Dysfunctional Coupling of Cerebral Blood Flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Nondialysis Patients with CKD

Article Urology & Nephrology

New insights into cognitive decline in chronic kidney disease

Wei Ling Lau et al.

Summary: Chronic kidney disease (CKD) is an independent risk factor for cognitive decline due to cerebral small vessel disease, according to a recent study. The exact mechanisms underlying the kidney-brain connection are still unclear.

NATURE REVIEWS NEPHROLOGY (2023)

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Article Urology & Nephrology

Association of Kidney Function Measures With Signs of Neurodegeneration and Small Vessel Disease on Brain Magnetic Resonance Imaging: The Atherosclerosis Risk in Communities (ARIC) Study

Johannes B. Scheppach et al.

Summary: This study evaluated the association of eGFR and UACR with structural brain abnormalities visible on MRI. The results showed that lower eGFR and higher UACR were associated with reduced brain volume and increased white matter lesions.

AMERICAN JOURNAL OF KIDNEY DISEASES (2023)

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Article Anatomy & Morphology

Quantitative susceptibility atlas construction in Montreal Neurological Institute space: towards histological-consistent iron-rich deep brain nucleus subregion identification

Chenyu He et al.

Summary: This study constructed a high-quality Multi-modal-fused magnetic Susceptibility (MuSus-100) human brain atlas, which can be used for the research of neurological and psychiatric diseases. The atlas showed higher accuracy and robustness in segmentation of iron-rich deep brain nuclei, and it can be applied for pathological identification of Parkinson's Disease patients and target planning in deep brain stimulation surgery.

BRAIN STRUCTURE & FUNCTION (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Brain iron deposition is positively correlated with cognitive impairment in patients with chronic cerebral hypoperfusion: a MRI susceptibility mapping study

J. -J. Yu et al.

Summary: The relationship between brain iron deposition and cognitive impairment in patients with chronic cerebral hypoperfusion (CHP) was investigated. The study used quantitative susceptibility mapping (QSM) to detect brain iron deposition and employed neuropsychological tests to assess cognitive function. The results showed that CHP patients had higher susceptibility values in the bilateral hippocampus and substantia nigra, as well as cognitive impairment. Furthermore, the susceptibility values in specific areas were closely correlated with the scores of neuropsychological tests.

CLINICAL RADIOLOGY (2023)

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Article Neurosciences

Neurovascular decoupling measured with quantitative susceptibility mapping is associated with cognitive decline in patients with type 2 diabetes

Min-Hua Ni et al.

Summary: This study explores the mechanism of neurovascular coupling in T2DM-associated mild cognitive impairment (MCI) and identifies brain regions and NVC coefficients that are associated with cognitive decline using quantitative susceptibility mapping and functional connectivity analysis.

CEREBRAL CORTEX (2023)

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Article Endocrinology & Metabolism

Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis

Hao Wang et al.

Summary: Hemodialysis may lead to brain injuries, and ferritin level may play a key role in the alteration of cerebral blood flow and iron deposition. The putamen in patients undergoing HD showed iron dyshomeostasis and vascular damage, which could be potential neural mechanisms for neurodegenerative processes.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Long-term hemodialysis may affect enlarged perivascular spaces in maintenance hemodialysis patients: evidence from a pilot MRI study

Hao Wang et al.

Summary: HD patients showed increased number of CS-PVS and CW-PVS in WM regions compared to healthy controls, with CW-PVS number positively associated with higher CBF and lower WMV in the CW region. Blood pressure readings also differed significantly pre-HD, intra-HD, and post-HD in HD patients.

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY (2022)

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Review Geriatrics & Gerontology

Iron Dyshomeostasis and Ferroptosis: A New Alzheimer's Disease Hypothesis?

Feixue Wang et al.

