Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 33, Issue 10, Pages 2735-2743Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msw124
Keywords
phylogenetics; evolution; tree metrics; genetics; sequencing
Funding
- Engineering and Physical Sciences Research Council [EP/K026003/1]
- EPSRC [EP/K026003/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K026003/1] Funding Source: researchfish
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Evolutionary relationships are frequently described by phylogenetic trees, but a central barrier in many fields is the difficulty of interpreting data containing conflicting phylogenetic signals. We present a metric-based method for comparing trees which extracts distinct alternative evolutionary relationships embedded in data. We demonstrate detection and resolution of phylogenetic uncertainty in a recent study of anole lizards, leading to alternate hypotheses about their evolutionary relationships. We use our approach to compare trees derived from different genes of Ebolavirus and find that the VP30 gene has a distinct phylogenetic signature composed of three alternatives that differ in the deep branching structure.
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