Universal and One-Step Modification to Render Diverse Materials Bioactivation

Bioactive materials that can support cell adhesion andtissue regenerationare greatly in demand in clinical applications. Surface modificationwith bioactive molecules is an efficient strategy to convert conventionalbioinert materials into bioactive materials. However, there is anurgent need to find a universal and one-step modification strategyto realize the above transformation for bioactivation. In this work,we report a universal and one-step modification strategy to easilymodify and render diverse materials bioactivation by dipping materialsinto the solution of dibutylamine-DOPA-lysine-DOPA (DbaYKY) tripeptide-terminated cell-adhesivemolecules, & beta;-peptide polymer, or RGD peptide for only 5 min.This strategy provides materials with a stable surface modificationlayer and does not cause an undesired surface color change like thewidely used polydopamine coating. This one-step strategy can endowmaterial surfaces with cell adhesion properties without concerns onnonspecific conjugation of proteins and macromolecules. This universaland one-step surface bioactivation strategy implies a wide range ofapplications in implantable biomaterials.

Automated summary

Bioactive materials are highly demanded in clinical applications to support cell adhesion and tissue regeneration. This work presents a universal and one-step surface modification strategy by dipping materials into the solution of cell-adhesive molecules, β-peptide polymer, or RGD peptide. This strategy provides stable surface modification without undesired color change, offering a wide range of applications in implantable biomaterials.