Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 27, Issue 21, Pages 3210-3213Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E16-02-0098
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Funding
- Skin Cancer Foundation
- American Skin Association
- Searles Foundation
- Smith Family Foundation
- Melanoma Research Alliance
- National Institutes of Health [CA154531-05, GM117150-01]
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The nuclear envelope, composed of two lipid bilayers and numerous accessory proteins, has evolved to house the genetic material of all eukaryotic cells. In so doing, the nuclear envelope provides a physical barrier between chromosomes and the cytoplasm. Once believed to be highly stable, recent studies demonstrate that the nuclear envelope is prone to rupture. These rupture events expose chromosomal DNA to the cytoplasmic environment and have the capacity to promote DNA damage. Thus nuclear rupture may be an unappreciated mechanism of mutagenesis.
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