☆ 4.8 Article

Nebulized Therapy of Early Orthotopic Lung Cancer by Iron-Based Nanoparticles: Macrophage-Regulated Ferroptosis of Cancer Stem Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Related references

Note: Only part of the references are listed.

Article Immunology

Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

Chuanlin Ding et al.

Summary: By inducing trained immunity, reprogrammed pre-metastatic niche myeloid cells inhibit tumor metastasis and prolong survival. The metabolic sphingolipid-mitochondrial fission pathway is identified as the mechanism for WGP-induced trained immunity.

NATURE IMMUNOLOGY (2023)

Add to Collection

Article Multidisciplinary Sciences

Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice

Meng-Meng Han et al.

Summary: A nanoengineered platform based on mesenchymal stem cells (MSCs) and nintedanib-loaded liposomes modified with type I collagenase (Lip@NCAF) was constructed to treat severe pulmonary fibrosis (PF). The platform effectively delivered the drug to fibrotic lungs and inhibited fibroblast overactivation. Additionally, MSCs differentiated into alveolar epithelial cells to repair lung tissue. This study suggests that MSCs-Lip@NCAF is a promising therapeutic candidate for PF, especially in aged patients.

SCIENCE ADVANCES (2023)

Add to Collection

Article Cell Biology

Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy

Chen Chen et al.

Summary: Researchers have developed a cavity-injectable nanoporter-hydrogel superstructure to prevent relapse of glioblastoma multiforme (GBM). This superstructure introduces glioma stem cell-specific chimeric antigen receptor (CAR) genes into macrophages/microglia, stimulating an antitumor immune response and preventing postoperative relapse.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Medicine, Research & Experimental

SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling

Chuan Xu et al.

Summary: Signal regulatory protein gamma (SIRP gamma) determines the properties and immune evasiveness of cancer stem-like cells (CSLCs) in a small population of lung adenocarcinoma (LUAD) cancer cells. SIRP gamma activates the Hippo/YAP signaling pathway to release cytokines and stimulate CD47 expression in tumor cells, inhibiting their phagocytosis. Targeting SIRP gamma can inhibit CSLC phenotypes and promote tumor phagocytosis, making it an immune and CSLC-targeting strategy for lung cancer therapy.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Add to Collection

Review Cell Biology

Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment

Lesang Shen et al.

Summary: Leukocytes and iron metabolism play important roles in tumorigenesis, with interplay in the tumor microenvironment. Combining immunotherapy with targeted regulation of iron metabolism may be a future research focus.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

The Dynamic Interactions between Nanoparticles and Macrophages Impact Their Fate in Brain Tumors

Qishuai Feng et al.

Summary: This study systematically investigated the dynamic interactions between the FDA-approved iron oxide nanoparticle ferumoxytol and immune cells in brain tumors. The results demonstrated the key role of dynamic biointeractions in determining the efficiency of targeting tumor cells and the fate of nanoparticles in vivo.

SMALL (2021)

Add to Collection

Article Multidisciplinary Sciences

Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination

Ved P. Sharma et al.

Summary: Research has shown that cancer stem cells (CSCs) play an important role in tumor metastasis, with non-stem cancer cells induced to become stem cells through direct contact with macrophages. In human breast cancer, TMEM doorways are not only entry portals for cancer cell intravasation, but also sites for CSC programming.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Microbiology

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

Shea A. Lowery et al.

Summary: Severe disease from COVID-19 is characterized by significant immunopathology driven by unbalanced innate immune response with limited and delayed interferon response, leading to excessive proinflammatory cytokine production and cellular infiltrates in the respiratory tract causing lung pathology. Effective therapeutics for severe COVID-19 patients depend on understanding the pathological elements of this dysregulated innate immune response, as well as identifying therapeutic strategies targeting these elements of the innate response.

CELL HOST & MICROBE (2021)

Add to Collection

Review Cell Biology

Ferroptosis: Cancer Stem Cells Rely on Iron until to Die for It

Emma Cosialls et al.

Summary: Iron metabolism plays a crucial role in cancer stem cells, providing a new direction for targeting CSC therapeutic strategies. The dependency of CSCs on iron and the induction of iron death suggest that iron could be an effective means to treat cancer.

CELLS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

CD44: A Multifunctional Mediator of Cancer Progression

Malak Hassn Mesrati et al.

