk J. Duncker et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2015)

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Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

Timothy Wai et al.

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Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L

Chengli Song et al.

ONCOTARGET (2015)

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Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

Rebecca Lamb et al.

ONCOTARGET (2015)

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Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

Rebecca Lamb et al.

ONCOTARGET (2015)

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Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

Rebecca Lamb et al.

ONCOTARGET (2015)

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RADIOTHERAPY Gazing at the crystal ball of European radiotherapy

Jens Overgaard

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

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A Metabolomic Study of Rats with Doxorubicin-Induced Cardiomyopathy and Shengmai Injection Treatment

Yu Chen et al.

PLOS ONE (2015)

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A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine

Mohammad Reza Eskandari et al.

XENOBIOTICA (2015)

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Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Yoshiyuki Ikeda et al.

CIRCULATION RESEARCH (2015)

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Mitophagy and cancer

Aparajita H. Chourasia et al.

CANCER & METABOLISM (2015)

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An Overview of Autophagy: Morphology, Mechanism, and Regulation

Katherine R. Parzych et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death

Ivan Zaja et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Article Cardiac & Cardiovascular Systems

Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion

Christelle Kamga Pride et al.

CARDIOVASCULAR RESEARCH (2014)

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Article Cardiac & Cardiovascular Systems

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

Luciana Grazziotin Rossato et al.

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Article Cardiac & Cardiovascular Systems

Inhibition of Gene Expression of Carnitine Palmitoyltransferase I and Heart Fatty Acid Binding Protein in Cyclophosphamide and Ifosfamide-Induced Acute Cardiotoxic Rat Models

Mohamed M. Sayed-Ahmed et al.

CARDIOVASCULAR TOXICOLOGY (2014)

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Receptor-mediated mitophagy in yeast and mammalian systems

Lei Liu et al.

CELL RESEARCH (2014)

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Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

Yusuke Kageyama et al.

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Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia- reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

Willard W. Sharp et al.

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Sirtuin inhibitors as anticancer agents

Jing Hu et al.

FUTURE MEDICINAL CHEMISTRY (2014)

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Vitamin E-based micelles enhance the anticancer activity of doxorubicin

Fabienne Danhier et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Virginija Jovaisaite et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2014)

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SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

Sadhana A. Samant et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

SirT3 Regulates the Mitochondrial Unfolded Protein Response

Luena Papa et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Anila K. Madiraju et al.

NATURE (2014)

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Intracellular autofluorescence: a biomarker for epithelial cancer stem cells

Irene Miranda-Lorenzo et al.

NATURE METHODS (2014)

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MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

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Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

Xian Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation

Angelo Vozza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Pharmacology & Pharmacy

Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts

Kendra K. S. Nordgren et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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Article Clinical Neurology

IDH Mutation in Glioma: New Insights and Promises for the Future

Zorbey Turkalp et al.

JAMA NEUROLOGY (2014)

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Defects in mitochondrial metabolism and cancer

Edoardo Gaude et al.

CANCER & METABOLISM (2014)

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Cardiovascular toxicity associated with adjuvant trastuzumab therapy: prevalence, patient characteristics, and risk factors

Adedayo A. Onitilo et al.

THERAPEUTIC ADVANCES IN DRUG SAFETY (2014)

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Changes of mitochondria in atherosclerosis: Possible determinant in the pathogenesis of the disease

Igor A. Sobenin et al.

ATHEROSCLEROSIS (2013)

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Autophagy Regulation and role in development

Amber N. Hale et al.

AUTOPHAGY (2013)

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Mitochondrial dysfunction in breast cancer cells prevents tumor growth Understanding chemoprevention with metformin

Rosa Sanchez-Alvarez et al.

CELL CYCLE (2013)

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The pathways of mitophagy for quality control and clearance of mitochondria

G. Ashrafi et al.

CELL DEATH AND DIFFERENTIATION (2013)

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Kαλos και Aγαθoζ kyoteas: how mitochondrial beauty translates into biological virtue

Gyorgy Szabadkai et al.

CURRENT OPINION IN CELL BIOLOGY (2013)

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OXPHOS mutations and neurodegeneration

Werner J. H. Koopman et al.

EMBO JOURNAL (2013)

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The mitochondrial transporter family SLC25: Identification, properties and physiopathology

Ferdinando Palmieri

MOLECULAR ASPECTS OF MEDICINE (2013)

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CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

Brian F. Teske et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

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Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

Oliver C. Loson et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

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Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia

Stephan A. Grupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Mitochondrial dynamics regulates migration and invasion of breast cancer cells

J. Zhao et al.

ONCOGENE (2013)

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The Price of Tumor Control: An Analysis of Rare Side Effects of Anti-CTLA-4 Therapy in Metastatic Melanoma from the Ipilimumab Network

Caroline J. Voskens et al.