Summary: Iron plays a crucial role in the human body, but its accumulation in the brain is associated with cognitive decline in Alzheimer's disease. Abnormal iron metabolism leads to iron deposition and promotes the progression of Alzheimer's disease. Furthermore, iron deposition can trigger iron-mediated cell death and result in neuronal loss. Therefore, targeting iron metabolism could be a promising therapeutic approach for Alzheimer's disease.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Abnormal cerebral micro-structures in end-stage renal disease patients related to mild cognitive impairment

Jiahui Zheng et al.

Summary: This study investigates the mediating effect of abnormal brain micro-structures on the relationship between clinical risk factors and mild cognitive impairment (MCI) in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis. The results show disrupted brain micro-structures in ESRD patients with MCI and demonstrate that DKI metrics and clinical characteristics can be used to efficiently predict cognitive function associated with ESRD.

EUROPEAN JOURNAL OF RADIOLOGY (2022)

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Article Urology & Nephrology

Reserve and resilience in CKD: concept introduction and baseline results from the Physical REsilience Prediction in Advanced REnal Disease (PREPARED) study

C. Barrett Bowling et al.

Summary: This study introduces the novel concepts of reserve and resilience in the research of chronic kidney disease. It provides baseline data from a prospective cohort study and shows that older adults with similar levels of kidney function have a wide range of reserve in other health domains.

BMC NEPHROLOGY (2022)

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Article Neurosciences

Abnormal regional homogeneity and amplitude of low frequency fluctuation in chronic kidney patients with and without dialysis

Huan Yu et al.

Summary: This study characterized the regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in abnormal brain regions of patients with chronic kidney disease (CKD). The findings suggest that abnormal activity in basal ganglia, cerebellar, and hippocampal regions may be involved in the cognitive decline of CKD patients.

FRONTIERS IN NEUROSCIENCE (2022)

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Article Clinical Neurology

Diffusion tensor imaging of the brain white matter microstructure in patients with chronic kidney disease and its correlation with cognition

Chaoyang Zhang et al.

Summary: Neurological damage is commonly observed in individuals with chronic kidney disease (CKD), and this is associated with microstructural damage to the brain white matter and cognitive dysfunction. This study aimed to investigate the correlation between cognitive impairment and diffusion parameters obtained from diffusion tensor imaging (DTI) of abnormal white matter tracts in CKD patients. The results showed extensive white matter microstructural changes and impaired cognitive function in CKD patients, with worse cognitive function and more severe microstructural damage in dialysis-dependent CKD patients compared to non-dialysis-dependent CKD patients.

FRONTIERS IN NEUROLOGY (2022)

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Review Cell Biology

Association of kidney function and brain health: A systematic review and meta-analysis of cohort studies

Xingyao Tang et al.

Summary: This study aimed to evaluate the bidirectional association between kidney dysfunction and brain health. The results showed a positive association between kidney dysfunction and structural and functional brain abnormalities. However, the relationship between kidney dysfunction and structural brain abnormalities remains controversial.

AGEING RESEARCH REVIEWS (2022)

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Review Biochemistry & Molecular Biology

Iron Deposition in Brain: Does Aging Matter?

Eleonora Ficiara et al.

Summary: Alterations in iron homeostasis during aging can lead to increased iron levels and oxidative damage. Abnormal accumulation of iron in the brain has been proposed as a biomarker for neurodegeneration, but there is uncertainty regarding the link between brain iron accumulation and aging and neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neuroimaging

Altered resting-state functional networks in patients with hemodialysis: a graph-theoretical based study

Mei Jin et al.

Summary: Hemodialysis patients exhibit disruptions in global and regional brain functional connectivity compared to healthy controls, with significantly decreased parameters at the global level and widespread abnormal nodal metrics at the regional level. Disrupted neural circuits involving the salience, frontal-temporal-basal ganglia, and frontoparietal networks were detected, suggesting the graph-theory method as a potential tool for understanding neuropathology in this population.

