Journal
JOURNAL OF RHEUMATOLOGY
Volume 50, Issue 9, Pages 1103-1113Publisher
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.2022-0827
Keywords
autoimmunity; interferons; myositis; systemic lupus erythematosus; Sjogren syndrome
Categories
Ask authors/readers for more resources
This article reviews the role and potential drivers of IFN-I dysregulation in five prototypic autoimmune diseases and discusses current therapeutic strategies targeting the IFN-I system.
Type I interferon (IFN-I) is thought to play a role in many systemic autoimmune diseases. IFN-I pathway activation is associated with pathogenic features, including the presence of autoantibodies and clinical phenotypes such as more severe disease with increased disease activity and damage. We will review the role and potential drivers of IFN-I dysregulation in 5 prototypic autoimmune diseases: systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, primary Sjogren syndrome, and systemic sclerosis. We will also discuss current therapeutic strategies that directly or indirectly target the IFN-I system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available