Changes in human sweat metabolome conditioned by severity of obstructive sleep apnea and intermittent hypoxemia

Article Cardiac & Cardiovascular Systems

Large-Scale Metabolomics and the Incidence of Cardiovascular Disease

Lars Lind et al.

Summary: This study explored the relationship between a wide range of circulating metabolites and future cardiovascular disease (CVD) as well as subclinical markers of CVD in the general population.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2023)

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Article Respiratory System

[Translated article] International consensus document on obstructive sleep apnea

Olga Mediano et al.

ARCHIVOS DE BRONCONEUMOLOGIA (2022)

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Article Medicine, Research & Experimental

Plasma profiling reveals a blood-based metabolic fingerprint of obstructive sleep apnea

Lucia Pinilla et al.

Summary: The study investigated the plasma metabolome and lipidome of patients with suspected OSA to identify potential biomarkers for diagnosis and understand the underlying mechanisms of the disease. Results showed a plasma profile comprising 33 metabolites in OSA patients, with a specific 4-metabolite signature providing high accuracy for OSA detection. CPAP treatment led to changes in 5 plasma metabolites affected by OSA, indicating a potential for personalized OSA management using blood-based biomarkers and suggesting adaptive mechanisms in response to OSA-induced hypoxia.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

Severe Obstructive Sleep Apnea Disrupts Vigilance-State-Dependent Metabolism

Felix Schmidt et al.

Summary: This study aims to apply the latest findings on vigilance-state-dependent metabolism in healthy subjects to OSA patients, and investigate how symptomatic OSA affects metabolism, and whether these changes can explain the metabolic and cardiovascular consequences of OSA. The results show that there are differences in metabolism between symptomatic OSA patients and the control group, involving major metabolic pathways in carbohydrate, amino acid, and lipid metabolism.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Clinical Neurology

Impact of Desaturation Patterns versus Apnea- Hypopnea Index in the Development of Cardiovascular Comorbidities in Obstructive Sleep Apnea Patients

Nathan Blekic et al.

Summary: This article reviews the different phenotypes and clinical characteristics of obstructive sleep apnea (OSA), and analyzes various measurements of hypoxemia in OSA. It is found that new quantitative markers are associated with cardiovascular mortality. Therefore, using multidimensional models to classify patients and focusing on specific phenotypes that may develop cardiovascular comorbidities can help guide more aggressive management of OSA.

NATURE AND SCIENCE OF SLEEP (2022)

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Article Cardiac & Cardiovascular Systems

Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community

Shashwati Dutta et al.

Summary: The study found that metabolites were associated with cardiac function, energy- and lipid-storage metabolites were related to left ventricular wall thickness and mass, and plasma levels of nicotine metabolite cotinine were linked to increased time spent with a sleep oxygen saturation less than 90%. Smokers with sleep apnoea had a significantly higher risk for adverse outcomes. Central sleep apnoea was significantly associated with heart failure with preserved ejection fraction (HFpEF) but not heart failure with reduced ejection fraction.

ESC HEART FAILURE (2022)

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Review Medicine, Research & Experimental

The Value of Oxygen Desaturation Index for Diagnosing Obstructive Sleep Apnea: A Systematic Review

Nur H. A. Rashid et al.

Summary: There is significant heterogeneity in studies comparing ODI and AHI, with a suggestion to consider a 4% ODI of >= 15 events/hour for diagnosing adult OSA and a further evaluation recommendation for a 4% ODI >= 10 events/hour. Screening with oximetry may be indicated for detecting OSA in select patients. Further research is required before a definitive recommendation can be made.

LARYNGOSCOPE (2021)

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Review Pathology

Salivary biomarkers associated with obstructive sleep apnea: a systematic review

Sompop Bencharit et al.

Summary: The study aimed to define and characterize salivary biomarker changes in sleep apnea. Findings show that biomarkers like alpha-amylase, myeloperoxidase, and IL-6 are associated with OSA. Salivary cortisol and alpha-amylase appear to be related to the severity of OSA and its treatment outcomes.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2021)

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Review Peripheral Vascular Disease

Obstructive sleep apnea and ambulatory blood pressure monitoring: current evidence and research gaps

Andrea Pio-Abreu et al.