BRAIN IMAGING AND BEHAVIOR (2021)

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Article Neuroimaging

Cerebral blood flow alterations in hemodialysis patients with and without restless legs syndrome: an arterial spin labeling study

Hao Wang et al.

Summary: Hemodialysis patients with restless legs syndrome (HD-RLS) exhibit altered cerebral blood flow patterns, with increased CBF in the primary motor cortex. Both HD subgroups, with and without RLS, show consistent CBF changes, suggesting a potential involvement of abnormal hyperperfusion in sensory processing disorder in RLS pathogenesis in HD patients.

BRAIN IMAGING AND BEHAVIOR (2021)

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Article Endocrinology & Metabolism

Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma

Qian Wang et al.

Summary: The study found that disturbed neurovascular coupling may exist in the visual and higher order cognitive cortices in POAG patients, correlating with disease stage and visual field defects. These findings could help in monitoring disease progression and shedding light on the pathophysiology of neurodegeneration in POAG.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

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Article Neuroimaging

Increased cerebral blood flow is correlated with neurocognitive impairment in long-term hemodialysis patients: an arterial spin labeling MRI study

Chao Chai et al.

Summary: Long-term hemodialysis patients showed increased cerebral blood flow (CBF) associated with neurocognitive impairment, and the correlation remained after adjusting for the effect of anemia.

BRAIN IMAGING AND BEHAVIOR (2021)

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Article Neuroimaging

Abnormal brain activity patterns during spatial working memory task in patients with end-stage renal disease on maintenance hemodialysis: a fMRI study

Jinzhuang Huang et al.

Summary: Research found that abnormal brain activity patterns in spatial working memory were associated with cognitive impairment in hemodialysis patients, indicating the neural mediation of SWM impairment.

BRAIN IMAGING AND BEHAVIOR (2021)

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Article Clinical Neurology

Immediate Abnormal Intrinsic Brain Activity Patterns in Patients with End-stage Renal Disease During a Single Dialysis Session Resting-state Functional MRI Study

Cong Peng et al.

Summary: The study aimed to investigate cerebral amplitude of low-frequency fluctuations (ALFF) changes in ESRD patients during a single hemodialysis (HD) session. Patients showed altered brain activity and cognitive impairments. After HD, patients performed better in neuropsychological tests and had changes in left putamen activity, possibly associated with ultrafiltration volume.

CLINICAL NEURORADIOLOGY (2021)

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Article Biochemical Research Methods

MICA: A toolkit for multimodal image coupling analysis

Bo Hu et al.

Summary: This study developed a software package to automate and simplify tasks involved in analyzing the correlation between multimodal images in brain research. The software performs functions such as file renaming, ROI extraction, coupling analysis, and multiple comparison correction to improve accuracy and efficiency in data preparation and analysis.

JOURNAL OF NEUROSCIENCE METHODS (2021)

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Article Urology & Nephrology

The case for early identification and intervention of chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Michael G. Shlipak et al.

Summary: Chronic kidney disease (CKD) is a significant global burden associated with higher morbidity and mortality, especially among individuals with lower socioeconomic status. Despite the availability of guidelines for evaluating and managing early CKD, there is still a lack of consensus on prioritizing early identification and intervention for CKD without incentives or quality measures.

KIDNEY INTERNATIONAL (2021)

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Article Oncology

Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells

Bowen Li et al.

Summary: The study revealed that patients with AMD had iron deficiency, and this deficiency was associated with the development of AMD in hypertensive patients. Experiments on mice showed that iron-deficient feeding combined with Ang II injection promoted the formation of AMD and significantly shortened the survival time of mice. Additionally, iron deficiency significantly impaired the cytoskeleton of vascular smooth muscle cells.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment

Peng Li et al.

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Dysfunctional Coupling of Cerebral Blood Flow and Susceptibility Value in the Bilateral Hippocampus is Associated with Cognitive Decline in Nondialysis Patients with CKD

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