Journal
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Volume 31, Issue 21, Pages E940-E948Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.5435/JAAOS-D-23-00164
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This review discusses the impact of common human systemic diseases on bone homeostasis and the molecular mechanisms involved. Understanding key pathways in bone biology can lead to improved treatment and recognition of bone homeostasis-related diseases by surgeons.
Some of the most common human systemic diseases-both benign and malignant-affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.
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