Summary: Obstructive Sleep Apnea (OSA) is associated with blood pressure instability, particularly nocturnal hypertension. Non-dipping blood pressure pattern may be independently related to OSA and serve as a screening tool. OSA may also lead to white-coat effect, masked hypertension, and increased blood pressure variability.

JOURNAL OF HUMAN HYPERTENSION (2021)

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Article Physiology

Metabolomic profiles are reflective of hypoxia-induced insulin resistance during exercise in healthy young adult males

Lee M. Margolis et al.

Summary: This study reveals that during metabolically matched aerobic exercise in acute high-altitude conditions, exogenous glucose oxidation is decreased and insulin resistance is weakened, impacting metabolic profiles. These differences indicate that acute hypoxia-mediated insulin resistance may be the underlying cause for diminished exogenous glucose oxidative capacity.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community

Shashwati Dutta et al.

Summary: Metabolites were found to be associated with cardiac function, LV wall thickness, and mass, while nicotine metabolite cotinine was associated with increased time spent with a sleep oxygen saturation less than 90%, indicating a significant hazard for smokers with sleep apnoea.

ESC HEART FAILURE (2021)

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Article Medicine, General & Internal

Metabo-tip: a metabolomics platform for lifestyle monitoring supporting the development of novel strategies in predictive, preventive and personalised medicine

Julia Brunmair et al.

Summary: This study introduced a method called metabo-tip for analyzing metabolites in sweat, providing information about ingested substances and individual metabolic activities. Results showed that the assay could detect changes in sweat composition after consuming different substances and could be applied to observe metabolic processes of orally ingested medications, indicating the impact of daily endogenous metabolic activities on sweat composition.

EPMA JOURNAL (2021)

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Review Respiratory System

Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review

Xiaoman Zhang et al.

Summary: This study reviewed the changes in metabolomic and microbiome associated with obstructive sleep apnoea (OSA) and identified specific metabolites and microorganisms involved. The findings suggest that certain changes in metabolism and microbiota may play a key role in the pathophysiology of OSA and OSA-induced cardiovascular complications. Metabolomic and microbiome biomarkers provide insights into the pathogenesis of OSA and help in early diagnosis and treatment.

EUROPEAN RESPIRATORY REVIEW (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Beyond the classic risk factors in atherosclerosis - the promise of metabolomics and other-omics in life-style acquired cardiovascular diseases

Pawel Rubis

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Sleep Disordered Breathing and Cardiovascular Disease JACC State-of-the-Art Review

Martin R. Cowie et al.

Summary: Sleep disordered breathing can lead to nocturnal hypoxemia, excessive daytime sleepiness, and is common in people with cardiovascular disease or at risk. Current therapy includes weight loss, exercise, and positive airway pressure, but PAP treatment has not shown improvement in cardiovascular outcomes in randomized trials.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Multidisciplinary Sciences

The effect of obstructive sleep apnea on peripheral blood amino acid and biogenic amine metabolome at multiple time points overnight

Ott Kiens et al.

Summary: The study found significant alterations in serum profiles of amino acid and biogenic amines in patients with OSA compared to controls, suggesting vast pathophysiologic shifts reflected in the systemic metabolism. Significant elevations in alanine, proline, and kynurenine concentrations in OSA patients were detected, as well as changes in overnight dynamics of other amino acids.

SCIENTIFIC REPORTS (2021)

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Article Respiratory System

Evaluation of a multicomponent grading system for obstructive sleep apnoea: the Baveno classification

Winfried J. Randerath et al.

Summary: Recent research indicates that the Baveno classification system, which incorporates symptoms and comorbidities, offers a more effective stratification of obstructive sleep apnoea (OSA) patients and provides better guidance for treatment decisions.

ERJ OPEN RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Cardiovascular Diseases

Emilie Dubois-Deruy et al.

ANTIOXIDANTS (2020)

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Article Respiratory System

Cardiometabolic comorbidities in obstructive sleep apnea patients are related to disease severity, nocturnal hypoxemia, and decreased sleep quality

Stephanie Andre et al.

RESPIRATORY RESEARCH (2020)

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Review Genetics & Heredity

Urea cycle disorders-update

Shirou Matsumoto et al.

