☆ 4.7 Article

Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Review Gastroenterology & Hepatology

Global epidemiology of cirrhosis - aetiology, trends and predictions

Daniel Q. Huang et al.

Summary: Cirrhosis is a major cause of morbidity and mortality in people with chronic liver disease globally. The epidemiology and burden of cirrhosis are changing due to factors such as obesity, alcohol consumption, and improved management of viral hepatitis. This review highlights global trends in cirrhosis epidemiology, the contributions of various liver diseases, and suggests ways to tackle the increasing burden of cirrhosis.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2023)

Add to Collection

Article Gastroenterology & Hepatology

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF

Jiang Li et al.

Summary: This study suggests that immune-metabolism disorder triggered by HBV exacerbation may be a potential mechanism of HBV-ACLF, providing a novel diagnostic and treatment target to reduce HBV-ACLF-related mortality.

GUT (2022)

Add to Collection

Review Gastroenterology & Hepatology

Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis

Gabriel Mezzano et al.

Summary: The study revealed high global prevalence and mortality rates of ACLF, with regional variations possibly explained by triggers/aetiology of CLD or grade.

GUT (2022)

Add to Collection

Review Gastroenterology & Hepatology

Cirrhosis-associated immune dysfunction

Agustin Albillos et al.

Summary: CAID is a spectrum of immune alterations associated with end-stage liver disease, including systemic inflammation and immune deficiency. The severity of CAID progresses parallel with cirrhosis stage, involving low-grade and high-grade systemic inflammatory phenotypes. Therapies targeting modulation of this dysfunctional immune response are currently under evaluation in preclinical and clinical studies.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Article Oncology

Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer

Hongyu Zhang et al.

Summary: This study reveals the presence of a TAM subtype associated with immunotherapy response in non-small cell lung cancer (NSCLC), specifically, the TREM2 positive TAMs. NSCLC patients with high infiltration of TREM2(+) TAMs show advanced tumor progression and poor prognosis, as well as unique molecular characteristics. Low TREM2(+) TAMs predict higher response rates to PD-1-based immunotherapy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

Add to Collection

Article Medicine, General & Internal

Single-Cell RNA Transcriptomics Reveals the State of Hepatic Lymphatic Endothelial Cells in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

Pengpeng Zhang et al.

Summary: This study found that acute-on-chronic liver failure (ACLF) is associated with more severe liver injury and inflammation than cirrhosis, as well as a significant decrease in intrahepatic lymphatic vessels (LVs). Single-cell RNA sequencing revealed the presence of apoptotic and dysfunctional lymphatic endothelial cells (LyECs) in ACLF, which were caused by secreted phosphoprotein 1 (SPP1) released from infiltrating monocyte/macrophages. In vitro experiments showed that SPP1 significantly increased the proportion of dead LyECs and impaired their tube formation ability.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Review Pharmacology & Pharmacy

Metabolomics profiles in acute-on-chronic liver failure: Unveiling pathogenesis and predicting progression

Guofeng Liu et al.

Summary: This review focuses on the contributions of metabolomics in uncovering metabolic profiles in patients with ACLF, the key metabolic pathways involved in the progression of ACLF, and the potential metabolite-associated therapeutic targets for ACLF.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

Xiaopei Hao et al.

Summary: This study demonstrates that inhibiting APOC1 can promote the transformation of M2 macrophages into M1 macrophages via the ferroptosis pathway, thereby reshaping the tumor immune microenvironment and improving the anti-PD1 immunotherapy for hepatocellular carcinoma (HCC).

REDOX BIOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

Role of precipitants in transition of acute decompensation to acute-on-chronic liver failure in patients with HBV-related cirrhosis

Tongyu Wang et al.

Summary: This study identified three distinct clinical courses of patients with acute decompensation in HBV-related cirrhosis and developed a prediction model for ACLF using precipitants, indicators of inflammation, and organ injuries, showing high predictive value and potential clinical utility.

JHEP REPORTS (2022)

Add to Collection

Article Immunology

Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage

Ines Coelho et al.

Summary: The immune receptor Trem-2 plays a crucial role in controlling the transition of liver macrophages from inflammatory to restorative phenotypes during liver injury, impacting endothelial cell differentiation and influencing the resolution of hepatic damage. Its absence results in delayed repopulation of Kupffer cells and accumulation of liver-damage associated endothelial cell population, suggesting that Trem-2 promotes the acquisition of restorative properties in macrophages and is linked to the progression of liver pathology.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Gastroenterology & Hepatology

Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis

Candid Villanueva et al.