PLOS ONE (2013)

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Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation

Shabana Din et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Oncology

Ionising radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40 weeks after local heart exposure

Zarko Barjaktarovic et al.

RADIOTHERAPY AND ONCOLOGY (2013)

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PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

Yun Chen et al.

SCIENCE (2013)

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Mitochondrial dysfunction in cancer

Michelle L. Boland et al.

FRONTIERS IN ONCOLOGY (2013)

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Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

Stephanos Pavlides et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

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Sirtuin activators and inhibitors

Jose M. Villalba et al.

BIOFACTORS (2012)

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Mitophagy: mechanisms, pathophysiological roles, and analysis

Wen-Xing Ding et al.

BIOLOGICAL CHEMISTRY (2012)

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Review Cardiac & Cardiovascular Systems

5-fluorouracil induced cardiotoxicity: Review of the literature

Michael F. Sorrentino et al.

CARDIOLOGY JOURNAL (2012)

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Article Cell Biology

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

Adam Ertel et al.

CELL CYCLE (2012)

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Article Cardiac & Cardiovascular Systems

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca2+ Crosstalk

Yun Chen et al.

CIRCULATION RESEARCH (2012)

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IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

Hui Yang et al.

CLINICAL CANCER RESEARCH (2012)

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Article Biochemistry & Molecular Biology

Cancer stem cells

Zuoren Yu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes

Ting Zhao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Multidisciplinary Sciences

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

Celine Douarre et al.

PLOS ONE (2012)

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Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

Jie Zheng

ONCOLOGY LETTERS (2012)

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Article Cardiac & Cardiovascular Systems

OPA1 Mutation and Late-Onset Cardiomyopathy: Mitochondrial Dysfunction and mtDNA Instability

Le Chen et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2012)

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Article Pharmacology & Pharmacy

Chronic Anthracycline Cardiotoxicity: Molecular and Functional Analysis with Focus on Nuclear Factor Erythroid 2-Related Factor 2 and Mitochondrial Biogenesis Pathways

Eduard Jirkovsky et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

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Review Oncology

Mitochondria and cancer

Douglas C. Wallace

NATURE REVIEWS CANCER (2012)

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Article Cardiac & Cardiovascular Systems

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

Youngil Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

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Understanding the benefit of metformin use in cancer treatment

Ryan J. O. Dowling et al.

BMC MEDICINE (2011)

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Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

P. Hemachandra Reddy et al.

BRAIN RESEARCH REVIEWS (2011)

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Cardiovascular effects of systemic cancer treatment

Elzbieta Senkus et al.

CANCER TREATMENT REVIEWS (2011)

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Article Biochemistry & Molecular Biology

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

Xinnan Wang et al.

CELL (2011)

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Article Cardiac & Cardiovascular Systems

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

Yun Chen et al.

CIRCULATION RESEARCH (2011)

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Article Cardiac & Cardiovascular Systems

PGC-1β Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy

Christian Riehle et al.

CIRCULATION RESEARCH (2011)

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Article Medicine, Research & Experimental

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

Katarzyna Karwacz et al.

EMBO MOLECULAR MEDICINE (2011)

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Estrogen receptor mediates a distinct mitochondrial unfolded protein response

Luena Papa et al.

JOURNAL OF CELL SCIENCE (2011)

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ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer

Jian Pan et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

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Article Cell Biology

Doxorubicin induces mitochondrial permeability transition and contractile dysfunction in the human myocardium

David Montaigne et al.

MITOCHONDRION (2011)

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Article Biochemistry & Molecular Biology

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

Kyriakos N. Papanicolaou et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

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Article Biotechnology & Applied Microbiology

Analysis of the common deletions in the mitochondrial DNA is a sensitive biomarker detecting direct and non-targeted cellular effects of low dose ionizing radiation

Boglarka Schilling-Toth et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)

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Article Biochemical Research Methods

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation

Omid Azimzadeh et al.

PROTEOMICS (2011)

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Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells

Shu-Qi Wang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

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Article Oncology

Rare Incidence of Congestive Heart Failure in Gastrointestinal Stromal Tumor and Other Sarcoma Patients Receiving Imatinib Mesylate

Jonathan C. Trent et al.

CANCER (2010)

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The reverse Warburg effect Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

Gloria Bonuccelli et al.

