4.7 Article

Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma

Related references

Note: Only part of the references are listed.
Review Cell Biology

New insights into activation and function of the AMPK

Gregory R. Steinberg et al.

Summary: AMP-activated protein kinase (AMPK) is a cellular energy sensor that is activated by increases in AMP/ADP to ATP ratios. Recent studies have discovered non-canonical pathways for AMPK activation, involving calcium, nutrients, metabolites, DNA and lysosome damage. AMPK has been found to regulate carbohydrate and lipid metabolism, mitochondrial and lysosomal homeostasis, and DNA repair. Its role in cancer, obesity, diabetes, nonalcoholic steatohepatitis (NASH), and other disorders has been explored, suggesting potential therapeutic targets.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

Review Oncology

Targeting DNA damage response pathways in cancer

Florian J. Groelly et al.

Summary: Cells have a complex network called the DNA damage response (DDR) to prevent detrimental mutations and coordinate DNA repair, cell-cycle checkpoint activation, and other cellular responses. Mutations in DDR genes are frequently found in cancer, causing genomic instability and influencing the tumor's response to DNA damage treatments. Tumors with mutated BRCA1 or BRCA2 are particularly susceptible to chemotherapeutic inhibitors of PARP, which has become a targeted therapy for cancer.

NATURE REVIEWS CANCER (2023)

Article Cell Biology

The RPA inhibitor HAMNO sensitizes Fanconi anemia pathway-deficient cells

Seok-Won Jang et al.

Summary: The Fanconi anemia (FA) DNA repair pathway plays an important role in maintaining genome integrity, as well as in DNA inter-strand crosslink (ICL) repair and stabilizing stalled replication forks. In FA-deficient cells, inhibition of replication protein A (RPA) activates the FA pathway and enhances cellular sensitivity to cisplatin.

CELL CYCLE (2022)

Review Biochemistry & Molecular Biology

The multifaceted role of autophagy in cancer

Ryan C. Russell et al.

Summary: Autophagy is a cellular degradation pathway that plays a crucial role in maintaining cellular homeostasis. It can both suppress tumorigenesis and promote cancer development. This article summarizes the effects of autophagy on cancer initiation, progression, immune infiltration, and metabolism, as well as discussing the efforts to target autophagy pharmacologically and future research directions.

EMBO JOURNAL (2022)

Article Oncology

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Erika Durinikova et al.

Summary: In colorectal cancer, a subset of cases refractory to current therapies may benefit from inhibitors of DDR pathways and replication stress. By analyzing multiple biomarkers, colorectal cancers likely to respond to ATRi can be identified.

CLINICAL CANCER RESEARCH (2022)

Article Multidisciplinary Sciences

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

Seong-Su Han et al.

Summary: This study identifies a crucial role for WASp in the DNA stress-resolution pathway, specifically in promoting the function of Replication Protein A at replication forks after DNA damage. Deficiency of WASp leads to RPA dysfunction, resulting in genomic instability.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Evolving DNA repair synthetic lethality targets in cancer

Sanat Kulkarni et al.

BIOSCIENCE REPORTS (2022)

Article Medicine, General & Internal

Effect of Autophagy Inhibitors on Radiosensitivity in DNA Repair-Proficient and -Deficient Glioma Cells

Tareq Saleh et al.

Summary: Autophagy plays a role in DNA repair in radiation therapy, but the effect of autophagy inhibitors on DNA damage repair is not clear.

MEDICINA-LITHUANIA (2022)

Article Oncology

LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma

Qianping Chen et al.

Summary: The study identified LACTB2 as a potential biomarker for radioresistance in NPC, showing that its overexpression can promote PINK1-dependent mitophagy, enhancing radioresistance.

CANCER LETTERS (2021)

Article Biochemistry & Molecular Biology

lncRNA CASC19 Contributes to Radioresistance of Nasopharyngeal Carcinoma by Promoting Autophagy via AMPK-mTOR Pathway

Hongxia Liu et al.

Summary: The study discovered that lncRNA CASC19 contributes to radioresistance in NPC by regulating autophagy. Suppressing autophagy through inhibition of the AMPK/mTOR pathway and promoting apoptosis through the PARP1 pathway enhanced the radiosensitivity of NPC cells. These findings suggest CASC19 as a potential molecular biomarker and therapeutic target in NPC treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway

Weiqiang Huang et al.

Summary: The study revealed that cancer-associated fibroblasts (CAFs) infiltrated in radiation-resistant NPC tissues induced radioresistance and promoted NPC cell survival post-irradiation via the IL-8/NF-κB pathway. Treatment with Tranilast, a CAF inhibitor, restricted the survival of CAF-induced NPC cells and alleviated radioresistance properties, suggesting the potential value of Tranilast in sensitizing NPC cells to irradiation.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Causes and consequences of DNA damage-induced autophagy

Thomas Juretschke et al.

Summary: Autophagy is a quality control pathway that maintains cellular homeostasis by recycling surplus and dysregulated cell organelles, and different types of DNA damage can induce autophagy which is crucial for genomic stability. Recent studies have shed light on the pathways connecting autophagy with the DNA damage response, but the physiological role of autophagy and its targets after DNA damage remain unclear.

MATRIX BIOLOGY (2021)

Article Cell Biology

CRISPR/Cas9 genome-wide screening identifies LUC7L2 that promotes radioresistance via autophagy in nasopharyngeal carcinoma cells

Lin Shen et al.

Summary: The study revealed the essential role of the LUC7L2 gene in regulating radioresistance of nasopharyngeal carcinoma cells. Overexpression promoted cell viability, while knockdown slowed down DNA replication and impaired cell survival, making cells more sensitive to radiation.

CELL DEATH DISCOVERY (2021)

Review Biochemistry & Molecular Biology

Autophagy and autophagy-related proteins in cancer

Xiaohua Li et al.

MOLECULAR CANCER (2020)

Review Genetics & Heredity

DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons

Therese Wilhelm et al.

GENES (2020)

Article Biochemistry & Molecular Biology

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Kirsten L. Bryant et al.

NATURE MEDICINE (2019)

Review Medicine, General & Internal

Nasopharyngeal carcinoma

Yu-Pei Chen et al.

LANCET (2019)

Review Oncology

Targeting Autophagy in Cancer: Recent Advances and Future Directions

Ravi K. Amaravadi et al.

CANCER DISCOVERY (2019)

Review Oncology

Targeting Autophagy in Cancer

Angelique V. Onorati et al.

CANCER (2018)

Article Cell Biology

RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma

Chen Qu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

Review Cell Biology

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

Graeme Hewitt et al.

TRENDS IN CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Targeting the DNA Damage Response in Cancer

Mark J. O'Connor

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

RushikaM. Perera et al.

NATURE (2015)

Article Oncology

RPA Inhibition Increases Replication Stress and Suppresses Tumor Growth

Jason G. Glanzer et al.

CANCER RESEARCH (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)