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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.3c07919
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A nickel hydride-catalyzed regio- and enantioselective hydroalkylation reaction was developed to access a library of chiral beta- or gamma-branched aromatic N-heterocycles. This intriguing asymmetric transformation features excellent selectivities, step- and atom-economies, and generates two kinds of chiral products through one synthetic strategy. The possible reaction mechanism was extensively investigated using numerous control experiments and density functional theory calculations.
A nickel hydride-catalyzed regio- and enantioselective hydroalkylation reaction was developed to give access to a library of chiral beta- or gamma-branched aromatic N-heterocycles. This intriguing asymmetric transformation features excellent selectivities, step- and atom-economies, and generating two kinds of chiral products through one synthetic strategy. Furthermore, the possible reaction mechanism was extensively investigated using numerous control experiments and density functional theory calculations.
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