CELL CYCLE (2010)

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Article Cardiac & Cardiovascular Systems

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

Sang-Bing Ong et al.

CIRCULATION (2010)

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Article Pharmacology & Pharmacy

Cisplatin compromises myocardial contractile function and mitochondrial ultrastructure: Role of endoplasmic reticulum stress

Heng Ma et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2010)

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Article Cell Biology

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Noriyuki Matsuda et al.

JOURNAL OF CELL BIOLOGY (2010)

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Article Cell Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler et al.

NATURE CELL BIOLOGY (2010)

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Article Multidisciplinary Sciences

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Cristofol Vives-Bauza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

Anindita Das et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy

Rui A. Carvalho et al.

TOXICOLOGY (2010)

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Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

Eric Verdin et al.

TRENDS IN BIOCHEMICAL SCIENCES (2010)

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Cardiotoxicity induced by tyrosine kinase inhibitors

George S. Orphanos et al.

ACTA ONCOLOGICA (2009)

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Pretreatment with Statin Attenuates the Cardiotoxicity of Doxorubicin in Mice

Alexander Riad et al.

CANCER RESEARCH (2009)

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Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Heather A. Hirsch et al.

CANCER RESEARCH (2009)

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Article Cardiac & Cardiovascular Systems

Mitochondrial OPA1, apoptosis, and heart failure

Le Chen et al.

CARDIOVASCULAR RESEARCH (2009)

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Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

J. Zhang et al.

CELL DEATH AND DIFFERENTIATION (2009)

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Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

Risto Kerkela et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2009)

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PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Carles Canto et al.

CURRENT OPINION IN LIPIDOLOGY (2009)

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The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

Junko Wakabayashi et al.

JOURNAL OF CELL BIOLOGY (2009)

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The molecular composition of the mitochondrial permeability transition pore

Christopher P. Baines

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

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Article Multidisciplinary Sciences

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang et al.

NATURE (2009)

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

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Mitofusin 2: A mitochondria-shaping protein with signaling roles beyond fusion

Olga Martins De Brito et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

Inki Kim et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

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Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria

Lorenza Putignani et al.

BREAST CANCER RESEARCH AND TREATMENT (2008)

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OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

Zhiyin Song et al.

JOURNAL OF CELL BIOLOGY (2007)

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Serhiy Pankiv et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Cardiac autophagy is a maladaptive response to hemodynamic stress

Hongxin Zhu et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function

Vanessa J. Davies et al.

HUMAN MOLECULAR GENETICS (2007)

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Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo

Lu Fang et al.

LIFE SCIENCES (2007)

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DC-based cancer vaccines

Eli Gilboa

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Early and late arrhythmogenic effects of doxorubicin

Saadettin Kilickap et al.

SOUTHERN MEDICAL JOURNAL (2007)

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Analysis of Common Deletion (CD) and a novel deletion of mitochondrial DNA induced by ionizing radiation

Lu Wang et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2007)

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Article Education, Scientific Disciplines

PGC-1α:: a key regulator of energy metabolism

Huiyun Liang et al.

ADVANCES IN PHYSIOLOGY EDUCATION (2006)

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Cytokines in atherosclerosis: Pathogenic and regulatory pathways

A Tedgui et al.

PHYSIOLOGICAL REVIEWS (2006)

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Activity of d,l-α-tocopherol (vitamin E) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice

SK Bjelogrlic et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2005)

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Article Biochemistry & Molecular Biology

Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation

D Arnoult et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Autophagy and aging -: The importance of maintaining clean cells

Ana Maria Cuervo et al.

AUTOPHAGY (2005)

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The mitochondrial transporter family (SLC25): physiological and pathological implications

F Palmieri

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)

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Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1

PP Zhu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Mechanisms of disease: Mitochondrial respiratory-chain diseases

S DiMauro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Congestive heart failure in patients treated with doxorubicin - A retrospective analysis of three trials

SM Swain et al.

CANCER (2003)

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Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α):: Transcriptional coactivator and metabolic regulator

P Puigserver et al.

ENDOCRINE REVIEWS (2003)

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Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia.

H Kantarjian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Selective targeting of a redox-active ubiquinone to mitochondria within cells - Antioxidant and antiapoptotic properties

GF Kelso et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Effects by doxorubicin on the myocardium are mediated by oxygen free radicals

MF Xu et al.

LIFE SCIENCES (2001)

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The biosynthesis and functional role of cardiolipin

M Schlame et al.

PROGRESS IN LIPID RESEARCH (2000)

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