Summary: CD44, a non-kinase cell surface transmembrane glycoprotein, is widely implicated as a cancer stem cell marker in multiple cancers. Cells overexpressing CD44 possess CSC traits and resistance to therapy. The CD44 gene undergoes alternative splicing, resulting in different isoforms that interact with various ligands and drive cancer-associated signaling pathways. However, the association between CD44 expression levels and clinicopathological features is contradictory, although high CD44 expression significantly contributes to tumorigenic mechanisms.

BIOMOLECULES (2021)

Add to Collection

Article Oncology

Tumor-associated macrophage-derived transforming growth factor-β promotes colorectal cancer progression through HIF1-TRIB3 signaling

Changfu Liu et al.

Summary: TAMs promote colorectal cancer progression by inducing glycolytic state, stem-like phenotypes, and invasion through HIF1 alpha/TRIB3-dependent activation of beta-catenin/Wnt signaling pathway. Blocking HIF1 alpha signals may improve chemotherapy outcomes in colorectal cancer treatment.

CANCER SCIENCE (2021)

Add to Collection

Article Multidisciplinary Sciences

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Maria Casanova-Acebes et al.

Summary: Macrophages play a crucial role in shaping the tumor microenvironment and tumor immunity, with tissue-resident macrophages identified as key contributors to early lung cancer progression. Targeting tissue-resident macrophages may offer new possibilities for prevention and treatment of early lung cancer lesions.

NATURE (2021)

Add to Collection

Article Multidisciplinary Sciences

Intratumoral synthesis of nano-metalchelate for tumor catalytic therapy by ligand field-enhanced coordination

Bowen Yang et al.

Summary: Iron gall chelate (GA-Fe) can promote chemical corrosion through oxygen reduction reactions and reactive oxygen species generation, inspiring a composite cancer nanomedicine using gallate loaded into a Fe-engineered mesoporous silica nanocarrier. This nanocomposite degrades in acidic tumors to release Fe3+ and gallate, forming GA-Fe nanocomplex in situ for direct oxidative damage to tumors, providing insights for future anticancer research.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Oncology

IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells

Ksenia Magidey-Klein et al.

Summary: Our study uncovers a new role for tumor-derived IL-6 in promoting the differentiation of HSPCs into prometastatic MDPs, which further differentiate into immunosuppressive monocytes to facilitate the metastatic process.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Add to Collection

Article Engineering, Biomedical

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Melissa P. Lokugamage et al.

Summary: This study optimized the design of lipid nanoparticles for the efficient delivery of therapeutic mRNA to the lungs via nebulization, resulting in protection of mice from a lethal challenge of H1N1 influenza A virus and more efficient delivery of mRNA compared to LNPs previously optimized for systemic delivery. The cluster approach to LNP design may facilitate the optimization of LNPs for other administration routes and therapeutics.

NATURE BIOMEDICAL ENGINEERING (2021)

Add to Collection

Review Oncology

Cancer stem cell-immune cell crosstalk in tumour progression

Defne Bayik et al.

Summary: The development of tumors is affected by cellular heterogeneity and an immunosuppressive tumor microenvironment, which interact with each other and lead to therapeutic resistance. The interaction between cancer stem cells and infiltrating immune cell populations in the tumor microenvironment promotes tumor development and immune evasion.

NATURE REVIEWS CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

Ashley M. Laughney et al.

NATURE MEDICINE (2020)

Add to Collection

Review Oncology

Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update

Joseph A. Clara et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Add to Collection

Article Engineering, Environmental

Citrate Controls Fe(II)-Catalyzed Transformation of Ferrihydrite by Complexation of the Labile Fe(III) Intermediate

Anxu Sheng et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

CD44 regulates epigenetic plasticity by mediating iron endocytosis

Sebastian Mueller et al.

NATURE CHEMISTRY (2020)

Add to Collection

Review Cell Biology

Iron Metabolism in Ferroptosis

Xin Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Iron and redox cycling. Do's and don'ts

W. H. Koppenol et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

DMT1 and iron transport

Izumi Yanatori et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Add to Collection

Article Multidisciplinary Sciences

Biosynthesis of magnetic nanoparticles from nano-degradation products revealed in human stem cells

Aurore Van de Walle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Transferrin Cycle and Clinical Roles of Citrate and Ascorbate in Improved Iron Metabolism

Aviva Levina et al.