Summary: This study found that bacterial infections have a significant impact on the natural history of compensated cirrhosis, significantly increasing the risk of decompensation and death.

JOURNAL OF HEPATOLOGY (2021)

Add to Collection

Article Gastroenterology & Hepatology

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis

Jonel Trebicka et al.

Summary: This study analyzed the precipitants leading to acute decompensation in cirrhosis patients, identifying proven bacterial infections and severe alcoholic hepatitis as the main causes. The number of precipitants was significantly associated with 90-day mortality, emphasizing the need for specific preventive and therapeutic strategies targeting these events.

JOURNAL OF HEPATOLOGY (2021)

Add to Collection

Article Chemistry, Analytical

Molecular classification and clinical diagnosis of acute-on-chronic liver failure patients by serum metabolomics

Meng Yu et al.

Summary: The research identified potential serum metabolites as biomarkers for early accurate diagnosis of acute-on-chronic liver failure (ACLF) patients, as well as clinical markers to differentiate between different types of ACLF. The study suggests that molecular markers will serve as objective criteria for the diagnosis of clinical types in traditional Chinese medicine practice.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

Add to Collection

Article Gastroenterology & Hepatology

Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis

Joan Claria et al.

Summary: This study focused on blood lipidomics in cirrhosis patients, revealing a generalized suppression of lipids in circulation. Specific lipid fingerprints were identified for distinguishing AD and ACLF, with liver dysfunction and infections playing key roles in their dynamics. Moreover, blood lysophosphatidylcholine levels increased in patients after albumin therapy.

JOURNAL OF HEPATOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

Aleksandar Obradovic et al.

Summary: This study identified specific subpopulations and their master regulators through single-cell RNA sequencing, and found that TREM2/APOE/C1Q-positive macrophage infiltration could serve as a potential prognostic biomarker for ccRCC recurrence.

CELL (2021)

Add to Collection

Article Gastroenterology & Hepatology

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

Richard Moreau et al.

JOURNAL OF HEPATOLOGY (2020)

Add to Collection

Review Immunology

New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages

Ana Batista-Gonzalez et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Medicine, General & Internal

Acute-on-Chronic Liver Failure

Vicente Arroyo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Letter Gastroenterology & Hepatology

Metabolomics to discriminate between acute decompensation and acute-on-chronic liver failure in cirrhosis

Mark J. W. McPhail et al.

JOURNAL OF HEPATOLOGY (2020)

Add to Collection

Review Cell Biology

Function of TREM1 and TREM2 in Liver-Related Diseases

Huifang Sun et al.

CELLS (2020)

Add to Collection

Article Gastroenterology & Hepatology

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

Maria J. Perugorria et al.

GUT (2019)

Add to Collection

Article Immunology

Nonclassical Monocytes in Health and Disease

Prakash Babu Narasimhan et al.

Annual Review of Immunology (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption

Marco A. Gianfrancesco et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2019)

Add to Collection

Review Gastroenterology & Hepatology

The immunological roles in acute-on-chronic liver failure: An update

Ping Chen et al.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2019)

Add to Collection

Review Immunology

Dysfunctional Immune Response in Acute-on-Chronic Liver Failure: It Takes Two to Tango

Rosa Martin-Mateos et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Review Immunology

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages

Marco Orecchioni et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Multidisciplinary Sciences

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

P. Ramachandran et al.

NATURE (2019)

Add to Collection

Article Gastroenterology & Hepatology

Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity

Hannelie Korf et al.

GUT (2019)

Add to Collection

Article Biochemistry & Molecular Biology

scFTD-seq: freeze-thaw lysis based, portable approach toward highly distributed single-cell 3 mRNA profiling

Burak Dura et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection

Article Immunology

Addressing Profiles of Systemic Inflammation Across the Different Clinical Phenotypes of Acutely Decompensated Cirrhosis

Jonel Trebicka et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Gastroenterology & Hepatology

CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure

Christine Bernsmeier et al.

GUT (2018)

Add to Collection

Article Gastroenterology & Hepatology

Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Tianzhou Wu et al.

