Hyperperfusion syndrome after superficial temporal artery-middle cerebral artery bypass for non-moyamoya steno-occlusive disease

Background and Objectives: Stroke is a major cause of morbidity and mortality world-wide, and intracranial stenoses increase the risk for stroke. Superficial temporal artery to middle cerebral artery bypass can be beneficial in selected patients with non-moya-moya steno-occlusive disease, however data is limited regarding the postoperative occurrence of hyperperfusion syndrome in this population. This case series describes the outcomes and complications, including hyperperfusion, in these patients who underwent bypass. Methods: This is a retrospective review of bypass procedures done for medically refractory intracranial stenosis ata single institution by a single surgeon between 2014 and 2021. Results: 30 patients underwent 33 bypass procedures for unequivocal non-moyamoya steno-occlusive disease. All patients had immediate bypass patency on post-operative day one. Major perioperative complications (9%) included one stroke and two cases of hyperperfusion syndrome. Minor perioperative complications (12%) included two seizures, one superficial wound infection and one deep vein thrombosis. Modified Rankin Score improved in 20 patients (74%), wors-ened in one patient (4%), and remained stable in seven patients (22%) at the last fol-low up. Twenty-three patients (85%) had scores < 2. The recurrent stroke rate was 3% at 30 days and 7% at two years. The bypass patency rate at one year was 87.5%. Conclusion: In this series, bypass for patients with medically refractory non-moya-moya steno-occlusive disease was well tolerated and effective, with overall favorable outcomes. The occurrence of hyperperfusion syndrome is rare but significant and should be considered in post-operative management of this population.

Automated summary

This case series retrospective study reports the outcomes and complications, including the occurrence of hyperperfusion syndrome, in patients who underwent vascular reconstruction surgery. The results suggest that vascular reconstruction is feasible and effective for patients with unequivocal non-moyamoya steno-occlusive disease, and overall favorable outcomes were observed. Although rare, the occurrence of hyperperfusion syndrome should still be considered in the postoperative management of patients.