Related references
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Article
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Summary: The aim of this study was to compare the incidences of adverse events and delirium in 3 cohorts: after COVID-19 vaccination, prepandemic, and SARS-CoV-2 PCR test positive. A total of 17,449 older people with dementia participated in the study, and the results showed no increased risk of delirium and most adverse events following vaccination compared to the prepandemic period and those tested positive for SARS-CoV-2. The findings provide evidence for the safe use of COVID-19 vaccines in older patients with dementia.
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Summary: This study examined whether there was an increase in all-cause mortality in Cyprus during the first two years of the COVID-19 pandemic and whether it was associated with vaccination rates. The results showed that although there were 552 excess deaths during this period, there was no association between vaccination rates and all-cause mortality, indicating the excellent safety profile of COVID-19 vaccines.
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Summary: Since the publication of successful clinical trial results of mRNA COVID-19 vaccines in December 2020, reports of cardiovascular complications following vaccination have emerged. This study provides a comprehensive account of various cardiovascular adverse events reported after the first or second dose of mRNA vaccines, including pericarditis/myopericarditis, myocarditis, hypotension, hypertension, arrhythmia, cardiogenic shock, stroke, myocardial infarction/STEMI, intracranial hemorrhage, thrombosis, and pulmonary embolism.
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Summary: This study describes autopsy findings of myocarditis in individuals who died unexpectedly after receiving anti-SARS-CoV-2 vaccination. Acute myocarditis was identified in four patients who received mRNA vaccination, with no other significant diseases or health issues detected. Histological examination revealed T-lymphocytic infiltration in the myocardium, predominantly involving the CD4 positive subset, and mild myocyte damage. Overall, the findings indicate that myocarditis can be a potentially lethal complication following mRNA-based anti-SARS-CoV-2 vaccination, and can help to diagnose unclear cases and establish timely in vivo diagnosis for monitoring and treating severe clinical cases.
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Public, Environmental & Occupational Health
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Summary: The binding of SARS-CoV-2 to ACE2 causes dysregulation of the renin-angiotensin system, leading to various complications. Activation of the Ang II-AT1R axis causes inflammation and lung injury, while RAS blockers may be potential drugs for COVID-19 treatment.
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Medicine, General & Internal
Jannis Kountouras et al.
Summary: The COVID-19 pandemic requires a comprehensive approach to guide healthcare policies and balance physical and mental health. Achieving widespread immunity is the priority, and preventing transmission relies on non-pharmacological measures. Treatment options after infection vary in terms of benefits and adverse events.
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Medicine, General & Internal
Noam Barda et al.
Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
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Medicine, General & Internal
Michael Doulberis et al.
Summary: The article underscores the urgent issues in the development of COVID-19 vaccines, including the risks of rapid vaccine development and the effectiveness of vaccines against new variants. It calls for scientists and clinicians to pay attention to these issues for more comprehensive management.
MEDICINA-LITHUANIA
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