JOURNAL OF HUMAN GENETICS (2019)

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Chronic paradoxical sleep deprivation-induced depressionlike behavior, energy metabolism and microbial changes in rats

Weini Ma et al.

LIFE SCIENCES (2019)

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Article Clinical Neurology

Nondipping Nocturnal Blood Pressure Predicts Sleep Apnea in Patients With Hypertension

Sophie J. Crinion et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2019)

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Article Multidisciplinary Sciences

The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis

Bahar Yetkin-Arik et al.

SCIENTIFIC REPORTS (2019)

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Article Cardiac & Cardiovascular Systems

Association Between Sleep Apnea and Blood Pressure Control Among Blacks: Jackson Heart Sleep Study

Dayna A. Johnson et al.

CIRCULATION (2019)

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Article Respiratory System

Sex differences in obstructive sleep apnoea

Maria R. Bonsignore et al.

EUROPEAN RESPIRATORY REVIEW (2019)

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Review Biochemistry & Molecular Biology

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

Eunae Sandra Cho et al.

BIOMOLECULES & THERAPEUTICS (2018)

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Article Clinical Neurology

Pediatric Obstructive Sleep Apnea is Associated With Changes in the Oral Microbiome and Urinary Metabolomics Profile: A Pilot Study

Huajun Xu et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2018)

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Review Clinical Neurology

Biomarkers of dementia in obstructive sleep apnea

Andree-Ann Baril et al.

SLEEP MEDICINE REVIEWS (2018)

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Article Otorhinolaryngology

The Ignored Parameter in the Diagnosis of Obstructive Sleep Apnea Syndrome: The Oxygen Desaturation Index

Dastan Temirbekov et al.

TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY (2018)

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Article Clinical Neurology

Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline

Vishesh K. Kapur et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2017)

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Article Cardiac & Cardiovascular Systems

Sleep Apnea Types, Mechanisms, and Clinical Cardiovascular Consequences

Shahrokh Javaheri et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Endocrinology & Metabolism

Urinary Metabolomic Signatures in Obstructive Sleep Apnea through Targeted Metabolomic Analysis: A Pilot Study

Kumsun Cho et al.

METABOLOMICS (2017)

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Article Pediatrics

Circulating branched-chain amino acids in children with obstructive sleep apnea

Antonia Barcelo et al.

PEDIATRIC PULMONOLOGY (2017)

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Article Chemistry, Analytical

Development of a method for enhancing metabolomics coverage of human sweat by gas chromatography-mass spectrometry in high resolution mode

M. M. Delgado-Povedano et al.

ANALYTICA CHIMICA ACTA (2016)

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Article Multidisciplinary Sciences

Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers

Huajun Xu et al.

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Review Critical Care Medicine

Intermittent Hypoxemia and OSA Implications for Comorbidities

Naresh A. Dewan et al.

CHEST (2015)

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Article Endocrinology & Metabolism

Fusion of the 1H NMR data of serum, urine and exhaled breath condensate in order to discriminate chronic obstructive pulmonary disease and obstructive sleep apnea syndrome

Adam Zabek et al.

METABOLOMICS (2015)

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Review Critical Care Medicine

On the cutting edge of obstructive sleep apnoea: where next?

Atul Malhotra et al.

LANCET RESPIRATORY MEDICINE (2015)

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Review Chemistry, Analytical

Sweat: A sample with limited present applications and promising future in metabolomics

A. Mena-Bravo et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2014)

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Effect of sleep deprivation on the human metabolome

Sarah K. Davies et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Fingerprinting-based metabolomic approach with LC-MS to sleep apnea and hypopnea syndrome: A pilot study

Alessia Ferrarini et al.

ELECTROPHORESIS (2013)

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Relationship of oxidative stress and endothelial dysfunction in sleep apnoea

B. Jurado-Gamez et al.

EUROPEAN RESPIRATORY JOURNAL (2011)

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Increased incidence of coronary artery disease in sleep apnoea: a long-term follow-up

Y. Peker et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

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Article Critical Care Medicine

Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea

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Changes in human sweat metabolome conditioned by severity of obstructive sleep apnea and intermittent hypoxemia

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