ACS CHEMICAL BIOLOGY (2019)

Add to Collection

Review Oncology

Targeting Ferroptosis to Iron Out Cancer

Behrouz Hassannia et al.

CANCER CELL (2019)

Add to Collection

Article Oncology

Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments

Shreya Raghavan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Add to Collection

Article Multidisciplinary Sciences

Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma

Carl Maximilian Thielmann et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Oncology

Kruppel like factor 6 splice variant 1 (KLF6-SV1) overexpression recruits macrophages to participate in lung cancer metastasis by up-regulating TWIST1

Jian Wang et al.

CANCER BIOLOGY & THERAPY (2019)

Add to Collection

Review Biotechnology & Applied Microbiology

Non-invasive delivery strategies for biologics

Aaron C. Anselmo et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Add to Collection

Article Cell Biology

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8(+) T cells

Ruihua Ma et al.

NATURE CELL BIOLOGY (2018)

Add to Collection

Article Oncology

Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment

Christina Mertens et al.

ONCOIMMUNOLOGY (2018)

Add to Collection

Review Medicine, General & Internal

The Role of Deferiprone in Iron Chelation

Robert C. Hider et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Cancer stem cells revisited

Eduard Batlle et al.

NATURE MEDICINE (2017)

Add to Collection

Review Biotechnology & Applied Microbiology

Targeting iron metabolism in drug discovery and delivery

Bart J. Crielaard et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Add to Collection

Article Immunology

Anti-CD47 Antibody As a Targeted Therapeutic Agent for Human Lung Cancer and Cancer Stem Cells

Liang Liu et al.

FRONTIERS IN IMMUNOLOGY (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies

C. Raggi et al.

ONCOGENE (2016)

Add to Collection

Article Oncology

Silencing stem cell factor attenuates stemness and inhibits migration of cancer stem cells derived from Lewis lung carcinoma cells

Li Wang et al.

TUMOR BIOLOGY (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Add to Collection

Review Immunology

Macrophages and Iron Metabolism

Miguel P. Soares et al.

IMMUNITY (2016)

Add to Collection

Article Multidisciplinary Sciences

Antiangiogenic therapy using endostatin increases the number of ALDH plus lung cancer stem cells by generating intratumor hypoxia

Yang Yu et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Dextran: Influence of Molecular Weight in Antioxidant Properties and Immunomodulatory Potential

Vinicius C. Soeiro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Add to Collection

Article Oncology

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

David L. Schonberg et al.

CANCER CELL (2015)

Add to Collection

Review Immunology

Macrophage iron homeostasis and polarization in the context of cancer

Michaela Jung et al.

IMMUNOBIOLOGY (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Nanotechnology approaches for inhalation treatment of lung diseases

Andriy Kuzmov et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection

Article Oncology

Cancer Stem-like Cells Derived from Chemoresistant Tumors Have a Unique Capacity to Prime Tumorigenic Myeloid Cells

Tsunaki Yamashina et al.

CANCER RESEARCH (2014)

Add to Collection

Review Biochemistry & Molecular Biology

The role of iron and reactive oxygen species in cell death

Scott J. Dixon et al.

NATURE CHEMICAL BIOLOGY (2014)

Add to Collection

Article Neurosciences

Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells

Susobhan Sarkar et al.

NATURE NEUROSCIENCE (2014)

Add to Collection

Article Multidisciplinary Sciences

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

Wan-Jiun Chen et al.

NATURE COMMUNICATIONS (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Lysosomal Iron, Iron Chelation, and Cell Death

Alexei Terman et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Add to Collection

News Item Pharmacology & Pharmacy

Comprehensive care and care at the center of the new recommendation HAS

Elisa Derrien

ACTUALITES PHARMACEUTIQUES (2012)

Add to Collection

Article Multidisciplinary Sciences

Interactions between cancer stem cells and their niche govern metastatic colonization

Ilaria Malanchi et al.

NATURE (2012)

Add to Collection

Review Immunology

Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype

Gaetano Cairo et al.

TRENDS IN IMMUNOLOGY (2011)

Add to Collection

Article Biochemistry & Molecular Biology

C11-BODIPY581/591, an oxidation-sensitive fluorescent lipid peroxidation probe:: (Micro)spectroscopic characterization and validation of methodology

GPC Drummen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.