GUT (2018)

Add to Collection

Article Cardiac & Cardiovascular Systems

Activation of the AKT Pathway in the Ascending Aorta With Bicuspid Aortic Valve

Yuichiro Hirata et al.

CIRCULATION JOURNAL (2018)

Add to Collection

Review Immunology

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

Anthony T. Phan et al.

IMMUNITY (2017)

Add to Collection

Article Dermatology

Sebum lipids influence macrophage polarization and activation

M. Lovaszi et al.

BRITISH JOURNAL OF DERMATOLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Metabolic Instruction of Immunity

Michael D. Buck et al.

CELL (2017)

Add to Collection

Article Pathology

Spatiotemporal Characterization of the Cellular and Molecular Contributors to Liver Fibrosis in a Murine Hepatotoxic-Injury Model

Michelle Melino et al.

AMERICAN JOURNAL OF PATHOLOGY (2016)

Add to Collection

Article Gastroenterology & Hepatology

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

Bruna Araujo David et al.

GASTROENTEROLOGY (2016)

Add to Collection

Article Gastroenterology & Hepatology

Systemic Inflammation in Decompensated Cirrhosis: Characterization and Role in Acute-on-Chronic Liver Failure

Joan Claria et al.

HEPATOLOGY (2016)

Add to Collection

Article Gastroenterology & Hepatology

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

Lynette Beattie et al.

JOURNAL OF HEPATOLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte L. Scott et al.

NATURE COMMUNICATIONS (2016)

Add to Collection

Article Gastroenterology & Hepatology

Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK

Christine Bernsmeier et al.

GASTROENTEROLOGY (2015)

Add to Collection

Review Gastroenterology & Hepatology

Advanced therapeutic strategies for HBV-related acute-on-chronic liver failure

Xin-Yu Liu et al.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2015)

Add to Collection

Article Immunology

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury

Daniela Dal-Secco et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Add to Collection

Article Medicine, General & Internal

Acute-on-chronic liver failure

William Bernal et al.

LANCET (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

Spatial reconstruction of single-cell gene expression data

Rahul Satija et al.

NATURE BIOTECHNOLOGY (2015)

Add to Collection

Article Immunology

Contribution of metabolic reprogramming to macrophage plasticity and function

Karim C. EL Kasmi et al.

SEMINARS IN IMMUNOLOGY (2015)

Add to Collection

Editorial Material Gastroenterology & Hepatology

Toward an Improved Definition of Acute-on-Chronic Liver Failure

Rajiv Jalan et al.

GASTROENTEROLOGY (2014)

Add to Collection

Review Gastroenterology & Hepatology

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

Agustin Albillos et al.

JOURNAL OF HEPATOLOGY (2014)

Add to Collection

Article Gastroenterology & Hepatology

Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure

Rajiv Jalan et al.

JOURNAL OF HEPATOLOGY (2014)

Add to Collection

Article Immunology

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

Ehud Zigmond et al.

JOURNAL OF IMMUNOLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

Modulation of Cytokine Release and Gene Expression by the Immunosuppressive Domain of gp41 of HIV-1

Joachim Denner et al.

PLOS ONE (2013)

Add to Collection

Article Gastroenterology & Hepatology

Hepatic Recruitment of the Inflammatory Gr1+ Monocyte Subset Upon Liver Injury Promotes Hepatic Fibrosis

Karlin Raja Karlmark et al.

HEPATOLOGY (2009)

Add to Collection

Review Cell Biology

Origins and tissue-context-dependent fates of blood monocytes

Chen Varol et al.

IMMUNOLOGY AND CELL BIOLOGY (2009)

Add to Collection

Article Gastroenterology & Hepatology

Longitudinal monocyte Human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis

Marie-Luise Berres et al.

LIVER INTERNATIONAL (2009)

Add to Collection

Article Cell Biology

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

Michael P. Holt et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification

Marit Westerterp et al.

JOURNAL OF LIPID RESEARCH (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells

GX Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Add to Collection

Article Gastroenterology & Hepatology

Patients with acute on chronic liver failure display 'sepsis-like' immune paralysis

HE Wasmuth et al.

JOURNAL OF HEPATOLOGY (2005)

Add to Collection

Article Gastroenterology & Hepatology

Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse

DM Dambach et al.

HEPATOLOGY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.