Related references
Note: Only part of the references are listed.A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate
Amelia K. Gilio et al.
ACS CATALYSIS (2023)
The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development
Scott P. France et al.
JACS AU (2023)
Substituents of life: The most common substituent patterns present in natural products
Peter Ertl
BIOORGANIC & MEDICINAL CHEMISTRY (2022)
Natural product drug discovery in the artificial intelligence era
F. I. Saldivar-Gonzalez et al.
CHEMICAL SCIENCE (2022)
Bio-click chemistry: a bridge between biocatalysis and click chemistry
Diego F. Rodriguez et al.
RSC ADVANCES (2022)
Diverse Catalytic Reactions for the Stereoselective Synthesis ofCyclic Dinucleotide MK-1454
Tamas Benkovics et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
A kinase-cGAS cascade to synthesize a therapeutic STING activator
John A. McIntosh et al.
NATURE (2022)
Multifunctional biocatalyst for conjugate reduction and reductive amination
Thomas W. Thorpe et al.
NATURE (2022)
Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines
Vanessa Harawa et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins
Anna Fryszkowska et al.
SCIENCE (2022)
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
Charles E. Hendrick et al.
ACS MEDICINAL CHEMISTRY LETTERS (2022)
Enzymatic Nitrogen Insertion into Unactivated C-H Bonds
Soumitra V. Athavale et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)
The Time and Place for Nature in Drug Discovery
Robert J. Young et al.
JACS AU (2022)
Enzymatic Late-Stage Modifications: Better Late Than Never
Elvira Romero et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination
James R. Marshall et al.
NATURE CHEMISTRY (2021)
Protein Modifications: From Chemoselective Probes to Novel Biocatalysts
Tomas Bohn Pessatti et al.
CATALYSTS (2021)
Biocatalytic reductive amination from discovery to commercial manufacturing applied to abrocitinib JAK1 inhibitor
Rajesh Kumar et al.
NATURE CATALYSIS (2021)
Engineering new catalytic activities in enzymes
Kai Chen et al.
NATURE CATALYSIS (2020)
Biocatalysis in drug discovery and development
Anna Fryszkowska et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2020)
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2020)
Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships
Sarah L. Montgomery et al.
SCIENCE ADVANCES (2020)
The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time
Peter Ertl et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Can easy chemistry produce complex, diverse, and novel molecules?
Anna Tomberg et al.
DRUG DISCOVERY TODAY (2020)
Biocatalysis: A Pharma Perspective
Joseph P. Adams et al.
ADVANCED SYNTHESIS & CATALYSIS (2019)
Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase
Markus Schober et al.
NATURE CATALYSIS (2019)
Imine Reductase-Catalyzed Enantioselective Reduction of Bulky α,β-Unsaturated Imines en Route to a Pharmaceutically Important Morphinan Skeleton
Peiyuan Yao et al.
ADVANCED SYNTHESIS & CATALYSIS (2019)
Evolution of commercially available compounds for HTS
Dmitriy M. Volochnyuk et al.
DRUG DISCOVERY TODAY (2019)
Enantioselective Biocatalytic Reduction of 2H-1,4-Benzoxazines Using Imine Reductases
Nadine Zumbraegel et al.
JOURNAL OF ORGANIC CHEMISTRY (2019)
Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination
Scott P. France et al.
CHEMCATCHEM (2018)
Synthesis of chiral amines using redox biocatalysis
Gideon Grogan
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Mahima Sharma et al.
ACS CATALYSIS (2018)
Extending the application of biocatalysis to meet the challenges of drug development
Paul N. Devine et al.
NATURE REVIEWS CHEMISTRY (2018)
Directed Evolution: Bringing New Chemistry to Life
Frances H. Arnold
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
A reductive aminase from Aspergillus oryzae
Godwin A. Aleku et al.
NATURE CHEMISTRY (2017)
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Dean G. Brow et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Stereoselectivity and Structural Characterization of an Irvine Reductase (IRED) from Amycolatopsis orientalis
Godwin A. Aleku et al.
ACS CATALYSIS (2016)
Diversity in Reduction with Short-Chain Dehydrogenases: Tetrahydroxynaphthalene Reductase, Trihydroxynaphthalene Reductase, and Glucose Dehydrogenase
David Conradt et al.
CHEMCATCHEM (2015)
Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones
Philipp N. Scheller et al.
CHEMCATCHEM (2015)
Advances in Chemical Protein Modification
Omar Boutureira et al.
CHEMICAL REVIEWS (2015)
Unprecedented Role of Hydronaphthoquinone Tautomers in Biosynthesis
Syed Masood Husain et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Direct Reductive Amination of Ketones: Structure and Activity of S-Selective Imine Reductases from Streptomyces
Tobias Huber et al.
CHEMCATCHEM (2014)
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective
Renato A. Bauer et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Christopher K. Savile et al.
SCIENCE (2010)