4.7 Article

Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation

Related references

Note: Only part of the references are listed.
Review Chemistry, Medicinal

Targeting the HSP90-CDC37-kinase chaperone cycle: A promising therapeutic strategy for cancer

Lei Wang et al.

Summary: Heat shock protein 90 (HSP90) is crucial in cancer cells, but its inhibitors have limited efficacy and side effects. Researchers are investigating the disruption of the HSP90-CDC37-kinase complex as an alternative solution to avoid limitations.

MEDICINAL RESEARCH REVIEWS (2022)

Review Chemistry, Medicinal

Inhibitors of bromodomain and extra-terminal proteins for treating multiple human diseases

Ewelina Kulikowski et al.

Summary: The clinical development of BET protein inhibitors is unique, as they are being widely evaluated for treating various human diseases due to their novel mechanism of action. Among the BET protein family, BRD4 is extensively studied, and its activity at latent enhancers is a representative example of BET protein function. The role of BET proteins in embryonic development, cancer, cardiovascular, autoimmune, and metabolic diseases makes them attractive targets for therapeutic intervention.

MEDICINAL RESEARCH REVIEWS (2021)

Article Cell Biology

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

Mariesa J. Slaughter et al.

Summary: The study demonstrates that HDAC inhibitors robustly increase a low-abundance histone 4 polyacetylation state, which then re-targets lysine-acetyl readers such as BRD4, affecting gene expression similarly to bromodomain inhibition.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

Julia Bergild McBrien et al.

NATURE (2020)

Article Multidisciplinary Sciences

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

Christopher C. Nixon et al.

NATURE (2020)

Article Cell Biology

HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer

Hengyi Shao et al.

MOLECULAR BIOLOGY OF THE CELL (2020)

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Review Cell Biology

Born to run: control of transcription elongation by RNA polymerase II

Fei Xavier Chen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Editorial Material Virology

Hsp90: a key target in HIV infection

Aaron P. Smith et al.

FUTURE VIROLOGY (2017)

Article Chemistry, Medicinal

Drug Discovery Targeting Bromodomain-Containing Protein 4

Zhiqing Liu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Cell Biology

The HSP90 chaperone machinery

Florian H. Schopf et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

The HSP90 Molecular Chaperone-An Enigmatic ATPase

Laurence H. Pearl

BIOPOLYMERS (2016)

Article Oncology

BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling

Guillaume Andrieu et al.

CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

Ballachanda N. Devaiah et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

Ballachanda N. Devaiah et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

Chen Shen et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Phthalimide conjugation as a strategy for in vivo target protein degradation

Georg E. Winter et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Heat shock protein 90 controls HIV-1 reactivation from latency

Ian Anderson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

Zichong Li et al.

NUCLEIC ACIDS RESEARCH (2013)

Review Biochemistry & Molecular Biology

RNA Polymerase II Elongation Control

Qiang Zhou et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Article Cell Biology

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

Camellia Banerjee et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2012)

Review Biochemical Research Methods

Assignment of Protein Interactions from Affinity Purification/Mass Spectrometry Data

Mercedes Pardo et al.

JOURNAL OF PROTEOME RESEARCH (2012)

Article Microbiology

Hyperthermia Stimulates HIV-1 Replication

Ferdinand Roesch et al.

PLOS PATHOGENS (2012)

Article Biochemical Research Methods

Differential Proteomics Based on 18O Labeling to Determine the Cyclin Dependent Kinase 9 lnteractome

Karel Bezstarosti et al.

JOURNAL OF PROTEOME RESEARCH (2010)

Article Biochemical Research Methods

Universal sample preparation method for proteome analysis

Jacek R. Wisniewski et al.

NATURE METHODS (2009)

Article Biochemistry & Molecular Biology

Brd4 recruits P-TER to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

Zhiyuan Yang et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Chemistry, Medicinal

Structure-based design of 7-carbamate analogs of geldanamycin

G Rastelli et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Biochemistry & Molecular Biology

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein brd4

ZY Yang et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

SH Chao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)