Medical and procedural treatment of androgenetic alopecia - Where are we?

Letter Dermatology

Randomized clinical trial of low-dose oral minoxidil for the treatment of female pattern hair loss: 0.25 mg versus 1 mg

Marcella Nascimento e Silva et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Letter Dermatology

Effects of exosome from adipose-derived stem cell on hair loss: A retrospective analysis of 39 patients

Byung-Soon Park et al.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

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Article Dermatology

Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients A Network Meta-analysis

Aditya K. Gupta et al.

Summary: This study compared the efficacy of minoxidil, dutasteride, and finasteride in the treatment of male androgenetic alopecia (AGA). The results revealed differences in efficacy among different drugs and doses at various endpoints, contributing to the comparative effectiveness literature for AGA therapies.

JAMA DERMATOLOGY (2022)

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Letter Dermatology

Efficacy and safety profile of oral spironolactone use for androgenic alopecia: A systematic review

JaBreia F. James et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

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Article Dermatology

Platelet-Rich Plasma Monotherapies for Androgenetic Alopecia: A Network Meta-Analysis and Meta-Regression Study

Aditya K. Gupta et al.

Summary: Our analysis of 25 trials showed that the efficacy of PRP treatment regimens is influenced by the frequency of PRP sessions, chemical activation, number of centrifugations, age and sex of patients, and the design of PRP administration. High session frequency, chemically-activated PRP, double centrifugation, younger age, female sex, and whole-head administration were associated with improved PRP efficacy in increasing total hair density at 6 months from baseline.

JOURNAL OF DRUGS IN DERMATOLOGY (2022)

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Review Dermatology

Photobiomodulation for the management of hair loss

Angeli Eloise Torres et al.

Summary: Photobiomodulation, also known as low-level laser therapy, is an emerging modality for hair loss treatment. It has been shown to be safe and potentially effective, with devices coming in various forms including LED models that are more affordable and easier for home use. However, limitations such as cost and risk of information bias need to be considered.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2021)

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Article Surgery

Photobiomodulation: The Clinical Applications of Low-Level Light Therapy

Graeme Ewan Glass

Summary: LLLT has shown clinical efficacy in skin rejuvenation, acne vulgaris, alopecia, and body contouring, but challenges remain in regulating and standardizing this therapy. The existing body of clinical evidence supports the effectiveness of low-energy red/near-infrared light, but methodological flaws and industry funding require improvement in evidence quality. The use of light-emitting diode sources and their comparative physiological effects to laser-based systems need further investigation in high-quality, independent clinical trials.

AESTHETIC SURGERY JOURNAL (2021)

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Article Dermatology

Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

David-Dan Nguyen et al.

Summary: This study investigated the potential association between finasteride use and suicidal tendencies, depression, and anxiety, finding a disproportional signal primarily in younger patients with alopecia. The findings suggest that younger patients and those with alopecia may be more vulnerable to these adverse effects of finasteride, but further research is needed to confirm these findings.

JAMA DERMATOLOGY (2021)

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Editorial Material Dermatology

Ongoing Concerns Regarding Finasteride for the Treatment of Male-Pattern Androgenetic Alopecia

Roger S. Ho

JAMA DERMATOLOGY (2021)

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Article Dermatology

Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients

Sergio Vano-Galvan et al.

Summary: The study showed that low-dose oral minoxidil has a good safety profile for treating hair loss, with hypertrichosis being the most common adverse effect. Systemic adverse effects were infrequent, and only a small percentage of patients discontinued treatment due to adverse effects.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

Temporal Trends and Clinician Variability in Potassium Monitoring of Healthy Young Women Treated for Acne With Spironolactone

John S. Barbieri et al.

Summary: Despite increasing evidence and guidelines supporting the elimination of potassium monitoring among healthy young women treated for acne with spironolactone, the present study findings suggest that potassium monitoring remains common, with substantial variability in clinician practices. There is a need for future implementation and dissemination research to understand underlying factors for this variation and to develop strategies to address this practice gap.

JAMA DERMATOLOGY (2021)

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Article Dermatology

Nutraceuticals

Glynis Ablon

DERMATOLOGIC CLINICS (2021)

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Article Dermatology

Hair transplantation: Basic overview

Francisco Jimenez et al.

Summary: This article discusses the basic techniques of modern hair restoration surgery and the evolution of hair transplantation techniques. It also focuses on male androgenetic alopecia, female pattern hair loss, and which scalp conditions are suitable for hair transplantation surgery.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Article Dermatology

Energy-based Devices for Hair Loss

James T. Pathoulas et al.

DERMATOLOGIC CLINICS (2021)

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Article Dermatology

Hair Transplantation and Follicular Unit Extraction

Kristina Collins et al.

Summary: Patient preoperative evaluation and management, as well as preoperative and postoperative medical management, are crucial for improving long-term hair loss results. Surgeons need to consider the long-term trajectory of hair loss to plan the transplant and choose the harvesting method based on patient characteristics.

DERMATOLOGIC CLINICS (2021)

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Article Pharmacology & Pharmacy