Journal
MOLECULAR BIOLOGY OF THE CELL
Volume 27, Issue 14, Pages 2145-2148Publisher
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E15-10-0698
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Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.
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